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Current Opinion in Endocrine and Metabolic Research最新文献

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Environmental challenges to thyroid homeostasis: Combined effects of iodine deficiency and endocrine disruption 环境对甲状腺稳态的挑战：碘缺乏和内分泌紊乱的综合影响
Current Opinion in Endocrine and Metabolic Research Pub Date : 2026-03-01 Epub Date: 2026-01-21 DOI: 10.1016/j.coemr.2026.100597
Patricia Rannaud-Bartaire , Anni Herranen , Giovanni Levi , Barbara Demeneix , Jean-Baptiste Fini
{"title":"Environmental challenges to thyroid homeostasis: Combined effects of iodine deficiency and endocrine disruption","authors":"Patricia Rannaud-Bartaire ,&nbsp;Anni Herranen ,&nbsp;Giovanni Levi ,&nbsp;Barbara Demeneix ,&nbsp;Jean-Baptiste Fini","doi":"10.1016/j.coemr.2026.100597","DOIUrl":"10.1016/j.coemr.2026.100597","url":null,"abstract":"<div><div>Thyroid hormone system is crucial for numerous physiological processes, including development, growth, and metabolism. Iodine, an indispensable micronutrient, is required for thyroid hormone (TH) synthesis. Inadequate supply or disruption of its metabolism can compromise thyroid function. Disruption of the thyroid hormone pathways by environmental endocrine-disrupting chemicals (EDCs) is being studied with growing interest. In several human populations, exposure to EDCs frequently co-occur with insufficient iodine intake, impairing thyroid function, and reducing the capacity to adapt to environmental changes. This brief review summarizes the current state of knowledge on the mechanisms through which EDCs and iodine deficiency can interfere with virtually every component of TH homeostasis. A better understanding of these combined effects is critical for maintaining a healthy population.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"42 ","pages":"Article 100597"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147420897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of pesticide exposure on thyroid function and neoplasia 农药暴露对甲状腺功能和肿瘤的影响
Current Opinion in Endocrine and Metabolic Research Pub Date : 2026-03-01 Epub Date: 2025-12-01 DOI: 10.1016/j.coemr.2025.100593
Joanne Lin, Whitney Goldner
{"title":"The impact of pesticide exposure on thyroid function and neoplasia","authors":"Joanne Lin,&nbsp;Whitney Goldner","doi":"10.1016/j.coemr.2025.100593","DOIUrl":"10.1016/j.coemr.2025.100593","url":null,"abstract":"<div><div>Environmental exposure to endocrine disrupting chemicals is a significant public health concern. Pesticides represent a subset of the potential environmental exposures impacting human health, including the thyroid. Some pesticides are considered persistent organic pollutants, and so are present in the soil, water, and food chain long after they have been used, creating the potential for exposure for decades, even after they have been removed from the market. Exposures can occur through occupational exposure, but there is increasing evidence for residential exposure in non-agricultural workers. Some pesticides are considered endocrine disruptors, and there are epidemiologic associations reported between specific pesticides and thyroid hormone alterations and thyroid carcinogenesis. In this review, we will discuss the relationship between pesticides and the thyroid.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"42 ","pages":"Article 100593"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial board page 编委会页面
Current Opinion in Endocrine and Metabolic Research Pub Date : 2026-03-01 Epub Date: 2026-03-21 DOI: 10.1016/S2451-9650(26)00004-9
{"title":"Editorial board page","authors":"","doi":"10.1016/S2451-9650(26)00004-9","DOIUrl":"10.1016/S2451-9650(26)00004-9","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"42 ","pages":"Article 100600"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147612359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of bone marrow adipose tissue evaluation in improving osteoporotic fracture risk assessment 骨髓脂肪组织评估在改善骨质疏松性骨折风险评估中的作用
Current Opinion in Endocrine and Metabolic Research Pub Date : 2026-03-01 Epub Date: 2026-02-12 DOI: 10.1016/j.coemr.2026.100598
Julien Paccou
{"title":"The role of bone marrow adipose tissue evaluation in improving osteoporotic fracture risk assessment","authors":"Julien Paccou","doi":"10.1016/j.coemr.2026.100598","DOIUrl":"10.1016/j.coemr.2026.100598","url":null,"abstract":"<div><div>Osteoporosis represents a major global health burden, and emerging data suggest that bone marrow adipose tissue (BMAT) may contribute to skeletal fragility beyond bone mineral density (BMD). BMAT varies with age, sex, and skeletal site, and recent advances in MRI- and HR-pQCT–based techniques allow accurate quantification. Although BMAT is consistently inversely associated with BMD, evidence linking BMAT to fractures is heterogeneous. Cross-sectional and longitudinal studies have indicated the limited added predictive value of BMAT over established clinical risk factors and BMD. Large-scale imaging and genetic analyses reinforce the biological relevance of BMAT but not its clinical utility. Future research should clarify the role of BMAT in specific secondary osteoporosis settings and in combination with advanced analytical approaches.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"42 ","pages":"Article 100598"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147420898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interplay of obesity and endocrine disrupting chemicals on thyroid 肥胖与内分泌干扰物对甲状腺的相互作用
