Current Addiction Reports最新文献

A Meta-Analysis of Bi-Directional Associations between Sleep Health and Substance Use among U.S. Youth: Racial/Ethnic Differences. 美国青少年睡眠健康与物质使用双向关联的荟萃分析：种族/民族差异

IF 4.6 2区医学

Current Addiction Reports Pub Date : 2025-12-01 Epub Date: 2025-02-24 DOI: 10.1007/s40429-025-00628-9

Fatima Dobani, Emma S Schillinger, Alison Vrabec, Katherine M Kidwell, Aesoon Park

{"title":"A Meta-Analysis of Bi-Directional Associations between Sleep Health and Substance Use among U.S. Youth: Racial/Ethnic Differences.","authors":"Fatima Dobani, Emma S Schillinger, Alison Vrabec, Katherine M Kidwell, Aesoon Park","doi":"10.1007/s40429-025-00628-9","DOIUrl":"10.1007/s40429-025-00628-9","url":null,"abstract":"Purpose of review: This paper aimed to estimate pooled bi-directional associations between multidimensional sleep health and substance use among youth and investigate whether these associations differed as a function of race/ethnicity.Recent findings: Empirical observational studies providing quantitative data on the association of sleep health (duration [sleep obtained per 24 hours], satisfaction [subjective assessment of sleep], alertness [ability to maintain attentive wakefulness], and timing [placement of sleep]) and substance use (i.e., alcohol and cannabis), and racial/ethnic demographic information among U.S. youth (10-25) were identified through a systematic literature search. Random effects meta-analyses were conducted using 95 effect sizes extracted from 38 studies.Summary: We found evidence for a bi-directional relationship between total sleep duration and substance use. Sleep satisfaction predicted substance use, but findings were inconclusive whether substance use predicted sleep satisfaction. Sleep alertness predicted alcohol (but not cannabis) use, whereas sleep timing predicted cannabis (but not alcohol) use. Nuanced racial/ethnic differences were also found in these sleep-substance use relationships, which differed across sleep domains and types of substance.","PeriodicalId":52300,"journal":{"name":"Current Addiction Reports","volume":"12 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12410696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of Illegally Manufactured Fentanyl in the United States: Current Trends. 非法制造芬太尼在美国的使用：当前趋势。

IF 4.6 2区医学

Current Addiction Reports Pub Date : 2025-12-01 Epub Date: 2025-01-29 DOI: 10.1007/s40429-025-00625-y

Nicole D Fitzgerald, Joseph J Palamar, Linda B Cottler

{"title":"Use of Illegally Manufactured Fentanyl in the United States: Current Trends.","authors":"Nicole D Fitzgerald, Joseph J Palamar, Linda B Cottler","doi":"10.1007/s40429-025-00625-y","DOIUrl":"10.1007/s40429-025-00625-y","url":null,"abstract":"Purpose of review: As the overdose crisis evolves, it is important to monitor fentanyl consumption patterns. This review provides an overview of recent findings regarding illegally manufactured fentanyl (IMF) availability, use, and associated harms in the US.Recent findings: Availability of IMF has increased, especially in pill form, and the increasing adulteration of IMF with veterinary tranquilizers such as xylazine complicates overdose response. Prevalence in the general population based on self-reported IMF use is rare, and likely underestimated. Transitions from injection to smoking have been documented in recent years, particularly in the western US. Fentanyl-stimulant polysubstance use has also been observed increasingly among IMF-related overdose deaths.Summary: Shifts in routes of administration, availability of counterfeit pills containing fentanyl, and common adulterants add complexity to the landscape of IMF use and related harms. Additional data is needed for monitoring changes in consumption patterns to inform prevention and harm reduction efforts.","PeriodicalId":52300,"journal":{"name":"Current Addiction Reports","volume":"12 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12346689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144857018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repetitive transcranial magnetic stimulation for substance use disorders and chronic pain: A review of the evidence and call for increased mechanistic understanding. 重复经颅磁刺激治疗物质使用障碍和慢性疼痛：证据回顾并呼吁增加机制理解。

IF 4.6 2区医学

Current Addiction Reports Pub Date : 2025-12-01 Epub Date: 2025-02-07 DOI: 10.1007/s40429-025-00620-3

