Current Opinion in Endocrine and Metabolic Research最新文献_第3页

Corrigendum to “Therapeutic treatments targeting communication between angiogenic and immune microenvironments in thyroid cancers” [Curr Opin Endocrine Metabol Res 37 (December 2024) 100544] “针对甲状腺癌中血管生成和免疫微环境之间通信的治疗治疗”的勘误表[当前观点内分泌代谢Res 37（十二月2024）100544]

Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-03-01 Epub Date: 2024-12-06 DOI: 10.1016/j.coemr.2024.100569

Alessandro Prete , Carmelo Nucera

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Editorial board page 编委会页面

Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-03-01 Epub Date: 2025-03-14 DOI: 10.1016/S2451-9650(25)00005-5

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Sex hormones–Gut microbiome axis: An update of what is known so far 性激素-肠道微生物轴：目前已知的最新进展

Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-03-01 Epub Date: 2025-01-11 DOI: 10.1016/j.coemr.2025.100571

Mohamed Zommiti, Marc G.J. Feuilloley

{"title":"Sex hormones–Gut microbiome axis: An update of what is known so far","authors":"Mohamed Zommiti, Marc G.J. Feuilloley","doi":"10.1016/j.coemr.2025.100571","DOIUrl":"10.1016/j.coemr.2025.100571","url":null,"abstract":"<div><div>The human gut microbiota is known to be shaped by a wide range of extrinsic factors (geography, lifestyle, sanitation, diet and drugs) and host intrinsic factors (genetics, age, sexual development and sex hormones). The intricate connection between organs, including glands, and different microbiota is well established with emerging evidence linking gut microbiota, composition, diversity and/or function as a key contributor to gut-organ/gland axis signaling. The observed differences in gut microbiota (GM) composition and diversity have led to numerous investigations highlighting the interaction between steroid hormones and the gut microbiome. In this review, we shed the light on how sex steroid hormones may modulate the composition and the function of the gut microbiota and vice-versa, via focusing on a unique crosstalk between these two main actors. We also highlight the role of the gut microbiota in modulating sex steroids signaling along the gut microbiome-sex hormones axis. Altogether, the evidence implies that gonadal steroids and gut microbiota exert a pivotal role in shifting host bacterial action, given the relevance of these factors in directly impacting physiology, metabolism, reproductive efficiency and even in the development of various ailments in both animals and humans.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"38 ","pages":"Article 100571"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143200765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Thyroid cancer—Editorial overview 甲状腺癌编辑综述

Current Opinion in Endocrine and Metabolic Research Pub Date : 2025-03-01 Epub Date: 2025-01-25 DOI: 10.1016/j.coemr.2025.100573

Jennifer A Sipos, Vicki E Smith

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Editorial board page 编委会页面

Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-12-01 Epub Date: 2024-11-28 DOI: 10.1016/S2451-9650(24)00061-9

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Impact of human communications molecules on respiratory tractus bacterial pathogen 人类通讯分子对呼吸道细菌病原体的影响

Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-12-01 Epub Date: 2024-10-18 DOI: 10.1016/j.coemr.2024.100557

Olivier Lesouhaitier, Adrien Forge, Anne-Sophie Tareau, Mathieu Gonzalez, Sylvie Chevalier, Ali Tahrioui

{"title":"Impact of human communications molecules on respiratory tractus bacterial pathogen","authors":"Olivier Lesouhaitier, Adrien Forge, Anne-Sophie Tareau, Mathieu Gonzalez, Sylvie Chevalier, Ali Tahrioui","doi":"10.1016/j.coemr.2024.100557","DOIUrl":"10.1016/j.coemr.2024.100557","url":null,"abstract":"<div><div>The rapid increase of bacteria becoming resistant to antibiotics means that alternative solutions to antibiotics must be found urgently. This observation particularly concerns respiratory pathogens such as <em>Pseudomonas aeruginosa</em>, <em>Acinetobacter baumanii</em>, or <em>Staphylococcus aureus</em>. Microbial endocrinology has paved a new way to identify specific bacterial targets related to several human communication molecules such as neurotransmitters, cytokines, and hormones. Here, we describe these human signaling compounds that are able to modify the physiology of major respiratory bacterial pathogens and their potential mechanism of action on bacteria. This review aims to better understand the effects of human communication molecules on the physiology of major respiratory bacterial pathogens and their consequences in terms of virulence, persistence, and interference with the action of antibiotics. These data should be considered to avoid promoting chronic infections in patients or to optimize antibiotic treatment.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"37 ","pages":"Article 100557"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adipose tissue-derived mediators of systemic inflammation and metabolic control 源自脂肪组织的全身炎症和代谢控制介质

Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI: 10.1016/j.coemr.2024.100560

Vasileia Ismini Alexaki

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Interaction of skin-born mediators with the cutaneous microbiota and beyond 皮肤生成的介质与皮肤微生物群的相互作用及其他

Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-12-01 Epub Date: 2024-08-22 DOI: 10.1016/j.coemr.2024.100545

Marc G.J. Feuilloley , Emilie Hadjiev , Lanyo J. Amegnona

{"title":"Interaction of skin-born mediators with the cutaneous microbiota and beyond","authors":"Marc G.J. Feuilloley , Emilie Hadjiev , Lanyo J. Amegnona","doi":"10.1016/j.coemr.2024.100545","DOIUrl":"10.1016/j.coemr.2024.100545","url":null,"abstract":"<div><p>Cutaneous microorganisms are growing in a microenvironment where skin hormones and neurohormones are present in abundance. These molecules are markers of the host physiology, and microorganisms have developed strategies for detecting host factors that can represent a threat for their survival. Until now, our knowledge of these mechanisms is limited to bacteria, although the skin microbiota also includes an abundance of yeasts, fungi, viruses, and even archaea. Several human hormones and neurotransmitters, including substance P, calcitonin gene-related peptides, natriuretic peptides, catecholamines, and even estradiol have been studied in this context. This was leading to the identification of original proteins, such as the thermo-unstable ribosomal elongation factor, the chaperone DnaK, or the enzyme AmiC, which have been developed by bacteria and have dual functions, in the cytoplasm where they were originally identified and in the bacterial membrane where they act as sensors for host factors. These sensors, designed as moonlighting proteins for their dual functions, are submitted to structural reorganizations and probably post-translational modifications. The occurrence of epigenetic mechanisms in the regulation of moonlighting proteins activity is a source of major complications since similar processes are activated during bacteria adaptation to the host physiology and even storage. Cutaneous bacterial endocrinology is a wide and complex emerging scientific field that requires a deep knowledge of both human and microbial physiology and careful experimental procedures.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"37 ","pages":"Article 100545"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142230373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cholinergic signaling in adipose tissue 脂肪组织中的胆碱能信号传递

Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-12-01 Epub Date: 2024-09-11 DOI: 10.1016/j.coemr.2024.100546

Vladimir S. Shavva , Laura Tarnawski , Ting Liu , Osman Ahmed , Peder S. Olofsson

引用次数: 0

Therapeutic treatments targeting communication between angiogenic and immune microenvironments in thyroid cancers 针对甲状腺癌血管生成和免疫微环境之间沟通的治疗方法

Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-12-01 Epub Date: 2024-08-14 DOI: 10.1016/j.coemr.2024.100544

Alessandro Prete , Carmelo Nucera

{"title":"Therapeutic treatments targeting communication between angiogenic and immune microenvironments in thyroid cancers","authors":"Alessandro Prete , Carmelo Nucera","doi":"10.1016/j.coemr.2024.100544","DOIUrl":"10.1016/j.coemr.2024.100544","url":null,"abstract":"<div><div>Thyroid cancer treatment has recently been revolutionized by the introduction of specific targeted therapies (e.g. BRAF<sup>V600E</sup> or highly selective RET inhibitors), anti-angiogenic agents (e.g. tyrosine kinase inhibitors (TKIs)) and immune checkpoint inhibitors, which significantly ameliorate outcomes in selected groups of thyroid cancer patients. Targeted and anti-angiogenic treatments are characterized by transient and partial efficacy, due to primary or secondary tumor resistance mechanisms, and toxicity profile. Immune therapy-based approaches are producing preliminary results. Herein, we review and prospectively discuss the immune microenvironment in non-medullary and medullary thyroid cancers and its interplays with the angiogenic microenvironment (endothelial cells and pericytes). In addition, we discuss how these interactions might be targeted using combined therapies. Furthermore, we will review chimeric antigen receptor (CAR) T cells treatment that potentially may ensure a more durable and effective response in advanced thyroid cancers. In sum, angiogenic and immune microenvironments show functional connectivity in TCs. Therapies with anti-angiogenic and immune checkpoint inhibitors combined with specific targeted therapy inhibitors with a tolerable toxicity profile may overcome drug resistance and provide better clinical outcomes than single agents.</div></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"37 ","pages":"Article 100544"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142442104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0