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How human hormones regulate human microbiota: Where are we in the middle of this terra incognita? 人体荷尔蒙如何调节人体微生物群：我们在这个未知领域的中间处于什么位置？
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-06-24 DOI: 10.1016/j.coemr.2024.100537
Andrei V. Gannesen , Sergey V. Mart'yanov, Vladimir K. Plakunov
{"title":"How human hormones regulate human microbiota: Where are we in the middle of this terra incognita?","authors":"Andrei V. Gannesen ,&nbsp;Sergey V. Mart'yanov,&nbsp;Vladimir K. Plakunov","doi":"10.1016/j.coemr.2024.100537","DOIUrl":"10.1016/j.coemr.2024.100537","url":null,"abstract":"<div><p>Human organism is tightly interconnected with its microbiota on physiological and signaling levels. Microbial endocrinology as an interdisciplinary area of studying host–microbiota interactions can focus on either player: how the microbiota affects the host via synthesis of host-targeted humoral factors and how the host-derived molecules regulate the microbial community homeostasis. The present mini-review presents the authors' perspective on the impact of human hormones on the microbiota. It discusses known effects, but especially outlines existing complications in this research area, and proposes directions for future investigation.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"36 ","pages":"Article 100537"},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141622178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Type 1 diabetes mellitus and host–bacterial interactions in the oral cavity 1 型糖尿病与口腔中宿主与细菌的相互作用
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-06-13 DOI: 10.1016/j.coemr.2024.100536
Ulvi Kahraman Gürsoy , Neslihan Yilmaz , Dogukan Yilmaz , Sanni Grönroos , Mervi Gürsoy
{"title":"Type 1 diabetes mellitus and host–bacterial interactions in the oral cavity","authors":"Ulvi Kahraman Gürsoy ,&nbsp;Neslihan Yilmaz ,&nbsp;Dogukan Yilmaz ,&nbsp;Sanni Grönroos ,&nbsp;Mervi Gürsoy","doi":"10.1016/j.coemr.2024.100536","DOIUrl":"10.1016/j.coemr.2024.100536","url":null,"abstract":"<div><p>Type 1 diabetes mellitus (T1DM) is an autoimmune disease which is characterized by the destruction of insulin-producing pancreatic β-cells. Current evidence supports the contribution of T-cells, macrophages, B-cells, and dendritic cells to the pathogenesis of T1DM as well. T1DM-associated risk factors, including defects in host immune response, socioeconomic conditions, and environmental factors create a dysbiotic environment in the oral cavity, which support the growth of pathogenic microbial biofilms. Changes in microbial composition, together with the diminished immune response, lead to the development of two most common oral diseases, caries and periodontal diseases. In the present review, we summarized the current evidence on oral manifestations of T1DM and described the shifts in oral microbial composition and oral immune response.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"36 ","pages":"Article 100536"},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451965024000346/pdfft?md5=a0dd3a5069cc0af9d23b75036a52e4d5&pid=1-s2.0-S2451965024000346-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141393221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial board page 编辑委员会页面
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-06-01 DOI: 10.1016/S2451-9650(24)00028-0
{"title":"Editorial board page","authors":"","doi":"10.1016/S2451-9650(24)00028-0","DOIUrl":"https://doi.org/10.1016/S2451-9650(24)00028-0","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"35 ","pages":"Article 100530"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451965024000280/pdfft?md5=afb92df077e57d999c2d686f337f6539&pid=1-s2.0-S2451965024000280-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular genetics of pheochromocytoma/paraganglioma 嗜铬细胞瘤/副神经胶质瘤的分子遗传学
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-05-31 DOI: 10.1016/j.coemr.2024.100527
Heather Wachtel , Katherine L. Nathanson
{"title":"Molecular genetics of pheochromocytoma/paraganglioma","authors":"Heather Wachtel ,&nbsp;Katherine L. Nathanson","doi":"10.1016/j.coemr.2024.100527","DOIUrl":"https://doi.org/10.1016/j.coemr.2024.100527","url":null,"abstract":"<div><p>Pheochromocytomas and paragangliomas (PPGL) are neuroendocrine tumors which secrete catecholamines, causing cardiovascular compromise. While isolated tumors and locoregional disease can be treated surgically, treatment options for metastatic disease are limited, and no targeted therapies exist. Approximately 25% of PPGL are causatively associated with germline pathogenic variants, which are known risk factors for multifocal and metastatic PPGL. Knowledge of somatic driver mutations continues to evolve. Molecular classification of PPGL has identified three genomic subtypes: Cluster 1 (pseudohypoxia), Cluster 2 (kinase signaling) and Cluster 3 (Wnt-altered). This review summaries recent studies characterizing the tumor microenvironment, genomic drivers of tumorigenesis and progression, and current research on molecular targets for novel diagnostic and therapeutic strategies in PPGL.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"36 ","pages":"Article 100527"},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141486494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum regarding missing Declaration of Competing Interest statements in previously published articles 关于以前发表的文章中缺少 "竞争利益声明 "的勘误
