发布求助
文献互助 智能选刊 最新文献

Current Opinion in Endocrine and Metabolic Research最新文献

筛选
英文 中文
Editorial board page 编委会页面
Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-10-01 Epub Date: 2023-09-22 DOI: 10.1016/S2451-9650(23)00053-4
{"title":"Editorial board page","authors":"","doi":"10.1016/S2451-9650(23)00053-4","DOIUrl":"https://doi.org/10.1016/S2451-9650(23)00053-4","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"32 ","pages":"Article 100486"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50177402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypoxia signaling in bone physiology and energy metabolism 缺氧信号在骨生理和能量代谢中的作用
Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-10-01 Epub Date: 2023-08-05 DOI: 10.1016/j.coemr.2023.100473
Roger Valle-Tenney, Seppe Melis, Christa Maes
{"title":"Hypoxia signaling in bone physiology and energy metabolism","authors":"Roger Valle-Tenney,&nbsp;Seppe Melis,&nbsp;Christa Maes","doi":"10.1016/j.coemr.2023.100473","DOIUrl":"10.1016/j.coemr.2023.100473","url":null,"abstract":"<div><p><span><span><span><span>Hypoxia-inducible factor (HIF) signaling activation in osteoblast lineage cells increases bone mass, likely through the combined actions of multiple key downstream effectors. These include the potent </span>angiogenesis<span> stimulator vascular endothelial growth factor (VEGF), which mediates coupled osteo-angiogenic responses in bone, among other non-cell-autonomous contributors. Additionally, local HIF activation in bone cells cell-intrinsically triggers increased glycolysis, which is associated with strongly enhanced osteoblastic glucose consumption. Strikingly, besides its local impact on bone mass, this boosting of cellular metabolism in the osteolineage has been linked to increased overall </span></span>glucose uptake by the </span>skeleton and concomitant effects on systemic </span>glucose homeostasis<span>. This review summarizes the cell-autonomous and non-cell-autonomous roles of the hypoxia signaling pathway in osteoblast lineage cells on bone physiology and the parallel systemic impact observed upon activation of the pathway in bone. New potential mechanisms extending the control of global energy metabolism by the skeleton will be discussed in light of the current evidence.</span></p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"32 ","pages":"Article 100473"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44998583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Neoadjuvant therapy prior to surgery for advanced thyroid cancer 晚期癌症术前新辅助治疗
Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-10-01 Epub Date: 2023-07-13 DOI: 10.1016/j.coemr.2023.100469
Curtis Hanba, Mark Zafereo
{"title":"Neoadjuvant therapy prior to surgery for advanced thyroid cancer","authors":"Curtis Hanba,&nbsp;Mark Zafereo","doi":"10.1016/j.coemr.2023.100469","DOIUrl":"10.1016/j.coemr.2023.100469","url":null,"abstract":"<div><p>This chapter aims to review historical perspective as well as detail recent progress in neoadjuvant systemic therapy prior to surgery for advanced thyroid cancer.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"32 ","pages":"Article 100469"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48245525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Osteoblast-lineage cells regulate metabolism and fat mass 成骨细胞系细胞调节新陈代谢和脂肪量
Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-08-01 Epub Date: 2023-07-15 DOI: 10.1016/j.coemr.2023.100470
Daniel Hägg , Per-Anders Jansson , Jakob Bellman , John-Olov Jansson , Claes Ohlsson
{"title":"Osteoblast-lineage cells regulate metabolism and fat mass","authors":"Daniel Hägg ,&nbsp;Per-Anders Jansson ,&nbsp;Jakob Bellman ,&nbsp;John-Olov Jansson ,&nbsp;Claes Ohlsson","doi":"10.1016/j.coemr.2023.100470","DOIUrl":"10.1016/j.coemr.2023.100470","url":null,"abstract":"<div><p>As energy depots in many circumstances have been limited during evolution, it is necessary to prioritize how to manage energy resources. In this review we summarize data from the last 15 years indicating that osteoblast-lineage cells are regulators of whole-body energy metabolism and fat mass. We focus mainly on three factors, osteocalcin, lipocalin-2 and sclerostin, that are released by osteoblast-lineage cells and proposed to exert endocrine effects on metabolism. In addition, we present a hypothesis on why osteoblast-lineage cells during evolution have developed a function to regulate metabolism and fat mass. We propose that osteoblast-lineage cells through the osteocyte network in bone are sensors of gravitational forces induced by body mass and gravity on land-living species. By sensing the body weight, the osteoblastlineage cells may then feed-back this information on the whole-body nutritional status via osteoblast-derived endocrine factors or via the nervous system to regulate energy metabolism and fat mass.