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Current Opinion in Endocrine and Metabolic Research最新文献

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Thyroid cancer incidence differences between men and women 男性和女性甲状腺癌发病率的差异
Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-08-01 DOI: 10.1016/j.coemr.2023.100472
Quynh-Lam Tran , Louise Davies
{"title":"Thyroid cancer incidence differences between men and women","authors":"Quynh-Lam Tran ,&nbsp;Louise Davies","doi":"10.1016/j.coemr.2023.100472","DOIUrl":"10.1016/j.coemr.2023.100472","url":null,"abstract":"<div><p><span>Early-stage thyroid<span><span> cancer is about 4 times more common in women than men, but the underlying subclinical prevalence is the same between the two sexes. As the lethality<span><span> of the cancer type increases, the ratio in incidence for women compared to men approaches 1:1. These facts suggest that differences in healthcare utilization may be a major reason </span>thyroid cancer is diagnosed more in women than men. Physiological elements could also contribute, as women have a higher prevalence of thyroid nodularity compared to men. Current research suggests estrogen does not play a major role, but </span></span>genetics may be a potential reason for increased rates of thyroid cancer in women compared to men. </span></span>Immune surveillance is greater in women and currently is thought to be protective against thyroid cancer development. This review summarizes recent evidence examining the role of these factors in modulating the sex-disparity observed in thyroid cancer incidence.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"31 ","pages":"Article 100472"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45055264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Menopause research: Looking back to move forward 更年期研究:回顾前进
Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-06-01 DOI: 10.1016/j.coemr.2023.100459
Chrisandra Shufelt, Stephanie Faubion
{"title":"Menopause research: Looking back to move forward","authors":"Chrisandra Shufelt,&nbsp;Stephanie Faubion","doi":"10.1016/j.coemr.2023.100459","DOIUrl":"10.1016/j.coemr.2023.100459","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"30 ","pages":"Article 100459"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47966023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
InTERTwined: How TERT promoter mutations impact BRAFV600E-driven thyroid cancers InTERTwined:TERT启动子突变如何影响BRAFV600E驱动的甲状腺癌
Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-06-01 DOI: 10.1016/j.coemr.2023.100460
Iñigo Landa
{"title":"InTERTwined: How TERT promoter mutations impact BRAFV600E-driven thyroid cancers","authors":"Iñigo Landa","doi":"10.1016/j.coemr.2023.100460","DOIUrl":"https://doi.org/10.1016/j.coemr.2023.100460","url":null,"abstract":"<div><p><span>Thyroid cancers are often initiated by the acquisition of a BRAF</span><sup>V600E</sup> mutation. BRAF<sup>V600E</sup><span><span><span>-driven thyroid tumors display a wide range of </span>behaviors, from the slow-growing </span>papillary carcinomas to the highly aggressive anaplastic. Mutations in the promoter of </span><em>TERT</em> (telomerase reverse transcriptase) gene were discovered a decade ago and identified as prevalent events in thyroid cancers. Multiple studies showed that <em>TERT</em> promoter mutations, particularly when co-occurring with BRAF<sup>V600E</sup>, are markers of poor prognosis across thyroid cancer subtypes, and can be implemented for routine clinical stratification. Mechanistically, <em>TERT</em><span> promoter mutations reactivate telomerase<span> expression via the differential recruitment of transcriptional complexes. Re-expression of TERT impacts tumor biology, plausibly via both the well-known function of telomerase maintaining telomeres and by affecting other cancer-relevant processes.</span></span></p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"30 ","pages":"Article 100460"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50173240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vasomotor symptoms and their links to cardiovascular disease risk 血管运动症状及其与心血管疾病风险的关系
Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-06-01 DOI: 10.1016/j.coemr.2023.100448
Mary Y. Carson , Rebecca C. Thurston
{"title":"Vasomotor symptoms and their links to cardiovascular disease risk","authors":"Mary Y. Carson ,&nbsp;Rebecca C. Thurston","doi":"10.1016/j.coemr.2023.100448","DOIUrl":"10.1016/j.coemr.2023.100448","url":null,"abstract":"<div><p><span><span>Hot flashes and night sweats, also known as </span>vasomotor symptoms (VMS), are common and bothersome symptoms of the menopause transition. In addition to negatively impacting </span>quality of life<span>, VMS have been associated with multiple indicators of cardiovascular disease (CVD) risk, including an unfavorable CVD risk factor<span> profile, increased subclinical CVD, and elevated risk of CVD events. Several facets of VMS have been associated with CVD risk, including the frequency, timing, duration, and severity of VMS. VMS may signify poor or degrading cardiovascular health among midlife women and indicate women who warrant focused CVD prevention efforts.</span></span></p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"30 ","pages":"Article 100448"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10198127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9503234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial board page 编委会页面
Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-06-01 DOI: 10.1016/S2451-9650(23)00030-3
{"title":"Editorial board page","authors":"","doi":"10.1016/S2451-9650(23)00030-3","DOIUrl":"https://doi.org/10.1016/S2451-9650(23)00030-3","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"30 ","pages":"Article 100463"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50173239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genomic landscape of anaplastic thyroid cancer and implications on therapy 癌症间变性的基因组景观及其治疗意义
Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-06-01 DOI: 10.1016/j.coemr.2023.100458
Leslie Cheng, Kate Newbold
{"title":"Genomic landscape of anaplastic thyroid cancer and implications on therapy","authors":"Leslie Cheng,&nbsp;Kate Newbold","doi":"10.1016/j.coemr.2023.100458","DOIUrl":"10.1016/j.coemr.2023.100458","url":null,"abstract":"<div><p>Anaplastic thyroid cancer<span><span> (ATC) is one of the most aggressive and lethal types of cancer and treatment options remain very limited. The majority of patients present initially with </span>metastatic disease<span><span> and require systemic therapy. The shift from conventional cytotoxic therapies to more specific, </span>molecularly targeted therapies<span> is a rapidly developing phenomenon. Despite the recent success of BRAF-directed therapies, druggable mutations in ATC remain scarce and disappointing. Translational research<span> in this area is key to unlocking therapeutic options in ATC, especially as molecular testing becomes increasingly routine. Increasing number of studies in the last decade have described the genomic alterations of ATC, vastly improving our understanding of its development and evolution. In this review, we provide a snapshot of the key DNA sequencing<span> studies of ATC and their potential applications in emerging targeted therapies. We also highlight the future directions of research to tackle this devastating diagnosis.</span></span></span></span></span></p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"30 ","pages":"Article 100458"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46785259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutrient uptake and metabolism in osteoblasts 成骨细胞的营养摄取和代谢
Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-06-01 DOI: 10.1016/j.coemr.2023.100447
Courtney M. Karner , Fanxin Long
{"title":"Nutrient uptake and metabolism in osteoblasts","authors":"Courtney M. Karner ,&nbsp;Fanxin Long","doi":"10.1016/j.coemr.2023.100447","DOIUrl":"10.1016/j.coemr.2023.100447","url":null,"abstract":"<div><p><span><span>Osteoblasts are the chief bone-making cells that specialize in producing and mineralizing large amounts of </span>type I collagen<span><span> and other matrix proteins. The </span>bioenergetics<span> in support of the energy-intensive osteoblast activity is not well understood but has gained renewed interest in recent years. Research in the past ten years has not only confirmed glucose as the main energy substrate for osteoblasts, but also identified contributions of amino acids and fatty acids to either bioenergetic or biosynthetic processes in the cell. Moreover, osteogenic signals have been functionally linked to </span></span></span>substrate utilization in osteoblasts. The brief review aims to summarize the recent findings, and to identify remaining questions in the emerging field.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"30 ","pages":"Article 100447"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46130315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial board page 编委会页面
Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-04-01 DOI: 10.1016/S2451-9650(23)00018-2
{"title":"Editorial board page","authors":"","doi":"10.1016/S2451-9650(23)00018-2","DOIUrl":"https://doi.org/10.1016/S2451-9650(23)00018-2","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"29 ","pages":"Article 100451"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50192774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bone mineralisation and glucose metabolism 骨矿化和葡萄糖代谢
Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-04-01 DOI: 10.1016/j.coemr.2023.100446
Fiona L. Roberts , Vicky E. MacRae
{"title":"Bone mineralisation and glucose metabolism","authors":"Fiona L. Roberts ,&nbsp;Vicky E. MacRae","doi":"10.1016/j.coemr.2023.100446","DOIUrl":"10.1016/j.coemr.2023.100446","url":null,"abstract":"<div><p>Recent advancements in the bone biology field have identified a novel bone-metabolism axis. In this review, we highlight several novel studies that further our knowledge of new endocrine functions of bone; explore remaining unanswered questions; and discuss translational challenges in this complex era of bone biology research.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"29 ","pages":"Article 100446"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41390103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erythropoietin and skeletal cells crosstalks in physiology and disease 促红细胞生成素和骨骼细胞在生理和疾病中的交叉作用
Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-04-01 DOI: 10.1016/j.coemr.2023.100436
Giulia Lanzolla , Mohd Parvez Khan , Elena Sabini , Amato Giaccia , Ernestina Schipani
{"title":"Erythropoietin and skeletal cells crosstalks in physiology and disease","authors":"Giulia Lanzolla ,&nbsp;Mohd Parvez Khan ,&nbsp;Elena Sabini ,&nbsp;Amato Giaccia ,&nbsp;Ernestina Schipani","doi":"10.1016/j.coemr.2023.100436","DOIUrl":"10.1016/j.coemr.2023.100436","url":null,"abstract":"<div><p><span>The hypoxia-inducible factor 2alpha (HIF-2), which is a member of the HIF family of transcription factors and a critical component of the hypoxia-driven pathway, regulates adult erythropoiesis through the renal production and secretion of </span>erythropoietin<span><span> (EPO). Notably, circulating EPO also affects bone mass through either direct or indirect actions on osteoblastic and osteoclastic cells. Adding complexity to the picture, we have recently reported that osteoblastic cells produce and secrete EPO upon activation of HIF-2. Although physiological role of osteoblastic EPO in controlling hematopoiesis remains to be determined, our findings could have translational implications for the </span>treatment of anemia.</span></p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"29 ","pages":"Article 100436"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43327511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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