Current Opinion in Endocrine and Metabolic Research最新文献_第8页

Recent basic and clinical findings concerning FGF23: A bone-derived hormone FGF23，一种骨源性激素的最新基础和临床发现

Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-04-01 DOI: 10.1016/j.coemr.2023.100445

Seiji Fukumoto

引用次数: 0

Endocrine functions of sclerostin 硬化素的内分泌功能

Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-02-01 DOI: 10.1016/j.coemr.2022.100433

Ryan C. Riddle

引用次数: 2

Premature ovarian insufficiency 卵巢早衰

Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-02-01 DOI: 10.1016/j.coemr.2023.100435

Ekta Kapoor

引用次数: 1

How preclinical models of menopause can inform clinical care: A focus on midlife and reciprocal communication between clinical and preclinical science 更年期的临床前模型如何指导临床护理:关注中年和临床与临床前科学的相互交流

Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-02-01 DOI: 10.1016/j.coemr.2023.100434

Heather A. Bimonte-Nelson , Victoria E. Bernaud

{"title":"How preclinical models of menopause can inform clinical care: A focus on midlife and reciprocal communication between clinical and preclinical science","authors":"Heather A. Bimonte-Nelson , Victoria E. Bernaud","doi":"10.1016/j.coemr.2023.100434","DOIUrl":"10.1016/j.coemr.2023.100434","url":null,"abstract":"<div>Midlife in women typically includes the menopausal transition, a time of hormonal transformation, adaptation, and reorganization. Coincident with this dynamic period of physiological change, there are putatively modifiable factors that influence disease, short-term and long-term health outcomes, symptom emergence, and longevity. The menopause transition could be considered a window of vulnerability; however, it is also a window of opportunity for intervention. Thus, the menopause transition is a critical sensitive window whereby there is opportunity for turning points for healthy aging trajectories. Preclinical research can aid in this pursuit of scientific discovery for modifiable factors and treatments, and their particular parameters. Rodent menopause models include surgical and transitional variations, allowing detection of precise determinants impacting menopause-related outcomes. These models permit systematic manipulation of endogenous and exogenous hormone exposures across the lifespan, with infinite outcome measurements ranging from molecular to behavioral. This research is uniquely poised to address complex, interactive hypotheses with extensive control in a relatively short timeframe, including dissociation of age and menopause effects. To understand the many dynamic changes with menopause, iterative and reciprocal communication between clinical and preclinical domains of science is key.</div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"28 ","pages":"Article 100434"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46112513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial board page 编委会页面

Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-02-01 DOI: 10.1016/S2451-9650(23)00006-6

引用次数: 0

Glucocorticoid action in osteoblasts and systemic energy metabolism 糖皮质激素在成骨细胞和全身能量代谢中的作用

Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-02-01 DOI: 10.1016/j.coemr.2022.100432

Hong Zhou , Markus J. Seibel

{"title":"Glucocorticoid action in osteoblasts and systemic energy metabolism","authors":"Hong Zhou , Markus J. Seibel","doi":"10.1016/j.coemr.2022.100432","DOIUrl":"10.1016/j.coemr.2022.100432","url":null,"abstract":"<div>Glucocorticoids are pleiotropic hormones with potent regulatory roles in tissue homeostasis, electrolyte balance, immune defence, central nervous function, stress response, growth and development, as well as fuel metabolism. Clinically, glucocorticoids are widely used for their unsurpassed anti-inflammatory and immunomodulatory effects. However, chronic exposure to excessive levels of endogenous or exogenous glucocorticoids causes insulin resistance, glucose intolerance, dyslipidaemia, central obesity, muscle wasting and bone loss. Topical studies in rodents have demonstrated that the effects of chronic hypercortisolism on systemic fuel metabolism and body composition are in part mediated through their actions on osteoblasts. Interestingly, targeted abrogation of glucocorticoid signalling in osteoblasts also attenuates the effects of high fat intake as well as ageing on body composition and systemic fuel metabolism. Here we briefly review the physiology of glucocorticoid action and discuss emerging concepts regarding the molecular mechanisms underlying the adverse effects of glucocorticoid excess.</div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"28 ","pages":"Article 100432"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49172988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modelling KNDy neurons and gonadotropin-releasing hormone pulse generation 模拟KNDy神经元和促性腺激素释放激素脉冲的产生

Current Opinion in Endocrine and Metabolic Research Pub Date : 2022-12-01 DOI: 10.1016/j.coemr.2022.100407