Current Opinion in Endocrine and Metabolic Research Pub Date : 2026-03-01 Epub Date: 2025-11-25 DOI: 10.1016/j.coemr.2025.100592
Laura Sterian Ward, Sophia de Alcantara Rodrigues, Elisangela de Souza Teixeira
{"title":"Interplay of obesity and endocrine disrupting chemicals on thyroid","authors":"Laura Sterian Ward,&nbsp;Sophia de Alcantara Rodrigues,&nbsp;Elisangela de Souza Teixeira","doi":"10.1016/j.coemr.2025.100592","DOIUrl":"10.1016/j.coemr.2025.100592","url":null,"abstract":"<div><div>The thyroid gland is a sensitive target of endocrine-disrupting chemicals (EDCs), which can interfere with hormone synthesis, metabolism, and receptor signaling. Concurrently, obesity is increasingly recognized as both a modifier and potential amplifier of EDCs toxicity, particularly within the hypothalamic–pituitary–thyroid axis. Current evidence suggests that bisphenols, phthalates, perfluoroalkyl compounds, and polychlorinated biphenyls are linked to modest but measurable changes in thyroid hormone balance, often influenced by body weight. Adipose tissue may serve as a reservoir for lipophilic EDCs, sustaining internal exposure, and exacerbating metabolic dysregulation. However, the extent to which these associations reflect causal mechanisms remains unclear. Future research should prioritize longitudinal and mechanistic studies to clarify directionality, identify vulnerable populations, and inform precision-based approaches for exposure mitigation.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"42 ","pages":"Article 100592"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in medical and surgical therapies for transgender and gender-diverse individuals 跨性别者和性别多样化个体的医疗和外科治疗进展
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-12-01 Epub Date: 2025-09-30 DOI: 10.1016/j.coemr.2025.100588
Aaron L. Misakian , Maja Marinkovic
{"title":"Advances in medical and surgical therapies for transgender and gender-diverse individuals","authors":"Aaron L. Misakian ,&nbsp;Maja Marinkovic","doi":"10.1016/j.coemr.2025.100588","DOIUrl":"10.1016/j.coemr.2025.100588","url":null,"abstract":"<div><div>This review aims to highlight new advances in transgender medicine, including innovative approaches to pubertal and menstrual suppression, gender-affirming hormone therapy, and management of voice dysphoria for both adolescent and adult patients.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"41 ","pages":"Article 100588"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145364207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disparities in endocrine-disrupting chemical exposures and thyroid disorders 内分泌干扰化学物质暴露与甲状腺疾病的差异
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-12-01 Epub Date: 2025-11-10 DOI: 10.1016/j.coemr.2025.100591
Luyu Wang , Jennifer Flores , Robert M. Sargis
{"title":"Disparities in endocrine-disrupting chemical exposures and thyroid disorders","authors":"Luyu Wang ,&nbsp;Jennifer Flores ,&nbsp;Robert M. Sargis","doi":"10.1016/j.coemr.2025.100591","DOIUrl":"10.1016/j.coemr.2025.100591","url":null,"abstract":"<div><div>Over the last twenty years, thyroid disorder prevalence has more than doubled in the United States, with notable disparities emerging in disease incidence and outcomes. While partially attributable to inequities in healthcare delivery, whether environmental factors such as exposure to endocrine-disrupting chemicals (EDCs) contribute to differences in thyroid disease pathogenesis in vulnerable populations is plausible but understudied. To better understand how environmental factors may contribute to thyroid disease disparities, this review discusses differences in exposure to several thyroid-disrupting EDCs among historically disadvantaged communities, including polychlorinated biphenyls, bisphenols, brominated flame retardants, organochlorine pesticides, phthalates, per-/polyfluoroalkyl substances, and non-ess metals. Coupled with knowledge of exposure sources, these data may empower individual- and policy-level interventions to address thyroid disease disparities and promote health equity.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"41 ","pages":"Article 100591"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145684306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perchlorate and thyroid function 高氯酸盐和甲状腺功能
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-12-01 Epub Date: 2025-09-27 DOI: 10.1016/j.coemr.2025.100589
Stacy N. Handler, Maria A. Luna Cuadros, Elizabeth N. Pearce
