Arthroplasty最新文献

{"title":"Prosthetic articulating spacers as a preferred option for two-stage revision arthroplasty in chronic periprosthetic joint infection.","authors":"Jiamin Lin, Hongyan Li, Yang Chen, Haiqi Ding, Qijin Wang, Jianhua Lv, Wenbo Li, Wenming Zhang, Xinyu Fang","doi":"10.1186/s42836-024-00288-6","DOIUrl":"10.1186/s42836-024-00288-6","url":null,"abstract":"<p><strong>Purpose: </strong>The study aimed to compare the infection control rates, mechanical complications, and functional outcomes between prosthetic and cement spacers in two-stage revision arthroplasty for chronic periprosthetic joint infection (PJI).</p><p><strong>Patients and methods: </strong>Data from patients treated for chronic PJI in our center from 2014 to 2023 were retrospectively collected and the patients were divided into the prosthetic spacer (PS) and cement spacer (CS) groups based on the type of spacer used for the first-stage surgeries. Data on patients' demographics and clinical scores were harvested. Infection control rates and mechanical complications were compared between the two groups by using chi-square tests and log-rank analysis.</p><p><strong>Results: </strong>The study involved 113 cases, with a mean age of 64 ± 11.45 years (range, 31-88 years), with 48 cases in the PS group, 65 in the CS group, and all patients were followed up for at least 1 year (average 52.68 ± 26.07 months). Five patients in the PS group (10.42%) and six in the CS group (9.23%) developed recurrent infections, with no significant difference found in infection control rates (P = 0.833). The joint function score after the first-stage surgeries was higher in the PS group than in the CS group (P = 0.021). The incidence of mechanical complications, including dislocation, spacer fracture, and periprosthetic fracture, was significantly lower in the PS group than in the CS group (P = 0.024). The proportion of patients who underwent second-stage surgeries was lower in the PS group than in the CS group (58.3% vs 70.77%, P = 0.169).</p><p><strong>Conclusion: </strong>For most patients with chronic PJI, PS can be used as the preferred option for two-stage revision arthroplasty.</p>","PeriodicalId":52831,"journal":{"name":"Arthroplasty","volume":"7 1","pages":"4"},"PeriodicalIF":2.3,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11714949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of three cryotherapy techniques for early post-TKA pain control in terms of efficacy and patient satisfaction: a randomized controlled trial.","authors":"Keerati Chareancholvanich, Worawut Keesukpunt, Chaturong Pornrattanamaneewong, Rapeepat Narkbunnam, Atthakorn Jarusriwanna","doi":"10.1186/s42836-024-00287-7","DOIUrl":"https://doi.org/10.1186/s42836-024-00287-7","url":null,"abstract":"<p><strong>Background: </strong>Cryotherapy is a non-pharmacological option that complements drug therapy to achieve the most comprehensive multimodal analgesia. Various techniques are currently available, including the conventional gel cold pack, the cryo-cuff, and a novel mobile cold compression device (MCCD). This study aimed to evaluate and compare three cryotherapy techniques in terms of efficacy and patient satisfaction in patients undergoing total knee arthroplasty (TKA).</p><p><strong>Methods: </strong>This prospective randomized study included 108 patients who were scheduled for primary unilateral TKA. The patients were allocated to 3 groups for postoperative cryotherapy techniques: gel cold pack, cryo-cuff, and MCCD. Scores on the visual analog scale (VAS) for pain intensity, morphine consumption, knee range of motion (ROM), knee swelling, length of hospital stay, and patient satisfaction were collected.</p><p><strong>Results: </strong>Postoperative VAS scores showed a significant difference among the groups at 8 and 72 h after surgery (P = 0.002 and 0.026, respectively). At the earliest postoperative time point, post hoc analysis demonstrated that patients in the MCCD group had lower pain scores than those in the gel cold pack (P < 0.001) and the cryo-cuff group (P = 0.030). However, cryo-cuff reduced knee swelling significantly compared to gel cold pack (P = 0.028) and MCCD (P = 0.011) at postoperative 72 h. The total satisfaction score was 86.8, 82.8, and 89.1 with gel cold pack, cryo-cuff, and MCCD, respectively.