Current Opinion in Endocrine and Metabolic Research最新文献

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Corrigendum to “Therapeutic treatments targeting communication between angiogenic and immune microenvironments in thyroid cancers” [Curr Opin Endocrine Metabol Res 37 (December 2024) 100544] “针对甲状腺癌中血管生成和免疫微环境之间通信的治疗治疗”的勘误表[当前观点内分泌代谢Res 37(十二月2024)100544]
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-12-06 DOI: 10.1016/j.coemr.2024.100569
Alessandro Prete , Carmelo Nucera
{"title":"Corrigendum to “Therapeutic treatments targeting communication between angiogenic and immune microenvironments in thyroid cancers” [Curr Opin Endocrine Metabol Res 37 (December 2024) 100544]","authors":"Alessandro Prete , Carmelo Nucera","doi":"10.1016/j.coemr.2024.100569","DOIUrl":"10.1016/j.coemr.2024.100569","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"38 ","pages":"Article 100569"},"PeriodicalIF":0.0,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial board page 编委会页面
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-12-01 DOI: 10.1016/S2451-9650(24)00061-9
{"title":"Editorial board page","authors":"","doi":"10.1016/S2451-9650(24)00061-9","DOIUrl":"10.1016/S2451-9650(24)00061-9","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"37 ","pages":"Article 100563"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adipose tissue-derived mediators of systemic inflammation and metabolic control 源自脂肪组织的全身炎症和代谢控制介质
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-10-28 DOI: 10.1016/j.coemr.2024.100560
Vasileia Ismini Alexaki
{"title":"Adipose tissue-derived mediators of systemic inflammation and metabolic control","authors":"Vasileia Ismini Alexaki","doi":"10.1016/j.coemr.2024.100560","DOIUrl":"10.1016/j.coemr.2024.100560","url":null,"abstract":"<div><div>Obesity increases the risk for a number of diseases, including type 2 diabetes, liver and cardiovascular disease, or neurological disorders. Low-grade chronic systemic inflammation typically accompanying obesity is considered driving these disorders. The inflammatory factors produced by the hypertrophic adipose tissue can have systemic effects. The present review summarizes current knowledge on the most investigated in this context, inflammatory cytokines: Tumor necrosis factor (TNF), interleukin 6 (IL6), IL1β, and interferon γ. Their metabolic effects on organs such as the liver, the skeletal muscle, the pancreas and the brain, and therapeutic interventions targeting systemic inflammation in obesity are discussed.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"37 ","pages":"Article 100560"},"PeriodicalIF":0.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142707074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
“Regulation of adipose-derived fatty acid flux to the liver”-Impact on metabolic dysfunction-associated steatotic liver disease "脂肪源性脂肪酸流向肝脏的调节"--对代谢功能障碍相关脂肪肝的影响
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-10-28 DOI: 10.1016/j.coemr.2024.100559
Erika Folestad, Annelie Falkevall
{"title":"“Regulation of adipose-derived fatty acid flux to the liver”-Impact on metabolic dysfunction-associated steatotic liver disease","authors":"Erika Folestad,&nbsp;Annelie Falkevall","doi":"10.1016/j.coemr.2024.100559","DOIUrl":"10.1016/j.coemr.2024.100559","url":null,"abstract":"<div><div>Obesity is now considered a global epidemic, increasing the prevalence of obesity-related metabolic disorders. Obesity is characterized by an increase in white adipose tissue (WAT) mass that induce local inflammation and insulin resistance in the WAT, causing dysregulation of whole-body homeostasis. WAT is the primary organ for energy storage in the form of triacylglycerols, which are released as fatty acids (FAs) upon energy demand, a process named lipolysis. Under chronic high energy intake, adipocytes can expand to accommodate more triacylglycerols but when the storage capacity is impaired or lipolysis is dysregulated, FAs are redirected to other organs. The systemic overload of FAs contributes to the development of obesity-associated metabolic complications such as metabolic dysfunction-associated steatotic fatty liver disease (MASLD), formerly named non-alcoholic fatty liver disease. This minireview aims to discuss adipose-derived FA flux as a determinator for development of MASLD from an adipocentric perspective, underlining the contribution of WAT dysfunction in this disease.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"37 ","pages":"Article 100559"},"PeriodicalIF":0.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142707073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: Cilia and endocrinology 编辑综述:纤毛与内分泌学
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-10-23 DOI: 10.1016/j.coemr.2024.100558
Rex A. Hess, Clémence Belleannée
{"title":"Editorial overview: Cilia and endocrinology","authors":"Rex A. Hess,&nbsp;Clémence Belleannée","doi":"10.1016/j.coemr.2024.100558","DOIUrl":"10.1016/j.coemr.2024.100558","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"37 ","pages":"Article 100558"},"PeriodicalIF":0.0,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of human communications molecules on respiratory tractus bacterial pathogen 人类通讯分子对呼吸道细菌病原体的影响
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-10-18 DOI: 10.1016/j.coemr.2024.100557
Olivier Lesouhaitier, Adrien Forge, Anne-Sophie Tareau, Mathieu Gonzalez, Sylvie Chevalier, Ali Tahrioui
