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Current Opinion in Endocrine and Metabolic Research最新文献

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Editorial overview: Endocrinology of bone 编辑综述：骨内分泌学
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-03-19 DOI: 10.1016/j.coemr.2024.100520
Gerard Karsenty, Vijay K. Yada, Julian M. Berger
{"title":"Editorial overview: Endocrinology of bone","authors":"Gerard Karsenty, Vijay K. Yada, Julian M. Berger","doi":"10.1016/j.coemr.2024.100520","DOIUrl":"10.1016/j.coemr.2024.100520","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"35 ","pages":"Article 100520"},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140270158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of primary cilia in the testis 睾丸初级纤毛的作用
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-03-01 DOI: 10.1016/j.coemr.2024.100508
Nathalia de Lima e Martins Lara, Anja Elsenhans, Rkia Dardari, Ina Dobrinski
{"title":"The role of primary cilia in the testis","authors":"Nathalia de Lima e Martins Lara,&nbsp;Anja Elsenhans,&nbsp;Rkia Dardari,&nbsp;Ina Dobrinski","doi":"10.1016/j.coemr.2024.100508","DOIUrl":"https://doi.org/10.1016/j.coemr.2024.100508","url":null,"abstract":"<div><p>A better understanding of the role primary cilia play in the testis is becoming increasingly important in the context of male reproductive health since defects in cilia have been associated with male infertility and reproductive disorders. Primary cilia are found on most somatic cell types within the testis, including Sertoli cells, peritubular myoid cells, and Leydig cells, especially during embryonic and neonatal stages. Primary cilia are involved in signaling pathways that are important for differentiation and function of testicular somatic cells, and cilia are also implicated in testicular morphogenesis. These observations indicate that testicular primary cilia play an integral role in regulating testis development and function.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"34 ","pages":"Article 100508"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140024341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary cilia and Sonic hedgehog signaling in adrenal gland physiology and cancer 肾上腺生理和癌症中的初级纤毛和音速刺猬信号传导
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-03-01 DOI: 10.1016/j.coemr.2024.100507
Ivona Mateska
{"title":"Primary cilia and Sonic hedgehog signaling in adrenal gland physiology and cancer","authors":"Ivona Mateska","doi":"10.1016/j.coemr.2024.100507","DOIUrl":"https://doi.org/10.1016/j.coemr.2024.100507","url":null,"abstract":"<div><p>The adrenal gland is the major steroidogenic organ in mammals, and the Sonic hedgehog (SHH) pathway is particularly important for its development and homeostatic maintenance. In addition, the SHH pathway upregulation has been observed in adrenocortical carcinoma, a rare but deadly cancer. However, many aspects of how the spatial pattern of SHH secretion and signal reception is established and how this pathway signals during cancer remain less clear. Recent studies show that in the adrenal gland, as in other vertebrate tissues, the primary cilium and ciliary-specific proteins are particularly important for SHH pathway activity. Thus, the presence of primary cilia in the adrenal capsule could be limiting the SHH signaling effects to the adrenocortical progenitors in this region.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"34 ","pages":"Article 100507"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S245196502400005X/pdfft?md5=3a3594580781906e7563efb0db33c7e8&pid=1-s2.0-S245196502400005X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140031374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cilia structure and function in human disease 人类疾病中的纤毛结构和功能
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-03-01 DOI: 10.1016/j.coemr.2024.100509
Gregory J. Pazour
{"title":"Cilia structure and function in human disease","authors":"Gregory J. Pazour","doi":"10.1016/j.coemr.2024.100509","DOIUrl":"https://doi.org/10.1016/j.coemr.2024.100509","url":null,"abstract":"<div><p>Ciliary dysfunction causes a large group of developmental and degenerative human diseases known as ciliopathies. These diseases reflect the critical roles that cilia play in sensing the environment and in force generation for motility. Sensory functions include our senses of vision and olfaction. In addition, primary and motile cilia throughout our body monitor the environment allowing cells to coordinate their biology with the cells around them. This coordination is critical to organ development and maintenance, and ciliary dysfunction causes diverse structural birth defects and degenerative diseases. Deficiencies in motility lead to various health issues: lung diseases arise from impaired mucociliary clearance; male infertility results from compromised sperm motility and their inability to traverse the efferent ducts effectively; and disruptions in the left-right axis stem from nodal cilia's failure to establish accurate left-right cues.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"34 ","pages":"Article 100509"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140031375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial board page 编辑委员会页面
