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Stimuli-Responsive Drug Delivery Systems Based on Bilayer Lipid Vesicles: New Trends 基于双层脂质囊泡的刺激响应型给药系统：新趋势
IF 1.4 4区 化学
Colloid Journal Pub Date : 2023-12-12 DOI: 10.1134/S1061933X23600690
A. A. Efimova, A. V. Sybachin
{"title":"Stimuli-Responsive Drug Delivery Systems Based on Bilayer Lipid Vesicles: New Trends","authors":"A. A. Efimova,&nbsp;A. V. Sybachin","doi":"10.1134/S1061933X23600690","DOIUrl":"10.1134/S1061933X23600690","url":null,"abstract":"<p>The development of new efficient methods for combating serious diseases, among which, oncological and infectious diseases hold a special place, remains to be an urgent challenge of biomedicine and biotechnology. Currently, the efforts of scientists are focused on the search for drug systems that provide high efficiency of treatment with minimal impacts on a human body. The development of this field has led to the creation of stimuli-responsive liposomes that can release an encapsulated drug under a specific stimulus, such as temperature, pH, electromagnetic field, light, etc. Being stimulated, lipid bilayer vesicles change their structure, size, surface charge, or phase state, thus leading to a controlled release of the drug in a specific place of the body, thereby resulting in a more accurate and efficient delivery. This review discusses the current trends in the development of liposome-based stimuli-responsive systems for the controlled delivery of biologically active substances.</p>","PeriodicalId":521,"journal":{"name":"Colloid Journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138631094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enzyme-Like Activity of Cerium Dioxide Colloidal Solutions Stabilized with L-Malic Acid 用 L-苹果酸稳定的二氧化铈胶体溶液的酶样活性
IF 1.4 4区 化学
Colloid Journal Pub Date : 2023-12-12 DOI: 10.1134/S1061933X23600653
A. D. Filippova, A. E. Baranchikov, V. K. Ivanov
{"title":"Enzyme-Like Activity of Cerium Dioxide Colloidal Solutions Stabilized with L-Malic Acid","authors":"A. D. Filippova,&nbsp;A. E. Baranchikov,&nbsp;V. K. Ivanov","doi":"10.1134/S1061933X23600653","DOIUrl":"10.1134/S1061933X23600653","url":null,"abstract":"<p>For the first time, stable aqueous colloidal solutions of cerium dioxide stabilized with L-malic acid have been obtained at ligand : CeO<sub>2</sub> molar ratios of 0.2, 0.5, 1.0, and 2.0. Using dynamic light scattering, it has been shown that CeO<sub>2</sub> sols are characterized by a narrow monomodal size distribution of aggregates, and the sols remain to be aggregatively stable in a Tris-HCl buffer solution. According to the chemiluminescence analysis of the enzyme-like activity of cerium dioxide sols with respect to hydrogen peroxide, the surface modification of the cerium dioxide particles with malic acid increases the enzyme-like activity of СеО<sub>2</sub> up to 4.5 times.</p>","PeriodicalId":521,"journal":{"name":"Colloid Journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138630761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Colloidal Objects in Biomedicine: Modern Trends and Prospects 生物医学中的胶体物：现代趋势与前景
IF 1.4 4区 化学
Colloid Journal Pub Date : 2023-12-12 DOI: 10.1134/S1061933X2360077X
E. V. Kuznetsova, N. M. Kuznetsov
{"title":"Colloidal Objects in Biomedicine: Modern Trends and Prospects","authors":"E. V. Kuznetsova,&nbsp;N. M. Kuznetsov","doi":"10.1134/S1061933X2360077X","DOIUrl":"10.1134/S1061933X2360077X","url":null,"abstract":"<p>This review presents historical retrospective on the development of biomedicine as a science and indicates the role of colloidal objects, as well as contains the summary of the reviews and research articles included in the special issue.</p>","PeriodicalId":521,"journal":{"name":"Colloid Journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139325583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipid Nanoparticles for Lutein Encapsulation and Delivery 用于叶黄素封装和输送的脂质纳米颗粒
