The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease最新文献_第3页

Trends and treatment outcomes of TB among people living with HIV: a nationwide cohort study, 2011-2022. 艾滋病毒感染者结核病趋势和治疗结果：2011-2022年全国队列研究

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-07-31 DOI: 10.5588/ijtld.25.0756

C Chung, W Choi, S W Lee, D Jeong, H Choi, H Sohn, Y A Kang

{"title":"Trends and treatment outcomes of TB among people living with HIV: a nationwide cohort study, 2011-2022.","authors":"C Chung, W Choi, S W Lee, D Jeong, H Choi, H Sohn, Y A Kang","doi":"10.5588/ijtld.25.0756","DOIUrl":"10.5588/ijtld.25.0756","url":null,"abstract":"<sec><title>BACKGROUND</title>Recent trends and treatment outcomes of TB among people living with HIV (PLHIV) have been understudied in Korea.</sec><sec><title>METHODS</title>Using the nationwide K-TB-N cohort, we identified individuals with TB registered between 2011 and 2022. Among 373,812 TB cases, 931 had TB-HIV co-infection. TB treatment outcomes were compared between PLHIV and the general population using propensity score matching. Multivariable Cox proportional hazards models, including stratified and sensitivity analyses, were used to identify factors associated with death during TB treatment among PLHIV.</sec><sec><title>RESULTS</title>Most of TB-HIV patients were males (91.9%), under 60 years old (82.1%), and approximately 90% received antiretroviral therapy (ART). The number of TB-HIV cases declined from 120 in 2011 to 35 in 2022. Lost to follow-up and not evaluated outcomes decreased over time, whereas mortality remained stable at 10%-20%. The overall TB treatment success rate was 76.9% and mortality was higher than general population. Mortality was associated with older age and comorbidity burden, whereas ART showed a protective association only when initiated before TB diagnosis.</sec><sec><title>CONCLUSION</title>TB incidence among PLHIV in South Korea has declined over the past decade, but mortality during TB treatment remains high, driven largely by host-related factors including age and comorbidities.</sec>.","PeriodicalId":520801,"journal":{"name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","volume":"30 8","pages":"358-364"},"PeriodicalIF":3.1,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148650526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TB burden and control in penitentiary institutions: a retrospective analysis in Kazakhstan from 2012 to 2024. 监狱机构结核病负担和控制：2012年至2024年哈萨克斯坦回顾性分析

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-07-31 DOI: 10.5588/ijtld.25.0772

K D Erimbetov, E V Arbuzova, G B Umutbaeva, M M Adenov, K K Kassymbekova, N T Kemelkhanov, D Ainakulov, B S Assembekov

引用次数: 0

Comparing adherence strategies and facility DOT in TB care: a systematic review with meta-analysis. 比较结核病治疗的依从性策略和设施DOT：一项荟萃分析的系统综述。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-07-31 DOI: 10.5588/ijtld.25.0604

J P Ramos, M Vieira, M Araújo, L L Ferreira, P Barbosa, A Aguiar, R Duarte

{"title":"Comparing adherence strategies and facility DOT in TB care: a systematic review with meta-analysis.","authors":"J P Ramos, M Vieira, M Araújo, L L Ferreira, P Barbosa, A Aguiar, R Duarte","doi":"10.5588/ijtld.25.0604","DOIUrl":"10.5588/ijtld.25.0604","url":null,"abstract":"<sec><title>BACKGROUND</title>Adherence to TB treatment is crucial for successful outcomes. While facility-based directly observed therapy (FB-DOT) is a common strategy, recognition of its limitations has spurred the development of flexible approaches. We have compared the effectiveness of alternative adherence-enhancing strategies with FB-DOT.</sec><sec><title>METHODS</title>We searched three databases and four registries from June 2013 to May 2025. We included comparative studies evaluating interventions designed to improve adherence to TB treatment in people aged 15 years or older, excluding adherence to multiple therapies. Meta-analyses were conducted for treatment success, treatment completion, cure rate, and loss to follow-up.</sec><sec><title>RESULTS</title>Twenty-five studies involving 19,103 participants were included. Self-administered treatment and reminder-based interventions achieved treatment success comparable to FB-DOT. Community-based DOT showed similar cure and completion rates but was effective at reducing loss to follow-up (71% reduction). Video-supported treatment and digital adherence technologies demonstrated neutral effects across treatment outcomes. Multicomponent strategies showed heterogeneous results.</sec><sec><title>CONCLUSION</title>Alternative adherence strategies can offer improvements over FB-DOT in specific contexts. However, their variable effectiveness limits universal implementation. Adherence support, community engagement, and social determinants should guide programmatic design and implementation.</sec>.","PeriodicalId":520801,"journal":{"name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","volume":"30 8","pages":"350-357"},"PeriodicalIF":3.1,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148650255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of microscopically quantitative loads of bacilli as early predictors of TB treatment outcome. 评价结核杆菌的显微定量负荷作为结核病治疗结果的早期预测指标。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-07-31 DOI: 10.5588/ijtld.26.0051

