Current Opinion in Endocrine and Metabolic Research最新文献_第4页

Impact of human communications molecules on respiratory tractus bacterial pathogen 人类通讯分子对呼吸道细菌病原体的影响

Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-12-01 Epub Date: 2024-10-18 DOI: 10.1016/j.coemr.2024.100557

Olivier Lesouhaitier, Adrien Forge, Anne-Sophie Tareau, Mathieu Gonzalez, Sylvie Chevalier, Ali Tahrioui

{"title":"Impact of human communications molecules on respiratory tractus bacterial pathogen","authors":"Olivier Lesouhaitier, Adrien Forge, Anne-Sophie Tareau, Mathieu Gonzalez, Sylvie Chevalier, Ali Tahrioui","doi":"10.1016/j.coemr.2024.100557","DOIUrl":"10.1016/j.coemr.2024.100557","url":null,"abstract":"<div><div>The rapid increase of bacteria becoming resistant to antibiotics means that alternative solutions to antibiotics must be found urgently. This observation particularly concerns respiratory pathogens such as <em>Pseudomonas aeruginosa</em>, <em>Acinetobacter baumanii</em>, or <em>Staphylococcus aureus</em>. Microbial endocrinology has paved a new way to identify specific bacterial targets related to several human communication molecules such as neurotransmitters, cytokines, and hormones. Here, we describe these human signaling compounds that are able to modify the physiology of major respiratory bacterial pathogens and their potential mechanism of action on bacteria. This review aims to better understand the effects of human communication molecules on the physiology of major respiratory bacterial pathogens and their consequences in terms of virulence, persistence, and interference with the action of antibiotics. These data should be considered to avoid promoting chronic infections in patients or to optimize antibiotic treatment.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"37 ","pages":"Article 100557"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interaction of skin-born mediators with the cutaneous microbiota and beyond 皮肤生成的介质与皮肤微生物群的相互作用及其他

Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-12-01 Epub Date: 2024-08-22 DOI: 10.1016/j.coemr.2024.100545

Marc G.J. Feuilloley , Emilie Hadjiev , Lanyo J. Amegnona

{"title":"Interaction of skin-born mediators with the cutaneous microbiota and beyond","authors":"Marc G.J. Feuilloley , Emilie Hadjiev , Lanyo J. Amegnona","doi":"10.1016/j.coemr.2024.100545","DOIUrl":"10.1016/j.coemr.2024.100545","url":null,"abstract":"<div><p>Cutaneous microorganisms are growing in a microenvironment where skin hormones and neurohormones are present in abundance. These molecules are markers of the host physiology, and microorganisms have developed strategies for detecting host factors that can represent a threat for their survival. Until now, our knowledge of these mechanisms is limited to bacteria, although the skin microbiota also includes an abundance of yeasts, fungi, viruses, and even archaea. Several human hormones and neurotransmitters, including substance P, calcitonin gene-related peptides, natriuretic peptides, catecholamines, and even estradiol have been studied in this context. This was leading to the identification of original proteins, such as the thermo-unstable ribosomal elongation factor, the chaperone DnaK, or the enzyme AmiC, which have been developed by bacteria and have dual functions, in the cytoplasm where they were originally identified and in the bacterial membrane where they act as sensors for host factors. These sensors, designed as moonlighting proteins for their dual functions, are submitted to structural reorganizations and probably post-translational modifications. The occurrence of epigenetic mechanisms in the regulation of moonlighting proteins activity is a source of major complications since similar processes are activated during bacteria adaptation to the host physiology and even storage. Cutaneous bacterial endocrinology is a wide and complex emerging scientific field that requires a deep knowledge of both human and microbial physiology and careful experimental procedures.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"37 ","pages":"Article 100545"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142230373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cholinergic signaling in adipose tissue 脂肪组织中的胆碱能信号传递

Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-12-01 Epub Date: 2024-09-11 DOI: 10.1016/j.coemr.2024.100546

Vladimir S. Shavva , Laura Tarnawski , Ting Liu , Osman Ahmed , Peder S. Olofsson

引用次数: 0

Therapeutic treatments targeting communication between angiogenic and immune microenvironments in thyroid cancers 针对甲状腺癌血管生成和免疫微环境之间沟通的治疗方法

Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-12-01 Epub Date: 2024-08-14 DOI: 10.1016/j.coemr.2024.100544