IF 1.4 4区 化学
Colloid Journal Pub Date : 2023-12-12 DOI: 10.1134/S1061933X2360063X
A. D. Shirokikh, Y. A. Guruleva, E. A. Marinets, M. Y. Koroleva
{"title":"Lipid Nanoparticles for Lutein Encapsulation and Delivery","authors":"A. D. Shirokikh,&nbsp;Y. A. Guruleva,&nbsp;E. A. Marinets,&nbsp;M. Y. Koroleva","doi":"10.1134/S1061933X2360063X","DOIUrl":"10.1134/S1061933X2360063X","url":null,"abstract":"<p>Recently, lipid nanoparticles have been intensively studied as carriers of lipophilic drugs. In this work, we have studied the stability of nanoemulsions with paraffin oil, solid lipid nanoparticles with stearic acid, and nanostructured lipid particles with paraffin oil and stearic acid in a mass ratio of 1 : 1. The obtained results have shown that all studied lipid systems stabilized with nonionic surfactants Tween 60 and Span 60 were stable to aggregation and subsequent sedimentation for more than 30 days. The incorporation of lutein into the lipid particles has almost no effect on their stability, while the size of solid lipid nanoparticles and nanostructured lipid nanoparticles decreases from 28–30 to 15–17 nm. The bioavailability of lutein loaded in lipid nanoparticles is evaluated from their effect on the restoration of blood flow velocity by simulating hemic hypoxia. Almost immediately after the application of lipid nanoparticles, the blood flow velocity ceases to decrease, and a tendency to its restoration is observed in 5–10 min. This shows that lipid nanoparticles with paraffin oil and stearic acid are promising candidates for the delivery of lipophilic drugs.</p>","PeriodicalId":521,"journal":{"name":"Colloid Journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138630807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanoparticle Concentration as an Important Parameter for Characterization of Dispersion and Its Applications in Biomedicine 纳米粒子浓度作为表征分散性的重要参数及其在生物医学中的应用
IF 1.4 4区 化学
Colloid Journal Pub Date : 2023-12-12 DOI: 10.1134/S1061933X23600720
T. N. Pashirova, Z. M. Shaihutdinova, E. B. Souto, P. Masson, V. F. Mironov
{"title":"Nanoparticle Concentration as an Important Parameter for Characterization of Dispersion and Its Applications in Biomedicine","authors":"T. N. Pashirova,&nbsp;Z. M. Shaihutdinova,&nbsp;E. B. Souto,&nbsp;P. Masson,&nbsp;V. F. Mironov","doi":"10.1134/S1061933X23600720","DOIUrl":"10.1134/S1061933X23600720","url":null,"abstract":"<p>Currently, there are problems to standardize methods for determining the concentration of nanoparticles and creation of etalon materials for calibrating measured concentrations. Accurate determination of nanoparticle concentration is necessary to assess the maximum dose of administered nanotherapeutics for diagnostics and therapy in vivo, to determine the order of reaction in enzymatic nanoreactors. In addition, this parameter determines biological effects, such as the formation of a protein corona on the outer surface of nanoparticles that precedes nanoparticles’ absorption and internalization in cells. This review discusses the most common methods for determining the concentration of nanoparticles based on direct visualization, using microscopy, light absorption or light scattering, direct counting of nanoparticles, and gravimetry. Results may differ from one method to the other. Thus, the use of a combination of several methods provides more reliable results. The advantages, disadvantages and ways to improve accuracy of results are also presented.</p>","PeriodicalId":521,"journal":{"name":"Colloid Journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138630821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biocompatible Hydrogels Based on Biodegradable Polyesters and Their Copolymers 基于生物可降解聚酯及其共聚物的生物相容性水凝胶