</p><p><strong>Conclusions: </strong>Cryotherapy is an adjunct to post-TKA pain control at the surgical site. MCCD has shown superior efficacy in pain reduction during the earliest postoperative period, and achieved high patient satisfaction.</p><p><strong>Trial registration: </strong>This study was registered in the Thai Clinical Trials Registry database (no. TCTR20200517002).</p>","PeriodicalId":52831,"journal":{"name":"Arthroplasty","volume":"7 1","pages":"5"},"PeriodicalIF":2.3,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11707991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to monitor and discriminate the causes of lower limb swelling during home-based rehabilitation after total knee arthroplasty? A delphi study.","authors":"Lin Yang, Hui-Wu Li, Zan-Jing Zhai, Cai-Feng Wang, Bei-Ying Wu, Jia Zhou, Wei-Wei Bian, Hong Ruan","doi":"10.1186/s42836-024-00285-9","DOIUrl":"https://doi.org/10.1186/s42836-024-00285-9","url":null,"abstract":"<p><strong>Purpose: </strong>Swelling in the lower limbs after total knee arthroplasty (TKA) affects surgical outcomes. Prolonged swelling requires monitoring and remote management during home-based rehabilitation. Causes of swelling vary but, so far, no indicators are available to monitor and identify causes of lower limb swelling, making it difficult to implement targeted interventions. This study aimed to find the indicators to monitor and identify the causes of lower limb swelling during home-based rehabilitation after TKA by literature research and consulting experts from various disciplines.</p><p><strong>Methods: </strong>The Delphi method was used. Based on literature research and analysis, a set of candidate indicators was developed. Fifteen experts from different disciplines evaluated the validity of the indicators and provided modification suggestions.</p><p><strong>Results: </strong>After two rounds of Delphi consultations, consensus was reached. Agreement scores ranged from 4.40 to 5.00, with low variability (standard deviation 0.00-0.91) and high consistency (coefficient of variation 0.00-0.20). P was less than 0.05 in Kendall's W with an agreement rate of 80.00-100%. In the final set of indicators, there were five primary indicators (representing four swelling causes and a general category), along with 23 secondary indicators and 40 tertiary indicators.</p><p><strong>Conclusions: </strong>This study preliminarily established indicators for at-home identification of post-TKA swelling caused by four distinct reasons. Further research is needed to validate the value of these indicators in distinguishing the causes of swelling.</p>","PeriodicalId":52831,"journal":{"name":"Arthroplasty","volume":"7 1","pages":"3"},"PeriodicalIF":2.3,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lewinnek zone not \"the be-all and end-all\" functional planning for acetabular component positioning in total hip arthroplasty.","authors":"Raffaele Iorio, Edoardo Viglietta, Federico Corsetti, Yuri Gugliotta, Carlo Massafra, Daniele Polverari, Andrea Redler, Nicola Maffulli","doi":"10.1186/s42836-024-00284-w","DOIUrl":"https://doi.org/10.1186/s42836-024-00284-w","url":null,"abstract":"<p><strong>Background: </strong>Proper positioning of a total hip arthroplasty (THA) plays a crucial role in the success and long-term survivorship of the implant. Cup positioning within the Lewinnek Safe Zone (LSZ) does not, however, avoid implant dislocation. Thus, the concept of a functional cup position has been introduced. The purpose of this study was to assess the discrepancy between LSZ and the acetabular cup position suggested by the patient's specific functional planning. The hypothesis was that a mismatch does exist.</p><p><strong>Methods: </strong>One hundred consecutive patients with primary hip osteoarthritis undergoing primary THA with a personalized functional preoperative planning and patient-specific cup implantation system were enrolled. Anatomical and spino-pelvic functional parameters were recorded and, for each patient, a \"safe cup orientation\" was suggested. The suggested functional safe zone was compared to the LSZ.