Zoe Plain , Margaritis Voliotis , Craig A. McArdle , Krasimira Tsaneva-Atanasova

{"title":"Modelling KNDy neurons and gonadotropin-releasing hormone pulse generation","authors":"Zoe Plain , Margaritis Voliotis , Craig A. McArdle , Krasimira Tsaneva-Atanasova","doi":"10.1016/j.coemr.2022.100407","DOIUrl":"10.1016/j.coemr.2022.100407","url":null,"abstract":"<div>The pulsatile release of gonadotropin-releasing hormone (GnRH) and its frequency are crucial for healthy reproductive function. To understand what drives GnRH pulses, a combination of experimental and mathematical modelling approaches has been used. Early work focussed on the possibility that GnRH pulse generation is an intrinsic feature of GnRH neurons, with autocrine feedback generating pulsatility. However, there is now ample evidence suggesting that a network of upstream neurons secreting kisspeptin, neurokinin-B and dynorphin are the source of this GnRH pulse generator. The interplay of slow positive and negative feedback via neurokinin-B and dynorphin, respectively, allows the network to act as a relaxation oscillator, driving pulsatile secretion of kisspeptin, and consequently, of GnRH and LH. Here, we review the mathematical modelling approaches exploring both scenarios and suggest that with pulsatile GnRH secretion driven by the KNDy pulse generator, autocrine feedback still has the potential to modulate GnRH output.</div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"27 ","pages":"Article 100407"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9072199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Weight gain in midlife women: Understanding drivers and underlying mechanisms 中年妇女体重增加:了解驱动因素和潜在机制

Current Opinion in Endocrine and Metabolic Research Pub Date : 2022-12-01 DOI: 10.1016/j.coemr.2022.100406

Maria G. Grammatikopoulou , Meletios P. Nigdelis , Dimitrios G. Goulis

{"title":"Weight gain in midlife women: Understanding drivers and underlying mechanisms","authors":"Maria G. Grammatikopoulou , Meletios P. Nigdelis , Dimitrios G. Goulis","doi":"10.1016/j.coemr.2022.100406","DOIUrl":"10.1016/j.coemr.2022.100406","url":null,"abstract":"<div>Overweight and obesity patterns demonstrate a sexual dimorphism, with women being more prone to weight gain and overweight/obesity compared to men. As a result, weight gain is an important concern in women, particularly during midlife, when reproductive and physiological aging coincide, altering body composition. During this time, multiple factors contribute to the accumulation of body weight and adipose tissue, inducing a decrease in lean mass. These factors include hormonal changes -mainly hypoestrogenism-, genetic and exogenous factors, poor nutritional intake and physical inactivity, all of which might act synergistically to promote weight gain. Basal metabolic rate is also reduced due to aging, muscle mass loss, and the reduction in brown tissue activity. Impairments of the circadian system are associated with reduced endogenous melatonin secretion, altered sleep–wake cycles and metabolic inflexibility. Inflammaging, gut dysbiosis and physical inactivity further promote weight gain and the loss of lean skeletal muscle, leading to sarcopenic obesity.</div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"27 ","pages":"Article 100406"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43247028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cardiovascular disease in women: Does menopause matter? 女性心血管疾病:更年期重要吗?

Current Opinion in Endocrine and Metabolic Research Pub Date : 2022-12-01 DOI: 10.1016/j.coemr.2022.100419

Samar R. El Khoudary, Alexis Nasr

{"title":"Cardiovascular disease in women: Does menopause matter?","authors":"Samar R. El Khoudary, Alexis Nasr","doi":"10.1016/j.coemr.2022.100419","DOIUrl":"10.1016/j.coemr.2022.100419","url":null,"abstract":"<div>It is known that the menopause transition (MT) is a complex period during a woman's life, but there has been an ongoing debate on whether the increase in cardiovascular disease (CVD) during midlife is due to chronological aging or ovarian aging. The purpose of this review is to summarize the recent findings on the role of ovarian aging versus chronological aging on CVD outcomes and its risk factors in women.Recent data from longitudinal studies have shown that menopause-related factors, such as earlier age at menopause and surgical menopause are associated with higher CVD outcomes. The MT is also associated with detrimental changes in vascular health as well as cardiometabolic risk factors including body composition, visceral fat accumulation, lipids/lipoproteins, blood pressure, and the metabolic syndrome.The robust evidence from recent research indicating increases in CVD risk over the MT beyond aging call for immediate efforts to raise awareness among women and their health care providers of CVD risk acceleration accompanying the MT. Efforts should also be directed toward developing and testing novel preventive approaches that target women during this time period to counteract the expected increase in CVD risk.</div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"27 ","pages":"Article 100419"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9636824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Diversity of menopause experience in the workplace: Understanding confounding factors 工作场所更年期经历的多样性:了解混杂因素

Current Opinion in Endocrine and Metabolic Research Pub Date : 2022-12-01 DOI: 10.1016/j.coemr.2022.100391

Kathleen Riach , Margaret Rees

引用次数: 1