I Vellere, B K Jacobs, A K J Maug, M A Hossain, B C De Jong, L Rigouts, N Lorent, T Decroo

{"title":"Evaluation of microscopically quantitative loads of bacilli as early predictors of TB treatment outcome.","authors":"I Vellere, B K Jacobs, A K J Maug, M A Hossain, B C De Jong, L Rigouts, N Lorent, T Decroo","doi":"10.5588/ijtld.26.0051","DOIUrl":"10.5588/ijtld.26.0051","url":null,"abstract":"<sec><title>BACKGROUND</title>Two-month smear conversion has been adopted instead of cultures to predict unfavourable bacteriological outcomes in TB treatment. However, this approach is limited by lower sensitivity and specificity.</sec><sec><title>OBJECTIVE</title>In absence of early-stage biomarkers of treatment response, we investigated the association between bacteriological outcome and microscopy data with auramine and fluorescein diacetate stains at baseline and during the first 2 weeks of treatment in the context of the OneRIF trial. This is a secondary analysis of data collected during the OneRIF trial.</sec><sec><title>RESULTS</title>Failure or relapse occurred in 15 patients of 321 treated with double-dose R. Only quantitative baseline auramine significantly predicted failure or relapse: for every 100 bacilli per field increase, there was 5% higher odds of having an unfavourable bacteriological outcome.</sec><sec><title>CONCLUSION</title>While quantitative baseline auramine predicted having an unfavourable bacteriological outcome, considering our small data we could not identify any added value in implementing quantitative bacillary load in the first 2 weeks of treatment. These findings should be interpreted with caution as we were limited by the relatively low number of failure and relapse.</sec>.","PeriodicalId":520801,"journal":{"name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","volume":"30 8","pages":"365-370"},"PeriodicalIF":3.1,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148650364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel near-point-of-care TB molecular tests: navigating the repercussions of sensitivity tradeoffs. 新型近护理点结核病分子检测：导航敏感性权衡的影响。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-07-31 DOI: 10.5588/ijtld.25.0793

E A Kendall

{"title":"Novel near-point-of-care TB molecular tests: navigating the repercussions of sensitivity tradeoffs.","authors":"E A Kendall","doi":"10.5588/ijtld.25.0793","DOIUrl":"10.5588/ijtld.25.0793","url":null,"abstract":"New near-point-of-care, swab-based molecular tests for TB offer substantial operational advantages including improved accessibility and cost. However, early data suggest some loss of sensitivity: in particular, these tests tend to miss the lowest-positive molecular signals, such as 'trace' Xpert MTB/RIF Ultra sputum test results. Recent cohort studies suggest most trace signals represent TB disease, even if not currently confirmable by culture. However, the underdiagnosis arising from reduced sensitivity will be greatest in populations with mild disease, where immediate clinical and transmission risks may be lowest and benefits of expanded access may be greatest. Altered test characteristics may also alter empiric TB treatment practices, with variable effects on over-diagnosis. The improved access and yield offered by near-point-of-care platforms and swab specimens are likely to justify these tradeoffs, more than offsetting detrimental effects on case detection in most contexts. Implementation strategies are proposed to mitigate potential harms.","PeriodicalId":520801,"journal":{"name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","volume":"30 8","pages":"342-349"},"PeriodicalIF":3.1,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148650517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TB and mental health integration: lessons from WHO feasibility pilots in Ghana, Kenya, and Pakistan. 结核病和精神卫生一体化：世卫组织在加纳、肯尼亚和巴基斯坦开展可行性试点的经验教训。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-07-31 DOI: 10.5588/ijtld.25.0173

A C Sweetland, J Galea, I Parupudi, Y Adusi-Poku, A Boadu, R P Frimpong-Mansoh, S Gilani, A Gitonga, L Gyimah, I Kathure, S A Khan, K L Ahmad, J N Nato, E Omesa, B Okotu, M A Safdar, K Senya, M van Den Boom, A Malik, E Jaramillo

引用次数: 0

Health care worker attitudes toward long-acting injectables for TB prevention. 卫生保健工作者对用于结核病预防的长效针剂的态度。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-07-31 DOI: 10.5588/ijtld.25.0764

V C Ontiveros, M Kipiani, L Khelaia, P Papuashvili, N Tsereteli, Z Avaliani, L F Collins, R Demissie, R R Kempker, M J Magee

引用次数: 0

Miliary TB - a retrospective cohort study of diagnostic and clinical features. 军人结核病-诊断和临床特征的回顾性队列研究。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-07-31 DOI: 10.5588/ijtld.25.0824

