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Current Opinion in Endocrine and Metabolic Research最新文献

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Bacterial gene expression in response to catecholamine stress hormones 细菌基因表达对儿茶酚胺应激激素的反应
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-09-01 DOI: 10.1016/j.coemr.2024.100543
{"title":"Bacterial gene expression in response to catecholamine stress hormones","authors":"","doi":"10.1016/j.coemr.2024.100543","DOIUrl":"10.1016/j.coemr.2024.100543","url":null,"abstract":"<div><p>Bacteria–host communication plays a crucial role in symbiosis and pathogenesis. Investigations of pathogenic bacterial responses to host neurotransmitters, including catecholamines, have been the subject of several studies. Both Epinephrine (Epi) and Norepinephrine (NE) catecholamines can modulate bacterial physiology, affecting growth, motility, biofilm formation, virulence, and interactions with eukaryotic cells. This has been widely described in Gram-negative bacteria and mostly for pathogens (<em>i.e</em>. <em>Escherichia coli</em>, <em>Campylobacter jejuni</em>, <em>Salmonella enterica,</em> and <em>Vibrio cholerae</em>). In this review, we focused on whole and targeted bacterial gene expression that have been modulated upon exposure to Epi and NE catecholamines. A wide range of these genes were involved in various physiological aspects (<em>i.e</em>. general metabolism, stress responses, uptake/transport, motility, biofilm, and virulence).</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142149430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial board page 编辑委员会页面
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-09-01 DOI: 10.1016/S2451-9650(24)00049-8
{"title":"Editorial board page","authors":"","doi":"10.1016/S2451-9650(24)00049-8","DOIUrl":"10.1016/S2451-9650(24)00049-8","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451965024000498/pdfft?md5=2c19a62866a91cc227023f75c0207427&pid=1-s2.0-S2451965024000498-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interaction of skin-born mediators with the cutaneous microbiota and beyond 皮肤生成的介质与皮肤微生物群的相互作用及其他
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-08-22 DOI: 10.1016/j.coemr.2024.100545
{"title":"Interaction of skin-born mediators with the cutaneous microbiota and beyond","authors":"","doi":"10.1016/j.coemr.2024.100545","DOIUrl":"10.1016/j.coemr.2024.100545","url":null,"abstract":"<div><p>Cutaneous microorganisms are growing in a microenvironment where skin hormones and neurohormones are present in abundance. These molecules are markers of the host physiology, and microorganisms have developed strategies for detecting host factors that can represent a threat for their survival. Until now, our knowledge of these mechanisms is limited to bacteria, although the skin microbiota also includes an abundance of yeasts, fungi, viruses, and even archaea. Several human hormones and neurotransmitters, including substance P, calcitonin gene-related peptides, natriuretic peptides, catecholamines, and even estradiol have been studied in this context. This was leading to the identification of original proteins, such as the thermo-unstable ribosomal elongation factor, the chaperone DnaK, or the enzyme AmiC, which have been developed by bacteria and have dual functions, in the cytoplasm where they were originally identified and in the bacterial membrane where they act as sensors for host factors. These sensors, designed as moonlighting proteins for their dual functions, are submitted to structural reorganizations and probably post-translational modifications. The occurrence of epigenetic mechanisms in the regulation of moonlighting proteins activity is a source of major complications since similar processes are activated during bacteria adaptation to the host physiology and even storage. Cutaneous bacterial endocrinology is a wide and complex emerging scientific field that requires a deep knowledge of both human and microbial physiology and careful experimental procedures.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142230373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Timing of physical activity in the pursuit of fat mass loss and weight maintenance 把握体育锻炼的时机，减少脂肪量和保持体重
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-08-03 DOI: 10.1016/j.coemr.2024.100542