Alyssa Michel, Dongyu Kang, Roger B Fillingim, Nicholas L Balderston, Dale S Bond, Vaughn R Steele

{"title":"Repetitive transcranial magnetic stimulation for substance use disorders and chronic pain: A review of the evidence and call for increased mechanistic understanding.","authors":"Alyssa Michel, Dongyu Kang, Roger B Fillingim, Nicholas L Balderston, Dale S Bond, Vaughn R Steele","doi":"10.1007/s40429-025-00620-3","DOIUrl":"10.1007/s40429-025-00620-3","url":null,"abstract":"Purpose of review: Both substance use disorders (SUD) and chronic pain are highly prevalent, require new effective interventions, and share similar underlying neurocircuitry. A promising intervention for both is repetitive transcranial magnetic stimulation (rTMS) which is a tool to modulate brain circuits. In this narrative review, we surveyed the current state of rTMS used to address SUDs and chronic pain by focusing on 132 reports published since 2010.Recent findings: The field agrees that rTMS application in these clinical samples is safe and potentially effective, even in co-occurring disease or with recent substance use. Overall, the pain field has come to a stronger consensus about how best to apply rTMS to reduce diverse chronic pain conditions compared to the SUD field. We argue for standardization of methods within fields to rapidly address each clinical group. Such a standardization will require a concerted effort to test applications head-to-head to evaluate relative efficacy across applications. A coordinated effort in this regard is needed between research groups and funding agencies to accomplish this goal.Summary: One of the most effective steps the field can take toward this goal is to measure the neuromechanisms that underlie SUD and pain before and after an rTMS intervention. Only 18% of reviewed reports included any brain measurement such as functional magnetic resonance imaging, electroencephalography, and event-related potentials. We argue that such measurements are essential for optimizing rTMS as an intervention for clinical populations. If rTMS is ostensibly applied to modulate neurocircuits, measurement of those circuits to verify, iterate, and optimize application is fundamental for developing effective treatments.","PeriodicalId":52300,"journal":{"name":"Current Addiction Reports","volume":"12 ","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12467114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Efficacy as a Mechanism of Behavior Change in Addiction Science and Practice. 自我效能感是成瘾科学与实践中行为改变的机制。

IF 4.6 2区医学

Current Addiction Reports Pub Date : 2025-12-01 Epub Date: 2025-02-27 DOI: 10.1007/s40429-025-00632-z

Molly Magill, Samuel Meisel, David I K Moniz-Lewis, Stephan Maisto, Katie Witkiewitz

{"title":"Self-Efficacy as a Mechanism of Behavior Change in Addiction Science and Practice.","authors":"Molly Magill, Samuel Meisel, David I K Moniz-Lewis, Stephan Maisto, Katie Witkiewitz","doi":"10.1007/s40429-025-00632-z","DOIUrl":"https://doi.org/10.1007/s40429-025-00632-z","url":null,"abstract":"Purpose of review: This review examines self-efficacy and traces the construct from theory and operationalization to clinical practice and intervention design in addiction science.Recent findings: Self-efficacy is a construct with a strong theoretical and methodological foundation. While evidence for self-efficacy as a statistical mediator in the context of clinical trials of addictions treatments is mixed, it is most conclusive in within-condition, non-experimental designs. Consistency in empirical support across research methods, populations, and outcomes strengthens support for self-efficacy as a mechanism of alcohol or other substance consumption outcomes.Summary: The current review provides evidence for self-efficacy as a mechanism worthy of direct attention in clinical care for alcohol or other substance use disorders. It is likely a common mechanism of human behavior change that can be harnessed in a range of treatment modalities and client-identified goals. Future work should target self-efficacy directly in intervention development, implementation, and dissemination.","PeriodicalId":52300,"journal":{"name":"Current Addiction Reports","volume":"12 1","pages":""},"PeriodicalIF":4.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12380254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144978185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Problem Recognition as A Discrete Concept for Change Processes in Problematic Alcohol Use. 问题识别作为问题酒精使用变化过程的离散概念。

IF 4.1 2区医学

Current Addiction Reports Pub Date : 2025-01-01 Epub Date: 2025-02-19 DOI: 10.1007/s40429-025-00634-x

