Jane Metrik, Nicholas Bush, Rachel L Gunn, Denis M McCarthy
{"title":"Recent Advances in the Science of Cannabis-Impaired Driving.","authors":"Jane Metrik, Nicholas Bush, Rachel L Gunn, Denis M McCarthy","doi":"10.1007/s40429-025-00712-0","DOIUrl":"10.1007/s40429-025-00712-0","url":null,"abstract":"<p><strong>Purpose of review: </strong>To examine cannabis-induced effects on driving performance. Prior systematic reviews consistently reveal that Δ⁹-tetrahydrocannabinol (THC) impairs driving performance. The present narrative review summarized evidence on the acute and residual effects of cannabis on driving performance from controlled experimental research completed in the past five years. Expanding on prior research, recent studies examine individual and combined effects of THC and cannabidiol (CBD), combined effects of cannabis and alcohol, and a variety of cannabis administration modes.</p><p><strong>Recent findings: </strong>Cannabis with THC acutely impairs driving without significant residual deficits. CBD does not acutely impair driving performance, although relatively low doses (< 300 mg) were used in most studies. The combination of alcohol and THC results in additive effects that amplifies impairment. In line with prior research findings, cannabis-induced driving impairment is consistently observed within the first hour after use and impairment remains detectable for ~ 4-5 h post-inhalation; studies testing oral and sublingual cannabis administrations were sparse. Participants were willing and ready to drive shortly after using cannabis while their driving skills were objectively impaired.</p><p><strong>Summary: </strong>Despite clear evidence of cannabis-induced driving impairment, a consistent impairment standard that can be used outside the laboratory is lacking. More research focused on sensitive biomarkers combined with technologically-advanced behavioral methods is needed to improve the precision and accuracy in determining cannabis-induced driving impairment. Future studies should focus on novel oral and oromucosal formulations emerging on the legal cannabis market.</p>","PeriodicalId":52300,"journal":{"name":"Current Addiction Reports","volume":"13 1","pages":"8"},"PeriodicalIF":4.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12864297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146121135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fight, Flight, Fawn, Freeze: Rethinking Substance Use Through a Stress Response Lens.","authors":"Angel B Algarin, Ji-Young Lee, Xiangming Zhan","doi":"10.1007/s40429-026-00723-5","DOIUrl":"10.1007/s40429-026-00723-5","url":null,"abstract":"<p><strong>Purpose of review: </strong>This paper proposes a stress-response framework for understanding substance use in the context of adversity, integrating fight (resistance), flight (adaptive coping), freeze (maladaptive coping), and fawn (strategic assimilation/appeasement) responses, with resilience as a moderating factor.</p><p><strong>Recent findings: </strong>Evidence indicates that adaptive resistance and coping can protect against substance use, while maladaptive resistance, maladaptive coping, and fawning may increase long-term risk despite short-term relief. Resilience, both individual and collective, can buffer adversity's effects and enhance positive stress responses, though measurement and conceptual inconsistencies limit cross-study synthesis.</p><p><strong>Summary: </strong>Advancing research on adversity and substance use requires the use of validated measures, the simultaneous assessment of multiple stress responses to capture their interactions, and greater theorization of resistance and fawning/strategic assimilation, which remain underdeveloped and understudied in substance use research.</p>","PeriodicalId":52300,"journal":{"name":"Current Addiction Reports","volume":"13 1","pages":"21"},"PeriodicalIF":4.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12960391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ransom J Wyse, David C Samuels, Sandra Sanchez-Roige, Lori Schirle, Bethany A Rhoten, Seo Yoon Lee, Alvin D Jeffery
