The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease最新文献_第4页

Accuracy of a fluorescent dye-qPCR for diagnosis of pulmonary TB in HIV-associated adults. 荧光染料qpcr诊断hiv相关成人肺结核的准确性

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-06-29 DOI: 10.5588/ijtld.25.0693

J H Reyna-Verdugo, J R Chávez-Méndez, J M Cornejo-Bravo, J Isaías de León-Ramírez, V A Reyes-Villegas, A Serrano-Medina, N A Castillo-Martínez

{"title":"Accuracy of a fluorescent dye-qPCR for diagnosis of pulmonary TB in HIV-associated adults.","authors":"J H Reyna-Verdugo, J R Chávez-Méndez, J M Cornejo-Bravo, J Isaías de León-Ramírez, V A Reyes-Villegas, A Serrano-Medina, N A Castillo-Martínez","doi":"10.5588/ijtld.25.0693","DOIUrl":"10.5588/ijtld.25.0693","url":null,"abstract":"<sec><title>BACKGROUND</title>TB remains a major public health concern in Baja California, Mexico, where access to molecular diagnostics is limited.</sec><sec><title>METHODS</title>We evaluated the diagnostic performance of a fluorescent dye-based real-time quantitative PCR (SYBR-qPCR) assay targeting the IS6110 sequence for the detection of pulmonary TB (PTB). This was a cross-sectional diagnostic accuracy study conducted using sputum samples from 113 adults with clinical suspicion of PTB. Samples were analysed by acid-fast bacilli (AFB) smear microscopy, Löwenstein-Jensen culture as the reference standard, and SYBR-qPCR. Diagnostic performance was assessed using sensitivity, specificity, predictive values, and likelihood ratios. Receiver operating characteristic analysis was used to determine the optimal cycle threshold (Ct) cut-off.</sec><sec><title>RESULTS</title>SYBR-qPCR showed a sensitivity of 98.3% and a specificity of 92.5%. Sensitivity remained high among HIV-positive participants (96.6%), although specificity was lower (78.6%). In HIV-negative participants, both sensitivity and specificity exceeded 97%. The combination of SYBR-qPCR and AFB smear microscopy improved sensitivity (100%), and mean Ct values did not differ by HIV status.</sec><sec><title>CONCLUSION</title>SYBR-qPCR demonstrated consistent diagnostic performance across HIV strata, supporting its feasibility as a low-cost molecular tool for TB detection in resource-limited settings.</sec>.","PeriodicalId":520801,"journal":{"name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","volume":"30 7","pages":"309-315"},"PeriodicalIF":3.1,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148355412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Work efficiency at treatment completion for TB: addressing issues beyond bacteriological cure. 结核病完成治疗时的工作效率：解决细菌治疗以外的问题。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-06-29 DOI: 10.5588/ijtld.25.0510

P Sarma, P Mrigpuri, S Spalgais, M V Basil, B Menon

引用次数: 0

Strengthening the operational quality of TB laboratories to support accurate diagnosis and safe clinical trials. 加强结核病实验室的业务质量，支持准确诊断和安全的临床试验。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-06-29 DOI: 10.5588/ijtld.26.0087

G Rojas-Ponce

引用次数: 0

Acceptability of long-acting injectables for TB preventative treatment among high-risk groups. 在高危人群中，长效注射剂用于结核病预防治疗的可接受性。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-06-29 DOI: 10.5588/ijtld.25.0740

R L Demissie, M Kipiani, L Goginashvili, P Papuashvili, Z Avaliani, L F Collins, V C Ontiveros, M J Magee, R R Kempker

引用次数: 0

Attitudes towards adjunctive surgical therapy for pulmonary TB in Europe: an ESGMYC, ESTS, and TBnet collaborative survey. 欧洲对辅助手术治疗肺结核的态度：ESGMYC、ESTS和TBnet合作调查。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-06-29 DOI: 10.5588/ijtld.25.0707

R Idris, A Bertani, L Guglielmetti, G Günther, S Tunesi, N Wetzstein

{"title":"Attitudes towards adjunctive surgical therapy for pulmonary TB in Europe: an ESGMYC, ESTS, and TBnet collaborative survey.","authors":"R Idris, A Bertani, L Guglielmetti, G Günther, S Tunesi, N Wetzstein","doi":"10.5588/ijtld.25.0707","DOIUrl":"10.5588/ijtld.25.0707","url":null,"abstract":"<sec><title>BACKGROUND</title>Data on the benefits of thoracic surgery for the treatment of pulmonary TB (PTB) are scarce. The majority of studies pertain to patients with multi- or extensively drug-resistant TB. We conducted this Europe-wide survey to evaluate attitudes towards thoracic surgery in TB care.</sec><sec><title>METHODS</title>We compiled a questionnaire of 17 questions on the respondents and their patients and on the modalities, indications, and outcomes of adjunctive surgery for PTB. The questions were distributed via the Tuberculosis Network European Trials Group (TBnet), ESCMID Study Group for Mycobacterial Infections (ESGMYC), and the European Society of Thoracic Surgeons (ESTS).</sec><sec><title>RESULTS</title>We received answers from 63 participants in 23 countries of the WHO European region. Surgery was mainly perceived to be reserved for specific clinical situations such as a differential diagnosis of cancer, a cavity with fungi/sequester, or a scarred stenosis of the draining bronchus. We observed substantial variations of attitudes towards surgical treatment between different specialties.</sec><sec><title>CONCLUSION</title>This study underscores a case-specific approach to adjunctive thoracic surgery in PTB. Differences in surgical availability and treatment attitudes suggest a need for specific, standardised guidelines. Future studies should aim to clarify the role of certain procedures and measure long-term outcomes of surgical treatment.</sec>.","PeriodicalId":520801,"journal":{"name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","volume":"30 7","pages":"316-321"},"PeriodicalIF":3.1,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148355406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systematic review and meta-analysis of steroid use for treatment of TB meningitis. 使用类固醇治疗结核性脑膜炎的系统回顾和荟萃分析。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-06-29 DOI: 10.5588/ijtld.25.0588

