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Current Opinion in Endocrine and Metabolic Research最新文献

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Endocrine disruptive chemicals (EDCs) and autoimmune thyroid diseases (AITD): A systematic literature review 内分泌干扰物（EDCs）与自身免疫性甲状腺疾病（AITD）：系统的文献综述
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-09-03 DOI: 10.1016/j.coemr.2025.100585
Mathilda Monaghan , Sonia Rodrigues , Shiven Sharma , Angela M. Leung , Maaike van Gerwen
{"title":"Endocrine disruptive chemicals (EDCs) and autoimmune thyroid diseases (AITD): A systematic literature review","authors":"Mathilda Monaghan ,&nbsp;Sonia Rodrigues ,&nbsp;Shiven Sharma ,&nbsp;Angela M. Leung ,&nbsp;Maaike van Gerwen","doi":"10.1016/j.coemr.2025.100585","DOIUrl":"10.1016/j.coemr.2025.100585","url":null,"abstract":"<div><div>The association between endocrine disruptive chemicals (EDCs) and autoimmune thyroid disease (AITD) has not been well established. This systematic review aimed to summarize existing literature and provide an up-to-date overview of EDCs and their association with AITD. A search of the National Library of Medicine PubMed and Scopus databases was completed to identify relevant articles published in English through September 2024. A total of 4 studies met inclusion criteria. Results of the included studies varied, ranging from significant positive to significant negative associations with AITD for different EDCs. This comprehensive review highlights the limited knowledge of this association. Besides investigating individual EDCs, it is important to include dose–response studies and exposures to EDC mixtures.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"41 ","pages":"Article 100585"},"PeriodicalIF":0.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial board page 编委会页面
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-09-01 DOI: 10.1016/S2451-9650(25)00017-1
{"title":"Editorial board page","authors":"","doi":"10.1016/S2451-9650(25)00017-1","DOIUrl":"10.1016/S2451-9650(25)00017-1","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"40 ","pages":"Article 100586"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oxysterol-related disorders Oxysterol-related障碍
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-06-25 DOI: 10.1016/j.coemr.2025.100583
Akira Honda , Hajime Ueda , Teruo Miyazaki , Tadashi Ikegami
{"title":"Oxysterol-related disorders","authors":"Akira Honda ,&nbsp;Hajime Ueda ,&nbsp;Teruo Miyazaki ,&nbsp;Tadashi Ikegami","doi":"10.1016/j.coemr.2025.100583","DOIUrl":"10.1016/j.coemr.2025.100583","url":null,"abstract":"<div><div>Recent advances in oxysterol analysis and studies on their molecular targets indicate that oxysterols, enzymatic or non-enzymatic cholesterol derivatives, are active molecules involved in the pathophysiology of various diseases. This review describes and discusses the recent developments in several oxysterol-related disorders, including atherosclerosis, metabolic dysfunction-associated steatotic liver disease, Alzheimer’s disease, multiple sclerosis, and breast and lung cancers. Unlike congenital abnormalities of oxysterol-metabolizing enzymes, such as cerebrotendinous xanthomatosis and hereditary spastic paraplegia type 5, it is often difficult to assess whether altered oxysterol levels in acquired diseases are the cause or the consequence of disease. In addition, oxysterols exert beneficial or deleterious effects on diseases depending on their structures. Despite these limitations, accumulated experimental evidence is beginning to clarify the impact of oxysterols on the pathophysiology of various diseases.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"40 ","pages":"Article 100583"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
25-hydroxycholesterol in inflammation 25-羟基胆固醇在炎症中的作用
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-06-25 DOI: 10.1016/j.coemr.2025.100582
Romeo Carre, Solenne Vigne, Caroline Pot
{"title":"25-hydroxycholesterol in inflammation","authors":"Romeo Carre,&nbsp;Solenne Vigne,&nbsp;Caroline Pot","doi":"10.1016/j.coemr.2025.100582","DOIUrl":"10.1016/j.coemr.2025.100582","url":null,"abstract":"<div><div>Oxysterols, biological active oxidized forms of cholesterol, regulate cholesterol metabolism and intracellular cholesterol levels. They have been attributed additional roles during inflammation and recent data have highlighted their implication in human diseases. The oxysterol downstream of cholesterol 25-hydroxylase (Ch25h), 25-Hydroxycholesterol (25-HC), is largely produced during inflammatory processes. 25-HC and its derived oxysterols play critical roles in immune cell chemotaxis, viral replication inhibition, and neuroinflammation. Mechanistically, mitochondrial function, inflammasomes, endoplasmic reticulum stress, cell death, and cellular metabolism are involved. This review aims to bring the latest knowledge about the role of Ch25h-derived oxysterols under inflammatory conditions related to human diseases, specifically autoimmunity, neurological disorders, and cancers.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"40 ","pages":"Article 100582"},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A revised Oxysterol Hypothesis highlighting the special roles played by 24(S),25-Epoxycholesterol 修正后的氧甾醇假说强调了24(S)，25-环氧胆固醇的特殊作用
