The Journal of clinical endocrinology and metabolism最新文献

{"title":"Clinical Significance of Successful Ablation in Follicular Thyroid Carcinoma.","authors":"Haruhiko Yamazaki, Kiminori Sugino, Ryohei Katoh, Kenichi Matsuzu, Wataru Kitagawa, Mitsuji Nagahama, Aya Saito, Koichi Ito","doi":"10.1210/clinem/dgaf326","DOIUrl":"https://doi.org/10.1210/clinem/dgaf326","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study is to investigate the clinical characteristics of follicular thyroid carcinoma (FTC) patients who received postoperative ablation, the predictive factors for successful ablation, and the association between successful ablation and the clinical outcomes of FTC.</p><p><strong>Patients: </strong>The study included 428 patients with FTC (216 in ablation group and 212 in observation group). A multivariate logistic regression model was used to identify factors independently associated with successful ablation.</p><p><strong>Results: </strong>Patients in the ablation group were significantly older (p < 0.001), had a higher prevalence of widely invasive-FTC histology (p < 0.001), had vascular invasion ≥ 2, and had a higher rate of anti-thyroglobulin antibody positivity (p = 0.007) in comparison to patients in the observation group. Among the 116 patients with postoperative ablation following diagnostic I-131 scintigraphy, 65 (56%) achieved successful ablation. In the multivariate analysis, the thyroglobulin level at ablation as the only independent predictor successful ablation (odds ratio, 0.952; 95% confidence interval, 0.909-0.996; p = 0.034). Among the ablation group, the 10-year cause-specific survival (CSS) rates of patients with (n = 65) and without successful ablation (n = 151) were 100% and 98.4% (p = 0.246), respectively. None of the patients with successful ablation died during the follow-up period. The 10-year distant-metastasis free survival (DMFS) rates of patients with and without successful ablation were 100% and 81.7% (p < 0.001), respectively. None of the patients with successful ablation experienced distant metastatic recurrence during the follow-up period.</p><p><strong>Conclusions: </strong>FTC patients with successful ablation achieved excellent 10-year CSS and DMFS rates of 100%. Therefore, careful follow-up may be unnecessary for these patients even if they have negative prognostic factors.</p>","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: \"Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline\".","authors":"","doi":"10.1210/clinem/dgaf310","DOIUrl":"https://doi.org/10.1210/clinem/dgaf310","url":null,"abstract":"","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor from Lai: The beneficial effects of sodium-glucose cotransporter 2 inhibitors on anemia in type 2 diabetes-a real world study.","authors":"Shih-Wei Lai","doi":"10.1210/clinem/dgaf325","DOIUrl":"https://doi.org/10.1210/clinem/dgaf325","url":null,"abstract":"","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes Progression and Its Impact on Kidney Cancer Risk: Insights From a Longitudinal Korean Cohort Study.","authors":"Jin Yu, Bongseong Kim, Kyungdo Han, Mee Kyoung Kim","doi":"10.1210/clinem/dgaf249","DOIUrl":"https://doi.org/10.1210/clinem/dgaf249","url":null,"abstract":"<p><strong>Context: </strong>The incidence of kidney cancer is rising in Korea, with lifestyle and metabolic factors such as smoking, obesity, and hypertension contributing to this trend.</p><p><strong>Objective: </strong>This study assessed the relationship between diabetes progression and kidney cancer risk.</p><p><strong>Methods: </strong>Using data from the National Health Information Database in South Korea, analyzing 2 365 294 patients with type 2 diabetes mellitus who underwent health examinations in 2015 and 2016, excluding those with pre-existing cancer or who died within a year. Patients were monitored until 2022 to determine the incidence of kidney cancer, defined by ICD-10 code C64. Diabetes progression was assessed using a scoring system (range 0-6) based on the number of oral glucose-lowering drugs (GLDs), diabetes duration, insulin use, and the presence of chronic kidney disease (CKD), diabetic retinopathy (DR), or cardiovascular disease.