M J Nasiri, G Hamzelouee, M Rezaeinasab, H Souri, E Eghbal, N Ghafari, L D'Ambrosio, R Centis, V Venketaraman, G B Migliori

{"title":"A systematic review and meta-analysis of steroid use for treatment of TB meningitis.","authors":"M J Nasiri, G Hamzelouee, M Rezaeinasab, H Souri, E Eghbal, N Ghafari, L D'Ambrosio, R Centis, V Venketaraman, G B Migliori","doi":"10.5588/ijtld.25.0588","DOIUrl":"10.5588/ijtld.25.0588","url":null,"abstract":"<sec><title>BACKGROUND</title>TB meningitis (TBM) is the most severe form of extra-pulmonary TB. This study evaluated the efficacy and safety of adjunctive steroid therapy in TBM.</sec><sec><title>METHODS</title>We searched PubMed/MEDLINE, Embase, and Cochrane CENTRAL for controlled trials of steroids in TBM. Pooled risk ratios (RRs) with 95% confidence intervals (CIs) were calculated for mortality, neurological complications, functional recovery, and adverse events.</sec><sec><title>RESULTS</title>Fourteen trials with 2,028 patients were included. Steroids reduced mortality in adults (RR = 0.83; 95% CI: 0.72-0.95) but not in children (RR = 0.68; 95% CI: 0.36-1.29). No significant benefit was seen for neurological complications (RR = 1.03; 95% CI: 0.74-1.44) or functional recovery (RR = 1.16; 95% CI: 0.86-1.57). Results were consistent across steroid types, doses, and routes.</sec><sec><title>CONCLUSION</title>Adjunctive steroids reduce mortality in adult TBM but not in children, nor do they improve neurological or functional outcomes.</sec>.","PeriodicalId":520801,"journal":{"name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","volume":"30 7","pages":"297-302"},"PeriodicalIF":3.1,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determinants of TB detection yield in Kaduna State, Nigeria. 尼日利亚卡杜纳州结核病检出率的决定因素。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-06-29 DOI: 10.5588/ijtld.25.0730

J B Gajere, E N Effiong, A P Garkuwa, A Y Goje

引用次数: 0

Impact of processing delays on molecular detection of childhood pulmonary TB from gastric lavage samples. 处理延迟对儿童洗胃样本中肺结核分子检测的影响。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-06-29 DOI: 10.5588/ijtld.25.0627

A D Shukla, S Singh, A Singh, R K Thakur, A Shrivastava

引用次数: 0

TB risk during treatment with biological agents and Janus kinase inhibitors: an umbrella review. 生物制剂和Janus激酶抑制剂治疗期间的结核病风险：综述。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-06-01 DOI: 10.5588/ijtld.25.0518

R F Alves, C Hilário, N B Ferreira, M Cascais, J P Ramos, M Vieira, A Aguiar, R Duarte

{"title":"TB risk during treatment with biological agents and Janus kinase inhibitors: an umbrella review.","authors":"R F Alves, C Hilário, N B Ferreira, M Cascais, J P Ramos, M Vieira, A Aguiar, R Duarte","doi":"10.5588/ijtld.25.0518","DOIUrl":"10.5588/ijtld.25.0518","url":null,"abstract":"<sec><title>BACKGROUND</title>Biological therapies and Janus kinase (JAK) inhibitors have revolutionised the management of immune-mediated and oncologic diseases, but concerns remain regarding their potential to increase TB risk.</sec><sec><title>OBJECTIVE</title>To systematically synthesise evidence from previous systematic reviews on the risk of TB disease associated with different biological classes and JAK inhibitors.</sec><sec><title>METHODS</title>Following Preferred Reporting Items for Overviews of Reviews guidelines, we conducted an umbrella review of systematic reviews and meta-analyses, registered in PROSPERO (CRD42024497515). Twenty-five reviews met the inclusion criteria. Data were extracted on TB incidence, risk estimates, type, and time to onset. Risk of bias was assessed using ROBIS.</sec><sec><title>RESULTS</title>Anti-TNF monoclonal antibodies (infliximab, adalimumab) were consistently associated with the highest TB risk (odds ratio commonly 3-5), with greater proportions of disseminated/extra-pulmonary disease compared to etanercept. Combination immunosuppression further increased risk. IL-6, IL-17, and IL-23 inhibitors showed low TB reactivation rates under screening and prophylaxis protocols. JAK inhibitors (notably tofacitinib) conferred geographically variable risk, higher in intermediate/high-burden countries. Immune checkpoint inhibitors, especially PD-1/PD-L1 agents, were linked to TB incidence far above background rates.</sec><sec><title>CONCLUSION</title>TB risk varies markedly across biologic and targeted agents. Risk-based TB infection screening and tailored prophylaxis beyond anti-TNF therapy are warranted, particularly in endemic regions.</sec>.","PeriodicalId":520801,"journal":{"name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","volume":"30 6","pages":"244-254"},"PeriodicalIF":3.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148146136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extra-pulmonary TB: a comparison of HIV-positive and HIV-negative patients. 肺外结核：hiv阳性和hiv阴性患者的比较。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-06-01 DOI: 10.5588/ijtld.25.0625

L T Kayano, W D S P Bezerra, E D C A de Brito, C E Volpe-Chaves, A A Bertucci, B J de Brito, S M D V L de Oliveira, A M M Paniago

引用次数: 0