{"title":"Natural Language Processing for Substance Use Disorder Information Extraction: A Systematic Literature Review.","authors":"Ransom J Wyse, David C Samuels, Sandra Sanchez-Roige, Lori Schirle, Bethany A Rhoten, Seo Yoon Lee, Alvin D Jeffery","doi":"10.1007/s40429-026-00733-3","DOIUrl":"10.1007/s40429-026-00733-3","url":null,"abstract":"<p><strong>Purpose of review: </strong>To examine the use of natural language processing (NLP) for substance use disorder (SUD) information extraction.</p><p><strong>Recent findings: </strong>623 studies were reviewed, of which 35 met inclusion criteria. 1 paper (2.9%) was alcohol-related, 12 (34.3%) were opioid-related, 6 (17.1%) were tobacco-related, and 16 (45.7%) included multiple SUDs. Of the three types of NLP categorized for this analysis, 65.7% followed a Rule-Based approach, 37.1% followed a Machine-Learning approach, and 11.4% followed a Deep-Learning approach. NLP methods were categorized into three groups, with 43% as \"Most common use\" (e.g., concept extraction), 20-35% as \"Regular use\" (e.g., regular expressions), and < 10% as \"Rare use\" (e.g., sentiment analysis). Various software applications were used in each included paper, with Python leading (10 papers), followed by cTAKES (9 papers), NegEx (6 papers), R (4 papers) and others. Multiple evaluation metrics were used in each included paper; Multiple SUDs (6 papers) utilized a comparison of F1 scores and ROC AUC, followed by Tobacco (4 papers), Opioids (3 papers), and Alcohol (1 paper), each with acceptable-to-outstanding ROC AUC scores ( > = 0.7) and good-to-excellent F1 scores ( > = 0.7).</p><p><strong>Summary: </strong>Most papers included in this systematic review encompassed multiple SUDs following Rule-Based approaches, \"Most common use\" NLP methods (e.g. concept extraction), and familiar software applications (e.g. Python). Evaluation metrics for SUD papers utilizing NLP included common performance metrics, with ROC AUC and F1 scores achieving acceptable-to-outstanding discrimination between classes and good-to-excellent balance between precision and recall, respectively. The future direction of NLP for SUD information extraction could make use of Machine- or Deep-Learning approaches, advanced methods including Regular expressions or Sentiment analysis, and/or advanced software packages designed specifically for NLP endeavors, to better inform public health research and clinical decision making.</p>","PeriodicalId":52300,"journal":{"name":"Current Addiction Reports","volume":"13 1","pages":"34"},"PeriodicalIF":4.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Association of Emotion Dysregulation with the Co-Occurrence of PTSD and SUD: A Systematic Review of Recent Literature.","authors":"Eileen Barden, Craig Polizzi, Robyn Ellis, Cathryn Glanton Holzhauer","doi":"10.1007/s40429-026-00720-8","DOIUrl":"10.1007/s40429-026-00720-8","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review focused on literature from the past five years that examined the role of emotion dysregulation in co-occurring symptoms of posttraumatic stress disorder (PTSD) and substance use disorder (SUD) among adults.</p><p><strong>Recent findings: </strong>Evidence from recent studies indicates that emotion dysregulation operates directly by exacerbating symptoms of PTSD and SUD and functions as both a moderator and mediator in the PTSD-SUD relation. Greater emotion dysregulation tends to strengthen the association between PTSD and SUD symptoms. Moreover, evidence supports emotion dysregulation as a key target in trauma- and SUD-focused treatments, with reductions in emotion dysregulation contributing to better clinical outcomes across diverse treatment settings.</p><p><strong>Summary: </strong>Emotion dysregulation is a critical factor that underlies the co-occurrence of PTSD and SUD. Understanding the nuanced role of emotion dysregulation in co-occurring PTSD-SUD offers critical insights for alleviating PTSD symptoms and SUD behaviors, especially intrusive memories and using substances as avoidance.</p>","PeriodicalId":52300,"journal":{"name":"Current Addiction Reports","volume":"13 ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13056375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Affective Factors in the Co-Occurrence of Personality Disorders and Substance Use Disorders.","authors":"Andrea M Wycoff, Timothy J Trull","doi":"10.1007/s40429-026-00719-1","DOIUrl":"https://doi.org/10.1007/s40429-026-00719-1","url":null,"abstract":"<p><strong>Purpose of review: </strong>Personality disorders (PDs) and substance use disorders (SUDs) co-occur at high rates. Transdiagnostic mechanisms such as affective processes could improve our understanding of etiology, maintenance, and treatment of co-occurring disorders. We review the role that affective factors play in the overlap between PDs and SUDs and focus on current directions in assessment and evaluation of affective processes.