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-03-01 DOI: 10.1016/S2451-9650(24)00011-5
{"title":"Editorial board page","authors":"","doi":"10.1016/S2451-9650(24)00011-5","DOIUrl":"https://doi.org/10.1016/S2451-9650(24)00011-5","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"34 ","pages":"Article 100513"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451965024000115/pdfft?md5=ad05e98ebc3bd0b444cb03e0cf56da26&pid=1-s2.0-S2451965024000115-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140180482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular genetics of parathyroid tumors 甲状旁腺肿瘤的分子遗传学
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-03-01 DOI: 10.1016/j.coemr.2024.100510
Francesca Marini , Francesca Giusti , Maria Luisa Brandi
{"title":"Molecular genetics of parathyroid tumors","authors":"Francesca Marini ,&nbsp;Francesca Giusti ,&nbsp;Maria Luisa Brandi","doi":"10.1016/j.coemr.2024.100510","DOIUrl":"https://doi.org/10.1016/j.coemr.2024.100510","url":null,"abstract":"<div><p>Parathyroid tumors affect less than 0.5% of the general population. They commonly manifest as benign parathyroid adenoma (PA) in about 98% of cases, as atypical parathyroid adenoma (aPA) in 1.2%–1.3% of cases, or as malignant parathyroid carcinoma (PC) in less than 1% of patients. Over 90% of cases present as a sporadic disease, caused by somatic mutations occurred in a single parathyroid chief cell, leading to the development of a single-gland neoplasm. In less than 10% of cases, parathyroid tumors occur as a part of congenital non-syndromic or syndromic endocrine disorders, caused by a germline autosomal dominant mutation inherited by one parent, independently by sex, or, in extremely rare cases, by a <em>de novo</em> mutation occurred during the embryo development.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"34 ","pages":"Article 100510"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary cilia and gonadotropin-releasing hormone neurons 初级纤毛和促性腺激素释放激素神经元
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-02-20 DOI: 10.1016/j.coemr.2024.100504
Toneisha Stubbs, Kirk Mykytyn
{"title":"Primary cilia and gonadotropin-releasing hormone neurons","authors":"Toneisha Stubbs,&nbsp;Kirk Mykytyn","doi":"10.1016/j.coemr.2024.100504","DOIUrl":"https://doi.org/10.1016/j.coemr.2024.100504","url":null,"abstract":"<div><p>Non-sensory neurons in the mammalian brain possess a primary cilium. Neuronal cilia act as antenna and receive inputs from the extracellular environment to modulate developmental pathways and neuronal activity. These functions require ciliary enrichment of specific proteins, such as G protein-coupled receptors (GPCRs). Although most neurons possess only one cilium, gonadotropin-releasing hormone (GnRH) neurons extend multiple primary cilia. GnRH neurons are central effectors of reproductive function and cilia on GnRH neurons are enriched for the kisspeptin receptor, a GPCR required for sexual maturation and reproductive function. Here, we provide a brief background on reproduction and primary cilia, discuss what is known about primary cilia on GnRH neurons, and present approaches for further elucidating the roles of cilia on GnRH neurons.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"34 ","pages":"Article 100504"},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451965024000024/pdfft?md5=a0ae59178287b9a7231b6e0f9df1905a&pid=1-s2.0-S2451965024000024-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139942229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bend or break: The primary cilium as a potential regulator of electrolyte reabsorption in the kidney 弯曲或断裂作为肾脏电解质重吸收潜在调节器的初级纤毛膜
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-02-20 DOI: 10.1016/j.coemr.2024.100506
Wouter H. van Megen, Joost G.J. Hoenderop
