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Systematic Review and Meta-analysis of Admission Inflammatory Biomarkers for Evaluating Prognosis in Acute Type A Aortic Dissection. 急性A型主动脉夹层入院炎症生物标志物评价预后的系统评价和荟萃分析。
AORTA Pub Date : 2025-10-07 DOI: 10.1055/a-2693-4070
Sarah Shirley, Alana Maerivoet, Helen L Wright, Mark Field, Jillian Madine
{"title":"Systematic Review and Meta-analysis of Admission Inflammatory Biomarkers for Evaluating Prognosis in Acute Type A Aortic Dissection.","authors":"Sarah Shirley, Alana Maerivoet, Helen L Wright, Mark Field, Jillian Madine","doi":"10.1055/a-2693-4070","DOIUrl":"https://doi.org/10.1055/a-2693-4070","url":null,"abstract":"<p><p>Acute type A aortic dissection (ATAAD) is traumatic and life-threatening involving a split of the intima media along a variable length of the aorta from aortic root to aortic bifurcation. The pathology results in a local and systemic inflammatory process with elevated inflammatory markers observed at hospital admission. This systematic literature review aimed to compare the effectiveness of admission inflammatory markers in predicting adverse outcomes in postoperative ATAAD patients. Eligibility criteria included studies reporting postoperative outcomes or receiver operating characteristic results stratified by routine admission markers of inflammation in ATAAD patients. The study protocol was registered with PROSPERO (CRD42022366509). Following abstract and full-text screening, 79 studies were included in the analysis, with 39 included in the meta-analysis. Meta-analyses using random effects models of white blood cell count, neutrophil count, and neutrophil to lymphocyte ratio stratified by survival indicated that levels were significantly lower in survivors than nonsurvivors. The mean difference for white blood cell count was 1.51 (confidence interval [CI = 1.07, 1.95]), neutrophil count 1.50 [CI = 1.05, 1.95], and neutrophil to lymphocyte ratio 3.45 [CI = 2.50, 4.41]. Similarly, survivors had lower C-reactive protein levels than nonsurvivors (standardized mean difference = 0.5227 [CI = 0.1781, 0.8672]). Conversely, lymphocyte counts were higher in survivors than nonsurvivors (mean difference = -0.12 [CI = -0.18, -0.06]). All models had significant heterogeneity despite using random effects models, likely due to the multitude of presentations. Hierarchical summary receiver operating characteristic models were performed for neutrophil-to-lymphocyte ratio and C-reactive protein and showed similar sensitivity at detecting mortality in ATAAD patients for each fixed specificity. Data showed that deranged inflammatory markers are associated with poorer outcomes in ATAAD; however, none of these measures provide suitable prognostic markers alone. Continued development of multifactorial risk scores, including inflammatory markers and other factors, such as thrombotic measures, may enable clinically relevant prognostic tools and risk stratification.</p>","PeriodicalId":52392,"journal":{"name":"AORTA","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential Protective Role of Diabetes Mellitus on Aortic Aneurysms. 糖尿病对主动脉瘤的潜在保护作用。
AORTA Pub Date : 2025-04-01 Epub Date: 2025-08-04 DOI: 10.1055/a-2624-0594
Eliza Epstein, John A Elefteriades
{"title":"Potential Protective Role of Diabetes Mellitus on Aortic Aneurysms.","authors":"Eliza Epstein, John A Elefteriades","doi":"10.1055/a-2624-0594","DOIUrl":"10.1055/a-2624-0594","url":null,"abstract":"<p><p>Prior research provided evidence that diabetes mellitus (DM) may convey protection to patients with abdominal aortic aneurysm (AAA) and/or thoracic aortic aneurysm (TAA).We sought recent publications that support or elaborate on this concept using PubMed and Cochrane, searching for publications that combine the search terms \"aortic aneurysm\" and \"diabetes mellitus.