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The Journal of clinical endocrinology and metabolism最新文献

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Correction to: "Efficacy and Safety of Targeted Therapy for Radioiodine-Refractory Differentiated Thyroid Cancer". 更正：“放射性碘难治性分化甲状腺癌靶向治疗的疗效和安全性”。
IF 5.1
The Journal of clinical endocrinology and metabolism Pub Date : 2025-09-16 DOI: 10.1210/clinem/dgaf407
{"title":"Correction to: \"Efficacy and Safety of Targeted Therapy for Radioiodine-Refractory Differentiated Thyroid Cancer\".","authors":"","doi":"10.1210/clinem/dgaf407","DOIUrl":"10.1210/clinem/dgaf407","url":null,"abstract":"","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":"e3554"},"PeriodicalIF":5.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the Editor From Mauvais-Jarvis and Dhindsa: "Approach to the Patient: Low Testosterone Concentrations in Men With Obesity". Mauvais-Jarvis和Dhindsa致编辑的信：“接近病人：肥胖男性睾酮浓度低”。
IF 5.1
The Journal of clinical endocrinology and metabolism Pub Date : 2025-09-16 DOI: 10.1210/clinem/dgaf333
Franck Mauvais-Jarvis, Sandeep Dhindsa
{"title":"Letter to the Editor From Mauvais-Jarvis and Dhindsa: \"Approach to the Patient: Low Testosterone Concentrations in Men With Obesity\".","authors":"Franck Mauvais-Jarvis, Sandeep Dhindsa","doi":"10.1210/clinem/dgaf333","DOIUrl":"10.1210/clinem/dgaf333","url":null,"abstract":"","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":"e3543-e3544"},"PeriodicalIF":5.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glucose Parameters, Inflammation Markers, and Gut Microbiota Changes of Gut Microbiome-Targeted Therapies in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 2型糖尿病肠道微生物组靶向治疗的血糖参数、炎症标志物和肠道菌群变化：随机对照试验的系统回顾和荟萃分析
IF 5.1
The Journal of clinical endocrinology and metabolism Pub Date : 2025-09-16 DOI: 10.1210/clinem/dgaf340
Xin Zhou, Wenbin Zheng, Wen Kong, Jiaoyue Zhang, Yunfei Liao, Jie Min, Tianshu Zeng
{"title":"Glucose Parameters, Inflammation Markers, and Gut Microbiota Changes of Gut Microbiome-Targeted Therapies in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Xin Zhou, Wenbin Zheng, Wen Kong, Jiaoyue Zhang, Yunfei Liao, Jie Min, Tianshu Zeng","doi":"10.1210/clinem/dgaf340","DOIUrl":"10.1210/clinem/dgaf340","url":null,"abstract":"<p><strong>Purpose: </strong>This meta-analysis aims to summarize the effects of gut microbiome-targeted therapies (MTTs) on glucometabolic, inflammatory factors and gut microbiota in patients with type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>Four databases were searched for randomized controlled trials (RCTs) that included subjects with T2DM who received MTTs. All results were presented as standardized mean difference (SMD) or mean difference (MD) and 95% CIs. In addition, subgroup analyses were performed according to region, type of MTTs, number of probiotic strains, probiotics dose, prebiotics dose, duration of MTTs, mean age, and baseline body mass index.</p><p><strong>Results: </strong>A total of 54 RCTs were included, encompassing 60 groups and 3390 subjects. Overall, MTTs intervention decreased fasting plasma glucose (MD = -7.97 mg/dL [95% CI = -10.82, -5.12]; P < .00001), 2-hour postprandial blood glucose (MD =  -43.30 mg/dL [95% CI = -75.83, -10.77]; P = .009), fasting insulin (MD = -1.73 uU/mL [95% CI = -2.63, -0.84]; P = .0001), HbA1c (MD = -0.28%, [95% CI = -0.39, -0.17]; P < .00001), and homeostatic model assessment of insulin resistance (MD =-0.53 [95% CI = -0.85, -0.20]; P = .0002). Furthermore, MTTs supplementation reduced high-sensitivity C-reactive protein, tumor necrosis factor alpha, and lipopolysaccharides. Meanwhile, the levels of interleukin-10 were increased. Moreover, the abundance of Actinobacteria, Lactobacillus, and Lactobacillus casei subgroup increased.