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[Prognostic Counseling in Patients with Isolated REM Sleep Behavior Disorder].
Brain and Nerve Pub Date : 2025-03-01 DOI: 10.11477/mf.188160960770030271
Masayuki Miyamoto
{"title":"[Prognostic Counseling in Patients with Isolated REM Sleep Behavior Disorder].","authors":"Masayuki Miyamoto","doi":"10.11477/mf.188160960770030271","DOIUrl":"https://doi.org/10.11477/mf.188160960770030271","url":null,"abstract":"<p><p>Long-term follow-up studies have shown that middle-aged and elderly people with isolated REM sleep behavior disorder (RBD) have a high risk of developing alpha-synucleinopathy. In order to respond appropriately to these patients, it is necessary to confirm the diagnosis of RBD using video-polysomnography(v-PSG) and provide prognostic counseling that takes into account future life plans based on patient backgrounds and family conditions. This article provides an overview of prognostic counseling for isolated RBD, including a sleep specialist's perspective on disclosing the risks of phenoconversion associated with isolated RBD.</p>","PeriodicalId":52507,"journal":{"name":"Brain and Nerve","volume":"77 3","pages":"271-279"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Diagnostic Communication for Alzheimer's Disease].
Brain and Nerve Pub Date : 2025-03-01 DOI: 10.11477/mf.188160960770030251
Kenji Wada
{"title":"[Diagnostic Communication for Alzheimer's Disease].","authors":"Kenji Wada","doi":"10.11477/mf.188160960770030251","DOIUrl":"https://doi.org/10.11477/mf.188160960770030251","url":null,"abstract":"<p><p>The introduction of amyloid positron emission tomography and cerebrospinal fluid biomarkers, along with the advent of anti-amyloid β antibodies, has brought about significant changes in the diagnosis and treatment of dementia. Furthermore, new technologies, such as plasma biomarkers, are being developed. Therefore, it is increasingly important to accurately convey the latest and most appropriate information in daily clinical practice. This paper outlines the latest diagnostic criteria, advancements in diagnostic technology, and anti-amyloid β antibody therapy for Alzheimer's disease, and discusses important points in communicating diagnoses.</p>","PeriodicalId":52507,"journal":{"name":"Brain and Nerve","volume":"77 3","pages":"251-257"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Women's Life Stages and Migraine].
Brain and Nerve Pub Date : 2025-03-01 DOI: 10.11477/mf.188160960770030221
Hisaka Igarashi
{"title":"[Women's Life Stages and Migraine].","authors":"Hisaka Igarashi","doi":"10.11477/mf.188160960770030221","DOIUrl":"https://doi.org/10.11477/mf.188160960770030221","url":null,"abstract":"<p><p>Migraine is a neurological disorder characterized by a high degree of disruption to life. The prevalence of migraines is high among women in their 20s to 40s. The hormonal milieu has a substantial effect on migraines in women. An understanding of these hormonal influences at various stages of life (menstrual cycle, pregnancy, puerperium, menopause, and use of hormone therapy) is essential for the management and prevention of migraines. It is important to identify patients' priorities and consider them to select and support treatment options, such as the treatment of severe menstrual migraine, treatment options when complicated by endometriosis, and the choice of medication during pregnancy and lactation.</p>","PeriodicalId":52507,"journal":{"name":"Brain and Nerve","volume":"77 3","pages":"221-226"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Gender-Specific Medicine and Shared Decision-Making in Parkinson's Disease].
Brain and Nerve Pub Date : 2025-03-01 DOI: 10.11477/mf.188160960770030227
Masahiro Nagai
{"title":"[Gender-Specific Medicine and Shared Decision-Making in Parkinson's Disease].","authors":"Masahiro Nagai","doi":"10.11477/mf.188160960770030227","DOIUrl":"https://doi.org/10.11477/mf.188160960770030227","url":null,"abstract":"<p><p>Sex differences have been reported to influence the clinical symptoms of Parkinson's disease and the pharmacokinetics and side effects of anti-Parkinsonian drugs. However, these aspects have rarely been considered in clinical practice. Information regarding drug therapy during pregnancy is insufficient owing to the high proportion of elderly patients. Device-aided therapies are used to treat motor complications in patients with advanced Parkinson's disease. As it is a highly invasive therapy, shared decision-making is important for its introduction.</p>","PeriodicalId":52507,"journal":{"name":"Brain and Nerve","volume":"77 3","pages":"227-231"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Shared Decision-Making in Patients with Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder].