</p><p><strong>Results: </strong>Among the indicators of diabetes progression, prolonged diabetes duration and the presence of CKD or DR were linked to higher hazard ratios (HRs) for kidney cancer. The risk of kidney cancer increased progressively with higher diabetes progression scores. Compared to participants with a score of 0, the adjusted HRs for kidney cancer were 1.21 (95% CI 1.13-1.30) for a score of 1, 1.28 (1.18-1.38) for a score of 2, 1.37 (1.23-1.51) for a score of 3, and 1.73 (1.49-2.01) for scores of 4 or higher.</p><p><strong>Conclusion: </strong>Diabetes progression is strongly associated with an increased risk of kidney cancer. These findings underscore the importance of targeted screening and awareness programs for kidney cancer in individuals with advanced diabetes.</p>","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A missense mutation in close proximity of ALS-linked PFN1 mutations causes only early-onset Paget's disease of bone.","authors":"Rou Weng, Xiaoxiang Li, Hua Yue, Yang Xu, Zhe Wei, Shuqin Xu, Baojie Li, Zhenlin Zhang","doi":"10.1210/clinem/dgaf314","DOIUrl":"https://doi.org/10.1210/clinem/dgaf314","url":null,"abstract":"<p><strong>Context: </strong>Paget's disease of bone (PDB) is a metabolic disorder characterized by abnormal osteoclast activation. Recently, mutations in the PFN1 gene, which encodes Profilin 1, an actin-binding protein controlling actin dynamics and cell movement, have been linked to early-onset PDB. Interestingly, mutations in PFN1 (C71G, T109M, M114T, E117G, G118V, etc.) are associated with amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder affecting motor neurons.</p><p><strong>Objective: </strong>To provide insights into the underlying molecular mechanism of early-onset PDB.</p><p><strong>Methods: </strong>We observed the clinical responses to denosumab in early-onset PDB patients. Additionally, a mouse model carrying the c.335T>C mutation in the Pfn1 gene was generated.</p><p><strong>Results: </strong>We reported a second Chinese family affected by early-onset PDB with malignant giant cell tumor (GCTs), in which we indentified the same heterozygous missense mutation (c.335T>C/p. L112P) in PFN1 that we have reported previously in another family. Despite its proximity to ALS-linked PFN1 mutations, the PFN1 L112P mutation did not induce ALS in affected individuals. These early-onset PDB patients exhibited a significantly poorer response to denosumab compared to typical PDB patients. The heterozygous mice displayed PDB-like phenotypes, including skeletal deformities and focal osteoclastic lesions with giant osteoclasts, and did not show ALS-like phenotypes. We further show that mutation of Pfn1 leads to enhanced actin ring-like structures at the bone surfaces without affecting NF-κB activation in osteoclast cultures.</p><p><strong>Conclusion: </strong>The observation of recurrent mutations highlights the causative role of PFN1 (L112P) in early-onset PDB/GCT within the Chinese population and provides insights into the physio-pathological functions of Profilin 1.</p>","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hair Cortisone Levels and the Metabolic Syndrome: Stronger Links in Younger Compared to Older Adults.","authors":"Susanne Kuckuck, Robin Lengton, Julius März, Nina van Gerwen, Dimitris Rizopoulos, Manon H J Hillegers, Maryam Kavousi, Sjoerd A A van den Berg, Erik J Giltay, Brenda W J H Penninx, Mariëtte R Boon, Elisabeth F C van Rossum","doi":"10.1210/clinem/dgaf322","DOIUrl":"https://doi.org/10.1210/clinem/dgaf322","url":null,"abstract":"<p><strong>Background: </strong>The striking link between Cushing's syndrome, the metabolic syndrome (MetS), and cardiovascular disease suggests that long-term exposure to high glucocorticoid levels catalyzes cardiometabolic deterioration. However, the relation of subtle variations in long-term glucocorticoid levels with MetS remains poorly understood. Specifically, little is known about potential moderating roles of age, sex and mental health status in this association.</p><p><strong>Design: </strong>We investigated the association of long-term glucocorticoid levels with MetS using data of 1,405 participants (73.4% women) of the Netherlands Study of Depression and Anxiety (NESDA). Predictors included hair cortisol and cortisone levels. Outcomes were MetS presence, number of MetS components, and each individual component (i.e., diastolic blood pressure, waist circumference, and fasting glucose, HDL cholesterol, and triglycerides). We investigated potential interactions with age, sex and mental health status.