</p><p><strong>Results: </strong>The mean suggested inclination was 39° ± 3° (range 32°-45°). The mean suggested anteversion was 21° ± 3° (range 12°-28°). The patient's functional acetabular inclination (AI) corresponded to the LSZ in one of the 100 patients, whereas the acetabular anteversion (AV) was outside the LSZ in 8 of the 100 patients. The mean pelvic tilt while standing and sitting were 0.5° ± 7° (range 21°-45°) and -6° ± 16.7° (range -63°-33°), respectively. The mean pelvic incidence was 52° ± 9.7° (range 33°-83°).</p><p><strong>Conclusion: </strong>When a functional patient's specific preoperative planning is performed, the LZS does not correspond to the patient's functional safe zone in about 8% of patients. The concept of a universal safe zone should be revisited, and a functional personalized safe zone may have to be more widely considered.</p>","PeriodicalId":52831,"journal":{"name":"Arthroplasty","volume":"7 1","pages":"2"},"PeriodicalIF":2.3,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current status of bicompartmental arthroplasty.","authors":"Yingjian Gao, Bing Yue, Weiwei Xin","doi":"10.1186/s42836-024-00283-x","DOIUrl":"10.1186/s42836-024-00283-x","url":null,"abstract":"<p><strong>Background: </strong>Bicompartmental arthroplasty (BCA) serves as a less invasive alternative to total knee arthroplasty. This review aims to present the current status of BCA. BODY: Recent literature on BCA was reviewed and synthesized from the perspectives of function, radiological assessment, patient satisfaction, survival rate, patellar tracking, satisfaction survey, and revision rate.</p><p><strong>Conclusion: </strong>BCA is beneficial for patients with bicompartmental arthritis and those suffering from deterioration in other compartments after unicompartmental knee arthroplasty (UKA). Compared to total knee arthroplasty, BCA reduces trauma, accelerates recovery, and improves sports ability. While BCA is evolving towards a more exciting future, more clinical studies are warranted to exploit its potential and validate its efficacy, eventually improving outcomes and patient satisfaction.</p>","PeriodicalId":52831,"journal":{"name":"Arthroplasty","volume":"7 1","pages":"1"},"PeriodicalIF":2.3,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conference Proceedings for the 10th Annual Meeting of Arthroplasty Society in Asia (ASIA), 26th Annual Meeting of the Thai Hip and Knee Society (THKS), and the 16th Annual Meeting of the ASEAN Arthroplasty Association (AAA).","authors":"","doi":"10.1186/s42836-024-00286-8","DOIUrl":"10.1186/s42836-024-00286-8","url":null,"abstract":"","PeriodicalId":52831,"journal":{"name":"Arthroplasty","volume":"6 Suppl 1","pages":"62"},"PeriodicalIF":2.3,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11660440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DAIR for periprosthetic joint infections-One week to save the joint?","authors":"Vatsal Gupta, Shafiq Shahban, Michael Petrie, Peter K Kimani, Jakub Kozdryk, Bryan Riemer, Richard King, Richard Westerman, Pedro Foguet","doi":"10.1186/s42836-024-00282-y","DOIUrl":"10.1186/s42836-024-00282-y","url":null,"abstract":"<p><strong>Background: </strong>Predicting the success of a Debridement, Antibiotics, and Implant Retention (DAIR) procedure for periprosthetic joint infection (PJI) for hip and knee joint arthroplasty remains a challenge. A failed DAIR might adversely affect the outcome of any future revision surgery for PJI. Hence, the ability to identify and optimize factors predictive of DAIR success would help target the procedure to the appropriate patient cohort and avoid unnecessary surgery for patients where a DAIR is unlikely to eradicate infection.</p><p><strong>Methods: </strong>A retrospective review of our prospective Bone Infection Group database was performed to identify all patients who underwent a DAIR of their primary or revision hip or knee arthroplasty. All patients had a confirmed PJI as per MSIS 2013 criteria and an outcome according to the MSIS working group outcome-reporting tool. DAIR surgery was then grouped into groups of \"successful\" or \"unsuccessful\" outcomes.