25-羟基胆固醇在炎症中的作用

Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-06-25 DOI:10.1016/j.coemr.2025.100582

Romeo Carre, Solenne Vigne, Caroline Pot

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引用次数: 0

摘要

氧化甾醇是胆固醇的生物活性氧化形式，调节胆固醇代谢和细胞内胆固醇水平。它们被认为在炎症过程中起着额外的作用，最近的数据强调了它们在人类疾病中的意义。胆固醇25-羟化酶（Ch25h）下游的羟甾醇，25-羟基胆固醇（25-HC），在炎症过程中大量产生。25-HC及其衍生的氧甾醇在免疫细胞趋化、病毒复制抑制和神经炎症中发挥关键作用。机制上涉及线粒体功能、炎性小体、内质网应激、细胞死亡和细胞代谢。本文综述了ch25h衍生的氧化甾醇在与人类疾病相关的炎症条件下的作用的最新知识，特别是自身免疫、神经系统疾病和癌症。

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25-hydroxycholesterol in inflammation

Oxysterols, biological active oxidized forms of cholesterol, regulate cholesterol metabolism and intracellular cholesterol levels. They have been attributed additional roles during inflammation and recent data have highlighted their implication in human diseases. The oxysterol downstream of cholesterol 25-hydroxylase (Ch25h), 25-Hydroxycholesterol (25-HC), is largely produced during inflammatory processes. 25-HC and its derived oxysterols play critical roles in immune cell chemotaxis, viral replication inhibition, and neuroinflammation. Mechanistically, mitochondrial function, inflammasomes, endoplasmic reticulum stress, cell death, and cellular metabolism are involved. This review aims to bring the latest knowledge about the role of Ch25h-derived oxysterols under inflammatory conditions related to human diseases, specifically autoimmunity, neurological disorders, and cancers.

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来源期刊

Current Opinion in Endocrine and Metabolic Research Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

4.10

自引率

0.00%

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