{"title":"Perchlorate and thyroid function","authors":"Stacy N. Handler,&nbsp;Maria A. Luna Cuadros,&nbsp;Elizabeth N. Pearce","doi":"10.1016/j.coemr.2025.100589","DOIUrl":"10.1016/j.coemr.2025.100589","url":null,"abstract":"<div><div>Perchlorate is an environmental contaminant found around the world. Perchlorate disrupts thyroid function by inhibiting the sodium iodide symporter, which transports iodide into the thyroid. The impact of perchlorate on thyroid function is of particular concern during gestation. This review focuses on human studies related to the thyroidal effects of perchlorate. Some of the earliest human studies of perchlorate and thyroid function studied high-dose exposure through randomized control trials and occupational studies. These gave way to epidemiologic and cohort studies focusing on environmental exposures. The results of these studies have been variable but suggest that high levels of environmental perchlorate exposure, particularly in the setting of iodine deficiency, may impair thyroid function and fetal neurological development. Regulatory efforts have been supported by the advent of biologically dose-dependent response models. Understanding this body of the literature is critical for developing policies aimed at regulating perchlorate exposures and protecting society’s most vulnerable populations.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"41 ","pages":"Article 100589"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145322046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cholesterol metabolism and oxysterols in neurodegenerative disorders: Spotlight on Alzheimer's disease 神经退行性疾病中的胆固醇代谢和氧甾醇：聚焦于阿尔茨海默病
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-12-01 Epub Date: 2025-10-16 DOI: 10.1016/j.coemr.2025.100590
Ljerka Delac , Silvia Maioli
{"title":"Cholesterol metabolism and oxysterols in neurodegenerative disorders: Spotlight on Alzheimer's disease","authors":"Ljerka Delac ,&nbsp;Silvia Maioli","doi":"10.1016/j.coemr.2025.100590","DOIUrl":"10.1016/j.coemr.2025.100590","url":null,"abstract":"<div><div>Cholesterol metabolism in the brain is tightly regulated and differs from the periphery due to the blood–brain barrier (BBB). Oxysterols, oxidized cholesterol metabolites, can cross the BBB and play key roles in brain cholesterol homeostasis and neurodegeneration, particularly in Alzheimer's disease (AD). This review highlights two major oxysterols: brain-derived 24S-hydroxycholesterol (24-OH) and peripherally derived 27-hydroxycholesterol (27-OH). Both have been studied as potential AD biomarkers, with altered levels observed in cerebrospinal fluid and plasma, though findings vary due to sex, age, and comorbidities. Animal studies suggest that CYP46A1 and its product 24-OH support cognitive function, reduce neuroinflammation, and attenuate AD pathology, especially in females. Conversely, increased 27-OH is linked to metabolic dysfunction, synaptic deficits, and memory loss, possibly bridging peripheral hypercholesterolemia and AD risk. This review summarizes recent advances in oxysterol research and their implications for AD, emphasizing sex-specific effects and their potential as biomarkers and therapeutic targets.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"41 ","pages":"Article 100590"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145466888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endocrine disruptive chemicals (EDCs) and autoimmune thyroid diseases (AITD): A systematic literature review 内分泌干扰物（EDCs）与自身免疫性甲状腺疾病（AITD）：系统的文献综述
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-12-01 Epub Date: 2025-09-03 DOI: 10.1016/j.coemr.2025.100585
Mathilda Monaghan , Sonia Rodrigues , Shiven Sharma , Angela M. Leung , Maaike van Gerwen
{"title":"Endocrine disruptive chemicals (EDCs) and autoimmune thyroid diseases (AITD): A systematic literature review","authors":"Mathilda Monaghan ,&nbsp;Sonia Rodrigues ,&nbsp;Shiven Sharma ,&nbsp;Angela M. Leung ,&nbsp;Maaike van Gerwen","doi":"10.1016/j.coemr.2025.100585","DOIUrl":"10.1016/j.coemr.2025.100585","url":null,"abstract":"<div><div>The association between endocrine disruptive chemicals (EDCs) and autoimmune thyroid disease (AITD) has not been well established. This systematic review aimed to summarize existing literature and provide an up-to-date overview of EDCs and their association with AITD. A search of the National Library of Medicine PubMed and Scopus databases was completed to identify relevant articles published in English through September 2024. A total of 4 studies met inclusion criteria. Results of the included studies varied, ranging from significant positive to significant negative associations with AITD for different EDCs. This comprehensive review highlights the limited knowledge of this association. Besides investigating individual EDCs, it is important to include dose–response studies and exposures to EDC mixtures.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"41 ","pages":"Article 100585"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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