</p><p><strong>Recent findings: </strong>Recent affect-related work informing PD and SUD co-occurrence has focused on conceptualizing PDs dimensionally, testing affective processes as transdiagnostic constructs, issues in affect measurement, using ecological momentary assessment to identify proximal risk pathways, and debate on the role of affect in SUD.</p><p><strong>Summary: </strong>Affective changes can be reliably measured in daily life, and evidence supports using dimensional models of PDs compared to categorical diagnoses. Future work should build on these strengths and focus on careful translations of SUD theories to research.</p>","PeriodicalId":52300,"journal":{"name":"Current Addiction Reports","volume":"13 1","pages":"17"},"PeriodicalIF":4.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12950023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147345815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Benjamin L Berey, Sarah A Thomas, Alexander W Sokolovsky, Rachel L Gunn, Mary Beth Miller
{"title":"Joint Relations Among Cannabis, Sleep, and Affective Symptomatology: A Scoping Review.","authors":"Benjamin L Berey, Sarah A Thomas, Alexander W Sokolovsky, Rachel L Gunn, Mary Beth Miller","doi":"10.1007/s40429-026-00735-1","DOIUrl":"10.1007/s40429-026-00735-1","url":null,"abstract":"<p><strong>Purpose of review: </strong>This scoping review used a five-stage framework to evaluate empirical studies positing anxiety and depression as mechanisms or moderators in associations between cannabis use and sleep. Applicable peer-reviewed studies were identified in Google Scholar and PubMed using relevant search terms (e.g., cannabis, sleep, depression, anxiety).</p><p><strong>Recent findings: </strong>Of the 20 articles included, most examined cannabis effects on sleep using prospective designs with adults recruited based on anxiety and/or depression symptomatology. Fewer studies tested bidirectional associations between cannabis and sleep. Among adults reporting clinically significant symptoms of anxiety and depression at baseline, certain cannabis product formulations were associated with concurrent and prospective improvements in subjective sleep phenotypes. However, this pattern of findings was not evident among those without anxiety/depression, none of the designs were experimental, and only one study included objective sleep measures.</p><p><strong>Summary: </strong>Providers should be aware that cannabis' perceived sleep benefits are more pronounced among those with anxiety/depressive disorders. Experimental research with objective measures testing how and for whom sleep and cannabis are linked is needed.</p>","PeriodicalId":52300,"journal":{"name":"Current Addiction Reports","volume":"13 1","pages":"39"},"PeriodicalIF":4.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147724283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mica Komarnyckyj, Nima Norbu Sherpa, Will Lawn, Elsa Fouragnan
{"title":"Transcranial Ultrasound Stimulation as an Emerging Treatment for Substance use Disorder: Promise and Precaution.","authors":"Mica Komarnyckyj, Nima Norbu Sherpa, Will Lawn, Elsa Fouragnan","doi":"10.1007/s40429-026-00734-2","DOIUrl":"https://doi.org/10.1007/s40429-026-00734-2","url":null,"abstract":"","PeriodicalId":52300,"journal":{"name":"Current Addiction Reports","volume":"13 1","pages":"45"},"PeriodicalIF":4.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13133219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Does the Habit Theory of Addictions Extend to Disordered Gambling?","authors":"Tim van Timmeren, Luke Clark","doi":"10.1007/s40429-026-00715-5","DOIUrl":"https://doi.org/10.1007/s40429-026-00715-5","url":null,"abstract":"<p><strong>Purpose of review: </strong>'Habit theory' is a pervasive framework that describes addiction as a transition from goal-directed use (e.g. of drugs) to habitual response, accompanied by a neurobiological shift in fronto-striatal brain circuitry. As a theory that has been explored in the context of substance addictions, this article evaluates the conceptual fit of habit theory to gambling behavior and gambling disorder, and summarizes recent empirical evidence.</p><p><strong>Recent findings: </strong>Relevant research falls into two main themes. First, studies have compared behavioral markers of habit (e.g. the two-step task, Pavlovian-to-Instrumental Transfer effects) in groups with and without gambling problems. These studies find limited direct support for the hypothesis. Second, psychological research has begun to examine habit-like behaviors in naturalistic gambling. These studies find behavioral expressions consistent with habit formation, primarily during engagement with slot machines, but are yet to test key tenets of habit theory such as insensitivity to outcome devaluation.