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Current Opinion in Endocrine and Metabolic Research最新文献

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Disparities in endocrine-disrupting chemical exposures and thyroid disorders 内分泌干扰化学物质暴露与甲状腺疾病的差异
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-12-01 Epub Date: 2025-11-10 DOI: 10.1016/j.coemr.2025.100591
Luyu Wang , Jennifer Flores , Robert M. Sargis
{"title":"Disparities in endocrine-disrupting chemical exposures and thyroid disorders","authors":"Luyu Wang ,&nbsp;Jennifer Flores ,&nbsp;Robert M. Sargis","doi":"10.1016/j.coemr.2025.100591","DOIUrl":"10.1016/j.coemr.2025.100591","url":null,"abstract":"<div><div>Over the last twenty years, thyroid disorder prevalence has more than doubled in the United States, with notable disparities emerging in disease incidence and outcomes. While partially attributable to inequities in healthcare delivery, whether environmental factors such as exposure to endocrine-disrupting chemicals (EDCs) contribute to differences in thyroid disease pathogenesis in vulnerable populations is plausible but understudied. To better understand how environmental factors may contribute to thyroid disease disparities, this review discusses differences in exposure to several thyroid-disrupting EDCs among historically disadvantaged communities, including polychlorinated biphenyls, bisphenols, brominated flame retardants, organochlorine pesticides, phthalates, per-/polyfluoroalkyl substances, and non-ess metals. Coupled with knowledge of exposure sources, these data may empower individual- and policy-level interventions to address thyroid disease disparities and promote health equity.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"41 ","pages":"Article 100591"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145684306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Perchlorate and thyroid function 高氯酸盐和甲状腺功能
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-12-01 Epub Date: 2025-09-27 DOI: 10.1016/j.coemr.2025.100589
Stacy N. Handler, Maria A. Luna Cuadros, Elizabeth N. Pearce
{"title":"Perchlorate and thyroid function","authors":"Stacy N. Handler,&nbsp;Maria A. Luna Cuadros,&nbsp;Elizabeth N. Pearce","doi":"10.1016/j.coemr.2025.100589","DOIUrl":"10.1016/j.coemr.2025.100589","url":null,"abstract":"<div><div>Perchlorate is an environmental contaminant found around the world. Perchlorate disrupts thyroid function by inhibiting the sodium iodide symporter, which transports iodide into the thyroid. The impact of perchlorate on thyroid function is of particular concern during gestation. This review focuses on human studies related to the thyroidal effects of perchlorate. Some of the earliest human studies of perchlorate and thyroid function studied high-dose exposure through randomized control trials and occupational studies. These gave way to epidemiologic and cohort studies focusing on environmental exposures. The results of these studies have been variable but suggest that high levels of environmental perchlorate exposure, particularly in the setting of iodine deficiency, may impair thyroid function and fetal neurological development. Regulatory efforts have been supported by the advent of biologically dose-dependent response models. Understanding this body of the literature is critical for developing policies aimed at regulating perchlorate exposures and protecting society’s most vulnerable populations.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"41 ","pages":"Article 100589"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145322046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cholesterol metabolism and oxysterols in neurodegenerative disorders: Spotlight on Alzheimer's disease 神经退行性疾病中的胆固醇代谢和氧甾醇：聚焦于阿尔茨海默病
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-12-01 Epub Date: 2025-10-16 DOI: 10.1016/j.coemr.2025.100590
Ljerka Delac , Silvia Maioli