J Morris, D K Richards, I P Albery

{"title":"Problem Recognition as A Discrete Concept for Change Processes in Problematic Alcohol Use.","authors":"J Morris, D K Richards, I P Albery","doi":"10.1007/s40429-025-00634-x","DOIUrl":"10.1007/s40429-025-00634-x","url":null,"abstract":"Purpose of review: Alcohol problem recognition reflects the extent to which a person with any level of problematic alcohol use (PAU), including hazardous alcohol use, acknowledges the associated risks/harms as potentially/actually problematic with a relative degree of objectivity. Notably, alcohol problem recognition is typically low amongst people with PAU not engaged in treatment or support. This review evaluates existing PAU problem recognition measures and related concepts such as ambivalence, readiness to change, motivation, cognitive biases and other self-evaluative appraisal processes.Recent findings: Alcohol problem recognition has been operationalised via various measures but is often conflated with other related but theoretically distinct concepts. Limited conceptual work examines the nature of problem recognition as a discrete concept and its function in relation to behaviour change outcomes and key variables.Summary: Problem recognition is proposed as an important theoretically distinct process that warrants further conceptual development and testing for advancing understanding of change processes across the PAU spectrum.","PeriodicalId":52300,"journal":{"name":"Current Addiction Reports","volume":"12 1","pages":"23"},"PeriodicalIF":4.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in understanding how compulsivity is related to behavioural addictions over their timecourse. 强迫性与行为成瘾在时间过程中的关系的最新研究进展。

IF 4.1 2区医学

Current Addiction Reports Pub Date : 2025-01-01 Epub Date: 2025-02-25 DOI: 10.1007/s40429-025-00621-2

Jeremy E Solly, Lucy Albertella, Konstantinos Ioannidis, Naomi A Fineberg, Jon E Grant, Samuel R Chamberlain

{"title":"Recent advances in understanding how compulsivity is related to behavioural addictions over their timecourse.","authors":"Jeremy E Solly, Lucy Albertella, Konstantinos Ioannidis, Naomi A Fineberg, Jon E Grant, Samuel R Chamberlain","doi":"10.1007/s40429-025-00621-2","DOIUrl":"10.1007/s40429-025-00621-2","url":null,"abstract":"Purpose of review: Behavioural addictions involve loss of control over initially rewarding behaviours, which continue despite adverse consequences. Theoretical models suggest that these patterns of behaviour evolve over time, with compulsive and habitual behaviours held to reflect a loss of behavioural control. Compulsivity can be broadly described as a propensity for (or engagement in) repetitive behaviours that are not aligned with overall goals. Here, we consider whether compulsivity is associated with behavioural addictions at different stages of their development, based on self-report and neurocognitive measures.Recent findings: This review found that there is initial evidence that compulsive traits might predispose individuals to engage in problematic behaviours, and that self-report and neurocognitive measures of compulsivity are associated with severity of problematic behaviours even in the early stages of behavioural addictions. In the later stages of behavioural addiction, there is strong evidence for an association of gambling disorder with cognitive inflexibility, but less evidence for an association between compulsivity and other types of behavioural addiction.Summary: Moving forwards, well-powered longitudinal studies, including studies using ecological momentary assessment (EMA), will be important in robustly developing our understanding of how compulsivity is related to behavioural addictions over their timecourse.","PeriodicalId":52300,"journal":{"name":"Current Addiction Reports","volume":"12 1","pages":"26"},"PeriodicalIF":4.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Scoping Review of Interventions for Tobacco Cessation Among African American Individuals. 非裔美国人戒烟干预措施的范围综述。

IF 4.1 2区医学

Current Addiction Reports Pub Date : 2025-01-01 Epub Date: 2025-05-13 DOI: 10.1007/s40429-025-00660-9