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"31 ","pages":"Article 100470"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45656773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evidence in humans for bone as an endocrine organ regulating energy metabolism 人类骨骼作为调节能量代谢的内分泌器官的证据
Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-08-01 Epub Date: 2023-07-29 DOI: 10.1016/j.coemr.2023.100471
Sundeep Khosla
{"title":"Evidence in humans for bone as an endocrine organ regulating energy metabolism","authors":"Sundeep Khosla","doi":"10.1016/j.coemr.2023.100471","DOIUrl":"10.1016/j.coemr.2023.100471","url":null,"abstract":"<div><p><span>There is increasing evidence from animal models that bone, in addition to its traditional function of providing structural support for the organism, has a rich network of interactions with multiple other tissues. This perspective focuses on evidence from human studies demonstrating that bone is an endocrine organ regulating energy metabolism, with the specific examples being </span>osteocalcin<span><span><span>, lipocalin 2<span>, RANKL, and sclerostin. Conversely, animal studies have also demonstrated that a key hormone regulating energy metabolism, leptin, regulates </span></span>bone metabolism via the </span>sympathetic nervous system<span><span>. Studies in humans have established a role for the sympathetic nervous system in regulating bone turnover; indeed, the potential therapeutic benefit of targeting this pathway in humans to prevent postmenopausal </span>bone loss is currently being evaluated.</span></span></p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"31 ","pages":"Article 100471"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10417886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10003016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Editorial board page 编委会页面
Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-08-01 Epub Date: 2023-08-22 DOI: 10.1016/S2451-9650(23)00044-3
{"title":"Editorial board page","authors":"","doi":"10.1016/S2451-9650(23)00044-3","DOIUrl":"10.1016/S2451-9650(23)00044-3","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"31 ","pages":"Article 100477"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46002785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anxiety and depression in midlife transition and beyond: The role of estrogens 中年及以后的焦虑和抑郁：雌激素的作用
Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-08-01 Epub Date: 2023-05-30 DOI: 10.1016/j.coemr.2023.100457
Claudio N. Soares
{"title":"Anxiety and depression in midlife transition and beyond: The role of estrogens","authors":"Claudio N. Soares","doi":"10.1016/j.coemr.2023.100457","DOIUrl":"https://doi.org/10.1016/j.coemr.2023.100457","url":null,"abstract":"<div><p>Depression and anxiety are amongst the most prevalent and disabling conditions worldwide, imposing significant burden to individuals, families, and their communities. It is now known that both conditions affect females more often than males, and that some can be particularly more vulnerable to symptoms (new, recurrent) during reproductive-related windows of vulnerability, including the menopause transition and early postmenopausal years.</p><p><span><span>As estrogen exerts neuro-modulatory effects on mood, cognition, and behaviour through </span>monoaminergic systems<span> (e.g., 5-HT, NE), rapid fluctuations of estradiol (E2) levels seem to be associated with heightened risk for/emergency of anxiety and depression during midlife years, along with other menopause-associated complaints such as </span></span>vasomotor symptoms and sleep disturbances.</p><p><span>Psychopharmacologic and behavioural interventions remain the first-line treatment for depression and anxiety across the life span; however, estrogen-based therapies, particularly </span>transdermal estradiol, should be considered as part of the treatment armamentarium for symptomatic, midlife women.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"31 ","pages":"Article 100457"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50172066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thyroid cancer incidence differences between men and women 男性和女性甲状腺癌发病率的差异
Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-08-01 Epub Date: 2023-07-29 DOI: 10.1016/j.coemr.2023.100472
Quynh-Lam Tran , Louise Davies
{"title":"Thyroid cancer incidence differences between men and women","authors":"Quynh-Lam Tran ,&nbsp;Louise Davies","doi":"10.1016/j.coemr.2023.100472","DOIUrl":"10.1016/j.coemr.2023.100472","url":null,"abstract":"<div><p><span>Early-stage thyroid<span><span> cancer is about 4 times more common in women than men, but the underlying subclinical prevalence is the same between the two sexes. As the lethality<span><span> of the cancer type increases, the ratio in incidence for women compared to men approaches 1:1. These facts suggest that differences in healthcare utilization may be a major reason </span>thyroid cancer is diagnosed more in women than men. Physiological elements could also contribute, as women have a higher prevalence of thyroid nodularity compared to men. Current research suggests estrogen does not play a major role, but </span></span>genetics may be a potential reason for increased rates of thyroid cancer in women compared to men. </span></span>Immune surveillance is greater in women and currently is thought to be protective against thyroid cancer development. This review summarizes recent evidence examining the role of these factors in modulating the sex-disparity observed in thyroid cancer incidence.</p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"31 ","pages":"Article 100472"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45055264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Menopause research: Looking back to move forward 更年期研究:回顾前进
Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-06-01 Epub Date: 2023-05-21 DOI: 10.1016/j.coemr.2023.100459
Chrisandra Shufelt, Stephanie Faubion
{"title":"Menopause research: Looking back to move forward","authors":"Chrisandra Shufelt,&nbsp;Stephanie Faubion","doi":"10.1016/j.coemr.2023.100459","DOIUrl":"10.1016/j.coemr.2023.100459","url":null,"abstract":"","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"30 ","pages":"Article 100459"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47966023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
InTERTwined: How TERT promoter mutations impact BRAFV600E-driven thyroid cancers InTERTwined:TERT启动子突变如何影响BRAFV600E驱动的甲状腺癌
Current Opinion in Endocrine and Metabolic Research Pub Date : 2023-06-01 Epub Date: 2023-05-26 DOI: 10.1016/j.coemr.2023.100460
Iñigo Landa
{"title":"InTERTwined: How TERT promoter mutations impact BRAFV600E-driven thyroid cancers","authors":"Iñigo Landa","doi":"10.1016/j.coemr.2023.100460","DOIUrl":"https://doi.org/10.1016/j.coemr.2023.100460","url":null,"abstract":"<div><p><span>Thyroid cancers are often initiated by the acquisition of a BRAF</span><sup>V600E</sup> mutation. BRAF<sup>V600E</sup><span><span><span>-driven thyroid tumors display a wide range of </span>behaviors, from the slow-growing </span>papillary carcinomas to the highly aggressive anaplastic. Mutations in the promoter of </span><em>TERT</em> (telomerase reverse transcriptase) gene were discovered a decade ago and identified as prevalent events in thyroid cancers. Multiple studies showed that <em>TERT</em> promoter mutations, particularly when co-occurring with BRAF<sup>V600E</sup>, are markers of poor prognosis across thyroid cancer subtypes, and can be implemented for routine clinical stratification. Mechanistically, <em>TERT</em><span> promoter mutations reactivate telomerase<span> expression via the differential recruitment of transcriptional complexes. Re-expression of TERT impacts tumor biology, plausibly via both the well-known function of telomerase maintaining telomeres and by affecting other cancer-relevant processes.</span></span></p></div>","PeriodicalId":52218,"journal":{"name":"Current Opinion in Endocrine and Metabolic Research","volume":"30 ","pages":"Article 100460"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50173240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书