\" We collate and summarize evidence from the literature on this topic.We examined pertinent data on AAA, TAA, and aortic aneurysms in general (AA). Patients with DM have lower risk of developing AAA and a lower rate of growth of AAA. Patients with DM have a lower risk of mortality following hospitalizations for AA. That said, however, patients with DM who undergo AAA repair show higher risk of mortality. Patients with DM have lower aneurysm diameter and lower homocysteine and D-dimer levels. Research is emerging regarding a possible genetic explanation: the gene <i>PSMD12</i> may play a role in the connection between AAA and DM. Patients with AAA taking diabetic medication metformin show reduced rate of growth of AAA as well as decreased mortality and complications. In TAA, however, no statistically significant differences in mortality or complications are consistently found. We find positive evidence to support the concept that diabetes does confer protection from AAA rupture. Current data does confirm significant protective effect for TAA.We confirm that metformin does exert protective properties. Diabetic protection against AAA may be mediated via Laplace's Law, as diabetic aortas have thicker walls, thus decreasing wall tension.</p>","PeriodicalId":52392,"journal":{"name":"AORTA","volume":" ","pages":"39-45"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144785894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Valve-Sparing Aortic Root Reimplantation: Early- and Mid-Term Outcomes. 保留瓣膜的主动脉根部再植:早期和中期结果。
AORTA Pub Date : 2025-04-01 Epub Date: 2025-07-19 DOI: 10.1055/a-2642-8919
Joshua R Chen, Vishal N Shah, Scott H Koeneman, Colin King, Jacqueline McGee, Konstadinos Plestis
{"title":"Valve-Sparing Aortic Root Reimplantation: Early- and Mid-Term Outcomes.","authors":"Joshua R Chen, Vishal N Shah, Scott H Koeneman, Colin King, Jacqueline McGee, Konstadinos Plestis","doi":"10.1055/a-2642-8919","DOIUrl":"10.1055/a-2642-8919","url":null,"abstract":"<p><p>Valve-sparing root replacement (VSRR) is an alternative to traditional valve-replacing root replacement. We examined early- and mid-term outcomes after VSRR.We performed a retrospective review of a prospectively maintained aortic registry. All patients undergoing VSRR from 2005 to 2023 were included. Statistical analysis was performed in R version 4.3.1. Kaplan-Meier curves were used to describe mortality and freedom from mortality, aortic insufficiency (AI) > 1 + , and aortic valve-related reoperation.Eighty-one patients underwent VSRR, 59 (72.8%) through full sternotomy (FS) and 22 (27.2%) through upper hemisternotomy. There were no cases of AI > 1+ in the perioperative period, 1 (1.2%) stroke, and no in-hospital mortality. Mean intensive care unit and hospital stay were 3 and 7 days, respectively. Mean follow-up time was 8 years. Freedom from all-cause mortality at 1, 5, and 10 years was 100, 96.6, and 94.4%, respectively. Composite freedom from reoperation, recurrence, or mortality at 1, 5, and 10 years was 98.8, 92.1, and 87.3%, respectively.With careful preoperative selection, VSRR is a durable procedure for patients with aortic root aneurysm.</p>","PeriodicalId":52392,"journal":{"name":"AORTA","volume":" ","pages":"46-55"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Cooling Strategies on Transfusion Requirements in Aortic Hemiarch Surgery. 冷却策略对主动脉弓手术输血需求的影响。
AORTA Pub Date : 2025-04-01 Epub Date: 2025-09-17 DOI: 10.1055/a-2693-4175
Anthony V Norman, Sanjana Challa, Genevieve Lyons, Alexander M Wisniewski, Raymond J Strobel, Michael Mazzeffi, Mark Joseph, Daniel Tang, Ramesh Singh, Michael C Kontos, Mohammed Quader, Kenan Yount, Nicholas R Teman, Ourania Preventza, Jared P Beller
{"title":"Impact of Cooling Strategies on Transfusion Requirements in Aortic Hemiarch Surgery.","authors":"Anthony V Norman, Sanjana Challa, Genevieve Lyons, Alexander M Wisniewski, Raymond J Strobel, Michael Mazzeffi, Mark Joseph, Daniel Tang, Ramesh Singh, Michael C Kontos, Mohammed Quader, Kenan Yount, Nicholas R Teman, Ourania Preventza, Jared P Beller","doi":"10.1055/a-2693-4175","DOIUrl":"10.1055/a-2693-4175","url":null,"abstract":"<p><p>Deep hypothermic circulatory arrest (DHCA) is associated with coagulopathy but facilitates aortic arch surgery. Conflicting data suggest moderate hypothermic circulatory arrest (MHCA) may reduce