Current Opinion in Endocrine and Metabolic Research最新文献_第6页

Hormonal regulation of cilia in the female reproductive tract 女性生殖道纤毛的激素调节

Current Opinion in Endocrine and Metabolic Research Pub Date : 2024-01-06 DOI: 10.1016/j.coemr.2024.100503

Mark I. Hunter, Karen M. Thies, Wipawee Winuthayanon

{"title":"Hormonal regulation of cilia in the female reproductive tract","authors":"Mark I. Hunter, Karen M. Thies, Wipawee Winuthayanon","doi":"10.1016/j.coemr.2024.100503","DOIUrl":"10.1016/j.coemr.2024.100503","url":null,"abstract":"<div>This review intends to bridge the gap between our knowledge of steroid hormone regulation of motile cilia and the potential involvement of the primary cilium, focusing on female reproductive tract functions. The review emphasizes hormonal regulation of the motile and primary cilia in the oviduct and uterus. Steroid hormones, including estrogen, progesterone, and testosterone, act through their cognate receptors to regulate the development and biological function of the reproductive tracts. These hormones modulate motile ciliary beating and, in some cases, primary cilia function. Dysfunction of motile or primary cilia due to genetic anomalies, hormonal imbalances, or loss of steroid hormone receptors impairs mammalian fertility. However, further research on hormonal modulation of ciliary function, especially in the primary cilium, and its signaling cascades will provide insights into the pathogenesis of mammalian infertility and the development of contraceptives or infertility treatments targeting primary and/or motile cilia.</div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"34 ","pages":"Article 100503"},"PeriodicalIF":0.0,"publicationDate":"2024-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451965024000012/pdfft?md5=efeb961ffbf8b9a3e158dc23c9815a9a&pid=1-s2.0-S2451965024000012-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139394954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial board page 编辑委员会页面

Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-12-01 DOI: 10.1016/S2451-9650(23)00062-5

引用次数: 0

Molecular mechanisms underlying sodium iodide symporter expression at the plasma membrane in the thyroid follicular cell 甲状腺滤泡细胞质膜上碘化钠同转运蛋白表达的分子机制

Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-12-01 DOI: 10.1016/j.coemr.2023.100492

Gerardo Hernán Carro , Juan Pablo Nicola

{"title":"Molecular mechanisms underlying sodium iodide symporter expression at the plasma membrane in the thyroid follicular cell","authors":"Gerardo Hernán Carro , Juan Pablo Nicola","doi":"10.1016/j.coemr.2023.100492","DOIUrl":"10.1016/j.coemr.2023.100492","url":null,"abstract":"<div>Sodium iodide symporter (NIS)-mediated radioiodine accumulation in thyroid cancer cells is the cornerstone of radioiodine therapy for differentiated thyroid cancer. A recurring limitation of radioiodine therapy is the development of radioiodine-refractory metastatic thyroid cancer. Thyroid cancer cell dedifferentiation is the major cause of loss of radioiodine accumulation, resulting in a decreased NIS plasma membrane expression involving a plethora of transcriptional, post-transcriptional, and post-translational mechanisms. Immunohistochemical analysis revealed that most differentiated thyroid tumors preserve NIS protein expression, but NIS is often retained intracellularly, suggesting the presence of post-translational mechanisms that repress NIS plasma membrane expression. This review aims to discuss the current knowledge regarding the post-translational mechanisms that regulate NIS trafficking to the plasma membrane under physiological and pathological conditions. A thorough understanding of the molecular mechanisms underlying NIS expression at the plasma membrane would have multiple implications for radioiodine therapy, a pursuit that could uncover novel therapeutic interventions for radioiodine-refractory thyroid tumors.</div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"33 ","pages":"Article 100492"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135763902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The osteoblast sodium-citrate co-transporter (SLC13A5): A gatekeeper between global citrate homeostasis and tissue mineralization 成骨细胞柠檬酸钠共转运蛋白(SLC13A5):整体柠檬酸稳态和组织矿化之间的看门人。

Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-10-01 DOI: 10.1016/j.coemr.2023.100474

