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[Lights and Shadows of Lecanemab: Post-diagnosis Support for People with Dementia Receiving Early Diagnosis]. [来卡尼单抗的光与影：为接受早期诊断的痴呆症患者提供诊断后支持]。
Brain and Nerve Pub Date : 2024-09-01 DOI: 10.11477/mf.1416202724
Naoko Tsunoda, Mamoru Hashimoto
{"title":"[Lights and Shadows of Lecanemab: Post-diagnosis Support for People with Dementia Receiving Early Diagnosis].","authors":"Naoko Tsunoda, Mamoru Hashimoto","doi":"10.11477/mf.1416202724","DOIUrl":"10.11477/mf.1416202724","url":null,"abstract":"<p><p>The advent of lecanemab is a hope not only for people with dementia and their families but also for society as a whole. However, the effectiveness of lecanemab is limited, and the need to inform patients of their dementia may emphasize negative aspects more than ever as \"early diagnosis leads to early despair.\" In this situation, it is important to provide post-diagnostic support to make the \"time spent living with dementia,\" which is prolonged by lecanemab, as meaningful as possible. In this review, the authors introduce the \"Peer Support Activities for people with mild dementia and their families,\" a post-diagnosis support program for those diagnosed early in the course of the disease.</p>","PeriodicalId":52507,"journal":{"name":"Brain and Nerve","volume":"76 9","pages":"997-1003"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Advances in Headache and Future Prospects]. [头痛研究进展与未来展望]。
Brain and Nerve Pub Date : 2024-08-01 DOI: 10.11477/mf.1416202709
Eiichiro Nagata
{"title":"[Advances in Headache and Future Prospects].","authors":"Eiichiro Nagata","doi":"10.11477/mf.1416202709","DOIUrl":"10.11477/mf.1416202709","url":null,"abstract":"<p><p>Headache is the most common condition encountered in neurological practice. However, despite the burden to patients, migraine, a typical primary headache, is not life-threatening, and evaluation shows no abnormalities; therefore, it is often treated using analgesics. Moreover, patients often do not visit hospitals and clinics because over-the-counter analgesics, such as nonsteroidal anti-inflammatory drugs are easily available. However, many patients continue to experience headaches. Migraine therapy has progressed remarkably following the advent of calcitonin gene-related peptide antibody drugs in recent years. Many patients with migraine do not visit hospitals and clinics and do not receive appropriate treatment. Therefore, in the future, neurologists will need to play a key role in patient education and in training physicians to enable accurate diagnosis of headaches.</p>","PeriodicalId":52507,"journal":{"name":"Brain and Nerve","volume":"76 8","pages":"923-931"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Peripheral Neuropathy (Numbness): Role of Neurologists as Primary Gatekeepers]. [周围神经病（麻木）：神经科医生作为主要守门人的作用]。
Brain and Nerve Pub Date : 2024-08-01 DOI: 10.11477/mf.1416202711
Michiaki Koga
{"title":"[Peripheral Neuropathy (Numbness): Role of Neurologists as Primary Gatekeepers].","authors":"Michiaki Koga","doi":"10.11477/mf.1416202711","DOIUrl":"10.11477/mf.1416202711","url":null,"abstract":"<p><p>The prevalence of peripheral neuropathies has increased over the years, and novel treatments for management of several neuropathies have emerged over the past decade. Following a literature search of the ICHUSHI database, we observed that recent literature on peripheral neuropathy most frequently includes reports from the orthopedic specialty, followed by studies reported by the neurology service. Notably, the number of studies reported by the neurology departments has increased over the past decade. However, most patients with common peripheral neuropathies do not visit the neurology department. Therefore, it is necessary to highlight the role of neurologists for comprehensive evaluation and management of neuromuscular disorders. This may result in acknowledgement of neurology as the primary gatekeeper of peripheral neurological diseases.</p>","PeriodicalId":52507,"journal":{"name":"Brain and Nerve","volume":"76 8","pages":"947-951"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Tumefactive Demyelinating Lesions]. [肿瘤活动性脱髓鞘病变］
Brain and Nerve Pub Date : 2024-08-01 DOI: 10.11477/mf.1416202712
Yuki Mizumoto, Tetsuya Abe