</p><p><strong>Results: </strong>Sixty-four consecutive patients with an acute PJI underwent a DAIR procedure between 2009 and 2020, with 46 procedures performed for knees and 18 for hips. Treatment was successful in 69% (37 knees and 7 hips). The chance of a successful DAIR was significantly greater if performed at or within one week of symptom onset compared to greater than one-week duration (adjusted odds ratio (OR) 0.11; P = 0.027; 95% CI [0.02-0.78])). For DAIR performed at or within one week of symptom onset, the success rate was 93% for knees and 80% for hips. The chance of a successful DAIR however was not influenced by whether the surgeon was an arthroplasty or non-arthroplasty surgeon (OR 0.28; P = 0.13; 95% CI [0.05-1.48])). Isolated Streptococcus infection had a success rate of 100%. Next came Coagulase-negative Staphylococci (71%) and Methicillin-susceptible Staphylococcus Aureus (65%). Polymicrobial infection had the worst outcome, with a success rate of 40%.</p><p><strong>Conclusion: </strong>In our experience, DAIR surgery performed within one week of symptom onset significantly increased the chance of successful infection eradication. Collaborative work is required to ensure arthroplasty patients can access prompt appropriate surgical decision-making as soon as concerns arise, remove barriers to early assessment and minimise delays to surgery.</p>","PeriodicalId":52831,"journal":{"name":"Arthroplasty","volume":"6 1","pages":"61"},"PeriodicalIF":2.3,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11619623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The distribution of Coronal Plane Alignment of the Knee (CPAK) phenotypes in the Malaysian population and their correlation with demographic variables.","authors":"Wai Kit Wong, Azliana Abu Bakar Sajak, Hwa Sen Chua","doi":"10.1186/s42836-024-00281-z","DOIUrl":"10.1186/s42836-024-00281-z","url":null,"abstract":"<p><strong>Background: </strong>Only 80% of patients are satisfied with their outcomes post-TKA. Mounting attention has been paid to constitutional limb alignment and individualized alignment strategies in recent years. MacDessi et al. proposed the CPAK classification, which takes into account the patients' arithmetic hip-knee-ankle axis (aHKA) and joint line obliquity (JLO). In this study, we aimed to establish local demographic data, compare them with published data, and assess their correlations with modifiable variables.</p><p><strong>Methods: </strong>A total of 500 end-stage osteoarthritic knees subjected to TKA were radiologically analyzed. The lateral distal femoral angle (LDFA) and medial proximal tibial angle (MPTA) were calculated from long limb radiographs before the aHKA and JLO were derived and a CPAK phenotype was assigned. Demographic data were harvested and analyzed for possible correlations.</p><p><strong>Results: </strong>There were 160 males (32%) and 340 females (68%), with a mean age of 66.42 years (range, 47-88). The mean MPTA was 85.8° (± 3.0)°, and the mean LDFA was 87.6° (± 2.4)°. The average aHKA was a varus of 1.8° (± 4.2)°, and the average JLO was 173.4° (± 3.45)°. The most common CPAK phenotype was Type 1 (43.4%). The Intraclass Correlation Coefficient demonstrated excellent reliability (> 0.9). No correlation existed between CPAK phenotypes and age, height, weight, or body mass index (BMI), but CPAK phenotype was significantly correlated with gender.</p><p><strong>Conclusion: </strong>An urban Malaysian population with osteoarthritic knees was found to be constitutionally varus, with the most common phenotype being varus aHKA with an apex-distal JLO. Constitutional alignment is not influenced by factors such as age, height, weight, or BMI.</p><p><strong>Level of evidence: </strong>Retrospective Observational Study-III.</p>","PeriodicalId":52831,"journal":{"name":"Arthroplasty","volume":"6 1","pages":"60"},"PeriodicalIF":2.3,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11616210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is the clinical utility of acoustic and vibrational analyses in uncemented total hip arthroplasty?","authors":"Shlok Patel, Christian J Hecht, Yasuhiro Homma, Atul F Kamath","doi":"10.1186/s42836-024-00280-0","DOIUrl":"10.1186/s42836-024-00280-0","url":null,"abstract":"<p><strong>Background: </strong>Despite recent developments in THA, a more objective method is needed to assist orthopedic surgeons in identifying the insertion endpoint of the broaching procedure. Therefore, this systematic review evaluated the in-vivo efficacy of various acoustic and vibration analyses in detecting proper implant seating, identifying intraoperative complications, and quantifying the accuracy of predictive modeling using acoustics.