Emily Y. Chu , Jasmine Wu , Thomas L. Clemens , Naomi Dirckx

{"title":"The osteoblast sodium-citrate co-transporter (SLC13A5): A gatekeeper between global citrate homeostasis and tissue mineralization","authors":"Emily Y. Chu , Jasmine Wu , Thomas L. Clemens , Naomi Dirckx","doi":"10.1016/j.coemr.2023.100474","DOIUrl":"10.1016/j.coemr.2023.100474","url":null,"abstract":"<div>It has been known for decades that bone stores high concentrations of citrate, a pivotal TCA cycle intermediate, but surprisingly little attention has been paid to explaining this curious phenomenon. Recent studies linking mutations in the sodium-citrate co-transporter (SLC13A5) to a rare neonatal epilepsy have sparked renewed interest in the study of the mechanisms controlling citrate homeostasis and mineral citrate deposition as all affected children display tooth hypomineralization. Studies from our lab using metabolic flux analysis indicate that SLC13A5 is at the center of a specialized metabolic pathway in bone, which finetunes the uptake of extracellular citrate and endogenous production in the mitochondria enabling the osteoblast to deposit citrate during cycles of bone mineralization. Loss of function of this pathway impacts circulating citrate levels and compromises bone mineral structure. These findings implicate SLC13A5 as a gatekeeper for global citrate homeostasis and is required for normal biomechanical physiological functions of bone.</div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"32 ","pages":"Article 100474"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45188422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoxia signaling in bone physiology and energy metabolism 缺氧信号在骨生理和能量代谢中的作用

Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-10-01 DOI: 10.1016/j.coemr.2023.100473

Roger Valle-Tenney, Seppe Melis, Christa Maes

{"title":"Hypoxia signaling in bone physiology and energy metabolism","authors":"Roger Valle-Tenney, Seppe Melis, Christa Maes","doi":"10.1016/j.coemr.2023.100473","DOIUrl":"10.1016/j.coemr.2023.100473","url":null,"abstract":"<div>Hypoxia-inducible factor (HIF) signaling activation in osteoblast lineage cells increases bone mass, likely through the combined actions of multiple key downstream effectors. These include the potent angiogenesis stimulator vascular endothelial growth factor (VEGF), which mediates coupled osteo-angiogenic responses in bone, among other non-cell-autonomous contributors. Additionally, local HIF activation in bone cells cell-intrinsically triggers increased glycolysis, which is associated with strongly enhanced osteoblastic glucose consumption. Strikingly, besides its local impact on bone mass, this boosting of cellular metabolism in the osteolineage has been linked to increased overall glucose uptake by the skeleton and concomitant effects on systemic glucose homeostasis. This review summarizes the cell-autonomous and non-cell-autonomous roles of the hypoxia signaling pathway in osteoblast lineage cells on bone physiology and the parallel systemic impact observed upon activation of the pathway in bone. New potential mechanisms extending the control of global energy metabolism by the skeleton will be discussed in light of the current evidence.</div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"32 ","pages":"Article 100473"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44998583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Editorial board page 编委会页面

Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-10-01 DOI: 10.1016/S2451-9650(23)00053-4

引用次数: 0

Neoadjuvant therapy prior to surgery for advanced thyroid cancer 晚期癌症术前新辅助治疗

Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-10-01 DOI: 10.1016/j.coemr.2023.100469

Curtis Hanba, Mark Zafereo

引用次数: 0

The evolving genomic landscape of pediatric papillary thyroid cancer 癌症的基因组演变

Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-09-09 DOI: 10.1016/j.coemr.2023.100483

Julio C. Ricarte-Filho , Aime T. Franco

引用次数: 0

Osteoblast-lineage cells regulate metabolism and fat mass 成骨细胞系细胞调节新陈代谢和脂肪量

Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-08-01 DOI: 10.1016/j.coemr.2023.100470

Daniel Hägg , Per-Anders Jansson , Jakob Bellman , John-Olov Jansson , Claes Ohlsson

引用次数: 0

Evidence in humans for bone as an endocrine organ regulating energy metabolism 人类骨骼作为调节能量代谢的内分泌器官的证据

Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-08-01 DOI: 10.1016/j.coemr.2023.100471

Sundeep Khosla

引用次数: 2