{"title":"[Tumefactive Demyelinating Lesions].","authors":"Yuki Mizumoto, Tetsuya Abe","doi":"10.11477/mf.1416202712","DOIUrl":"10.11477/mf.1416202712","url":null,"abstract":"<p><p>Tumefactive demyelinating lesions (TDL), defined as inflammatory demyelinating lesions, may develop either during treatment for multiple sclerosis and related disorders or as the first demyelinating episode without any past medical history suggesting demyelination. If the latter, it would be so delicate to diagnose as demyelination. Especially in such situations, biopsy is often necessary in addition to neuroimaging for distinction TDL with tumorous or infectious diseases. In this article, we will review about concept, epidemiology, diagnosis, and treatment of TDL.</p>","PeriodicalId":52507,"journal":{"name":"Brain and Nerve","volume":"76 8","pages":"953-960"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Progress and Challenges in Epilepsy Treatment]. [癫痫治疗的进展与挑战]。
Brain and Nerve Pub Date : 2024-08-01 DOI: 10.11477/mf.1416202708
Naoki Akamatsu
{"title":"[Progress and Challenges in Epilepsy Treatment].","authors":"Naoki Akamatsu","doi":"10.11477/mf.1416202708","DOIUrl":"10.11477/mf.1416202708","url":null,"abstract":"<p><p>Neurologists have played an important role in the treatment of adult epilepsy for more than 60 years since the establishment of the Japanese Society of Neurology. The terminology used in epileptology in Japan is adopted from that used by the International League Against Epilepsy. The terminology for seizures observed in temporal lobe epilepsy has transitioned from psychomotor to complex partial and currently to focal impaired awareness seizures. Second- and third-generation anti-seizure medications (ASM) are currently available, and several new first-line agents have emerged in clinical practice. ASM that are relatively safe for the fetus during pregnancy are currently available, and advances have been made in research and treatment of epilepsy in the elderly population. Although surgical treatment for epilepsy is advancing, it is not widely performed in Japan. We hope that neurologists continue to contribute to epilepsy care.</p>","PeriodicalId":52507,"journal":{"name":"Brain and Nerve","volume":"76 8","pages":"917-921"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Role of Neurologists in Stroke Treatment]. [神经科医生在中风治疗中的作用]。
Brain and Nerve Pub Date : 2024-08-01 DOI: 10.11477/mf.1416202707
Ichiro Deguchi, Masaki Takao
{"title":"[Role of Neurologists in Stroke Treatment].","authors":"Ichiro Deguchi, Masaki Takao","doi":"10.11477/mf.1416202707","DOIUrl":"10.11477/mf.1416202707","url":null,"abstract":"<p><p>Determination of indications for acute reperfusion therapy (intravenous recombinant tissue plasminogen activator administration and mechanical thrombectomy) and identification of stroke mimics and chameleons are essential components of effective stroke treatment. Moreover, neurologists select the appropriate medications and manage the patient's general condition. Therefore, a neurologist's solid diagnostic skills based on neurological symptomatology and an internist's broad knowledge and insight play key roles clinically.</p>","PeriodicalId":52507,"journal":{"name":"Brain and Nerve","volume":"76 8","pages":"911-916"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Role of Neurologists in Dementia Practice]. [神经科医生在痴呆症实践中的作用]。
Brain and Nerve Pub Date : 2024-08-01 DOI: 10.11477/mf.1416202706
Etsuro Mori
{"title":"[Role of Neurologists in Dementia Practice].","authors":"Etsuro Mori","doi":"10.11477/mf.1416202706","DOIUrl":"10.11477/mf.1416202706","url":null,"abstract":"<p><p>The September 2013 issue of this journal contains an article titled \"The Role of Neurologists in Dementia Practice\" in which I have highlighted the contributions of neurologists to dementia care. I have emphasized the importance of proactive leadership within interdisciplinary teams that include general practitioners and psychiatrists. Following the implementation of the Basic Act on Dementia to Promote an Inclusive Society and advances in medical science, such as introduction of the anti-Alzheimer drug lecanemab, neurologists are expected to play a more active role in dementia management and require more specialized skills. The emergence of lecanemab has led to more direct involvement of neurologists in dementia practice, which has resulted in the emergence of \"novice\" dementia specialists. However, a shortage of neurologists who specialize in behavioral neurology remains a significant concern in Japan. This challenge is compounded by the inadequate education of general neurologists in this domain, because dementia management requires deep knowledge and skills in behavioral neurology. The most important and urgent issue is to promptly address this shortage. Although neurologists' involvement in dementia practice is attributable to the introduction of lecanemab, I sincerely look forward to neurologists transitioning from \"novice\" to \"real\" experts in dementia. I reiterate this call as a recommendation to fellow neurologists, emphasizing the need to evolve into true specialists in the field.</p>","PeriodicalId":52507,"journal":{"name":"Brain and Nerve","volume":"76 8","pages":"903-910"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Vertigo/Dizziness as a Common Disease: Thinking in Terms of Risk]. [眩晕/头晕作为一种常见疾病：从风险角度思考]。