Shubekshya Upadhyay, Abena Duah, Victoria Francois, Sophia I Allen

{"title":"A Scoping Review of Interventions for Tobacco Cessation Among African American Individuals.","authors":"Shubekshya Upadhyay, Abena Duah, Victoria Francois, Sophia I Allen","doi":"10.1007/s40429-025-00660-9","DOIUrl":"10.1007/s40429-025-00660-9","url":null,"abstract":"Purpose of review: African American individuals in the US have the highest rates of mortality from diseases such as lung cancer, coronary heart disease, and stroke compared with other minoritized people due to tobacco smoking. Evidence-based interventions are useful for reducing the burden of diseases by helping those who smoke to quit. Despite a higher motivation to quit, African American adult smokers have lower success rates and less access to evidence-based interventions. Hence, it is important to study the factors associated with unsuccessful quit attempts among this population and to search the literature for gaps that need to be addressed.Recent findings: We identified 19 articles that focused on Quitlines and text messaging interventions to help African Americans to quit. The interventions used in the studies were Quitlines, text messaging, telephone counseling and media campaigns. We found that African Americans were more likely to use Quitlines than Whites. Studies indicated that interventions should be tailored according to patient preferences. For example, one of the findings was that participants had mixed feelings about the use of standard and non-standard Quitline services. Individuals aged over 60 years preferred standard services such as telephone counseling and printed materials. However, the younger generation were interested in non-standard services.Summary: There are only a few studies focused on the use of Quitlines and the utilization of their text messaging service among African Americans. Future studies should focus on the reasons disparities in smoking cessation rates exist among African American individuals and leverage the use of text messaging.Supplementary information: The online version contains supplementary material available at 10.1007/s40429-025-00660-9.","PeriodicalId":52300,"journal":{"name":"Current Addiction Reports","volume":"12 1","pages":"46"},"PeriodicalIF":4.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Dynorphin/-Opioid Receptor System at the Interface of Hyperalgesia/Hyperkatifeia and Addiction. 痛觉过敏/过度兴奋与成瘾性交界的啡啡/-阿片受体系统。

IF 4.1 2区医学

Current Addiction Reports Pub Date : 2025-01-01 Epub Date: 2025-02-04 DOI: 10.1007/s40429-025-00618-x

Renata C N Marchette, Leandro F Vendruscolo, George F Koob

{"title":"The Dynorphin/-Opioid Receptor System at the Interface of Hyperalgesia/Hyperkatifeia and Addiction.","authors":"Renata C N Marchette, Leandro F Vendruscolo, George F Koob","doi":"10.1007/s40429-025-00618-x","DOIUrl":"10.1007/s40429-025-00618-x","url":null,"abstract":"Purpose of review: Drug addiction is characterized by compulsive drug seeking and use, accompanied by negative emotional states (hyperkatifeia) and heightened pain sensitivity (hyperalgesia) during withdrawal. Both hyperalgesia and hyperkatifeia are integral components of substance use disorders, negatively impacting treatment and recovery. The underlying neurobiological mechanisms of hyperalgesia and hyperkatifeia involve alterations of brain reward and stress circuits, including the dynorphin/κ-opioid receptor (KOR) system. The dynorphin/KOR system modulates pain perception, negative affect, and addictive behaviors. Here, we review the preclinical evidence of dynorphin/KOR signaling in opioid withdrawal-induced hyperalgesia and hyperkatifeia.Recent findings: In opioid dependence models, pharmacological and genetic interventions of the dynorphin/KOR system attenuate somatic and motivational signs of withdrawal and addictive-like behaviors, highlighting its therapeutic potential. Understanding the intricate interplay between dynorphin/KOR signaling, hyperalgesia, hyperkatifeia, and addiction offers novel insights into treatment strategies for opioid use disorder and other substance use disorders.Summary: Further research is needed to elucidate precise mechanisms of the sexual dimorphism of dynorphin/KOR signaling and identify targeted interventions to mitigate hyperalgesia and hyperkatifeia and facilitate recovery from addiction.","PeriodicalId":52300,"journal":{"name":"Current Addiction Reports","volume":"12 1","pages":"11"},"PeriodicalIF":4.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11925990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cravings, Control, and Cessation: A Scoping Review of Perceptions of Nicotine Addiction. 渴望、控制和戒烟：对尼古丁成瘾认知的范围综述。

IF 4.1 2区医学

Current Addiction Reports Pub Date : 2025-01-01 Epub Date: 2025-07-11 DOI: 10.1007/s40429-025-00673-4

