A Case of Renal Metastasis of Urothelial Carcinoma With Trophoblastic Differentiation Successfully Treated With Robot-Assisted Partial Nephrectomy

Q4 Medicine

IJU Case Reports Pub Date : 2025-07-13 DOI:10.1002/iju5.70072

Seiichiro Honda, Koichi Uemura, Hiroki Ito, Erika Muraoka, Tomoyuki Tatenuma, Yusuke Ito, Kentaro Muraoka, Hisashi Hasumi, Naomi Kawano, Shoji Yamanaka, Kazuhide Makiyama

{"title":"A Case of Renal Metastasis of Urothelial Carcinoma With Trophoblastic Differentiation Successfully Treated With Robot-Assisted Partial Nephrectomy","authors":"Seiichiro Honda, Koichi Uemura, Hiroki Ito, Erika Muraoka, Tomoyuki Tatenuma, Yusuke Ito, Kentaro Muraoka, Hisashi Hasumi, Naomi Kawano, Shoji Yamanaka, Kazuhide Makiyama","doi":"10.1002/iju5.70072","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Introduction</h3>\n \n <p>There are no previous reports of solitary renal metastases from urothelial carcinoma with trophoblastic differentiation, a rare bladder cancer subtype that is pathologically hCGβ positive.</p>\n </section>\n \n <section>\n \n <h3> Case Presentation</h3>\n \n <p>A 77-year-old male with urothelial carcinoma with trophoblastic differentiation underwent robot-assisted radical cystectomy following neoadjuvant chemotherapy. Pathological examination revealed urothelial carcinoma, classified as ypT2b and ypN0 with detection of focal hCGβ positivity. Postoperatively, serum hCGβ levels decreased from 1.6 to < 0.2 mIU/mL. At the 9-month follow-up, serum hCGβ was elevated to 20.1 mIU/mL with no recurrence on PET-CT. Gemcitabine–cisplatin chemotherapy was initiated; however, a solitary renal tumor was detected. Partial nephrectomy confirmed that the tumor was a renal metastasis of bladder cancer. Serum hCGβ levels decreased and remained < 0.2 mIU/mL, even 20 months after partial nephrectomy.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>We report a case of urothelial carcinoma with trophoblastic differentiation and elevated serum hCGβ levels, in which a solitary renal metastasis was successfully resected by robot-assisted partial nephrectomy.</p>\n </section>\n </div>","PeriodicalId":52909,"journal":{"name":"IJU Case Reports","volume":"8 5","pages":"480-484"},"PeriodicalIF":0.0000,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/iju5.70072","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IJU Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/iju5.70072","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction

There are no previous reports of solitary renal metastases from urothelial carcinoma with trophoblastic differentiation, a rare bladder cancer subtype that is pathologically hCGβ positive.

Case Presentation

A 77-year-old male with urothelial carcinoma with trophoblastic differentiation underwent robot-assisted radical cystectomy following neoadjuvant chemotherapy. Pathological examination revealed urothelial carcinoma, classified as ypT2b and ypN0 with detection of focal hCGβ positivity. Postoperatively, serum hCGβ levels decreased from 1.6 to < 0.2 mIU/mL. At the 9-month follow-up, serum hCGβ was elevated to 20.1 mIU/mL with no recurrence on PET-CT. Gemcitabine–cisplatin chemotherapy was initiated; however, a solitary renal tumor was detected. Partial nephrectomy confirmed that the tumor was a renal metastasis of bladder cancer. Serum hCGβ levels decreased and remained < 0.2 mIU/mL, even 20 months after partial nephrectomy.

Conclusion

We report a case of urothelial carcinoma with trophoblastic differentiation and elevated serum hCGβ levels, in which a solitary renal metastasis was successfully resected by robot-assisted partial nephrectomy.

Abstract Image

查看原文本刊更多论文

机器人辅助部分肾切除术成功治疗滋养细胞分化的尿路上皮癌肾转移1例

尿路上皮癌伴滋养细胞分化，是一种罕见的膀胱癌亚型，病理上hCGβ阳性，目前尚无单独肾转移的报道。一例77岁男性尿路上皮癌伴滋养细胞分化患者在新辅助化疗后接受机器人辅助根治性膀胱切除术。病理检查显示尿路上皮癌，分类为ypT2b和ypN0，局灶性hCGβ阳性。术后血清hCGβ水平从1.6下降至0.2 mIU/mL。随访9个月，PET-CT显示血清hCGβ升高至20.1 mIU/mL，无复发。开始吉西他滨-顺铂化疗；然而，发现一个孤立的肾肿瘤。部分肾切除术证实肿瘤为膀胱癌的肾转移。血清hCGβ水平下降并保持0.2 mIU/mL，甚至在部分肾切除术后20个月。结论我们报告了一例尿路上皮癌伴滋养细胞分化和血清hCGβ水平升高，通过机器人辅助部分肾切除术成功切除了单发肾转移。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