{"title":"Impact of human communications molecules on respiratory tractus bacterial pathogen","authors":"Olivier Lesouhaitier,&nbsp;Adrien Forge,&nbsp;Anne-Sophie Tareau,&nbsp;Mathieu Gonzalez,&nbsp;Sylvie Chevalier,&nbsp;Ali Tahrioui","doi":"10.1016/j.coemr.2024.100557","DOIUrl":"10.1016/j.coemr.2024.100557","url":null,"abstract":"<div><div>The rapid increase of bacteria becoming resistant to antibiotics means that alternative solutions to antibiotics must be found urgently. This observation particularly concerns respiratory pathogens such as <em>Pseudomonas aeruginosa</em>, <em>Acinetobacter baumanii</em>, or <em>Staphylococcus aureus</em>. Microbial endocrinology has paved a new way to identify specific bacterial targets related to several human communication molecules such as neurotransmitters, cytokines, and hormones. Here, we describe these human signaling compounds that are able to modify the physiology of major respiratory bacterial pathogens and their potential mechanism of action on bacteria. This review aims to better understand the effects of human communication molecules on the physiology of major respiratory bacterial pathogens and their consequences in terms of virulence, persistence, and interference with the action of antibiotics. These data should be considered to avoid promoting chronic infections in patients or to optimize antibiotic treatment.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"37 ","pages":"Article 100557"},"PeriodicalIF":0.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic (re)programming in skeletal stem cell populations 骨骼干细胞群的代谢(再)编程
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-09-17 DOI: 10.1016/j.coemr.2024.100548
Milica Rajković , Nikola Bogosavljević , Marko Vujačić , Drenka Trivanović
{"title":"Metabolic (re)programming in skeletal stem cell populations","authors":"Milica Rajković ,&nbsp;Nikola Bogosavljević ,&nbsp;Marko Vujačić ,&nbsp;Drenka Trivanović","doi":"10.1016/j.coemr.2024.100548","DOIUrl":"10.1016/j.coemr.2024.100548","url":null,"abstract":"<div><div>Current findings imply that skeletal stem cell (SSC) populations intermittently utilize glycolysis and oxidative phosphorylation to satisfy energetic demands and accomplish their lineage specification, or even dedifferentiation. Metabolic reprogramming is one of the earliest processes that governs adult bone regeneration. Increasing numbers of findings indicate that SSCs reside in bone and bone marrow compartments and contribute to different phases of bone homeostasis, remodeling, and repair. All these processes have distinct microenvironmental landscapes imposing specific metabolic requirements to SSCs. Although glucose has been considered as the main source of energy for skeleton, novel findings emphasize the importance of still challenging metabolic profiling of SSCs at different stages of bone development, homeostasis, and repair for delicate control of stem cell-guided bone regeneration.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"37 ","pages":"Article 100548"},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142428169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Local and systemic impact of adipocyte senescence-associated secretory profile 脂肪细胞衰老相关分泌特征对局部和全身的影响
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-09-13 DOI: 10.1016/j.coemr.2024.100547
Yi Ching Esther Wan, Jeremy Dufau, Kirsty L. Spalding
{"title":"Local and systemic impact of adipocyte senescence-associated secretory profile","authors":"Yi Ching Esther Wan,&nbsp;Jeremy Dufau,&nbsp;Kirsty L. Spalding","doi":"10.1016/j.coemr.2024.100547","DOIUrl":"10.1016/j.coemr.2024.100547","url":null,"abstract":"<div><div>Obesity has become one of the most prevalent diseases worldwide. The accumulation of fat mass is associated with an increased risk of numerous comorbidities. Despite this, the precise mechanisms by which unhealthy fat cells contribute to the dysfunction of various tissues throughout the body remain poorly understood. Recently, cellular senescence in adipocytes has emerged as a significant factor in the pathological consequences of obesity. Here we review current knowledge regarding senescence in adipose tissue and adipocytes. We highlight the known mechanisms driving cellular senescence in mature adipocytes during obesity and summarize the deleterious crosstalk between senescent adipocytes and neighboring cells (as well as distant organs) as mediated by the senescence-associated secretory phenotype.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"37 ","pages":"Article 100547"},"PeriodicalIF":0.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142428167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cholinergic signaling in adipose tissue 脂肪组织中的胆碱能信号传递
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-09-11 DOI: 10.1016/j.coemr.2024.100546
Vladimir S. Shavva , Laura Tarnawski , Ting Liu , Osman Ahmed , Peder S. Olofsson
{"title":"Cholinergic signaling in adipose tissue","authors":"Vladimir S. Shavva ,&nbsp;Laura Tarnawski ,&nbsp;Ting Liu ,&nbsp;Osman Ahmed ,&nbsp;Peder S. Olofsson","doi":"10.1016/j.coemr.2024.100546","DOIUrl":"10.1016/j.coemr.2024.100546","url":null,"abstract":"<div><div>Until recently, the role of direct cholinergic regulation of adipose tissue function was unclear. With the identification of the α2 nicotinic acetylcholine receptor as a key regulator of adaptive thermogenesis in white adipose tissue, there is evidence of direct cholinergic regulation of adipocyte physiology. As in the spleen and the bone marrow, there is a local source of nonneuronal acetylcholine in adipose tissue: Macrophages release acetylcholine in response to a multiplicity of stimuli including cold, norepinephrine, and fibroblast growth factor 21, integrating cholinergic signaling in the adipose tissue microenvironment. The recent insights on this cholinergic signaling provides a useful framework for further mapping of the physiology of cholinergic signaling in adipose tissue.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"37 ","pages":"Article 100546"},"PeriodicalIF":0.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142428168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial board page 编辑委员会页面
Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-09-01 DOI: 10.1016/S2451-9650(24)00049-8
{"title":"Editorial board page","authors":"","doi":"10.1016/S2451-9650(24)00049-8","DOIUrl":"10.1016/S2451-9650(24)00049-8","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"36 ","pages":"Article 100551"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451965024000498/pdfft?md5=2c19a62866a91cc227023f75c0207427&pid=1-s2.0-S2451965024000498-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142238511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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