Zhangkang Li , Jamie LeBlanc , Hitendra Kumar , Hongguang Zhang , Weijun Yang , Xiao He , Qingye Lu , Jeffrey Van Humbeck , Keekyoung Kim , Jinguang Hu
{"title":"Super-anti-freezing, tough and adhesive titanium carbide and L-ornithine-enhanced hydrogels","authors":"Zhangkang Li , Jamie LeBlanc , Hitendra Kumar , Hongguang Zhang , Weijun Yang , Xiao He , Qingye Lu , Jeffrey Van Humbeck , Keekyoung Kim , Jinguang Hu","doi":"10.1016/j.jobab.2023.01.005","DOIUrl":"10.1016/j.jobab.2023.01.005","url":null,"abstract":"<div><p>Hydrogels are highly porous three-dimensional crosslinked polymer networks consisting of hydrophilic polymers, employed most practically in medicine and industry, often as biosensors. Simple hydrogels suffer limitations in their mechanical properties, such as tensile and compression, and freeze at sub-zero temperatures, which compromise their ability as useful biosensors. In this study, the incorporation of L-ornithine-based zwitterionic monomer (OZM), titanium carbide (MXene), and glycerol within polyacrylamide hydrogels was used to prepare a novel polyacrylamide/polyL-ornithine-based zwitterion/MXene (PAM/Porn/MXene) hydrogel to improve the mechanical, adhesion, and anti-freezing properties of pure polyacrylamide hydrogels. This study also analyzed the mechanical strength (tensile and compression), adhesion, and anti-freezing properties of a novel PAM/Porn/MXene hydrogel at 1%, 4%, and 10% MXene concentrations to establish to what extent the conductive MXene material enhanced these properties and concluded that the tensile and compressive properties improved linearly with the increase in the concentrations of MXene, adhesion decreased with the increased MXene concentrations, and synergistic interaction between MXene and OZM significantly improved the anti-freezing properties up to –80 °C.</p></div>","PeriodicalId":52344,"journal":{"name":"Journal of Bioresources and Bioproducts","volume":"8 2","pages":"Pages 136-145"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48414802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yi Tian , Xiaoting Zhu , Shuolin Zhou , Wenguang Zhao , Qiong Xu , Xianxiang Liu
{"title":"Efficient synthesis of alkyl levulinates fuel additives using sulfonic acid functionalized polystyrene coated coal fly ash catalyst","authors":"Yi Tian , Xiaoting Zhu , Shuolin Zhou , Wenguang Zhao , Qiong Xu , Xianxiang Liu","doi":"10.1016/j.jobab.2023.01.003","DOIUrl":"10.1016/j.jobab.2023.01.003","url":null,"abstract":"<div><p>In this study, sulfonic acid functionalized polystyrene coated coal fly ash catalyst (CFA@PS-SO<sub>3</sub>H) was designed and prepared by the post-synthesis method, which exhibited excellent catalytic performance for esterification of levulinic acid (LA) to afford alkyl levulinates. Four significant factors, including reaction time, catalyst dosage, alcohol-to-acid molar ratio and reaction temperature were evaluated systematically. Response surface methodology based on Box-Behnken design (BBD) was carried out to determine the optimal parameters. The maximum yield could reach 99.6% under the mild conditions. Furthermore, kinetics of the esterification reaction between levulinic acid and <em>n</em>-butanol were analyzed and the activation energies of the first and second step of esterification reaction were found to 52.18 and 59.81 kJ/mol, respectively. The CFA@PS-SO<sub>3</sub>H also showed high catalytic activity for the esterification of levulinic acid with other linear alcohols, which made it a low cost, environmentally friendly and promising solid catalyst for the synthesis of alkyl levulinates.</p></div>","PeriodicalId":52344,"journal":{"name":"Journal of Bioresources and Bioproducts","volume":"8 2","pages":"Pages 198-213"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43289731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eriola Betiku , Ebenezer O Olatoye , Lekan M. Latinwo