{"title":"Bend or break: The primary cilium as a potential regulator of electrolyte reabsorption in the kidney","authors":"Wouter H. van Megen,&nbsp;Joost G.J. Hoenderop","doi":"10.1016/j.coemr.2024.100506","DOIUrl":"https://doi.org/10.1016/j.coemr.2024.100506","url":null,"abstract":"<div><p>The epithelial cells lining the lumen of the tubular system in the kidney are exposed to a highly dynamic microenvironment, owing to the fluid flow of the pro-urine through this system. Renal flow sensing has been linked to various processes in the kidney, including electrolyte reabsorption. An important mediator of renal flow sensing is the primary cilium, which is found on almost all tubular epithelial cells. In this review, we describe the reported effects of fluid flow on electrolyte transport in the different segments of the nephron and whether these effects are dependent on the primary cilium. Collectively, these studies highlight the stimulatory effect of fluid flow on electrolyte reabsorption, with a variable degree of dependency on the primary cilium.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"34 ","pages":"Article 100506"},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451965024000048/pdfft?md5=b87e8a320dbb4e7a7c3965e8af27a270&pid=1-s2.0-S2451965024000048-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139986814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paracrine signaling by pancreatic islet cilia 胰岛纤毛的旁分泌信号
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-02-20 DOI: 10.1016/j.coemr.2024.100505
Samantha E. Adamson, Jing W. Hughes
{"title":"Paracrine signaling by pancreatic islet cilia","authors":"Samantha E. Adamson,&nbsp;Jing W. Hughes","doi":"10.1016/j.coemr.2024.100505","DOIUrl":"https://doi.org/10.1016/j.coemr.2024.100505","url":null,"abstract":"<div><p>The primary cilium is a sensory and signaling organelle present on most pancreatic islet endocrine cells, where it receives and interprets a wide range of intra-islet chemical cues, including hormones, peptides, and neurotransmitters. The ciliary membrane possesses a molecular composition distinct from the plasma membrane, with enrichment of signaling mediators including G protein-coupled receptors (GPCRs), tyrosine kinase family receptors, membrane transporters, and others. When activated, these membrane proteins interact with ion channels and adenylyl cyclases to trigger local Ca<sup>2+</sup> and cyclic adenosine monophosphate (cAMP) activity and transmit signals to the cell body. Here we review evidence supporting the emerging model in which primary cilia on pancreatic islet cells play a central role in the intra-islet communication network and discuss how changes in cilia-mediated paracrine function in islet cells might lead to diabetes.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"35 ","pages":"Article 100505"},"PeriodicalIF":0.0,"publicationDate":"2024-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451965024000036/pdfft?md5=eb05daf0946c1b5ba980bf7896c8f8a4&pid=1-s2.0-S2451965024000036-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140067402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategies to investigate migration and metastases in thyroid cancer 研究甲状腺癌迁移和转移的策略
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-02-01 DOI: 10.1016/j.coemr.2023.100502
Daniel M. Chopyk , Priya H. Dedhia
{"title":"Strategies to investigate migration and metastases in thyroid cancer","authors":"Daniel M. Chopyk ,&nbsp;Priya H. Dedhia","doi":"10.1016/j.coemr.2023.100502","DOIUrl":"10.1016/j.coemr.2023.100502","url":null,"abstract":"<div><p>Thyroid cancer is the most common endocrine malignancy and is also one of the most rapidly increasing cancers worldwide. Although most patients have an excellent prognosis, a significant portion of patients experience disease relapse and metastatic progression. Treatment options for these patients remain inadequate as traditional chemotherapy has limited efficacy, and aggressive disease frequently acquires resistance to radioactive iodine. Because the majority of thyroid cancer mortality is caused by metastatic disease, there is an urgent need to elucidate the mechanisms of thyroid cancer migration and metastasis. While the mechanisms behind thyroid cancer metastasis remains in its infancy, remarkable advancements in genomics, traditional 2-dimensional cell culture, murine models, and 3-dimensional cultures have yielded new insight. This review outlines methodological approaches that can be used to investigate thyroid cancer migration and metastases and in doing so will highlight a number of recent findings that have utilized these approaches.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"34 ","pages":"Article 100502"},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139686376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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