Allison A Temourian, Deanna M Halliday, Anna V Song

{"title":"Cravings, Control, and Cessation: A Scoping Review of Perceptions of Nicotine Addiction.","authors":"Allison A Temourian, Deanna M Halliday, Anna V Song","doi":"10.1007/s40429-025-00673-4","DOIUrl":"10.1007/s40429-025-00673-4","url":null,"abstract":"Purpose of review: Nicotine addiction is the result of repeated tobacco use and subsequently promotes continued consumption, potentially acting as both cause and consequence of tobacco use. This scoping review aims to describe the literature and catalogue existing measures regarding perceptions of nicotine addiction with special attention to scales that recognize its multidimensionality.Recent findings: Following a comprehensive review of 923 empirical articles, we found 252 articles that assessed perceptions of nicotine addiction, five of which utilized a validated measure. Single item assessments were categorized into affective concern, knowledge that tobacco is addictive, personal perceptions of addiction, other people's addiction, and comparative addictiveness. Scaled measures of perceptions of nicotine addiction largely assessed perceived susceptibility and severity.Summary: Despite decades of research demonstrating the importance of perceptions of risk and expectancies in risk-behavior decision-making, tools and items assessing perceptions of nicotine addiction are highly varied and do not account for the multidimensionality of nicotine addiction. We, as a field, lack a comprehensive assessment of perceptions of nicotine addiction that integrates the complexity of addiction into an individual's appraisal of risk, which is a critical component of prevention and intervention-based research.Supplementary information: The online version contains supplementary material available at 10.1007/s40429-025-00673-4.","PeriodicalId":52300,"journal":{"name":"Current Addiction Reports","volume":"12 1","pages":"66"},"PeriodicalIF":4.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12254085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex-based Influences on White Matter Tract Integrity in Alcohol Use Disorder: a Systematic Review. 性别对酒精使用障碍患者白质束完整性的影响：一项系统综述

IF 4.1 2区医学

Current Addiction Reports Pub Date : 2025-01-01 Epub Date: 2025-02-04 DOI: 10.1007/s40429-025-00624-z

Nathalie Barrios, Nathania Nartey, Johnny Yue, Will Riordan, Robert Kohler, Terril L Verplaetse, Walter Roberts, Rachel F Carretta, Bubu A Banini, Hang Zhou, Vernon Garcia-Rivas, Jennifer Urbano Blackford, Yasmin Zakiniaeiz

{"title":"Sex-based Influences on White Matter Tract Integrity in Alcohol Use Disorder: a Systematic Review.","authors":"Nathalie Barrios, Nathania Nartey, Johnny Yue, Will Riordan, Robert Kohler, Terril L Verplaetse, Walter Roberts, Rachel F Carretta, Bubu A Banini, Hang Zhou, Vernon Garcia-Rivas, Jennifer Urbano Blackford, Yasmin Zakiniaeiz","doi":"10.1007/s40429-025-00624-z","DOIUrl":"10.1007/s40429-025-00624-z","url":null,"abstract":"Purpose of the review: Women experience worse alcohol-related health consequences compared to men, including greater risk and susceptibility to the neurotoxic effects of alcohol. There is a critical need to identify underlying neurobiological mechanisms underlying sex differences in alcohol use disorder (AUD) phenotypes to better inform individualized treatment options. This report aimed to systematically review existing original literature that examined sex differences in white matter tract integrity in individuals with heavy drinking/AUD using diffusion magnetic resonance imaging (dMRI) and provide recommendations for future research. A systematic review was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and PubMed and Google Scholar databases from inception until January 1, 2024.Recent findings: Of 565 studies from the database search, 12 met study criteria. Nine (75%) showed evidence of sex-related differences in white matter tract integrity. Five studies showed greater vulnerability of white matter tract degradation in women with heavy drinking/AUD and four showed greater vulnerability in men with heavy drinking/AUD.Summary: This is the first study to systematically assess the existing literature on sex differences in AUD-related white matter tract integrity. The findings from this systematic review were equivocal. Future research should address the mixed literature by systematically examining sex differences in white matter tract integrity in larger, well-characterized samples to account for confounding factors such as alcohol use history, age, other substance use, and psychiatric comorbidities.","PeriodicalId":52300,"journal":{"name":"Current Addiction Reports","volume":"12 1","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12058214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0