K Toms, J Gafton, A M Malhotra, D Pope, B Fakim, J Jeyatheesan, R McDermott, H Kunst

{"title":"Miliary TB - a retrospective cohort study of diagnostic and clinical features.","authors":"K Toms, J Gafton, A M Malhotra, D Pope, B Fakim, J Jeyatheesan, R McDermott, H Kunst","doi":"10.5588/ijtld.25.0824","DOIUrl":"10.5588/ijtld.25.0824","url":null,"abstract":"<sec><title>BACKGROUND</title>TB remains a major global health challenge causing significant morbidity and mortality. Miliary TB, a severe form of the disease, remains poorly characterised in large cohorts, and often has poor outcomes, especially in high-prevalence resource-poor settings.</sec><sec><title>METHODS</title>This retrospective cohort study characterises diagnostic and clinical features of miliary TB in 84 confirmed cases over 9 years (2014-2022) across East London, UK. Demographic, clinical, microbiological, biochemical, and imaging data were collected retrospectively from electronic health records of all consecutive patients diagnosed with miliary TB at a large hospital trust.</sec><sec><title>RESULTS</title>The central nervous system (CNS) was the most common site of extra-pulmonary spread after intra- and extra-thoracic lymph nodes. Neurological symptoms were unreliable indicators of CNS involvement, supporting routine magnetic resonance imaging (MRI) brain for all miliary TB patients regardless of symptoms, given its superior sensitivity over lumbar puncture and computed tomography (CT) brain. Admission hyponatraemia, thrombocytopaenia, and lymphopaenia all predicted increased duration of hospital stay, supporting their use as biomarkers of disease severity.</sec><sec><title>CONCLUSION</title>Routine MRI brain should be considered for all miliary TB patients, and admission hyponatraemia robustly predicts increased disease severity. These findings help inform clinical decision making and guidelines for the management of miliary TB.</sec>.","PeriodicalId":520801,"journal":{"name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","volume":"30 8","pages":"371-377"},"PeriodicalIF":3.1,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148650522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Action is needed to reduce TB drug shortages in Europe. 需要采取行动减少欧洲的结核病药物短缺。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-06-29 DOI: 10.5588/ijtld.26.0154

S Tunesi, G Bothamley, L Guglielmetti, Y Kherabi, B Lange, C Lange, N Lorent, F Saluzzo, M Sester, X E S Iversen, M Tebruegge, C Tweed, A Vasiliu, G Günther, L Kuksa

引用次数: 0

Incidence and predictors of TB infection among children and adolescents in the SONET study. SONET研究中儿童和青少年结核感染的发病率和预测因素

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-06-29 DOI: 10.5588/ijtld.25.0592

R Abbott, E Kakande, B Ssekyanzi, W Ahiro, G Nattabi, J Temple, G Chamie, D Havlir, E D Charlebois, M R Kamya, L B Balzer, C Marquez

{"title":"Incidence and predictors of TB infection among children and adolescents in the SONET study.","authors":"R Abbott, E Kakande, B Ssekyanzi, W Ahiro, G Nattabi, J Temple, G Chamie, D Havlir, E D Charlebois, M R Kamya, L B Balzer, C Marquez","doi":"10.5588/ijtld.25.0592","DOIUrl":"https://doi.org/10.5588/ijtld.25.0592","url":null,"abstract":"<sec><title>BACKGROUND</title>Data are needed to guide TB prevention and case finding for children and adolescents. In this study, we hypothesised that risk factors for incident TB infection would change with age as young people spend more time outside the household, and the relative contribution of the household would therefore be low.</sec><sec><title>METHODS</title>We employed a longitudinal TB immunoreactivity survey in rural southwestern Uganda (ages 1-17 years). Our objectives were to 1) characterise overall and age-specific incidence and predictors of TB infection among children and adolescents and 2) estimate proportion of incident TB infections attributable to a household case. QuantiFERON (QFT) tests were used to test for TB infection, at baseline and at follow-up among participants who were QFT-negative at baseline.</sec><sec><title>RESULTS</title>Between June 2023 and September 2024, 3,145/4,707 (66.8%) eligible participants had a follow-up QFT. Estimated cumulative 1-year incidence of TB infection was 2.1% (95% confidence interval: 1.8%-4.1%), increasing with age. Household factors (alcohol use and outmigration) were predictive for children and community factors (participant-mobility and boarding school attendance) for adolescents. Household TB contact was predictive across age groups, but the relative contribution was low.</sec><sec><title>CONCLUSION</title>Our data reinforce the need for non-household, age-specific active case-finding programmes among young people.</sec>.","PeriodicalId":520801,"journal":{"name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","volume":"30 7","pages":"303-308"},"PeriodicalIF":3.1,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148355370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0