{"title":"Bioprocessing of underutilized Artocarpus altilis fruit to bioethanol by Saccharomyces cerevisiae: A fermentation condition improvement study","authors":"Eriola Betiku , Ebenezer O Olatoye , Lekan M. Latinwo","doi":"10.1016/j.jobab.2023.03.002","DOIUrl":"10.1016/j.jobab.2023.03.002","url":null,"abstract":"<div><p>Raw materials availability needed for commercial bioethanol production is one of the challenges against its global adoption. Identifying rich, cheap, underused, and readily available starch sources for bioethanol production could help address the problem. Thus, this current study investigated the bioconversion of underutilized <em>Artocarpus altilis</em> (breadfruit) starch to bioethanol using <em>Saccharomyces cerevisiae</em>. The effects of the essential fermentation conditions (fermentation time, breadfruit starch hydrolysate (BSH) concentration, pH, and inoculum size) and their interactions on bioethanol production were investigated. The central composite design was used to generate twenty-one experiments conducted under batch fermentation conditions in the laboratory. The breadfruit starch hydrolysis led to a BSH concentration of 108.9 g/L under a starch concentration of 122 g/L, microwave output of 720 W, and an incubation time of 6 min. For the fermentation of BSH, maximum bioethanol production of 4.99% (<em>V</em>) was reached under the cultivation conditions of BSH concentration of 80 g/L, medium pH of 4.7, inoculum size of 2% (<em>V</em>), and fermentation time of 20.41 h. Except for pH, the impact of each parameter on the bioethanol production was in this order: BSH concentration, inoculum size, and fermentation time. While for the interactions amongst the parameters, the impact is in this order: BSH concentration and inoculum size; BSH concentration and fermentation time; and fermentation time and inoculum size. The results of this study indicated breadfruit starch could be hydrolyzed using acid hydrolysis and microwave irradiation in a relatively short time. The BSH obtained could potentially add to other substrates for bioethanol production.</p></div>","PeriodicalId":52344,"journal":{"name":"Journal of Bioresources and Bioproducts","volume":"8 2","pages":"Pages 125-135"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48862790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yejun Deng , Xiang Wang , Caihong Zhang , Pujun Xie , Lixin Huang
{"title":"Inhibitory effect of a Chinese quince seed peptide on protein glycation: A mechanism study","authors":"Yejun Deng , Xiang Wang , Caihong Zhang , Pujun Xie , Lixin Huang","doi":"10.1016/j.jobab.2023.01.008","DOIUrl":"10.1016/j.jobab.2023.01.008","url":null,"abstract":"<div><p>Non-enzymatic glycation can cause the formation and accumulation of advanced glycation end products (AGEs), and it poses great threats to human health. It is urgent to search for safe and efficient inhibitors to prevent reducing sugar induced protein glycation. In this study, we investigated the anti-glycation activity and mechanism of an identified peptide, Asparagine-Tyrosine-Arginine-Arginine-Glutamic acid (NYRRE) from Chinese quince seed protein hydrolysate, by multispectroscopy, confocal imaging, and computational molecular simulation. Firstly, it was found that NYRRE could scavenge hydroxyl radicals and chelate Fe<sup>2+</sup>. Besides, the NYRRE was effective in every stage of fructose induced bovine serum albumin (BSA) glycation. The NYRRE could reduce the formation of fructosamine, carbonyl compounds, glycoxidation products and <em>β</em>-amyloid structure. Meanwhile, NYRRE could protect thiol groups and stabilize the spatial conformation of BSA. The NYRRE presented strong inhibition in fluorescent AGEs, and 68.19% of total AGEs formation was prevented with NYRRE at 15 mmol/L. The results of molecular simulation indicated that NYRRE could insert into the hydrophobic pocket of BSA and interact with hot spots, including arginine and lysine residues. The mechanism of NYRRE inhibiting protein glycation could be due to its antioxidant activity, BSA structure stabilizing ability, and specific bond with glycation sites of BSA. These results provided a valuable reference for developing NYRRE as an efficient antiglycation agent in preventing glycation-mediated diseases.</p></div>","PeriodicalId":52344,"journal":{"name":"Journal of Bioresources and Bioproducts","volume":"8 2","pages":"Pages 187-197"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44473239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amira Salim , Pierfrancesco Deiana , Francesco Fancello , Maria Giovanna Molinu , Mario Santona , Severino Zara