Brain and Nerve Pub Date : 2025-03-01 DOI: 10.11477/mf.188160960770030233
Nobuaki Yoshikura, Takayoshi Shimohata
{"title":"[Shared Decision-Making in Patients with Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder].","authors":"Nobuaki Yoshikura, Takayoshi Shimohata","doi":"10.11477/mf.188160960770030233","DOIUrl":"https://doi.org/10.11477/mf.188160960770030233","url":null,"abstract":"<p><p>In multiple sclerosis and neuromyelitis optica spectrum disorders, several new, highly effective drugs have been developed in recent years, and the prognosis for patients has improved. However, treatment has become more complex, and healthcare professionals should explain the efficacy and safety of drugs to patients and engage in shared decision-making (SDM) that considers the patient's preferences and values. Further studies are required to determine whether SDM is associated with patient outcomes.</p>","PeriodicalId":52507,"journal":{"name":"Brain and Nerve","volume":"77 3","pages":"233-237"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Sex-Based Differences and Shared Decision-Making in Myasthenia Gravis].
Brain and Nerve Pub Date : 2025-03-01 DOI: 10.11477/mf.188160960770030245
Noriko Isobe
{"title":"[Sex-Based Differences and Shared Decision-Making in Myasthenia Gravis].","authors":"Noriko Isobe","doi":"10.11477/mf.188160960770030245","DOIUrl":"https://doi.org/10.11477/mf.188160960770030245","url":null,"abstract":"<p><p>Myasthenia gravis is an autoimmune disease of the neuromuscular junctions. Studies have shown that its prevalence is slightly higher in females, that female patients are more refractory to treatment, and that their post-treatment quality of life is more difficult to improve. Recently, multiple novel treatment options have become available, and more opportunities for shared decision-making are being observed in the process of treatment selection. Thus, it is necessary to choose the best treatment for each patient through detailed explanations regarding the disease and adequate consideration of sex-based differences.</p>","PeriodicalId":52507,"journal":{"name":"Brain and Nerve","volume":"77 3","pages":"245-249"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Ethical Issues in Collaborative Decision-Making for Intractable Neurological Diseases: Focusing on Misunderstandings and Confusion regarding Advance Care Planning].
Brain and Nerve Pub Date : 2025-03-01 DOI: 10.11477/mf.188160960770030203
Koichiro Itai
{"title":"[Ethical Issues in Collaborative Decision-Making for Intractable Neurological Diseases: Focusing on Misunderstandings and Confusion regarding Advance Care Planning].","authors":"Koichiro Itai","doi":"10.11477/mf.188160960770030203","DOIUrl":"https://doi.org/10.11477/mf.188160960770030203","url":null,"abstract":"<p><p>Medical professionals should play the role of a guide runner in collaborative decision-making. If the guide runner is too fast compared to the athlete, the athlete is disqualified. If he is too slow, he is nothing but a nuisance. The guide runner provides firm guidance to the athlete so that he does not go off course; however, as the athlete is ultimately the main character, the guide runner must respect the athlete's autonomy. Doctors and other medical professionals should guide patients so that they do not \"go off course,\" but at the same time, support the patient, who is the main character, so that they can walk on their own two feet.</p>","PeriodicalId":52507,"journal":{"name":"Brain and Nerve","volume":"77 3","pages":"203-207"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Importance of "Sex- and Gender- Considerations" in Explaining Medical Conditions].
