The Dynorphin/-Opioid Receptor System at the Interface of Hyperalgesia/Hyperkatifeia and Addiction.

IF 4.1 2区医学 Q1 SUBSTANCE ABUSE

Current Addiction Reports Pub Date : 2025-01-01 Epub Date: 2025-02-04 DOI:10.1007/s40429-025-00618-x

Renata C N Marchette, Leandro F Vendruscolo, George F Koob

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引用次数: 0

Abstract

Purpose of review: Drug addiction is characterized by compulsive drug seeking and use, accompanied by negative emotional states (hyperkatifeia) and heightened pain sensitivity (hyperalgesia) during withdrawal. Both hyperalgesia and hyperkatifeia are integral components of substance use disorders, negatively impacting treatment and recovery. The underlying neurobiological mechanisms of hyperalgesia and hyperkatifeia involve alterations of brain reward and stress circuits, including the dynorphin/κ-opioid receptor (KOR) system. The dynorphin/KOR system modulates pain perception, negative affect, and addictive behaviors. Here, we review the preclinical evidence of dynorphin/KOR signaling in opioid withdrawal-induced hyperalgesia and hyperkatifeia.

Recent findings: In opioid dependence models, pharmacological and genetic interventions of the dynorphin/KOR system attenuate somatic and motivational signs of withdrawal and addictive-like behaviors, highlighting its therapeutic potential. Understanding the intricate interplay between dynorphin/KOR signaling, hyperalgesia, hyperkatifeia, and addiction offers novel insights into treatment strategies for opioid use disorder and other substance use disorders.

Summary: Further research is needed to elucidate precise mechanisms of the sexual dimorphism of dynorphin/KOR signaling and identify targeted interventions to mitigate hyperalgesia and hyperkatifeia and facilitate recovery from addiction.

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来源期刊

Current Addiction Reports Psychology-Clinical Psychology

CiteScore

6.60

自引率

4.70%

发文量

期刊介绍： This journal focuses on the prevention, assessment and diagnosis, and treatment of addiction. Designed for physicians and other mental health professionals who need to keep up-to-date with the latest research, Current Addiction Reports offers expert reviews on the most recent and important research in addiction. We accomplish this by appointing leaders in the field to serve as Section Editors in key subject areas and disciplines, such asAlcoholTobaccoStimulants, cannabis, and club drugsBehavioral addictionsGender disparities in addictionComorbid psychiatric disorders and addictionSubstance abuse disorders and HIVSection Editors, in turn, select the most pressing topics as well as experts to evaluate the latest research, report on any controversial discoveries or hypotheses of interest, and ultimately bring readers up-to-date on the topic. Articles represent interdisciplinary endeavors with research from fields such as psychiatry, psychology, pharmacology, epidemiology, and neuroscience.Additionally, an international Editorial Board—representing a range of disciplines within addiction medicine—ensures that the journal content includes current, emerging research and suggests articles of special interest to their country or region.