The Korean journal of helicobacter and upper gastrointestinal research最新文献_第7页

Severe Corrosive Injury Secondary to Chlorine Bleach Ingestion: A Case Report. 误食氯漂白剂致严重腐蚀性损伤1例。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2024-12-01 Epub Date: 2024-12-04 DOI: 10.7704/kjhugr.2024.0055

Yonghoon Choi

{"title":"Severe Corrosive Injury Secondary to Chlorine Bleach Ingestion: A Case Report.","authors":"Yonghoon Choi","doi":"10.7704/kjhugr.2024.0055","DOIUrl":"10.7704/kjhugr.2024.0055","url":null,"abstract":"Corrosive injuries to the upper gastrointestinal tract, particularly those caused by alkaline substances, often result in more severe and deeper tissue injuries than those observed after ingestion of acidic substances. We report a case of severe corrosive injury following ingestion of chlorine bleach (200 mL), an alkaline agent. Initial endoscopic evaluation revealed severe esophageal and gastric injuries with necrosis (Zargar grade 3b), without any signs of perforation. The treatment plan included prolonged fasting with total parenteral nutrition, and enteral feeding was initiated via jejunostomy 1 month after hospitalization. The patient was hospitalized and discharged on several occasions until we observed complete healing of the esophagus and stomach. Follow-up endoscopy performed 4 months after the injury showed improvement in the esophageal wall; however, severe stenosis prevented oral intake. Therefore, the patient underwent surgical intervention, including esophagectomy, total gastrectomy, and esophagocolojejunostomy, 7 months post-injury. Since the initial surgery, the patient underwent repeat wound revision procedures, percutaneous drainage, reconstruction, and bougienation owing to anastomotic leakage, infection, and stenosis for approximately a year. The patient received oral and jejunostomy tube feeding for approximately 2.5 years after the initial injury. Early endoscopy was useful to confirm the severity and predict the prognosis of corrosive injuries in this case. Severe corrosive injuries following ingestion of alkaline substances are associated with poor clinical prognosis, as anticipated. Caution is warranted for the diagnosis and treatment of this condition.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"24 4","pages":"365-369"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Efficacy of Vonoprazan-Tetracycline Dual Therapy in the Initial Treatment of Penicillin-Allergic Helicobacter pylori Infections]. vonoprazan -四环素双联治疗青霉素过敏幽门螺杆菌感染的初步疗效观察

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2024-12-01 Epub Date: 2024-12-04 DOI: 10.7704/kjhugr.2024.0062

Younghee Choe

引用次数: 0

Helicobacter pylori Isolation and Antibiotic Susceptibility Testing Using Rapidly Frozen Biopsy Samples. 快速冷冻活检标本幽门螺杆菌分离及抗生素敏感性试验

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2024-12-01 Epub Date: 2024-12-04 DOI: 10.7704/kjhugr.2024.0063

Kee Don Choi, Jung Mogg Kim, Gwang Ho Baik, Jun Chul Park, Hye-Kyung Jung, Han Seung Ryu, Soo-Jeong Cho, Cheol Min Shin, Hwoon-Yong Jung

{"title":"Helicobacter pylori Isolation and Antibiotic Susceptibility Testing Using Rapidly Frozen Biopsy Samples.","authors":"Kee Don Choi, Jung Mogg Kim, Gwang Ho Baik, Jun Chul Park, Hye-Kyung Jung, Han Seung Ryu, Soo-Jeong Cho, Cheol Min Shin, Hwoon-Yong Jung","doi":"10.7704/kjhugr.2024.0063","DOIUrl":"10.7704/kjhugr.2024.0063","url":null,"abstract":"Objectives: To involve institutions without the ability to perform susceptibility testing, long-term storage of tissue sample is critical to isolate the bacteria in a central laboratory. The aim of the study was to investigate the feasibility of H. pylori isolation and antibiotic susceptibility testing using rapidly frozen biopsy specimens collected from various institutions.Methods: Eight institutions located in various regions of Korea participated in the study. Patients requiring upper endoscopy and H. pylori testing were screened. Two biopsy samples were taken from the stomach. One was placed in a sterile Eppendorf tube and then immediately placed in a vacuum bottle containing dry ice, which was stored at -80°C. The other was used in a rapid urease test. Collected samples were delivered to a central laboratory. The bacteria were isolated from the frozen samples under microaerophilic conditions. The agar dilution method was used to determine the minimum inhibitory concentration (MIC) of amoxicillin, clarithromycin, metronidazole, tetracycline, ciprofloxacin, and levofloxacin for each H. pylori isolate.Results: Patients with a positive rapid urease test result (n=113) were enrolled. The mean age was 56.6±12.3 years. The male:female ratio was 64:49. The overall culture success rate was 77.0% (87/113). MIC values were determined using isolated 87 H. pylori strains. Rates of resistance to amoxicillin, clarithromycin, metronidazole, tetracycline, levofloxacin, and ciprofloxacin were 23.0%, 25.3%, 28.7%, 1.1%, 33.3%, and 34.5%, respectively.Conclusions: It is feasible to perform H. pylori isolation and antimicrobial susceptibility testing using rapidly frozen and transported biopsy specimens.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"24 4","pages":"360-364"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Oral Microbiota and Gastrointestinal/Extra-Gastrointestinal Diseases. 口腔微生物群与胃肠道/胃肠道外疾病的关系