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-05-30 DOI: 10.1016/j.coemr.2024.100526
{"title":"Erratum regarding missing Declaration of Competing Interest statements in previously published articles","authors":"","doi":"10.1016/j.coemr.2024.100526","DOIUrl":"https://doi.org/10.1016/j.coemr.2024.100526","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"36 ","pages":"Article 100526"},"PeriodicalIF":0.0,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451965024000243/pdfft?md5=1383e4c2531400c689038ed8bd3549a6&pid=1-s2.0-S2451965024000243-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141434208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic small talk during exercise: The role of metabokines and lipokines in interorgan signalling 运动中的代谢小对话：代谢物因子和脂肪因子在器官间信号传递中的作用
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-04-24 DOI: 10.1016/j.coemr.2024.100525
Shaimaa A. Gad , Hannah Smith , Lee D. Roberts
{"title":"Metabolic small talk during exercise: The role of metabokines and lipokines in interorgan signalling","authors":"Shaimaa A. Gad ,&nbsp;Hannah Smith ,&nbsp;Lee D. Roberts","doi":"10.1016/j.coemr.2024.100525","DOIUrl":"10.1016/j.coemr.2024.100525","url":null,"abstract":"<div><p>Metabolites in exercise have traditionally been viewed as a fuel source, waste product, or anabolic components required for exercise-induced biosynthetic processes. However, it is now recognised that metabolites and lipids may act as mediators of interorgan crosstalk to coordinate the local and systemic physiological adaptations required to meet the complex system-wide challenge of exercise. These bioactive metabolite and lipid signals have been termed metabokines and lipokines, respectively. There is emerging evidence that metabokines and lipokines contribute to the health benefits of exercise. This review highlights several of the key recent discoveries related to metabokine and lipokine signalling during exercise. The discovery of these metabokines and lipokines, and their signalling targets, may provide the basis of future therapies for human disease.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"35 ","pages":"Article 100525"},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451965024000231/pdfft?md5=238c91dfa8d3d15927c8756c92aa3f44&pid=1-s2.0-S2451965024000231-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140756257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adiponectin expressing skeletal stem/progenitor cells in the bone and bone marrow homeostasis 骨骼和骨髓平衡中表达脂肪素的骨骼干细胞/祖细胞
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-04-23 DOI: 10.1016/j.coemr.2024.100524
Biagio Palmisano , Alessandro Corsi , Mara Riminucci
{"title":"Adiponectin expressing skeletal stem/progenitor cells in the bone and bone marrow homeostasis","authors":"Biagio Palmisano ,&nbsp;Alessandro Corsi ,&nbsp;Mara Riminucci","doi":"10.1016/j.coemr.2024.100524","DOIUrl":"10.1016/j.coemr.2024.100524","url":null,"abstract":"<div><p>The bone marrow stroma supports hematopoiesis while replenishing osteoblasts and adipocytes. These functions rely on different stromal cell populations identified by lineage tracing, phenotypic markers and single-cell transcriptomic analysis. A marrow stromal cell subset expressing <em>Adiponectin</em> (Adipoq<sup>+</sup>) has been reported by different studies in mice. However, while there is a general agreement on the kinetics of Adipoq<sup>+</sup> stromal cells during mouse growth, their ability to generate bone marrow adipocytes and to support the bone vasculature, contrasting results have been reported on their osteogenic activity.</p><p>In this work, we review available data on Adipoq<sup>+</sup> stromal cells, with special focus on the experimental evidence demonstrating their osteoprogenitor function and the potential reasons for the divergence observed among different studies. Furthermore, we discuss the potential overlap of Adipoq<sup>+</sup> cells with other cell populations in the context of the widely recognized adipogenic bias that characterizes many marrow stromal stem cell populations.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"35 ","pages":"Article 100524"},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S245196502400022X/pdfft?md5=ab903d733ec060da6596c657520957f6&pid=1-s2.0-S245196502400022X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140791533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights into highly selective RET inhibitors in medullary thyroid cancer 对甲状腺髓样癌中高选择性 RET 抑制剂的见解
