Primary cilia and melanin-concentrating hormone

Abstract

There is a discrepancy between the distribution of melanin-concentrating hormone (MCH)-immunoreactive fibers and the mRNA expression of MCH receptors, particularly MCH₁. Furthermore, the presence of MCH₁ in the primary cilia of adjacent areas with richness of MCH-ir fibers, adds complexity to the neurochemical signaling dynamics. This intricate interplay, facilitated by volume transmission (VT) and the strategic positioning of receptors on structures like primary cilia, presents a novel perspective on neuroendocrine communication. An in-depth exploration of MCH, primary cilia, MCH₁, and VT interactions promises to uncover unprecedented insights that could enhance our understanding of their implications for health and disorders, like obesity. An exploration into the ciliary mechanisms of MCH action emerges as a promising venue for uncovering potential therapeutic targets.