IF 1.4 4区 化学
Colloid Journal Pub Date : 2023-12-12 DOI: 10.1134/S1061933X23600756
Yu. S. Fomina, A. S. Semkina, Yu. D. Zagoskin, M. M. Aleksanyan, S. N. Chvalun, T. E. Grigoriev
{"title":"Biocompatible Hydrogels Based on Biodegradable Polyesters and Their Copolymers","authors":"Yu. S. Fomina,&nbsp;A. S. Semkina,&nbsp;Yu. D. Zagoskin,&nbsp;M. M. Aleksanyan,&nbsp;S. N. Chvalun,&nbsp;T. E. Grigoriev","doi":"10.1134/S1061933X23600756","DOIUrl":"10.1134/S1061933X23600756","url":null,"abstract":"<p>Poly(ethylene glycol)-based hydrogels have long proved to be promising materials for various biomedical technologies. This review considers systems based on the most common and studied copolymers of poly(ethylene glycol) and biodegradable polyesters of lactide and glycolide. Traditional and modern approaches to the synthesis of the copolymers and the production of hydrogels have been considered, the studies of the structure and properties of the materials have been analyzed, and the main directions of the application of these products in practice have been described.</p>","PeriodicalId":521,"journal":{"name":"Colloid Journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138631081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Terminology and Mechanisms of Self-Emulsifying Systems for Biomedical Applications: A Comprehensive Review 用于生物医学应用的自乳化系统的术语和机制：全面回顾
IF 1.4 4区 化学
Colloid Journal Pub Date : 2023-12-10 DOI: 10.1134/S1061933X23600719
Manish Kumar, C. P. Jain, Ajay Kumar Shukla, Garima Verma, Vimal Kumar Yadav
{"title":"Terminology and Mechanisms of Self-Emulsifying Systems for Biomedical Applications: A Comprehensive Review","authors":"Manish Kumar,&nbsp;C. P. Jain,&nbsp;Ajay Kumar Shukla,&nbsp;Garima Verma,&nbsp;Vimal Kumar Yadav","doi":"10.1134/S1061933X23600719","DOIUrl":"10.1134/S1061933X23600719","url":null,"abstract":"<p>Self-emulsifying systems, such as self-emulsifying drug delivery systems (SEDDS) and self-nanoemulsifying drug delivery systems (SNEDDS), particularly used for enhancing the bioavailability of hydrophobic drugs. This review comprehensively examines the terminologies and mechanisms involved in self-emulsifying systems. The complex nature of self-emulsification is elucidated, encompassing diffusion, interfacial phenomena, and thermodynamic considerations. Three main mechanisms are explored in this review: diffusion and stranding, negative free energy for nanoemulsion formation, and the liquid crystalline (LC) phases formation at the interface. Diffusion and stranding cause rapid diffusion of water-miscible components, forming fine emulsion droplets. However, it lacks a clear thermodynamic explanation. Concept of negative free energy provides a thermodynamic explanation, while the formation of LC phases at the interface is an intermediary event during diffusion-driven self-emulsification. Understanding these mechanisms is crucial for developing optimum self-emulsifying formulation for pharmaceutical delivery, food bioactive delivery, and cosmetic applications.</p>","PeriodicalId":521,"journal":{"name":"Colloid Journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138568441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Aging and Modification on the Interfacial Interaction in Asphalt Mastics 老化和改性对沥青胶料界面相互作用的影响
IF 1.4 4区 化学
Colloid Journal Pub Date : 2023-12-10 DOI: 10.1134/S1061933X23600811
T. V. Dudareva, I. A. Krasotkina, I. V. Gordeeva, V. G. Nikolsky, L. A. Gorelisheva, V. N. Garmanov
