Adverse Outcome of a Solitary Fibrous Tumor Originating in the Bladder

Abstract

Introduction

Solitary fibrous tumors originating in the bladder are extremely rare. While generally associated with favorable outcomes, some show invasive behavior. We report a case of a solitary fibrous tumor originating in the bladder that was treated with multimodal therapy.

Case Presentation

A 68-year-old male presented with urinary retention. Imaging revealed a well-defined 6.0 cm mass compressing the prostate. A biopsy suggested stromal sarcoma. Robot-assisted cystoprostatectomy was performed. Pathological examination revealed a solitary fibrous tumor originating from the bladder invading the prostate. Despite negative margins, lung nodules and a pelvic mass appeared 43 months postoperatively. Initially, these were treated with pazopanib, followed by doxorubicin and eribulin due to disease progression. The patient eventually transitioned to palliative care and passed away 69 months after diagnosis.

Conclusion

There are no effective systemic treatments for solitary fibrous tumors, which can lead to poor outcomes. Individualized treatment approaches are necessary.