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2024-12-01 Epub Date: 2024-12-04 DOI: 10.7704/kjhugr.2024.0051

Do-Young Park, Young-Youn Kim, Chang Kee Kim, Inseong Hwang, Jeong-Hoo Lee, Jiyoung Hwang, Ju-Yeong Hwang

{"title":"Association Between Oral Microbiota and Gastrointestinal/Extra-Gastrointestinal Diseases.","authors":"Do-Young Park, Young-Youn Kim, Chang Kee Kim, Inseong Hwang, Jeong-Hoo Lee, Jiyoung Hwang, Ju-Yeong Hwang","doi":"10.7704/kjhugr.2024.0051","DOIUrl":"10.7704/kjhugr.2024.0051","url":null,"abstract":"Dental clinicians and researchers have recently recommended oral microbial examinations to more accurately diagnose and treat oral diseases, including periodontitis and dental caries. Theoretical and experimental evidence suggests that oral microbiota may also be associated with non-oral diseases, such as gastrointestinal and extra-gastrointestinal diseases. This review highlights studies demonstrating microbial alterations in the oral cavity associated with malignant tumors including gastric, colorectal, esophageal, and lung cancers, implying that these alterations may serve as early indicators for non-invasive diagnosis and risk assessment of cancer development. Furthermore, we addressed the implications of oral microbial co-occurrence with malignant tumors, such as Streptococcus anginosus, Fusobacterium nucleatum, and Veillonella parvula, which are recognized as tumor-enriched oral pathogens involved in the development and progression of cancers in the stomach, colon, and lungs, respectively. Notably, we explored the immune and inflammatory mechanisms underlying reciprocal interactions between oral microbiota and tumors, underscoring that targeting these mechanistic pathways can contribute to preventing cancer development.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"24 4","pages":"319-326"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Memoir of Seroepidemiological Study of Helicobacter pylori Infection in Asymptomatic People in South Korea Started in 1997]. [1997年开始的韩国无症状人群幽门螺杆菌感染血清流行病学研究回忆录]。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2024-12-01 Epub Date: 2024-12-04 DOI: 10.7704/kjhugr.2024.0056

Nayoung Kim

{"title":"[Memoir of Seroepidemiological Study of Helicobacter pylori Infection in Asymptomatic People in South Korea Started in 1997].","authors":"Nayoung Kim","doi":"10.7704/kjhugr.2024.0056","DOIUrl":"10.7704/kjhugr.2024.0056","url":null,"abstract":"To establish health policies for the prevention of Helicobacter pylori-related diseases, it is crucial to observe prevalence trends and identify risk factors for H. pylori infection. In 1997, the Korean H. pylori Study Group (currently the Korean College of Helicobacter and Upper Gastrointestinal Research) designed a nationwide multicenter study to assess H. pylori seroprevalence and identify risk factors in the asymptomatic Korean population. Sera were collected from 2687 females and 3049 males (mean age: 29.1 years; range: 1 month to 79 years) across Korea from March 1998 to October 1998. All asymptomatic participants completed an assessment questionnaire. An enzyme-linked immunosorbent assay (GENEDIA® H. pylori ELISA) was performed to detect immunoglobulin G antibodies to H. pylori. The seroprevalence rates were 17.2% in children (neonates to 15 years) and 66.9% in adults (16-79 years). A multivariate analysis indicated that variables such as sex, age, geographic area, crowding (number of persons per room) during childhood, economic status during childhood, and types of housing during childhood were significantly and independently associated with H. pylori seroprevalence in adults. For children, significant risk factors included age, geographic area, family income, maternal education, and drinking water sources. Socioeconomic conditions and close person-to-person contact during childhood were significant determinants of H. pylori infection in adults. Additionally, the source of drinking water emerged as a crucial risk factor for H. pylori infection in children, indicating fecal-oral transmission in Korea. This well-organized national study by the Korean H. pylori Study Group is an important milestone in the 30-year history of the Korean College of Helicobacter and Upper Gastrointestinal Research and should be remembered by the society's members.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"24 4","pages":"378-384"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Diagnosis and Risk Assessment of Gastric Cancer. 胃癌的早期诊断与风险评估。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2024-12-01 Epub Date: 2024-12-04 DOI: 10.7704/kjhugr.2024.0058

