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Current Opinion in Endocrine and Metabolic Research最新文献

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Current Opinion in Endocrine and Metabolic Research Pub Date : 2026-09-01 Epub Date: 2026-09-18 DOI: 10.1016/S2451-9650(26)00028-1
{"title":"Editorial board page","authors":"","doi":"10.1016/S2451-9650(26)00028-1","DOIUrl":"10.1016/S2451-9650(26)00028-1","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"44 ","pages":"Article 100624"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148995391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amphibian bioassays for thyroid disrupting chemical testing: Recent findings, methodological advances, and perspectives 用于甲状腺干扰化学测试的两栖动物生物测定：最新发现、方法学进展和前景
Current Opinion in Endocrine and Metabolic Research Pub Date : 2026-06-01 Epub Date: 2026-05-14 DOI: 10.1016/j.coemr.2026.100612
Alicia Tribondeau , Paisley Thomson , Yun-Bo Shi , Laurent M. Sachs
{"title":"Amphibian bioassays for thyroid disrupting chemical testing: Recent findings, methodological advances, and perspectives","authors":"Alicia Tribondeau ,&nbsp;Paisley Thomson ,&nbsp;Yun-Bo Shi ,&nbsp;Laurent M. Sachs","doi":"10.1016/j.coemr.2026.100612","DOIUrl":"10.1016/j.coemr.2026.100612","url":null,"abstract":"<div><div>Thyroid disrupting chemicals (TDCs) pose significant risks to vertebrate development, yet current screening tests may not capture the diverse molecular targets and indirect mechanisms of TDCs. Amphibian metamorphosis, mediated by thyroid hormone signaling, has been recognized for many years as a robust <em>in vivo</em> model for detecting thyroid disruption. This review synthesizes the peer-reviewed literature published from January 2023 to July 2025 that assesses TDCs in amphibians. We evaluate recent findings from <em>Xenopus</em> test guidelines, methodological refinements, and emerging endpoints, including molecular, neurological, and hepatic biomarkers. We also highlight contributions from non-<em>Xenopus</em> amphibian species that improve ecological relevance. Finally, we discuss how these data can be integrated into modern toxicological frameworks such as new approach methodologies and adverse outcome pathways.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"43 ","pages":"Article 100612"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial board page 编委会页面
IF 2.1
Current Opinion in Endocrine and Metabolic Research Pub Date : 2026-06-01 Epub Date: 2026-06-18 DOI: 10.1016/S2451-9650(26)00022-0
{"title":"Editorial board page","authors":"","doi":"10.1016/S2451-9650(26)00022-0","DOIUrl":"10.1016/S2451-9650(26)00022-0","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"43 ","pages":"Article 100618"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148523872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Searching for a generalist biomarker in aquatic ecotoxicity: The role of carboxylesterases 寻找水生生态毒性的通用生物标志物：羧酸酯酶的作用
Current Opinion in Endocrine and Metabolic Research Pub Date : 2026-06-01 Epub Date: 2026-05-14 DOI: 10.1016/j.coemr.2026.100614
Isabel Forner-Piquer, Montserrat Solé
{"title":"Searching for a generalist biomarker in aquatic ecotoxicity: The role of carboxylesterases","authors":"Isabel Forner-Piquer,&nbsp;Montserrat Solé","doi":"10.1016/j.coemr.2026.100614","DOIUrl":"10.1016/j.coemr.2026.100614","url":null,"abstract":"<div><div>Carboxylesterases (CEs), from the α/β hydrolase superfamily, play a major role in the hydrolysis of a wide variety of compounds, including fatty acids, hormones, and xenobiotics. Because of their promiscuous nature, CEs are detoxification enzymes also involved in diverse physiological functions, such as lipid metabolism. To date, several <em>in vitro</em> and <em>in vivo</em> evidences have reported the responsiveness of CEs to pesticides, plastic additives, or flame retardants in different aquatic species. Then, considering the role of CEs as the primary detoxification mechanism, this review will briefly examine 1) the link between environmental pollutants and CEs as a marker for general toxicity; 2) the role of CEs in environmental monitoring of aquatic fauna; 3) the relationship between CEs and the endocrine system, particularly, in lipid metabolism; and 4) CEs as key players in endocrine disruption.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"43 ","pages":"Article 100614"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148177685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Environmental challenges to thyroid homeostasis: Combined effects of iodine deficiency and endocrine disruption 环境对甲状腺稳态的挑战：碘缺乏和内分泌紊乱的综合影响