{"title":"Timing of physical activity in the pursuit of fat mass loss and weight maintenance","authors":"","doi":"10.1016/j.coemr.2024.100542","DOIUrl":"10.1016/j.coemr.2024.100542","url":null,"abstract":"<div><p>Obesity is a significant global burden for individuals and healthcare systems with its array of associated chronic cardiometabolic diseases. While lifestyle modifications such as dietary interventions and increased physical activity are effective in weight management, recent investigations highlight the critical role of timing these interventions in accordance with our body's circadian clock. Over the past decade, multiple studies and meta analyses have investigated how the timing of exercise training influences white adipose tissue (WAT) biology, fat mass loss, and obesity, but physical activity guidelines have not yet adopted a recommendation for exercise timing due to conflicting conclusions. This review aims to summarize the latest findings in this field and touches upon contributing factors such as sex disparities and nutrition timing.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451965024000401/pdfft?md5=c2a01dab6aa7129a7cbd8ed5b61bfefa&pid=1-s2.0-S2451965024000401-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142041076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fasting-regulated mechanisms in inter-organ crosstalk 器官间串扰的快速调节机制
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-07-17 DOI: 10.1016/j.coemr.2024.100540
{"title":"Fasting-regulated mechanisms in inter-organ crosstalk","authors":"","doi":"10.1016/j.coemr.2024.100540","DOIUrl":"10.1016/j.coemr.2024.100540","url":null,"abstract":"<div><p>The adaptation to changing environmental cues represents a key prerequisite for the survival of an organism. Mammals, including humans, have evolved intricate endocrine signals to convey information about the nutritional status to individual organs, cells, and eventually the cell nucleus, to trigger appropriate molecular-metabolic responses. To this end, mounting a proper fasting response is determined by not only intra-organ adaptations but also inter-tissue crosstalk mechanisms that orchestrate whole-body energy homeostasis under nutrient-deprived conditions. Here, we shortly summarize recent advances in our current understanding of the key processes driving the adaptive response to fasting with a focus on the crosstalk between the adipose tissue and liver ketogenesis.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451965024000383/pdfft?md5=bc170d1253de810829c6e33e4643659b&pid=1-s2.0-S2451965024000383-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141841118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Attenuation of adipose tissue inflammation by pro-resolving lipid mediators 促溶解脂质介质缓解脂肪组织炎症
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-07-16 DOI: 10.1016/j.coemr.2024.100539
{"title":"Attenuation of adipose tissue inflammation by pro-resolving lipid mediators","authors":"","doi":"10.1016/j.coemr.2024.100539","DOIUrl":"10.1016/j.coemr.2024.100539","url":null,"abstract":"<div><p>Adipose tissue inflammation drives systemic pathophysiology, for instance, obesity-related cardiometabolic disease. Specialized pro-resolving lipid mediators are a superfamily of endogenously produced lipids that promote the resolution of inflammation, an actively regulated process. New evidence suggests that such lipids (e.g. lipoxins) could resolve adipose tissue inflammation and, thus, subvert obesity-related diseases. A key feature of pro-resolving lipids is their ability to promote an M2-like macrophage phenotype and enhance efferocytosis while avoiding adverse side-effects typically associated with anti-inflammatory drugs, such as increased sensitivity to infections. This brief review discusses the therapeutic potential of pro-resolving lipid mediators in mitigating systemic disease fueled by adipose tissue inflammation in both experimental and human disease models.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451965024000371/pdfft?md5=4ae9fe6975231130f1cb7d542ac2f363&pid=1-s2.0-S2451965024000371-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141839662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetics of cortisol-secreting bilateral macro- and micronodular adrenal hyperplasias 分泌皮质醇的双侧大和小结节性肾上腺皮质增生症的遗传问题
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-07-16 DOI: 10.1016/j.coemr.2024.100541