Byung-Hoon Min

引用次数: 0

Addressing Diversity and Inclusion in Gastroenterology: A Broader Perspective on Endoscopic Practice. 解决胃肠病学的多样性和包容性：内窥镜实践的更广阔视角。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2024-12-01 Epub Date: 2024-12-04 DOI: 10.7704/kjhugr.2024.0061

Seon-Young Park

引用次数: 0

Female Endoscopists in Gastroenterology. 胃肠病学的女性内窥镜医师。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2024-12-01 Epub Date: 2024-12-04 DOI: 10.7704/kjhugr.2024.0049

Yeon Ji Kim

引用次数: 0

Association Between Oral Health and Gastric Cancer in Korean Adults. 韩国成人口腔健康与胃癌的关系

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2024-12-01 Epub Date: 2024-09-05 DOI: 10.7704/kjhugr.2024.0045

Sang Hoon Lee, Hyunseok Cho, Sung Chul Park, Sang Hoon Kim, Seung Young Kim, Han Jo Jeon, Sang Pyo Lee, Younghee Choe

{"title":"Association Between Oral Health and Gastric Cancer in Korean Adults.","authors":"Sang Hoon Lee, Hyunseok Cho, Sung Chul Park, Sang Hoon Kim, Seung Young Kim, Han Jo Jeon, Sang Pyo Lee, Younghee Choe","doi":"10.7704/kjhugr.2024.0045","DOIUrl":"10.7704/kjhugr.2024.0045","url":null,"abstract":"Objectives: Poor oral hygiene is known to be associated with gastric cancer, but this remains controversial. In this study, we investigated the association between oral health and gastric cancer in Korean adults using data from the Korea National Health and Nutrition Examination Survey.Methods: We analyzed data of 79501 patients with gastric cancer and 41856805 individuals without gastric cancer (control group) using the 7th and 8th Korea National Health and Nutrition Examination Survey (2016-2019) records. Layer and colony variables and weights were used for the complex sample design. We performed logistic regression analysis of complex samples to analyze factors that affect gastric cancer development.Results: Patients with gastric cancer were older and had a higher prevalence of hypertension, hyperlipidemia, and diabetes and a higher rate of current smoking and alcohol consumption than individuals without gastric cancer (p<0.001). Regarding oral health-related factors, the prevalence of very uncomfortable chewing difficulty was significantly higher in patients with gastric cancer (14.4% vs. 3.6%, p<0.001). On multivariate analysis of factors associated with gastric cancer, chewing difficulty showed the highest odds ratio (5.351, 95% confidence interval 2.128-8.982). Patients with very uncomfortable chewing difficulty had high rates of previous dental nerve treatment, gum disease treatment, tooth extraction or intraoral surgery, and prosthetic repair (p<0.001).Conclusions: Oral health-related chewing difficulties were associated with gastric cancer, which may be attributable to poor oral hygiene and degradation of oral microbiota. Patients at risk of gastric cancer warrant timely medical interventions to address their oral health and chewing difficulties.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"24 4","pages":"346-352"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic Diagnosis of Early Gastric Cancer and High-Risk Gastritis. 早期胃癌和高危胃炎的内镜诊断。

The Korean journal of helicobacter and upper gastrointestinal research Pub Date : 2024-12-01 Epub Date: 2024-12-04 DOI: 10.7704/kjhugr.2024.0047

Hidekazu Suzuki, Masaya Sano, Toshihiro Nishizawa, Osamu Toyoshima

{"title":"Endoscopic Diagnosis of Early Gastric Cancer and High-Risk Gastritis.","authors":"Hidekazu Suzuki, Masaya Sano, Toshihiro Nishizawa, Osamu Toyoshima","doi":"10.7704/kjhugr.2024.0047","DOIUrl":"10.7704/kjhugr.2024.0047","url":null,"abstract":"Many differentiated and undifferentiated gastric cancers are associated with Helicobacter pylori infection. Therefore, as a primary prevention method, the early diagnosis of H. pylori gastritis and eradication of these bacteria can prevent gastric cancer. As a secondary prevention method, the early diagnosis of gastric cancer and endoscopic treatment can also contribute to reducing overall mortality. Gastric mucosal atrophy and intestinal metaplasia are important findings in patients with H. pylori gastritis. The accurate diagnosis of other characteristic findings is also important to comprehensively assess gastric cancer risk. The identification of precancerous lesions and early gastric cancer by evaluating endoscopic gastric cancer risk scores, based on the Kyoto classification of gastritis, is similarly important. Recently, endoscopic image evaluation systems equipped with artificial intelligence have been developed to complement the diagnostic abilities of individual endoscopists and reduce interobserver variability; future developments in this area are highly anticipated.","PeriodicalId":520887,"journal":{"name":"The Korean journal of helicobacter and upper gastrointestinal research","volume":"24 4","pages":"311-318"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0