{"title":"Effect of Aging and Modification on the Interfacial Interaction in Asphalt Mastics","authors":"T. V. Dudareva,&nbsp;I. A. Krasotkina,&nbsp;I. V. Gordeeva,&nbsp;V. G. Nikolsky,&nbsp;L. A. Gorelisheva,&nbsp;V. N. Garmanov","doi":"10.1134/S1061933X23600811","DOIUrl":"10.1134/S1061933X23600811","url":null,"abstract":"<p>In the temperature range –10–30°С the influence of thermo-oxidative aging, frequency and deformation on the interfacial interaction according to the parameters <i>K–B–G*</i> and <i>К–В–</i>δ in asphalt mastics and modified mastics based on bitumen grade BND 60/90 has been investigated. The filler was introduced into bitumen in the ratio of 1/1 by weight. Active powder of discretely devulcanized rubber (APDDR) as a modifier was introduced in the ratio bitumen/APDDR = 87.5/12.5 by weight. It is shown that the modification of APDDR provides a greater thickness of adsorbed layer on the surface of filler particles under various conditions of external influences compared to mastic, and this thickness depends on the sequence of introduction of filler and APDDR.</p>","PeriodicalId":521,"journal":{"name":"Colloid Journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138567838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Influence of Inert Fluoropolymer on Equilibrium and Dynamic Hydration Characteristics of MF-4SC Membrane 惰性含氟聚合物对 MF-4SC 膜平衡和动态水合特性的影响
IF 1.4 4区 化学
Colloid Journal Pub Date : 2023-12-10 DOI: 10.1134/S1061933X23600732
N. A. Kononenko, S. A. Shkirskaya, M. V. Rybalko, D. A. Zotova
{"title":"The Influence of Inert Fluoropolymer on Equilibrium and Dynamic Hydration Characteristics of MF-4SC Membrane","authors":"N. A. Kononenko,&nbsp;S. A. Shkirskaya,&nbsp;M. V. Rybalko,&nbsp;D. A. Zotova","doi":"10.1134/S1061933X23600732","DOIUrl":"10.1134/S1061933X23600732","url":null,"abstract":"<p>The influence of the type and amount of an inert component in perfluorinated MF-4SC sulfonic cation-exchange membrane on its equilibrium physicochemical and transport properties has been studied. The exchange capacity, water content, specific conductivity, and diffusion and electroosmotic permeability of two series of MF-4SC membranes obtained by casting from polymer solutions in dimethylformamide with variable contents of inert fluoropolymers have been investigated. A relationship between the equilibrium and dynamic hydration characteristics of the samples has been found as a result of studying water distribution over water binding energies and effective pore radii and the numbers of water transport in an external electric field. The type and content of an inert component in the perfluorinated membrane have been found to affect more significantly the state of water under equilibrium conditions than the electroosmotic water transport.</p>","PeriodicalId":521,"journal":{"name":"Colloid Journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138567965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On the Rheology of Thixotropic and Rheopexic Suspensions 关于触变悬浮液和流变悬浮液的流变学
IF 1.4 4区 化学
Colloid Journal Pub Date : 2023-12-10 DOI: 10.1134/S1061933X23600628
A. I. Levinsky
{"title":"On the Rheology of Thixotropic and Rheopexic Suspensions","authors":"A. I. Levinsky","doi":"10.1134/S1061933X23600628","DOIUrl":"10.1134/S1061933X23600628","url":null,"abstract":"<p>Semi-empirical equations are derived that describe the dependence of shear stress on shear rate during the flow of a one-component suspension. The suspension is considered as consisting of two fractions: single grains of the solid phase and their dimers, between which a reversible dimerization reaction occurs. In this case, the dimerization of single grains is considered as a reaction with an invariable rate constant, and the dissociation of dimers is considered as an inverse reaction with a rate constant that increases linearly with the shear rate. The equations are based on the Krieger−Doherty formula, generalized to the case of a multicomponent suspension.</p>","PeriodicalId":521,"journal":{"name":"Colloid Journal","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138560919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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