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-06-01 DOI: 10.1016/j.coemr.2025.100578
Nicole M. Fenton, Laura J. Sharpe, Andrew J. Brown
{"title":"A revised Oxysterol Hypothesis highlighting the special roles played by 24(S),25-Epoxycholesterol","authors":"Nicole M. Fenton,&nbsp;Laura J. Sharpe,&nbsp;Andrew J. Brown","doi":"10.1016/j.coemr.2025.100578","DOIUrl":"10.1016/j.coemr.2025.100578","url":null,"abstract":"<div><div>First proposed in 1978, the Oxysterol Hypothesis asserted that oxysterols exert feedback regulation on cholesterol synthesis rather than cholesterol itself. We argue for a revised Oxysterol Hypothesis focussing on recent findings regarding one oxysterol in particular. 24(<em>S</em>),25-epoxycholesterol (24,25EC) is synthesised by a shunt in the cholesterol synthesis pathway, in addition to being produced in the brain from a cholesterol precursor by a sterol hydroxylase (CYP46A1). 24,25EC is implicated in biological processes far beyond just cholesterol metabolism, including being an agonist for Smoothened which transduces the signal in the Hedgehog development pathway, and exerting profound effects on immune functions. We discuss how manipulating 24,25EC is of clinical interest in treating a wide range of disorders, including liver diseases, neurological diseases, and cancers.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"39 ","pages":"Article 100578"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144204145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial board page 编委会页面
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-06-01 DOI: 10.1016/S2451-9650(25)00010-9
{"title":"Editorial board page","authors":"","doi":"10.1016/S2451-9650(25)00010-9","DOIUrl":"10.1016/S2451-9650(25)00010-9","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"39 ","pages":"Article 100579"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adipose tissue-driven inter-organ metabolite crosstalk 脂肪组织驱动的器官间代谢产物串扰
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-04-19 DOI: 10.1016/j.coemr.2025.100577
Carolina Hagberg , Zoi Michailidou
{"title":"Adipose tissue-driven inter-organ metabolite crosstalk","authors":"Carolina Hagberg ,&nbsp;Zoi Michailidou","doi":"10.1016/j.coemr.2025.100577","DOIUrl":"10.1016/j.coemr.2025.100577","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"39 ","pages":"Article 100577"},"PeriodicalIF":0.0,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial board page 编委会页面
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-03-01 DOI: 10.1016/S2451-9650(25)00005-5
{"title":"Editorial board page","authors":"","doi":"10.1016/S2451-9650(25)00005-5","DOIUrl":"10.1016/S2451-9650(25)00005-5","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"38 ","pages":"Article 100574"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thyroid cancer—Editorial overview 甲状腺癌编辑综述
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-01-25 DOI: 10.1016/j.coemr.2025.100573
Jennifer A Sipos, Vicki E Smith
{"title":"Thyroid cancer—Editorial overview","authors":"Jennifer A Sipos,&nbsp;Vicki E Smith","doi":"10.1016/j.coemr.2025.100573","DOIUrl":"10.1016/j.coemr.2025.100573","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"38 ","pages":"Article 100573"},"PeriodicalIF":0.0,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143429418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights into the role of adipose tissue-derived microRNAs in intercellular communication during cardiometabolic diseases 洞察脂肪组织来源的microrna在心脏代谢疾病期间细胞间通讯中的作用
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-01-22 DOI: 10.1016/j.coemr.2025.100572
Henver S. Brunetta , Stepheny C. de Campos Zani , Gabriel P. Ruiz , Marcelo A. Mori
{"title":"Insights into the role of adipose tissue-derived microRNAs in intercellular communication during cardiometabolic diseases","authors":"Henver S. Brunetta ,&nbsp;Stepheny C. de Campos Zani ,&nbsp;Gabriel P. Ruiz ,&nbsp;Marcelo A. Mori","doi":"10.1016/j.coemr.2025.100572","DOIUrl":"10.1016/j.coemr.2025.100572","url":null,"abstract":"<div><div>microRNAs (miRNAs) secreted by the adipose tissue (AT) have gained substantial attention over the last decade. Adipocytes produce and secrete large amounts of miRNAs that, in turn, can mediate physiological processes paracrinally or in distant organs. It is now clear that AT-derived miRNAs are important players in the development of obesity-associated comorbidities. Here, we provide an overview that supports this notion and bring insights into the intricate involvement of AT-derived miRNAs in the pathogenesis of cardiometabolic diseases, discussing some of their far-reaching effects on the liver, heart, vasculature, and other tissues. Moreover, we outline future research directions addressing current gaps in the field which we hope will further advance our comprehension of the role of AT-derived miRNAs.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"38 ","pages":"Article 100572"},"PeriodicalIF":0.0,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143378591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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