Brain and Nerve Pub Date : 2024-08-01 DOI: 10.11477/mf.1416202710
Toshio Fukutake
{"title":"[Vertigo/Dizziness as a Common Disease: Thinking in Terms of Risk].","authors":"Toshio Fukutake","doi":"10.11477/mf.1416202710","DOIUrl":"https://doi.org/10.11477/mf.1416202710","url":null,"abstract":"<p><p>Vertigo and dizziness are among the most common chief complaints in the neurology and emergency departments. Benign, self-limiting peripheral causes such as benign positional paroxysmal vertigo or vestibular neuropathy, Ménière's disease are the majority, but dangerous underlying conditions such as cerebrovascular or cardiovascular diseases are still overlooked. In this paper, the anatomy of the vestibular network from peripheral to central and the classification based on \"triggers and timing\" rather than the analysis of patient's word (rotational versus dizzy) are presented. Based on these, I classify various causes of vertigo and dizziness into three groups, i.e. highly dangerous, less dangerous but cautionary, and benign self-limiting ones, and explain them focusing on isolated vertigo or isolated vestibular syndrome.</p>","PeriodicalId":52507,"journal":{"name":"Brain and Nerve","volume":"76 8","pages":"933-946"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Stiff-Person Syndrome: Results of the First Nationwide Survey in Japan]. [僵人综合症：日本首次全国性调查的结果]。
Brain and Nerve Pub Date : 2024-08-01 DOI: 10.11477/mf.1416202713
Naoko Matsui, Keiko Tanaka, Yuishin Izumi
{"title":"[Stiff-Person Syndrome: Results of the First Nationwide Survey in Japan].","authors":"Naoko Matsui, Keiko Tanaka, Yuishin Izumi","doi":"10.11477/mf.1416202713","DOIUrl":"https://doi.org/10.11477/mf.1416202713","url":null,"abstract":"<p><p>Stiff-person syndrome (SPS) is a rare autoimmune neurological disorder characterized by progressive axial muscle stiffness, central nervous system hyperexcitability, and painful stimulus-sensitive muscle spasms. A nationwide survey performed in 2018 showed the estimated prevalence of SPS was 0.2 per 100,000 population. Most patients with SPS had antibodies against glutamic acid decarboxylase 65, followed by antibodies to the glycine receptor α-subunit. Usually, patients with SPS showed favorable outcomes; however, some studies have reported intractable SPS. Early diagnosis and aggressive immunotherapy are necessary for management of patients with SPS.</p>","PeriodicalId":52507,"journal":{"name":"Brain and Nerve","volume":"76 8","pages":"961-967"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Investigation of the Neural Basis of Social Interactions Using Hyperscanning Functional Magnetic Resonance Imaging]. [利用超扫描功能磁共振成像研究社会互动的神经基础]。
Brain and Nerve Pub Date : 2024-07-01 DOI: 10.11477/mf.1416202692
Norihiro Sadato
{"title":"[Investigation of the Neural Basis of Social Interactions Using Hyperscanning Functional Magnetic Resonance Imaging].","authors":"Norihiro Sadato","doi":"10.11477/mf.1416202692","DOIUrl":"10.11477/mf.1416202692","url":null,"abstract":"<p><p>Hyperscanning functional magnetic resonance imaging (fMRI) was developed to gain deeper insight into the neural basis of social cognition. Simultaneous imaging of brain activity in multiple subjects facilitates analysis of the neural basis of real-time interactions and communication. This method reveals the neural basis of social interactions, including inter-individual synchronization as a phenomenon that cannot be reduced to individuals. This modality enables research into the neural mechanisms underlying social interactions that are integral to many aspects of our lives. I will outline the background, current status, and prospects of development of hyperscanning fMRI, which may be an important methodology in the shift from \"first-person\" neuroscience (which refers to the interaction between individuals and the environment) to \"second-person\" neuroscience (which refers to the application of neuroscientific methods to investigate inter-individual associations).</p>","PeriodicalId":52507,"journal":{"name":"Brain and Nerve","volume":"76 7","pages":"843-850"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141545531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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