</p><p><strong>Results: </strong>Hair glucocorticoid levels were positively associated with MetS presence (OR=1.27; 95% CI=1.11-1.44, and OR=1.32; 95% CI=1.14-1.52 for hair cortisol and cortisone respectively), number of MetS components, waist circumference and triglyceride levels. Hair cortisol, but not cortisone, was in trend associated with diastolic blood pressure and HDL cholesterol levels. No associations were seen with blood glucose. Of note, the relationship of hair cortisone with MetS was stronger among younger compared to older individuals (OR=1.95; 95% CI=1.50-2.54 vs. OR=1.14; 95% CI=0.96-1.35 in younger vs. older participants).</p><p><strong>Conclusion: </strong>Long-term biological stress, measured through hair glucocorticoid levels, is associated with MetS presence, especially among younger individuals. Prospective studies need to evaluate the extent to which hair cortisol and cortisone add to standard risk factors when predicting future cardiometabolic diseases.</p>","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor From Yan and Chang: \"Long-Term Non-skeletal Complications in Patients with Thyroid Cancer and Hypoparathyroidism Post-total Thyroidectomy\".","authors":"Eu Jeong Ku, Jooyoung Lee, Won Sang Yoo, Janghyeon Bae, Eun Kyung Lee, Hwa Young Ahn","doi":"10.1210/clinem/dgaf317","DOIUrl":"https://doi.org/10.1210/clinem/dgaf317","url":null,"abstract":"","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144210761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor from Yan and Chang: \"Long-Term Non-skeletal Complications in Patients with Thyroid Cancer and Hypoparathyroidism Post-total Thyroidectomy\".","authors":"Bokang Yan, Shi Chang","doi":"10.1210/clinem/dgaf316","DOIUrl":"https://doi.org/10.1210/clinem/dgaf316","url":null,"abstract":"","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beneficial Effects of Carbohydrate Restriction in Type 2 Diabetes Can Be Traced to Changes in Hepatic Metabolism.","authors":"Barbara A Gower, Marian L Yurchishin, Amy M Goss, John Knight, William T Garvey","doi":"10.1210/clinem/dgaf324","DOIUrl":"https://doi.org/10.1210/clinem/dgaf324","url":null,"abstract":"<p><strong>Context: </strong>Carbohydrate restriction benefits metabolic health in patients with type 2 diabetes (T2D), possibly through changes in hepatic metabolism.</p><p><strong>Objective: </strong>To test the hypothesis that the ketogenic diet (KD) would decrease de novo lipogenesis (DNL) and liver fat, which would be associated with restored beta-cell function.</p><p><strong>Methods: </strong>Participants were 57 adults with mild T2D. A hyperglycemic clamp was used to assess acute C-peptide response (ACP), and magnetic resonance imaging to assess hepatic fat fraction, at baseline and after 12 weeks of either a eucaloric KD (∼9% energy from carbohydrate, 65% energy from fat) or a eucaloric low-fat diet (LFD) (∼55% energy from carbohydrate, 20% energy from fat).</p><p><strong>Results: </strong>The KD led to decreases in pyruvate (-23%, P<0.001) and palmitoleic acid, a marker of DNL (-32%, P<0.01). Participants on the KD had higher fasting glucagon (25%, P<0.05) and lower liver fat (28%, P<0.05) at week 12 than those on the LFD. In all combined, the change in liver fat was positively associated with the change in pyruvate (r = 0.45, P=0.05), and inversely associated with changes in glucagon (r = -0.34, P<0.05), the glucagon to C-peptide ratio (r = -0.44, P<0.01), and ACP (r = -0.34, P<0.05). The change in ACP was inversely associated with the change in pyruvate in the KD group (r = -0.5, P<0.05), but not in the LFD group.</p><p><strong>Conclusions: </strong>A shift in hepatic metabolism to favor fat oxidation over DNL may underlie the beneficial effects of carbohydrate restriction on hepatic steatosis and glucose-induced insulin secretion.</p>","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating Non-Esterified Fatty Acids in Older Adults - Revisiting the Lipid-Mortality Link.","authors":"Juliane Maushagen, Susanne Rospleszcz","doi":"10.1210/clinem/dgaf318","DOIUrl":"https://doi.org/10.1210/clinem/dgaf318","url":null,"abstract":"","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}