transfusion requirements. We hypothesized MHCA would reduce transfusion requirements.We studied patients undergoing aortic hemiarch surgery for nondissected, aneurysmal disease from July 2014 to May 2023 utilizing a multicenter collaborative. Patients were stratified by DHCA (14.1-20°C) and MHCA (20.1-28°C). Packed red blood cells (pRBC), fresh frozen plasma (FFP), cryoprecipitate, and platelet transfusion requirements were assessed. A negative binomial model accounting for hospital random effect was fitted to identify risk factors for increased transfusion requirements.Of the 451 patients undergoing hemiarch surgery, 373 (83%) had MHCA and 78 (17%) had DHCA. MHCA patients had shorter cardiopulmonary bypass (135 minutes [105, 182] vs. 216 minutes [183, 263], <i>p</i> < 0.001) and circulatory arrest times (12 minutes [8, 17] vs. 21 minutes [16, 34], <i>p</i> < 0.001). MHCA patients received fewer pRBC (0 [0, 1] vs. 1 [0, 3], <i>p</i> < 0.001), FFP (0 [0, 3] vs. 2 [0, 4], <i>p</i> = 0.003), cryoprecipitate (1 [0, 1] vs. 1 [0, 2], <i>p</i> = 0.045), and platelet transfusions (0 [0, 1] vs. 2 [0, 2], <i>p</i> < 0.001). Unadjusted operative mortality was lower in the MHCA group (1.9 vs. 7.7%, <i>p</i> < 0.01). After risk adjustment, MHCA was associated with reduced FFP transfusion requirements (β = -0.48, SE = 0.2, <i>p</i> = 0.017). Increasing bypass time per minute was associated with increased pRBC (β = +0.01, 95% CI = 0.006-0.013, <i>p</i> < 0.001), FFP (β = +0.006, 95% CI = 0.004-0.009, <i>p</i> < 0.001), cryoprecipitate (β = +0.008, 95% CI = 0.005-0.01, <i>p</i> < 0.001), and platelet transfusions (β = +0.009, 95% CI = 0.006-0.011, <i>p</i> < 0.001).MHCA was associated with decreased mortality and FFP transfusions in aortic hemiarch repair. MHCA may mitigate transfusion needs via shorter cardiopulmonary bypass time compared with DHCA.</p>","PeriodicalId":52392,"journal":{"name":"AORTA","volume":" ","pages":"56-64"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12472810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Western Aortic Collaborative: Multi-institutional Aortic Surgery, Education, and Research. 西方主动脉协作组:多机构主动脉手术、教育和研究。
AORTA Pub Date : 2025-02-01 Epub Date: 2025-05-29 DOI: 10.1055/s-0045-1809344
Fenton H McCarthy, Christopher R Burke, Jason P Glotzbach, Michael P Fischbein, Anthony Caffarelli, Fernando Fleischman, T Brett Reece
{"title":"The Western Aortic Collaborative: Multi-institutional Aortic Surgery, Education, and Research.","authors":"Fenton H McCarthy, Christopher R Burke, Jason P Glotzbach, Michael P Fischbein, Anthony Caffarelli, Fernando Fleischman, T Brett Reece","doi":"10.1055/s-0045-1809344","DOIUrl":"10.1055/s-0045-1809344","url":null,"abstract":"<p><p>The Western Aortic Collaborative (WAC) is a new, hybrid, multi-institutional academic model that seeks to perform aortic surgery research and education.The WAC has three fundamental thoracic aortic surgery goals: (1) advancing surgical techniques, (2) furthering education and development of aortic surgeons, and (3) performing multi-institutional clinical research. The WAC utilizes a hybrid model of annual in-person meetings at the Western Thoracic Surgical Association (WTSA) combined with videoconferencing platforms that regularly connect surgeons dispersed throughout the Western region. The structure of WAC is intentionally horizontal. The goal is to promote cross-pollination of ideas, techniques, and experiences between surgeons at different institutions.For its research goals, the WAC first identified the principal areas of aortic surgery with the greatest knowledge gaps and which of those knowledge gaps could best be addressed by institutional practice differences within WAC. Using this natural experiment design, five high-priority research topics from the aortic root to the left subclavian artery were created. In order to perform this subspecialized, multi-institutional research, the WAC created a novel, cloud-based database that piggybacks on the Society for Thoracic Surgeon database. The combined database also preserves the ability to generate subspecialized variables and to link with each institution's medical record system for semi-automated functionality.In its inaugural year, the WAC succeeded in its primary goals of utilizing remote technology platforms and the annual WTSA meeting to create a regional community of aortic surgeons with shared research and educational goals.</p>","PeriodicalId":52392,"journal":{"name":"AORTA","volume":" ","pages":"9-13"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating Patient Outcomes and Access to Care in Aortic Surgery Based on Ethnicity and Social Vulnerability. 基于种族和社会脆弱性评估主动脉手术患者结局和获得护理的机会。