{"title":"Cholesterol metabolism and oxysterols in neurodegenerative disorders: Spotlight on Alzheimer's disease","authors":"Ljerka Delac ,&nbsp;Silvia Maioli","doi":"10.1016/j.coemr.2025.100590","DOIUrl":"10.1016/j.coemr.2025.100590","url":null,"abstract":"<div><div>Cholesterol metabolism in the brain is tightly regulated and differs from the periphery due to the blood–brain barrier (BBB). Oxysterols, oxidized cholesterol metabolites, can cross the BBB and play key roles in brain cholesterol homeostasis and neurodegeneration, particularly in Alzheimer's disease (AD). This review highlights two major oxysterols: brain-derived 24S-hydroxycholesterol (24-OH) and peripherally derived 27-hydroxycholesterol (27-OH). Both have been studied as potential AD biomarkers, with altered levels observed in cerebrospinal fluid and plasma, though findings vary due to sex, age, and comorbidities. Animal studies suggest that CYP46A1 and its product 24-OH support cognitive function, reduce neuroinflammation, and attenuate AD pathology, especially in females. Conversely, increased 27-OH is linked to metabolic dysfunction, synaptic deficits, and memory loss, possibly bridging peripheral hypercholesterolemia and AD risk. This review summarizes recent advances in oxysterol research and their implications for AD, emphasizing sex-specific effects and their potential as biomarkers and therapeutic targets.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"41 ","pages":"Article 100590"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145466888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endocrine disruptive chemicals (EDCs) and autoimmune thyroid diseases (AITD): A systematic literature review 内分泌干扰物（EDCs）与自身免疫性甲状腺疾病（AITD）：系统的文献综述
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-12-01 Epub Date: 2025-09-03 DOI: 10.1016/j.coemr.2025.100585
Mathilda Monaghan , Sonia Rodrigues , Shiven Sharma , Angela M. Leung , Maaike van Gerwen
{"title":"Endocrine disruptive chemicals (EDCs) and autoimmune thyroid diseases (AITD): A systematic literature review","authors":"Mathilda Monaghan ,&nbsp;Sonia Rodrigues ,&nbsp;Shiven Sharma ,&nbsp;Angela M. Leung ,&nbsp;Maaike van Gerwen","doi":"10.1016/j.coemr.2025.100585","DOIUrl":"10.1016/j.coemr.2025.100585","url":null,"abstract":"<div><div>The association between endocrine disruptive chemicals (EDCs) and autoimmune thyroid disease (AITD) has not been well established. This systematic review aimed to summarize existing literature and provide an up-to-date overview of EDCs and their association with AITD. A search of the National Library of Medicine PubMed and Scopus databases was completed to identify relevant articles published in English through September 2024. A total of 4 studies met inclusion criteria. Results of the included studies varied, ranging from significant positive to significant negative associations with AITD for different EDCs. This comprehensive review highlights the limited knowledge of this association. Besides investigating individual EDCs, it is important to include dose–response studies and exposures to EDC mixtures.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"41 ","pages":"Article 100585"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145134832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychological outcomes of gender-affirming medical treatment in transgender youth 变性青年性别肯定医疗的心理结果
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-12-01 Epub Date: 2025-07-29 DOI: 10.1016/j.coemr.2025.100584
Puja Singh , Ximena Lopez
{"title":"Psychological outcomes of gender-affirming medical treatment in transgender youth","authors":"Puja Singh ,&nbsp;Ximena Lopez","doi":"10.1016/j.coemr.2025.100584","DOIUrl":"10.1016/j.coemr.2025.100584","url":null,"abstract":"<div><div>The evaluation and management for transgender and gender-diverse (TGD) youth is multidisciplinary, and treatment involves social support, mental health care, and gender affirming medical care such as use of puberty suppression and/or gender-affirming hormone therapy (GAH). Gender-affirming medical care has been proven to improve psychosocial outcomes in TGD youth. This includes decreased rates of depression and anxiety and decreased suicidal ideation. Furthermore, youth who receive GAH have improvements in experienced body dysphoria, general well-being, and quality of life. Available studies show that rates of regret are low. The goal of this article is to highlight the most significant research on the effects of gender-affirming medical treatments on the psychosocial health of TGD youth.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"41 ","pages":"Article 100584"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145269481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial board page 编委会页面
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-12-01 Epub Date: 2025-12-11 DOI: 10.1016/S2451-9650(25)00025-0