</p><p><strong>Conclusion: </strong>MTTs modestly improved glucometabolic parameters, reduced pro-inflammatory cytokines, and enriched beneficial microbes (eg, Actinobacteria, Lactobacillus) in subjects with T2DM. However, heterogeneity and limited long-term data highlight the need for large-scale RCTs.</p>","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":"2980-3008"},"PeriodicalIF":5.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12448586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma branched-chain amino acid and cardiovascular disease risk factors: a longitudinal analysis of a lifestyle trial. 血浆支链氨基酸与心血管疾病危险因素：一项生活方式试验的纵向分析
IF 5.1
The Journal of clinical endocrinology and metabolism Pub Date : 2025-09-16 DOI: 10.1210/clinem/dgaf509
Mahya Mehri Hajmir, Bahar Sayoldin, Ali Rahnavard, Matthew D Barberio, Rob M van Dam
{"title":"Plasma branched-chain amino acid and cardiovascular disease risk factors: a longitudinal analysis of a lifestyle trial.","authors":"Mahya Mehri Hajmir, Bahar Sayoldin, Ali Rahnavard, Matthew D Barberio, Rob M van Dam","doi":"10.1210/clinem/dgaf509","DOIUrl":"https://doi.org/10.1210/clinem/dgaf509","url":null,"abstract":"<p><strong>Context: </strong>Branched-chain amino acid (BCAAs) levels have been associated with a higher risk of cardiovascular diseases (CVD), but studies of the impact of BCAAs on CVD risk factors have mainly been cross-sectional.</p><p><strong>Objective: </strong>We examined the longitudinal association between changes in BCAA levels and CVD risk factors in a lifestyle trial.</p><p><strong>Method: </strong>We used data from 708 male and female participants, aged 25-78, of the U.S. PREMIER study. Data and biospecimens were from the NHLBI BioLINCC Repository. Participants received lifestyle advice or comprehensive counseling on diet, physical activity, and weight loss. Biomarkers were measured with NMR spectroscopy at baseline and the 6-month follow-up. Linear regression models assessed changes in BCAA levels in relation to changes in cardiometabolic risk factors. We adjusted for multiple testing by using false discovery rate-adjusted Q values.</p><p><strong>Results: </strong>Increases in BCAA levels over 6 months (per 1 SD) were associated with increases in insulin resistance (HOMA-IR: Beta = 0.22, SE = 0.07), inflammation (GlycA: Beta = 0.03 mmol/l, SE = 0.004), ApoB (Beta = 0.02 g/l, SE = 0.006), and VLDL-cholesterol (Beta = 0.03 mmol/l, SE = 0.007) over the same period (all Q-values <0.01). Associations with HDL-cholesterol and triglycerides differed for valine versus leucine and isoleucine. No significant associations were observed with fasting glucose or blood pressure.</p><p><strong>Conclusion: </strong>Increasing levels of BCAAs were associated with insulin resistance, inflammation, and unfavorable lipid profiles, indicating their potential as targets for CVD prevention. Further research is warranted to elucidate how individual BCAAs influence lipid metabolism.</p>","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: "Clinical Consequences of Delayed Gastric Emptying With GLP-1 Receptor Agonists and Tirzepatide". 更正：“GLP-1受体激动剂和替西肽延迟胃排空的临床后果”。
IF 5.1
The Journal of clinical endocrinology and metabolism Pub Date : 2025-09-16 DOI: 10.1210/clinem/dgaf387