Current Opinion in Endocrine and Metabolic Research Pub Date : 2026-03-01 Epub Date: 2026-01-21 DOI: 10.1016/j.coemr.2026.100597
Patricia Rannaud-Bartaire , Anni Herranen , Giovanni Levi , Barbara Demeneix , Jean-Baptiste Fini
{"title":"Environmental challenges to thyroid homeostasis: Combined effects of iodine deficiency and endocrine disruption","authors":"Patricia Rannaud-Bartaire ,&nbsp;Anni Herranen ,&nbsp;Giovanni Levi ,&nbsp;Barbara Demeneix ,&nbsp;Jean-Baptiste Fini","doi":"10.1016/j.coemr.2026.100597","DOIUrl":"10.1016/j.coemr.2026.100597","url":null,"abstract":"<div><div>Thyroid hormone system is crucial for numerous physiological processes, including development, growth, and metabolism. Iodine, an indispensable micronutrient, is required for thyroid hormone (TH) synthesis. Inadequate supply or disruption of its metabolism can compromise thyroid function. Disruption of the thyroid hormone pathways by environmental endocrine-disrupting chemicals (EDCs) is being studied with growing interest. In several human populations, exposure to EDCs frequently co-occur with insufficient iodine intake, impairing thyroid function, and reducing the capacity to adapt to environmental changes. This brief review summarizes the current state of knowledge on the mechanisms through which EDCs and iodine deficiency can interfere with virtually every component of TH homeostasis. A better understanding of these combined effects is critical for maintaining a healthy population.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"42 ","pages":"Article 100597"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147420897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of pesticide exposure on thyroid function and neoplasia 农药暴露对甲状腺功能和肿瘤的影响
Current Opinion in Endocrine and Metabolic Research Pub Date : 2026-03-01 Epub Date: 2025-12-01 DOI: 10.1016/j.coemr.2025.100593
Joanne Lin, Whitney Goldner
{"title":"The impact of pesticide exposure on thyroid function and neoplasia","authors":"Joanne Lin,&nbsp;Whitney Goldner","doi":"10.1016/j.coemr.2025.100593","DOIUrl":"10.1016/j.coemr.2025.100593","url":null,"abstract":"<div><div>Environmental exposure to endocrine disrupting chemicals is a significant public health concern. Pesticides represent a subset of the potential environmental exposures impacting human health, including the thyroid. Some pesticides are considered persistent organic pollutants, and so are present in the soil, water, and food chain long after they have been used, creating the potential for exposure for decades, even after they have been removed from the market. Exposures can occur through occupational exposure, but there is increasing evidence for residential exposure in non-agricultural workers. Some pesticides are considered endocrine disruptors, and there are epidemiologic associations reported between specific pesticides and thyroid hormone alterations and thyroid carcinogenesis. In this review, we will discuss the relationship between pesticides and the thyroid.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"42 ","pages":"Article 100593"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145799242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial board page 编委会页面
Current Opinion in Endocrine and Metabolic Research Pub Date : 2026-03-01 Epub Date: 2026-03-21 DOI: 10.1016/S2451-9650(26)00004-9
{"title":"Editorial board page","authors":"","doi":"10.1016/S2451-9650(26)00004-9","DOIUrl":"10.1016/S2451-9650(26)00004-9","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"42 ","pages":"Article 100600"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147612359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of bone marrow adipose tissue evaluation in improving osteoporotic fracture risk assessment 骨髓脂肪组织评估在改善骨质疏松性骨折风险评估中的作用