</p><p><strong>Methods: </strong>Four electronic databases were searched on July 23rd, 2023, to retrieve articles evaluating the use of acoustic analysis during THA. The search identified 835 unique articles, which were subsequently screened by two independent reviewers as per our inclusion and exclusion criteria. In total, 12 studies evaluating 580 THAs were found to satisfy our criteria and were included in this review.</p><p><strong>Results: </strong>Methodologically, analyses have suggested stopping broaching when consecutive blows emit similar acoustic profiles (maximum peak frequency ± 0.5 kHz), which indicates proper implant seating in terms of stability and mitigates subsidence. Also, abrupt large deviations from the typical progression of acoustic signals while broaching are indicative of an intraoperative fracture. Since height, weight, femoral morphological parameters, and implant type have been shown to alter acoustic emissions while hammering, incorporating these factors into models to predict subsidence or intraoperative fracture yielded virtually 100% accuracy in identifying these adverse events.</p><p><strong>Conclusion: </strong>These findings support that acoustic analyses during THA show promise as an accurate, objective, and non-invasive method to predict and detect proper implant fixation as well as to identify intraoperative fractures.</p><p><strong>Trial registration: </strong>PROSPERO registration of the study protocol: CRD42023447889, 23 July 2023.</p>","PeriodicalId":52831,"journal":{"name":"Arthroplasty","volume":"6 1","pages":"59"},"PeriodicalIF":2.3,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11613849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticle ultrasonication: a promising approach for reducing bacterial biofilm in total joint infection-an in vivo rat model investigation.","authors":"Itay Ashkenazi, Mark Longwell, Barbara Byers, Rachael Kreft, Roi Ramot, Muhammad A Haider, Yair Ramot, Ran Schwarzkopf","doi":"10.1186/s42836-024-00279-7","DOIUrl":"10.1186/s42836-024-00279-7","url":null,"abstract":"<p><strong>Background: </strong>While the benefits of sonication for improving periprosthetic joint infection (PJI) are well-documented, its potential therapeutic effect against bacterial biofilm remains unstudied. This study aimed to investigate the safety and efficacy of a novel nanoparticle ultrasonication process on methicillin-resistant Staphylococcus aureus (MRSA) bacterial biofilm formation in a PJI rat model.</p><p><strong>Methods: </strong>This novel ultrasonication process was designed to remove attached bacterial biofilm from implant and peri-articular tissues, without damaging native tissues or compromising implant integrity. Twenty-five adult Sprague-Dawley rats underwent a surgical procedure and were colonized with intra-articular MRSA, followed by the insertion of a titanium screw. Three weeks after the index surgery, the animals received a second procedure during which the screws were explanted, and soft tissue was sampled. The intraoperative use of the nanoparticle sonication treatment was employed to assess the device's safety, while ex vivo treatment on the retrieved tissue and implants was used to evaluate its efficacy.</p><p><strong>Results: </strong>Clinical and histological assessments did not indicate any macro- or micro-damage to the host tissue. Sonication of the retrieved tissues demonstrated an average bacterial removal of 2 × 10³ CFU/mL and 1 × 10⁴ CFU/gram of tissue. Compared to the standard-of-care group (n = 10), implants treated with sonication (n = 15) had significantly lower remaining bacteria, as indicated by crystal violet absorbance measurements (P = 0.012).</p><p><strong>Conclusions: </strong>This study suggests that nanoparticle sonication technology can successfully remove attached bacterial biofilms from explanted orthopedic hardware and the joint capsule, without negatively affecting native tissue. The study provides initial results supporting the potential of nanoparticle sonication as an adjuvant treatment option during a DAIR (debridement, antibiotics, and implant retention) procedure for PJI, paving the way for future clinical trials.</p>","PeriodicalId":52831,"journal":{"name":"Arthroplasty","volume":"6 1","pages":"57"},"PeriodicalIF":2.3,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11539774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}