{"title":"Editorial board page","authors":"","doi":"10.1016/S2451-9650(25)00025-0","DOIUrl":"10.1016/S2451-9650(25)00025-0","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"41 ","pages":"Article 100594"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial board page 编委会页面
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-09-01 Epub Date: 2025-09-10 DOI: 10.1016/S2451-9650(25)00017-1
{"title":"Editorial board page","authors":"","doi":"10.1016/S2451-9650(25)00017-1","DOIUrl":"10.1016/S2451-9650(25)00017-1","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"40 ","pages":"Article 100586"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
25-hydroxycholesterol in inflammation 25-羟基胆固醇在炎症中的作用
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-09-01 Epub Date: 2025-06-25 DOI: 10.1016/j.coemr.2025.100582
Romeo Carre, Solenne Vigne, Caroline Pot
{"title":"25-hydroxycholesterol in inflammation","authors":"Romeo Carre,&nbsp;Solenne Vigne,&nbsp;Caroline Pot","doi":"10.1016/j.coemr.2025.100582","DOIUrl":"10.1016/j.coemr.2025.100582","url":null,"abstract":"<div><div>Oxysterols, biological active oxidized forms of cholesterol, regulate cholesterol metabolism and intracellular cholesterol levels. They have been attributed additional roles during inflammation and recent data have highlighted their implication in human diseases. The oxysterol downstream of cholesterol 25-hydroxylase (Ch25h), 25-Hydroxycholesterol (25-HC), is largely produced during inflammatory processes. 25-HC and its derived oxysterols play critical roles in immune cell chemotaxis, viral replication inhibition, and neuroinflammation. Mechanistically, mitochondrial function, inflammasomes, endoplasmic reticulum stress, cell death, and cellular metabolism are involved. This review aims to bring the latest knowledge about the role of Ch25h-derived oxysterols under inflammatory conditions related to human diseases, specifically autoimmunity, neurological disorders, and cancers.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"40 ","pages":"Article 100582"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oxysterol-related disorders Oxysterol-related障碍
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-09-01 Epub Date: 2025-06-25 DOI: 10.1016/j.coemr.2025.100583
Akira Honda , Hajime Ueda , Teruo Miyazaki , Tadashi Ikegami
{"title":"Oxysterol-related disorders","authors":"Akira Honda ,&nbsp;Hajime Ueda ,&nbsp;Teruo Miyazaki ,&nbsp;Tadashi Ikegami","doi":"10.1016/j.coemr.2025.100583","DOIUrl":"10.1016/j.coemr.2025.100583","url":null,"abstract":"<div><div>Recent advances in oxysterol analysis and studies on their molecular targets indicate that oxysterols, enzymatic or non-enzymatic cholesterol derivatives, are active molecules involved in the pathophysiology of various diseases. This review describes and discusses the recent developments in several oxysterol-related disorders, including atherosclerosis, metabolic dysfunction-associated steatotic liver disease, Alzheimer’s disease, multiple sclerosis, and breast and lung cancers. Unlike congenital abnormalities of oxysterol-metabolizing enzymes, such as cerebrotendinous xanthomatosis and hereditary spastic paraplegia type 5, it is often difficult to assess whether altered oxysterol levels in acquired diseases are the cause or the consequence of disease. In addition, oxysterols exert beneficial or deleterious effects on diseases depending on their structures. Despite these limitations, accumulated experimental evidence is beginning to clarify the impact of oxysterols on the pathophysiology of various diseases.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"40 ","pages":"Article 100583"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144632096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adipose tissue-driven inter-organ metabolite crosstalk 脂肪组织驱动的器官间代谢产物串扰
Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-06-01 Epub Date: 2025-04-19 DOI: 10.1016/j.coemr.2025.100577
Carolina Hagberg , Zoi Michailidou
{"title":"Adipose tissue-driven inter-organ metabolite crosstalk","authors":"Carolina Hagberg ,&nbsp;Zoi Michailidou","doi":"10.1016/j.coemr.2025.100577","DOIUrl":"10.1016/j.coemr.2025.100577","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"39 ","pages":"Article 100577"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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