{"title":"Antimicrobial and antibiofilm activities of pomegranate peel phenolic compounds: Varietal screening through a multivariate approach","authors":"Amira Salim , Pierfrancesco Deiana , Francesco Fancello , Maria Giovanna Molinu , Mario Santona , Severino Zara","doi":"10.1016/j.jobab.2023.01.006","DOIUrl":"10.1016/j.jobab.2023.01.006","url":null,"abstract":"<div><p>Pomegranates are rich in phenolic compounds and known for their antioxidant, anti-inflammatory, and anticancer properties. The highest concentration of these compounds is found in the peel (exocarp and mesocarp), which constitutes about 50% of the whole fresh fruit. These bioactive phytochemicals exhibit a broad spectrum of antimicrobial effects against both Gram-negative and Gram-positive bacteria, as well as fungi. In the present paper, the chemical composition and antimicrobial activity of the peel (exocarp and mesocarp) from seven <em>Punica granatum</em> varieties (Wonderful, Mollar de Elche, Primosole, Sassari 1, Sassari 2, Sassari 3, and Arbara Druci) grown in Sardinia (Italy) were evaluated. Polar phenols, flavonoids, condensed tannins, and anthocyanin contents were evaluated by extraction with water at 20 and 40 °C. Orthogonal projections to latent structures discriminant analysis (OPLS-DA) was used to characterize each variety according to the chemical composition of the pomegranate peel extracts (PPEs). The antimicrobial and antibiofilm activities of each PPE were further tested in vitro against <em>Staphyloccocus aureus, Listeria monocytogenes, Salmonella bongori, Escherichia coli, Lacticaseibacillus casei</em> and <em>Limosilactobacillus reuteri</em>. Gram-positive species were more sensitive than Gram-negative to the extracts tested. Antimicrobial activity was shown against <em>S. aureus</em> and <em>L. monocytogenes</em> strains, whereas less, even no activity was found against <em>S. bongori</em> and <em>E. coli</em> strains. The PPEs from Mollar de Elche, Primosole, and Sassari 3 showed the highest antimicrobial activities at concentrations that varied from 0.19 to 1.50 mg/mL, with biofilm activity being reduced by more than 70%. These activities were positively related to the punicalagin, flavonoid, and chlorogenic acid content of the extracts. Finally, regarding the pro-technological bacterial strains, <em>La. casei</em> and <em>Li. reuteri</em> showed very low, even no sensitivity to the used of the specific PPEs with high concentrations. This study proposes a formulation of pomegranate peel extract that valorizes agro-industrial waste in the context of sustainability and circular economy. Pomegranate extracts should be considered potential sources of natural, plant-derived antimicrobials, providing an alternative to artificial antimicrobial products.</p></div>","PeriodicalId":52344,"journal":{"name":"Journal of Bioresources and Bioproducts","volume":"8 2","pages":"Pages 146-161"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46803603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of silica source on photocatalytic properties of Bi2O3/Bi2SiO5 heterostructure","authors":"O.D. Arefieva , M.S. Vasilyeva , L.A. Zemnukhova , D.P. Opra , D.A. Nikolaeva , V.V. Tkachev , D.H. Shlyk","doi":"10.1016/j.jobab.2023.03.003","DOIUrl":"10.1016/j.jobab.2023.03.003","url":null,"abstract":"<div><p>The Bi<sub>2</sub>O<sub>3</sub>/Bi<sub>2</sub>SiO<sub>5</sub> heterostructures were obtained with various samples of silica as a precursor: on the basis of biogenic silica isolated from rice husk and rice straw and the silica of mineral origin. A mixture of Bi(NO<sub>3</sub>)<sub>3</sub> and SiO<sub>2</sub> with a mass content of 15% was used for synthesizing all the samples. Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscope (SEM), X-ray phase, X-ray fluorescence, and ultraviolet-visible diffused reflectance spectroscopy (UV-vis DRS) were used to systematically characterize as-obtained materials. Photodegradation of methyl orange in neutral aqueous solutions (pH = 6.8) under UV irradiation was studied to evaluate their photocatalytic activities. Morphology, bandgaps, the value of the zero charge point, and photocatalytic activity of the samples depended on the characteristics of the original silica. The degree of methyl orange degradation reached the maximum values (81%−85%) for samples based on precipitated silica from rice husks, straw, and the minimum value (16%) for a composite with thermal silica from rice straw. Composites based on thermal silica from rice husks and reagents from mineral raw materials did not statistically differ from each other in the degree of methyl orange degradation (67%−74%).</p></div>","PeriodicalId":52344,"journal":{"name":"Journal of Bioresources and Bioproducts","volume":"8 2","pages":"Pages 176-186"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44516412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adrian Chun Minh Loy , Karen Gah Hie Kong , Juin Yau Lim , Bing Shen How
{"title":"Frontier of digitalization in Biomass-to-X supply chain: opportunity or threats?","authors":"Adrian Chun Minh Loy , Karen Gah Hie Kong , Juin Yau Lim , Bing Shen How","doi":"10.1016/j.jobab.2023.03.001","DOIUrl":"10.1016/j.jobab.2023.03.001","url":null,"abstract":"<div><p>The escalating climate crisis necessitates an urgent shift towards a sustainable business model. Under the context of bioeconomy, it has offered a promising alternative through its “Biomass-to-X” strategy for converting biological resources into value-added products or chemicals. However, the adoption of this approach remains scarce, which highlights the need to leverage digital technologies to enhance its feasibility. Thus, this paper provides a comprehensive overview of the potential role of digital technologies in the Biomass-to-X supply chain, encompassing the entire value chain from upstream to downstream activities, specifically in the areas of 1) lab-to-fabrication translation, 2) biomanufacturing stage, and lastly, 3) supply chain management stage. Furthermore, this study identifies and discusses research gaps in each niche area, along with potential future research prospects to facilitate the transition towards a sustainable bioeconomy, making it a crucial reference for stakeholders involved in decision-making processes.</p></div>","PeriodicalId":52344,"journal":{"name":"Journal of Bioresources and Bioproducts","volume":"8 2","pages":"Pages 101-107"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43360757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohd Saufi Md Zaini , Muhammad Arshad , Syed Shatir A. Syed-Hassan
{"title":"Adsorption Isotherm and Kinetic Study of Methane on Palm Kernel Shell-Derived Activated Carbon","authors":"Mohd Saufi Md Zaini , Muhammad Arshad , Syed Shatir A. Syed-Hassan","doi":"10.1016/j.jobab.2022.11.002","DOIUrl":"10.1016/j.jobab.2022.11.002","url":null,"abstract":"<div><p>Activated carbon (AC) was synthesized from palm kernel shell (PKS) using different activating agents, i.e., steam, carbon dioxide (CO<sub>2</sub>), and CO<sub>2</sub>-steam, in order to analyze the impact of activating agents on the pore opening of AC. In this study, AC produced from PKS was found to have great potential as an adsorbent for methane storage. The different molecular diffusivity and reactivity of the combination of CO<sub>2</sub> and steam succeeded in producing AC with the highest burn-off of 78.57%, a surface area of 869.82 m<sup>2</sup>/g, a total pore volume of 0.47 cm<sup>3</sup>/g, and leading to maximum methane gas adsorption capacity of 4.500 mol/kg. All types of ACs exhibited the best fit with the Freundlich isotherm model, with the correlation coefficient (<em>R</em><sup>2</sup>) ranging from 0.997 to 0.999, indicating the formation of multilayer adsorption. In addition, the adsorption kinetic data for all ACs followed the pseudo-first-order model showing that the rate of adsorption was dependent on both the adsorbent and the adsorbate and was governed primarily by physical adsorption between the pore surface and methane gas. The results of intraparticle diffusion model indicated that the adsorption of methane was affected by both pore diffusion and exterior layer diffusion due to the different adsorption rates.