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-04-19 DOI: 10.1016/j.coemr.2024.100521
Antonio Matrone, Rossella Elisei
{"title":"Insights into highly selective RET inhibitors in medullary thyroid cancer","authors":"Antonio Matrone,&nbsp;Rossella Elisei","doi":"10.1016/j.coemr.2024.100521","DOIUrl":"10.1016/j.coemr.2024.100521","url":null,"abstract":"<div><p>Medullary thyroid cancer (MTC) is a neuroendocrine malignant tumor that originates from parafollicular C-cells, producing calcitonin. Approximately 75% of cases are sporadic, while the remaining 25% are hereditary. The main molecular alteration implicated in MTC tumorigenesis, whether sporadic or hereditary, is a point mutation in the RET gene. Surgery is the initial treatment of choice, while subsequent treatments are determined based on the tumor burden and rate of progression. While in case of single metastases, low tumor burden with slow rate of progression local treatments are recommended, systemic treatments are warranted in cases with large metastatic disease and rapidly progressive conditions. Beyond multikinase inhibitors (MKIs), new highly selective compounds against RET mutation, with high efficacy and good safety profile, have been recently used in clinical trials for advanced MTC patients.</p><p>This review focuses on the details of systemic treatments with highly selective RET inhibitors for advanced and metastatic MTC.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"35 ","pages":"Article 100521"},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140790141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary cilia and melanin-concentrating hormone 初级纤毛和黑色素浓缩激素
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-04-19 DOI: 10.1016/j.coemr.2024.100522
Jackson C. Bittencourt , Heriberto Barbosa-Moyano , Ammir Y. Helou
{"title":"Primary cilia and melanin-concentrating hormone","authors":"Jackson C. Bittencourt ,&nbsp;Heriberto Barbosa-Moyano ,&nbsp;Ammir Y. Helou","doi":"10.1016/j.coemr.2024.100522","DOIUrl":"10.1016/j.coemr.2024.100522","url":null,"abstract":"<div><p>There is a discrepancy between the distribution of melanin-concentrating hormone (MCH)-immunoreactive fibers and the mRNA expression of MCH receptors, particularly MCH<sub>1</sub>. Furthermore, the presence of MCH<sub>1</sub> in the primary cilia of adjacent areas with richness of MCH-ir fibers, adds complexity to the neurochemical signaling dynamics. This intricate interplay, facilitated by volume transmission (VT) and the strategic positioning of receptors on structures like primary cilia, presents a novel perspective on neuroendocrine communication. An in-depth exploration of MCH, primary cilia, MCH<sub>1</sub>, and VT interactions promises to uncover unprecedented insights that could enhance our understanding of their implications for health and disorders, like obesity. An exploration into the ciliary mechanisms of MCH action emerges as a promising venue for uncovering potential therapeutic targets.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"35 ","pages":"Article 100522"},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140767623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adrenergic system: A gateway of reciprocal signaling between host and bacteria 肾上腺素能系统：宿主与细菌之间相互传递信号的通道
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-04-19 DOI: 10.1016/j.coemr.2024.100523
Arif Luqman , Knut Ohlsen
{"title":"Adrenergic system: A gateway of reciprocal signaling between host and bacteria","authors":"Arif Luqman ,&nbsp;Knut Ohlsen","doi":"10.1016/j.coemr.2024.100523","DOIUrl":"10.1016/j.coemr.2024.100523","url":null,"abstract":"<div><p>The adrenergic system plays a central role in human physiology. However, it can also affect commensal bacteria via adrenergic hormones. Bacteria use adrenergic hormones as xenosiderophore for iron supply, modulators of biofilm formation, quorum-sensing autoinducers regulating virulence factors and pathogenicity, and for interaction with other commensals influencing the microbiome profiles. Bacteria also produce biogenic amines through aromatic amino acid decarboxylation which is widely expressed in human commensals. These biogenic amines are capable of interacting with adrenergic receptors, leading to a variety of different effects on the human body. Phenylacetyl acid is another compound produced by bacteria found in the gut that acts as a precursor of phenylacetylglutamine, a compound that has been linked to cardiac diseases due to its ability to induce thrombosis by activating adrenergic receptors present in platelets.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"35 ","pages":"Article 100523"},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140758622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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