{"title":"Correction to: \"Clinical Consequences of Delayed Gastric Emptying With GLP-1 Receptor Agonists and Tirzepatide\".","authors":"","doi":"10.1210/clinem/dgaf387","DOIUrl":"10.1210/clinem/dgaf387","url":null,"abstract":"","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":"e3556"},"PeriodicalIF":5.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12539352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: "Central Precocious Puberty in Males, GnRH Analog Treated or Untreated, Did Not Impact Fertility and Health in Midadulthood". 更正：“男性中枢性性早熟，GnRH类似物治疗或未治疗，不影响中年生育和健康”。
IF 5.1
The Journal of clinical endocrinology and metabolism Pub Date : 2025-09-16 DOI: 10.1210/clinem/dgaf508
{"title":"Correction to: \"Central Precocious Puberty in Males, GnRH Analog Treated or Untreated, Did Not Impact Fertility and Health in Midadulthood\".","authors":"","doi":"10.1210/clinem/dgaf508","DOIUrl":"https://doi.org/10.1210/clinem/dgaf508","url":null,"abstract":"","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145093442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: "Approach to the Patient: Concept and Application of Targeted Radiotherapy in the Paraganglioma Patient". 更正：“走近患者：靶向放疗在副神经节瘤患者中的概念和应用”。
IF 5.1
The Journal of clinical endocrinology and metabolism Pub Date : 2025-09-16 DOI: 10.1210/clinem/dgaf443
{"title":"Correction to: \"Approach to the Patient: Concept and Application of Targeted Radiotherapy in the Paraganglioma Patient\".","authors":"","doi":"10.1210/clinem/dgaf443","DOIUrl":"10.1210/clinem/dgaf443","url":null,"abstract":"","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":"e3551"},"PeriodicalIF":5.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12448575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144839939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: "Anti-Androgen and Aromatase Inhibitor Do Not Enhance Height in Children With CAH". 更正：“抗雄激素和芳香化酶抑制剂不会增加CAH患儿的身高”。
IF 5.1
The Journal of clinical endocrinology and metabolism Pub Date : 2025-09-16 DOI: 10.1210/clinem/dgaf431
{"title":"Correction to: \"Anti-Androgen and Aromatase Inhibitor Do Not Enhance Height in Children With CAH\".","authors":"","doi":"10.1210/clinem/dgaf431","DOIUrl":"10.1210/clinem/dgaf431","url":null,"abstract":"","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":"e3553"},"PeriodicalIF":5.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144777603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: "Medullary Thyroid Cancer: Single Institute Experience Over 3 Decades and Risk Factors for Recurrence". 更正：“甲状腺髓样癌：单一研究所30多年的经验和复发的危险因素”。
IF 5.1
The Journal of clinical endocrinology and metabolism Pub Date : 2025-09-16 DOI: 10.1210/clinem/dgaf380
{"title":"Correction to: \"Medullary Thyroid Cancer: Single Institute Experience Over 3 Decades and Risk Factors for Recurrence\".","authors":"","doi":"10.1210/clinem/dgaf380","DOIUrl":"10.1210/clinem/dgaf380","url":null,"abstract":"","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":"e3557-e3558"},"PeriodicalIF":5.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: "A Systematic Review Supporting the Clinical Practice Guidelines on the Management of Preexisting Diabetes and Pregnancy". 更正：“支持既往糖尿病和妊娠管理临床实践指南的系统综述”。
IF 5.1
The Journal of clinical endocrinology and metabolism Pub Date : 2025-09-16 DOI: 10.1210/clinem/dgaf441
{"title":"Correction to: \"A Systematic Review Supporting the Clinical Practice Guidelines on the Management of Preexisting Diabetes and Pregnancy\".","authors":"","doi":"10.1210/clinem/dgaf441","DOIUrl":"10.1210/clinem/dgaf441","url":null,"abstract":"","PeriodicalId":520805,"journal":{"name":"The Journal of clinical endocrinology and metabolism","volume":" ","pages":"e3552"},"PeriodicalIF":5.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144839937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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