Current Opinion in Endocrine and Metabolic Research Pub Date : 2026-03-01 Epub Date: 2026-02-12 DOI: 10.1016/j.coemr.2026.100598
Julien Paccou
{"title":"The role of bone marrow adipose tissue evaluation in improving osteoporotic fracture risk assessment","authors":"Julien Paccou","doi":"10.1016/j.coemr.2026.100598","DOIUrl":"10.1016/j.coemr.2026.100598","url":null,"abstract":"<div><div>Osteoporosis represents a major global health burden, and emerging data suggest that bone marrow adipose tissue (BMAT) may contribute to skeletal fragility beyond bone mineral density (BMD). BMAT varies with age, sex, and skeletal site, and recent advances in MRI- and HR-pQCT–based techniques allow accurate quantification. Although BMAT is consistently inversely associated with BMD, evidence linking BMAT to fractures is heterogeneous. Cross-sectional and longitudinal studies have indicated the limited added predictive value of BMAT over established clinical risk factors and BMD. Large-scale imaging and genetic analyses reinforce the biological relevance of BMAT but not its clinical utility. Future research should clarify the role of BMAT in specific secondary osteoporosis settings and in combination with advanced analytical approaches.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"42 ","pages":"Article 100598"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147420898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interplay of obesity and endocrine disrupting chemicals on thyroid 肥胖与内分泌干扰物对甲状腺的相互作用
Current Opinion in Endocrine and Metabolic Research Pub Date : 2026-03-01 Epub Date: 2025-11-25 DOI: 10.1016/j.coemr.2025.100592
Laura Sterian Ward, Sophia de Alcantara Rodrigues, Elisangela de Souza Teixeira
{"title":"Interplay of obesity and endocrine disrupting chemicals on thyroid","authors":"Laura Sterian Ward,&nbsp;Sophia de Alcantara Rodrigues,&nbsp;Elisangela de Souza Teixeira","doi":"10.1016/j.coemr.2025.100592","DOIUrl":"10.1016/j.coemr.2025.100592","url":null,"abstract":"<div><div>The thyroid gland is a sensitive target of endocrine-disrupting chemicals (EDCs), which can interfere with hormone synthesis, metabolism, and receptor signaling. Concurrently, obesity is increasingly recognized as both a modifier and potential amplifier of EDCs toxicity, particularly within the hypothalamic–pituitary–thyroid axis. Current evidence suggests that bisphenols, phthalates, perfluoroalkyl compounds, and polychlorinated biphenyls are linked to modest but measurable changes in thyroid hormone balance, often influenced by body weight. Adipose tissue may serve as a reservoir for lipophilic EDCs, sustaining internal exposure, and exacerbating metabolic dysregulation. However, the extent to which these associations reflect causal mechanisms remains unclear. Future research should prioritize longitudinal and mechanistic studies to clarify directionality, identify vulnerable populations, and inform precision-based approaches for exposure mitigation.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"42 ","pages":"Article 100592"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in medical and surgical therapies for transgender and gender-diverse individuals 跨性别者和性别多样化个体的医疗和外科治疗进展
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-12-01 Epub Date: 2025-09-30 DOI: 10.1016/j.coemr.2025.100588
Aaron L. Misakian , Maja Marinkovic
{"title":"Advances in medical and surgical therapies for transgender and gender-diverse individuals","authors":"Aaron L. Misakian ,&nbsp;Maja Marinkovic","doi":"10.1016/j.coemr.2025.100588","DOIUrl":"10.1016/j.coemr.2025.100588","url":null,"abstract":"<div><div>This review aims to highlight new advances in transgender medicine, including innovative approaches to pubertal and menstrual suppression, gender-affirming hormone therapy, and management of voice dysphoria for both adolescent and adult patients.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"41 ","pages":"Article 100588"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145364207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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