</p><p><strong>Summary: </strong>Modern gambling products (e.g. slot machines, in-play sports betting) create rich learning environments that may be highly amenable to habit formation. Further research is needed to develop and validate new tools for testing habit formation and habit strength / persistence in the context of gambling.</p>","PeriodicalId":52300,"journal":{"name":"Current Addiction Reports","volume":"13 1","pages":"15"},"PeriodicalIF":4.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12945966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Positive Emotion Regulation in Addiction: A New Frontier for Recovery Science.","authors":"Eric L Garland","doi":"10.1007/s40429-026-00741-3","DOIUrl":"https://doi.org/10.1007/s40429-026-00741-3","url":null,"abstract":"<p><strong>Purpose of review: </strong>Addiction has traditionally been framed as a disorder of negative affect and impaired downregulation of distress, yet disturbances in positive emotional experience and regulation are equally fundamental to the development and persistence of substance use disorders (SUDs). This review synthesizes clinical and psychophysiological evidence documenting the impact of addictive substances on positive emotion dysregulation, and highlights the role of positive emotion regulation on craving and drug relapse.</p><p><strong>Recent findings: </strong>Individuals who engage in addictive use of opioids, nicotine, cannabis, and stimulants exhibit blunted positive affect, diminished responsiveness to natural rewards, and deficits in the volitional upregulation of positive emotion. These impairments reflect neuroplastic alterations in corticostriatal and corticolimbic circuits that weaken endogenous reward generation, and erode the capacity to derive pleasure from, and savor, everyday experiences.</p><p><strong>Summary: </strong>Addiction is underpinned by positive emotion dysregulation. Restoring positive affective functioning through positive emotion regulation interventions may revolutionize addiction recovery.</p>","PeriodicalId":52300,"journal":{"name":"Current Addiction Reports","volume":"13 1","pages":"32"},"PeriodicalIF":4.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13068684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147678574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatima Dobani, Emma S Schillinger, Alison Vrabec, Katherine M Kidwell, Aesoon Park
{"title":"A Meta-Analysis of Bi-Directional Associations between Sleep Health and Substance Use among U.S. Youth: Racial/Ethnic Differences.","authors":"Fatima Dobani, Emma S Schillinger, Alison Vrabec, Katherine M Kidwell, Aesoon Park","doi":"10.1007/s40429-025-00628-9","DOIUrl":"10.1007/s40429-025-00628-9","url":null,"abstract":"<p><strong>Purpose of review: </strong>This paper aimed to estimate pooled bi-directional associations between multidimensional sleep health and substance use among youth and investigate whether these associations differed as a function of race/ethnicity.</p><p><strong>Recent findings: </strong>Empirical observational studies providing quantitative data on the association of sleep health (duration [sleep obtained per 24 hours], satisfaction [subjective assessment of sleep], alertness [ability to maintain attentive wakefulness], and timing [placement of sleep]) and substance use (i.e., alcohol and cannabis), and racial/ethnic demographic information among U.S. youth (10-25) were identified through a systematic literature search. Random effects meta-analyses were conducted using 95 effect sizes extracted from 38 studies.</p><p><strong>Summary: </strong>We found evidence for a bi-directional relationship between total sleep duration and substance use. Sleep satisfaction predicted substance use, but findings were inconclusive whether substance use predicted sleep satisfaction. Sleep alertness predicted alcohol (but not cannabis) use, whereas sleep timing predicted cannabis (but not alcohol) use. Nuanced racial/ethnic differences were also found in these sleep-substance use relationships, which differed across sleep domains and types of substance.</p>","PeriodicalId":52300,"journal":{"name":"Current Addiction Reports","volume":"12 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12410696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}