AORTA Pub Date : 2025-02-01 Epub Date: 2025-06-03 DOI: 10.1055/a-2608-1346
Ananya Shah, Adam M Carroll, Nicolas Chanes, Kyndall Hadley, Cenea Kemp, Bo Chang Brian Wu, Alejandro Suarez-Pierre, Jessica Rove, Catherine Velopulos, Muhammad Aftab, T Brett Reece
{"title":"Evaluating Patient Outcomes and Access to Care in Aortic Surgery Based on Ethnicity and Social Vulnerability.","authors":"Ananya Shah, Adam M Carroll, Nicolas Chanes, Kyndall Hadley, Cenea Kemp, Bo Chang Brian Wu, Alejandro Suarez-Pierre, Jessica Rove, Catherine Velopulos, Muhammad Aftab, T Brett Reece","doi":"10.1055/a-2608-1346","DOIUrl":"10.1055/a-2608-1346","url":null,"abstract":"<p><p>We previously demonstrated the impact of ethnicity on aortic surgery, with underrepresentation and greater acuity in minority patients, raising concerns regarding access to care. The Centers for Disease Control and Prevention's social vulnerability index (SVI) measure is increasingly used to quantify patient socioeconomic and demographic factors. This study expands on our prior work by incorporating SVI and ethnicity to analyze patient presentation and outcomes in aortic arch surgery.We utilized a single-institution database of patients who underwent total arch replacement or hemiarch repair between 2009 and 2022. A total of 837 patients were placed into five cohorts based on their self-reported race: African American, Asian, Caucasian, Hispanic, and Other, with further subdivision based on SVI (high social vulnerability, ≥75%, normal social vulnerability < 75%). Additional analyses were performed using SVI alone. We compared patient presentation, operative variables, and outcomes based on the above cohorts.African American and Hispanic patients were underrepresented compared with city demographics. High SVI and minority patients presented at younger ages (<i>p</i> = 0.007) with higher blood pressures (<i>p</i> = 0.002). These groups also had more urgent/emergent presentations (<i>p</i> < 0.001) with aortic dissections (<i>p</i> = 0.006). Operatively, high SVI groups had longer cardiopulmonary bypass (<i>p</i> = 0.018), cross-clamp (<i>p</i> = 0.020), and circulatory arrest times (<i>p</i> = 0.002) but fewer adjunctive procedures (<i>p</i> = 0.018). High SVI patients more often required total arch replacement (<i>p</i> = 0.048) and postoperative mechanical circulatory support (<i>p</i> = 0.025). After discharge, African Americans had more emergency department (ED) visits within a year (<i>p</i> < 0.001), although no significant differences were observed in readmission rates or cardiovascular follow-up.Underrepresented groups face barriers to care, as reflected in disparities in demographics, surgical acuity, and postdischarge ED usage. Analyses-based solely on ethnicity overlooked critical differences between normal and high SVI groups, emphasizing the need for care strategies that are both tailored to high SVI groups and racially sensitive applied across all levels of health care.</p>","PeriodicalId":52392,"journal":{"name":"AORTA","volume":" ","pages":"29-38"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolution of Native Aortic Valve Function following Ascending Aorta Replacement for Acute Type A Dissection. 急性A型夹层升主动脉置换术后主动脉瓣功能的演变。
AORTA Pub Date : 2025-02-01 Epub Date: 2025-06-17 DOI: 10.1055/s-0045-1809171
Nicolas Everaert, Thierry Bové, Isabelle Claus, Jens Czapla, Thomas Martens, Tine Philipsen, Katrien François