{"title":"Genetics of cortisol-secreting bilateral macro- and micronodular adrenal hyperplasias","authors":"","doi":"10.1016/j.coemr.2024.100541","DOIUrl":"10.1016/j.coemr.2024.100541","url":null,"abstract":"<div><p>Bilateral adrenal cortex hyperplasias can present in various forms and are divided as either macronodular or micronodular. This review presents the recent identifications of the genetic alterations responsible for the various forms of cortisol-secreting adrenal hyperplasias. These include the tumor suppressor genes <em>ARMC5</em> in bilateral primary macronodular adrenal hyperplasia (PBMAH) and <em>KDM1A</em> in GIP-dependent PBMAH with Cushing’s syndrome. Other genetic alterations are found in PBMAH associated with rare syndromic forms and various cAMP/PKA pathway gene mutations are involved in both macronodular and micronodular adrenal hyperplasias. We present as well certain clinical recommendations for each genetic etiology, including that <em>ARMC5</em> or <em>KDM1A</em> genetic testing should be offered to all patients with PBMAH, depending on the Cushing syndrome’s GIP-dependence or not.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451965024000395/pdfft?md5=75ff7d13bafa41b57854769888e8b971&pid=1-s2.0-S2451965024000395-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141852507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: Genetics of endocrine tumors 编辑综述：内分泌肿瘤的遗传学
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-06-29 DOI: 10.1016/j.coemr.2024.100538
{"title":"Editorial overview: Genetics of endocrine tumors","authors":"","doi":"10.1016/j.coemr.2024.100538","DOIUrl":"10.1016/j.coemr.2024.100538","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141951272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How human hormones regulate human microbiota: Where are we in the middle of this terra incognita? 人体荷尔蒙如何调节人体微生物群：我们在这个未知领域的中间处于什么位置？
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-06-24 DOI: 10.1016/j.coemr.2024.100537
{"title":"How human hormones regulate human microbiota: Where are we in the middle of this terra incognita?","authors":"","doi":"10.1016/j.coemr.2024.100537","DOIUrl":"10.1016/j.coemr.2024.100537","url":null,"abstract":"<div><p>Human organism is tightly interconnected with its microbiota on physiological and signaling levels. Microbial endocrinology as an interdisciplinary area of studying host–microbiota interactions can focus on either player: how the microbiota affects the host via synthesis of host-targeted humoral factors and how the host-derived molecules regulate the microbial community homeostasis. The present mini-review presents the authors' perspective on the impact of human hormones on the microbiota. It discusses known effects, but especially outlines existing complications in this research area, and proposes directions for future investigation.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141622178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Type 1 diabetes mellitus and host–bacterial interactions in the oral cavity 1 型糖尿病与口腔中宿主与细菌的相互作用
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-06-13 DOI: 10.1016/j.coemr.2024.100536
Ulvi Kahraman Gürsoy , Neslihan Yilmaz , Dogukan Yilmaz , Sanni Grönroos , Mervi Gürsoy
{"title":"Type 1 diabetes mellitus and host–bacterial interactions in the oral cavity","authors":"Ulvi Kahraman Gürsoy ,&nbsp;Neslihan Yilmaz ,&nbsp;Dogukan Yilmaz ,&nbsp;Sanni Grönroos ,&nbsp;Mervi Gürsoy","doi":"10.1016/j.coemr.2024.100536","DOIUrl":"10.1016/j.coemr.2024.100536","url":null,"abstract":"<div><p>Type 1 diabetes mellitus (T1DM) is an autoimmune disease which is characterized by the destruction of insulin-producing pancreatic β-cells. Current evidence supports the contribution of T-cells, macrophages, B-cells, and dendritic cells to the pathogenesis of T1DM as well. T1DM-associated risk factors, including defects in host immune response, socioeconomic conditions, and environmental factors create a dysbiotic environment in the oral cavity, which support the growth of pathogenic microbial biofilms. Changes in microbial composition, together with the diminished immune response, lead to the development of two most common oral diseases, caries and periodontal diseases. In the present review, we summarized the current evidence on oral manifestations of T1DM and described the shifts in oral microbial composition and oral immune response.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451965024000346/pdfft?md5=a0dd3a5069cc0af9d23b75036a52e4d5&pid=1-s2.0-S2451965024000346-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141393221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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