Alessandro Prete , Carmelo Nucera

{"title":"Therapeutic treatments targeting communication between angiogenic and immune microenvironments in thyroid cancers","authors":"Alessandro Prete , Carmelo Nucera","doi":"10.1016/j.coemr.2024.100544","DOIUrl":"10.1016/j.coemr.2024.100544","url":null,"abstract":"<div><div>Thyroid cancer treatment has recently been revolutionized by the introduction of specific targeted therapies (e.g. BRAF<sup>V600E</sup> or highly selective RET inhibitors), anti-angiogenic agents (e.g. tyrosine kinase inhibitors (TKIs)) and immune checkpoint inhibitors, which significantly ameliorate outcomes in selected groups of thyroid cancer patients. Targeted and anti-angiogenic treatments are characterized by transient and partial efficacy, due to primary or secondary tumor resistance mechanisms, and toxicity profile. Immune therapy-based approaches are producing preliminary results. Herein, we review and prospectively discuss the immune microenvironment in non-medullary and medullary thyroid cancers and its interplays with the angiogenic microenvironment (endothelial cells and pericytes). In addition, we discuss how these interactions might be targeted using combined therapies. Furthermore, we will review chimeric antigen receptor (CAR) T cells treatment that potentially may ensure a more durable and effective response in advanced thyroid cancers. In sum, angiogenic and immune microenvironments show functional connectivity in TCs. Therapies with anti-angiogenic and immune checkpoint inhibitors combined with specific targeted therapy inhibitors with a tolerable toxicity profile may overcome drug resistance and provide better clinical outcomes than single agents.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"37 ","pages":"Article 100544"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Local and systemic impact of adipocyte senescence-associated secretory profile 脂肪细胞衰老相关分泌特征对局部和全身的影响

Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-12-01 Epub Date: 2024-09-13 DOI: 10.1016/j.coemr.2024.100547

Yi Ching Esther Wan, Jeremy Dufau, Kirsty L. Spalding

引用次数: 0

Editorial overview: Cilia and endocrinology 编辑综述：纤毛与内分泌学

Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-12-01 Epub Date: 2024-10-23 DOI: 10.1016/j.coemr.2024.100558

Rex A. Hess, Clémence Belleannée

引用次数: 0

Metabolic (re)programming in skeletal stem cell populations 骨骼干细胞群的代谢（再）编程

Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-12-01 Epub Date: 2024-09-17 DOI: 10.1016/j.coemr.2024.100548

Milica Rajković , Nikola Bogosavljević , Marko Vujačić , Drenka Trivanović

引用次数: 0

“Regulation of adipose-derived fatty acid flux to the liver”-Impact on metabolic dysfunction-associated steatotic liver disease "脂肪源性脂肪酸流向肝脏的调节"--对代谢功能障碍相关脂肪肝的影响

Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI: 10.1016/j.coemr.2024.100559

Erika Folestad, Annelie Falkevall

{"title":"“Regulation of adipose-derived fatty acid flux to the liver”-Impact on metabolic dysfunction-associated steatotic liver disease","authors":"Erika Folestad, Annelie Falkevall","doi":"10.1016/j.coemr.2024.100559","DOIUrl":"10.1016/j.coemr.2024.100559","url":null,"abstract":"<div><div>Obesity is now considered a global epidemic, increasing the prevalence of obesity-related metabolic disorders. Obesity is characterized by an increase in white adipose tissue (WAT) mass that induce local inflammation and insulin resistance in the WAT, causing dysregulation of whole-body homeostasis. WAT is the primary organ for energy storage in the form of triacylglycerols, which are released as fatty acids (FAs) upon energy demand, a process named lipolysis. Under chronic high energy intake, adipocytes can expand to accommodate more triacylglycerols but when the storage capacity is impaired or lipolysis is dysregulated, FAs are redirected to other organs. The systemic overload of FAs contributes to the development of obesity-associated metabolic complications such as metabolic dysfunction-associated steatotic fatty liver disease (MASLD), formerly named non-alcoholic fatty liver disease. This minireview aims to discuss adipose-derived FA flux as a determinator for development of MASLD from an adipocentric perspective, underlining the contribution of WAT dysfunction in this disease.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"37 ","pages":"Article 100559"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142707073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Erratum regarding missing Declaration of Competing Interest statements in previously published articles 关于以前发表的文章中缺少 "竞争利益声明 "的勘误

Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-09-01 Epub Date: 2024-05-30 DOI: 10.1016/j.coemr.2024.100526

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Editorial board page 编辑委员会页面

Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-09-01 Epub Date: 2024-09-16 DOI: 10.1016/S2451-9650(24)00049-8

引用次数: 0