{"title":"Evolution of Native Aortic Valve Function following Ascending Aorta Replacement for Acute Type A Dissection.","authors":"Nicolas Everaert, Thierry Bové, Isabelle Claus, Jens Czapla, Thomas Martens, Tine Philipsen, Katrien François","doi":"10.1055/s-0045-1809171","DOIUrl":"10.1055/s-0045-1809171","url":null,"abstract":"<p><p>This study investigates the evolution of aortic valve function following supracoronary ascending aorta replacement (SCR) for acute type A aortic dissection (ATAAD). Factors contributing to aortic valve stability and progression of aortic valve insufficiency (AI) were examined.Patients who survived SCR for ATAAD between 2000 and 2021 were included. Univariable analyses to identify risk factors for AI grade ≥ 2 were performed, including anatomical parameters, perioperative findings, and follow-up root diameters. Evolution of aortic root dimensions was also investigated.Seventy-eight patients were included. AI grade ≥ 2 was observed in 20 (29.4%) patients during follow-up. Cumulative incidence of AI grade ≥ 2 was 4.7 ± 2.2%, 7.9 ± 3.4%, and 15.1 ± 5.5% at 1, 5, and 10 years, respectively. Aortic root reoperation was performed in three patients (4.0%) within 3 years of the index operation. Significant predictors of AI grade ≥ 2 included preoperative AI grade ≥2 (<i>p</i> = 0.037, odds ratio [OR] 1.46, 95% confidence interval [CI]: 1.02-2.09) and significant preoperative AI grade ≥ 2 in presence of at least two dissected sinuses (<i>p</i> = 0.039, OR: 2.88, 95% CI: 1.05-7.89). Diameters of the sinus of Valsalva (<i>p</i> < 0.001), sinotubular junction (<i>p</i> < 0.001), and ascending aorta graft (<i>p</i> < 0.001) increased over time. Absence of sinus of Valsalva ≥ 45 mm was 90.9, 84.9, and 80.3% at 1, 5, and 10 years, respectively.Preserving the aortic valve after ATAAD offers a viable long-term surgical option with a low need for proximal root reoperations in patients without aortic root dilatation. Significant preoperative AI, particularly in presence of extensive root dissection, are significant predictors of late AI grade ≥ 2, suggesting valve-sparing root replacement in these patients.</p>","PeriodicalId":52392,"journal":{"name":"AORTA","volume":" ","pages":"14-23"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early Outcomes of Thoracofemoral Bypass for Aortoiliac Occlusive Disease: A 10-Year Single-Center Experience. 胸股旁路治疗主动脉髂闭塞性疾病的早期结果:10年单中心经验
AORTA Pub Date : 2025-02-01 Epub Date: 2025-06-12 DOI: 10.1055/s-0045-1809704
Anil Sharma, Sunil Dixit, Mohit Sharma, Sourabh Mittal, Apurva Shah, Shefali Goyal
{"title":"Early Outcomes of Thoracofemoral Bypass for Aortoiliac Occlusive Disease: A 10-Year Single-Center Experience.","authors":"Anil Sharma, Sunil Dixit, Mohit Sharma, Sourabh Mittal, Apurva Shah, Shefali Goyal","doi":"10.1055/s-0045-1809704","DOIUrl":"10.1055/s-0045-1809704","url":null,"abstract":"<p><p>Thoracofemoral bypass is primarily utilized as a secondary intervention for juxtarenal aortoiliac occlusive disease, with limited instances of its application as an initial treatment, leading to uncertain long-term outcomes. This analysis aims to scrutinize the 10-year experience and early outcomes of 90 patients who underwent thoracofemoral bypass as a primary procedure.A retrospective analysis was conducted on patients undergoing thoracofemoral bypass for severe aortoiliac occlusive disease between August 2012 and August 2022. The primary indication was complete abdominal aorta obstruction at the renal artery level with an unsuitable site for aorta clamping. The BARD IMPRA expanded polytetrafluoroethylene vascular graft was employed for thoracobifemoral bypass surgery.Among the 90 patients, 83 (92.22%) were male, and 7 (7.78%) were female, with ages ranging from 51 to 77 years. Intraoperative and postoperative data were analyzed, and the mean follow-up duration was 30 days. The 30-day mortality rate was 3.33% (<i>n</i> = 3). Major morbidities included graft occlusion in one patient, managed by embolectomy, and ascites in another patient, addressed conservatively.This study demonstrates that thoracic aorta to femoral artery bypass, as a simple extra-anatomic bypass technique, can yield favorable outcomes when chosen as the initial treatment for patients with juxtarenal total aortoiliac occlusive disease. Thoracofemoral bypass exhibits a safe, acceptable outcome with reliable patency.</p>","PeriodicalId":52392,"journal":{"name":"AORTA","volume":" ","pages":"24-28"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202022/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Root Remodeling versus Root Reimplantation in Patients with Bicuspid Aortic Valve and Root Aneurysm. 双尖瓣主动脉瓣合并根动脉瘤患者的根重塑与根再植术。