</p></div>","PeriodicalId":52344,"journal":{"name":"Journal of Bioresources and Bioproducts","volume":"8 1","pages":"Pages 66-77"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49247935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bidhan Nath , Guangnan Chen , Les Bowtell , Raid Ahmed Mahmood
{"title":"Assessment of densified fuel quality parameters: A case study for wheat straw pellet","authors":"Bidhan Nath , Guangnan Chen , Les Bowtell , Raid Ahmed Mahmood","doi":"10.1016/j.jobab.2022.10.001","DOIUrl":"10.1016/j.jobab.2022.10.001","url":null,"abstract":"<div><p>An investigation was conducted to examine the impact of additive mixing with wheat straw (WS) for pellet making. This study manufactured seven types of pellets with different additive combinations to evaluate pellet quality characteristics and their relationships. A laboratory-type hammer mill and a pellet mill were used for feedstock preparation and pellet production. Experimental investigations showed that the lignin content increased from 7.0% to 13.1%, which was a primary need for pelletization. Also, the heating value rose from 17.02 to 20.36 MJ/kg. However, the ash content also increased from 7.09% to 16.2%. Results showed that dimension (length and diameter), durability, and tensile strength increased significantly with additives while the fines content decreased. The fines content had an inverse relationship with durability and strength. Wheat straw (60%), together with 10% sawdust (SD), 10% corn starch (CS), 10% bentonite clay (BC), and 10% biochar (BiC), was optimal with good pellet performance (T7). In addition, both the T5 pellets (70% WS, 10% SD, 10% BiC, and 10% BC) and the T6 pellets (70% WS, 10% SD, 10% BiC, and 10% CS) provide suitable quality according to EN plus 2015 standard requirements. The ash content of produced pellet was higher than the recommended value, which suggests that further research onto the alternative additive use for ash reduction is needed.</p></div>","PeriodicalId":52344,"journal":{"name":"Journal of Bioresources and Bioproducts","volume":"8 1","pages":"Pages 45-58"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49540203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Electrochemical valorization of lignin: Status, challenges, and prospects","authors":"Jian Luo, Tianbiao Leo Liu","doi":"10.1016/j.jobab.2022.11.003","DOIUrl":"10.1016/j.jobab.2022.11.003","url":null,"abstract":"<div><p>As the second most abundant component of lignocellulosic biomass and the largest source of renewable aromatic compounds, lignin shows great potential to replace finite, non-renewable fossil oils and becomes a renewable feedstock for the production of fuel and aromatic chemicals. Therefore, it is highly important to develop efficient methods to convert lignin into biofuels and valuable chemicals. Electrochemical approaches are considered to be scalable, oxidant/reductant free, easy to control, and can be conducted under mild conditions. This review firstly overviews the structure and deconstruction methods of lignin. And then, different electrochemical lignin conversion approaches, including mediated electrooxidation, electroenzymatic oxidation, photoelectrochemical oxidation, and direct electrooxidation, are discussed in detail. The application of lignin-derived monomeric compounds is also briefly introduced. Finally, the advantages and challenges of different electrochemical lignin upgrading approaches are summarized; meanwhile, suggestions are made for future research on lignin biomass valorization.</p></div>","PeriodicalId":52344,"journal":{"name":"Journal of Bioresources and Bioproducts","volume":"8 1","pages":"Pages 1-14"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47226454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}