Brain and Nerve Pub Date : 2025-03-01 DOI: 10.11477/mf.188160960770030209
Miyuki Katai, Takiko Nagano
{"title":"[Importance of \"Sex- and Gender- Considerations\" in Explaining Medical Conditions].","authors":"Miyuki Katai, Takiko Nagano","doi":"10.11477/mf.188160960770030209","DOIUrl":"https://doi.org/10.11477/mf.188160960770030209","url":null,"abstract":"<p><p>Gender medicine aims to improve the quality and accuracy of medical care by considering the influence of sex difference, gender difference, and life stage (LS) in the pathophysiology, diagnosis, treatment, and prevention of diseases of the reproductive system and common diseases of both sexes. In particular, sex and gender differences exist in the risk of developing and the way symptoms manifest in cerebral and cardiovascular diseases, endocrine disorders, autoimmune diseases, and psychiatric disorders. Cranial nerve disorders also require medical care that considers gender differences and LS. In one outpatient clinic specializing in women's health, 27% of patients previously diagnosed by their previous physicians with complaints were found to have underlying organic diseases. Women are more likely to have menstrual and menopausal symptoms that mask other diseases, and the diagnosis is more likely to be missed. The tendency of women to report symptoms from the periphery, due to their reluctance to speak clearly, also makes differential diagnosis difficult in the limited clinic time available. The accuracy of diagnosis, explanation of medical conditions, and quality improvement of disease prevention and treatment is expected to be achieved when medical providers have a \"perspective and knowledge of sex and gender differences and LS.\"</p>","PeriodicalId":52507,"journal":{"name":"Brain and Nerve","volume":"77 3","pages":"209-214"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Shared Decision-Making in Chronic Inflammatory Demyelinating Polyradiculoneuropathy].
Brain and Nerve Pub Date : 2025-03-01 DOI: 10.11477/mf.188160960770030239
Yukari Sekiguchi, Sonoko Misawa
{"title":"[Shared Decision-Making in Chronic Inflammatory Demyelinating Polyradiculoneuropathy].","authors":"Yukari Sekiguchi, Sonoko Misawa","doi":"10.11477/mf.188160960770030239","DOIUrl":"https://doi.org/10.11477/mf.188160960770030239","url":null,"abstract":"<p><p>Chronic inflammatory demyelinating polyradiculoneuropathy includes various pathologies; therefore, the symptoms and course of patients are not uniform. Maintenance therapies such as intravenous and subcutaneous immunoglobulin have been introduced and require continuous outpatient care. A detailed explanation of the disease and shared decision-making with the patient are necessary to provide the best treatment for each patient. The key points for explanation in daily practice are described below.</p>","PeriodicalId":52507,"journal":{"name":"Brain and Nerve","volume":"77 3","pages":"239-243"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Challenges in Delivering the Diagnosis of Multiple System Atrophy].
Brain and Nerve Pub Date : 2025-03-01 DOI: 10.11477/mf.188160960770030265
Atsuhiko Sugiyama
{"title":"[Challenges in Delivering the Diagnosis of Multiple System Atrophy].","authors":"Atsuhiko Sugiyama","doi":"10.11477/mf.188160960770030265","DOIUrl":"https://doi.org/10.11477/mf.188160960770030265","url":null,"abstract":"<p><p>Multiple system atrophy (MSA) is a progressive, incurable neurodegenerative disease characterized by the risk of sudden death and various symptoms, including autonomic and cognitive dysfunction, as well as motor symptoms such as cerebellar ataxia and parkinsonism. These clinical features make the diagnosis of MSA challenging for neurologists. Our questionnaire survey on the delivery of an MSA diagnosis revealed that 92.3% of the participating neurologists found it difficult to deliver the diagnosis. However, 82.8% perceived explaining the risk of sudden death to be challenging. Factors independently associated with difficulties in delivering a diagnosis included perceived challenges in the differential diagnosis of MSA, conveying information about the risk of sudden death, and explaining the importance of the family's decision-making process in life-prolonging treatment. Further research is required to develop guidelines for delivering the diagnosis of MSA.</p>","PeriodicalId":52507,"journal":{"name":"Brain and Nerve","volume":"77 3","pages":"265-270"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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