AORTA Pub Date : 2025-02-01 Epub Date: 2025-06-12 DOI: 10.1055/s-0045-1809688
Fei Xiang, Lin Chen, Eric E Roselli, Brian Griffin, Milind Desai, Jeevanantham Rajeswaran, Austin Firth, Eugene H Blackstone, Lars G Svensson
{"title":"Root Remodeling versus Root Reimplantation in Patients with Bicuspid Aortic Valve and Root Aneurysm.","authors":"Fei Xiang, Lin Chen, Eric E Roselli, Brian Griffin, Milind Desai, Jeevanantham Rajeswaran, Austin Firth, Eugene H Blackstone, Lars G Svensson","doi":"10.1055/s-0045-1809688","DOIUrl":"10.1055/s-0045-1809688","url":null,"abstract":"<p><p>Valve-sparing root replacements are increasingly being performed in patients with bicuspid aortic valve (BAV) and root aneurysm. This study aims to compare the outcomes of patients who underwent root remodeling versus root reimplantation.From 2000 to 2022, 206 adults with BAV and root aneurysm (mean age: 47 ± 12 years, 183 [89%] male) underwent root remodeling (<i>n</i> = 32) or reimplantation (<i>n</i> = 174) at Cleveland Clinic. Compared with remodeling, patients in the reimplantation group had more aortic regurgitation (severe 61/174 [35%] vs. 3/32 [9.4%]) and smaller aortic roots (sinus diameter: 4.3 ± 0.56 vs. 4.6 ± 0.47 cm). Operative mortality and morbidity, durability, and time-related mortality were compared.Patients in both groups underwent additional aortic valve repair (reimplantation vs. remodeling group: figure-of-8 hitch-up stitch 10/174 [5.7%] vs. 14/32 [44%], <i>p</i> < 0.001; cusp plication 91/174 [52%] vs. 11/32 [34%], <i>p</i> = 0.06). Compared with the remodeling group, aortic clamp time was longer in the reimplantation group (median 136 vs. 76 minutes, <i>p</i> < 0.001). Two in-hospital reoperations occurred after remodeling from valve dysfunction. One operative death occurred in each group. At 5 years, severe aortic regurgitation was 16% after remodeling versus 5.0% after reimplantation (<i>p</i> = 0.06), mean gradient 11 versus 10 mm Hg (<i>p</i> = 0.12), aortic valve reoperation 23% versus 6.0% (<i>p</i> = 0.14), and survival 97% versus 95%, respectively (<i>p</i> = 0.71).Both root remodeling and reimplantation can be safely performed in patients with BAV and root aneurysms with similar midterm outcomes. Although root remodeling is a shorter surgery, less late aortic valve regurgitation and fewer valve reoperations lead us to recommend root reimplantation.</p>","PeriodicalId":52392,"journal":{"name":"AORTA","volume":" ","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Rare Encounter: Incidental Ectopic Origin of the Right Pulmonary Artery in an Adult. 一个罕见的遭遇:偶然异位的右肺动脉在成人。
AORTA Pub Date : 2024-12-01 Epub Date: 2025-04-29 DOI: 10.1055/a-2572-4238
Rupali Jain, Maruti Kumaran, Achala Donuru
{"title":"A Rare Encounter: Incidental Ectopic Origin of the Right Pulmonary Artery in an Adult.","authors":"Rupali Jain, Maruti Kumaran, Achala Donuru","doi":"10.1055/a-2572-4238","DOIUrl":"10.1055/a-2572-4238","url":null,"abstract":"<p><p>Ectopic origin of the right pulmonary artery (RPA) from the aorta is a rare congenital anomaly typically found in infants. We report an adult female presenting with shortness of breath diagnosed incidentally with ectopic RPA via computed tomography angiography. This case underscores the need to consider rare congenital anomalies in adults presenting with unexplained pulmonary symptoms.</p>","PeriodicalId":52392,"journal":{"name":"AORTA","volume":" ","pages":"162-163"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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