The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease最新文献

Modelling the health impact of TB active-case-finding interventions in Papua New Guinea. 模拟巴布亚新几内亚结核病主动病例发现干预措施对健康的影响。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-09-30 DOI: 10.5588/ijtld.26.0308

E Chapman-Banks, J González, M Kal, L N John, R G White, C Suñer, R A Clark

引用次数: 0

Factors associated with primary rifampicin-resistant/multidrug-resistant TB: a case-control study. 与原发性利福平耐药/耐多药结核病相关的因素：一项病例对照研究

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-09-30 DOI: 10.5588/ijtld.26.0038

T Zangpo, T Norbu, P Tenzin, G Nima, C Dorji, G P Dhakal, S Dorjee, T Tsheten

{"title":"Factors associated with primary rifampicin-resistant/multidrug-resistant TB: a case-control study.","authors":"T Zangpo, T Norbu, P Tenzin, G Nima, C Dorji, G P Dhakal, S Dorjee, T Tsheten","doi":"10.5588/ijtld.26.0038","DOIUrl":"https://doi.org/10.5588/ijtld.26.0038","url":null,"abstract":"<sec><title>BACKGROUND</title>Multidrug-resistant TB (MDR-TB) threatens TB control in Bhutan. According to the 2017 national Drug Resistance Surveillance report of the Royal Centre for Disease Control, 13.7% of new pulmonary TB cases had rifampicin resistance, of whom 98% were also resistant to isoniazid. We investigated the factors associated with primary rifampicin-resistant/multidrug-resistant TB (RR/MDR-TB) among new pulmonary TB patients.</sec><sec><title>METHODS</title>We conducted a nationwide case-control study including 46 laboratory-confirmed primary RR/MDR-TB cases and 138 drug-susceptible pulmonary TB controls (1:3 ratio). Multivariable logistic regression identified factors independently associated with primary RR/MDR-TB.</sec><sec><title>RESULTS</title>Factors associated with primary RR/MDR-TB were delay in diagnosis (adjusted odds ratio [AOR] 24.9, P < 0.001), poor household ventilation (AOR 3.6, P = 0.023), contact with MDR-TB patients (AOR 7.2, P < 0.001), living alone (AOR 10.8, P = 0.016), perceived health staff unfriendliness (AOR 9.6, P = 0.004), and TB medicine unavailability (AOR 16.5, P = 0.024). Increasing age was associated with lower odds of RR/MDR-TB (AOR 0.94 per year, P = 0.005).</sec><sec><title>CONCLUSION</title>Primary RR/MDR-TB in Bhutan was strongly associated with delayed diagnosis, contact with known MDR-TB patients and modifiable health-system factors. Expanding rapid molecular testing, strengthening contact investigation, and improving patient-centred care are critical to interrupt transmission and sustain TB control gains.</sec>.","PeriodicalId":520801,"journal":{"name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","volume":"30 10","pages":"448-453"},"PeriodicalIF":3.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149122985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chest radiography may underestimate TB during contact investigation in a school cluster. 在学校群接触调查中，胸片可能低估结核病。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-09-30 DOI: 10.5588/ijtld.26.0234

G Li, M Pang, X Pu, Y Xu, H Yu

引用次数: 0

Inequities in access to TB care: insights from a community, rights, and gender assessment. 获得结核病治疗方面的不公平：来自社区、权利和性别评估的见解。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-09-30 DOI: 10.5588/ijtld.26.0348

B K Pfouminzhouer, G S Manguinga, G Mombo

引用次数: 0

Comparative associations of mid-upper arm circumference and body mass index with radiographic cavitation among adults with pulmonary TB. 成人肺结核患者中上臂围度和体重指数与影像学空化的比较关系。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-09-30 DOI: 10.5588/ijtld.26.0189

M Duraiswamy, D P Dwivedi, M Rajaram, K M Jain, M Karoly, M R Dauphinais, C Cintron, M E Carwile, S Shaikh, N Rajkumari, L M Locks, S P Babu, S Sarkar, P B Narasimhan, P Sinha, S Lakshminarayanan

引用次数: 0

Unmasking isoniazid resistance in rifampicin-susceptible TB: a national multicentre study using Xpert MTB/XDR. 揭露利福平敏感结核中异烟肼耐药性：一项使用Xpert MTB/XDR的国家多中心研究

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-09-30 DOI: 10.5588/ijtld.26.0111

E M Goshu, A G Woldegiorgis, Z G Dememew, E D Gebremedihin, A A Tsega, T B Abraha, T A Abagero, J S Mohammed, D T Mekuria, G A Doti, T L Janfa, E A Abdisa, Y Kasaie, A Kumsa, D G Datiko

{"title":"Unmasking isoniazid resistance in rifampicin-susceptible TB: a national multicentre study using Xpert MTB/XDR.","authors":"E M Goshu, A G Woldegiorgis, Z G Dememew, E D Gebremedihin, A A Tsega, T B Abraha, T A Abagero, J S Mohammed, D T Mekuria, G A Doti, T L Janfa, E A Abdisa, Y Kasaie, A Kumsa, D G Datiko","doi":"10.5588/ijtld.26.0111","DOIUrl":"https://doi.org/10.5588/ijtld.26.0111","url":null,"abstract":"<sec><title>BACKGROUND</title>TB remains a major global health threat, worsened by drug resistance. Hr-TB (isoniazid resistance) in rifampicin-susceptible cases compromises outcomes. This study used Xpert MTB/XDR to determine Hr-TB prevalence and associated risk factors, informing national control strategies.</sec><sec><title>METHOD</title>A cross-sectional study was conducted in 74 Ethiopian health facilities (May-October 2024), including 841 rifampicin-susceptible TB cases. Hr-TB was evaluated using the Xpert MTB/XDR assay. Two-stage sampling and logistic regression estimated prevalence and identified significant predictors.</sec><sec><title>RESULTS</title>The overall Hr-TB prevalence was 2.7%, higher among previously treated TB cases (16.2%) than in new TB cases (0.9%). Regional variation showed the highest prevalence in Gambella (7.1%), Oromia (6.2%), and Sidama (5.7%). Multivariable analysis identified prior TB treatment as the main predictor, including other previously treated cases (AOR = 138.48), relapses (AOR = 5.59), and history of treatment after failure (AOR = 45.51).</sec><sec><title>CONCLUSIONS</title>Hr-TB remains a significant concern among rifampicin-susceptible TB patients in Ethiopia, particularly in previously treated cases, with regional variation underscoring a persistent challenge. Strengthening routine isoniazid resistance testing, expanding access to Xpert MTB/XDR, improving treatment adherence, and implementing targeted interventions with enhanced surveillance are essential to prevent resistance amplification, improve outcomes, and control Hr-TB spread.</sec>.","PeriodicalId":520801,"journal":{"name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","volume":"30 10","pages":"442-447"},"PeriodicalIF":3.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149123038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving childhood TB case notification through intensified clinical services. 通过加强临床服务改善儿童结核病病例通报。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-09-30 DOI: 10.5588/ijtld.26.0053

E N Mgeyi, C A Swai, P A Luge, I Kavishe, J J Gwimile, L B Komba, B T Kasambala, K P Mckenzie, E W Ketang'enyi, N E Kipiki, R Balama, G Sililo, R Kisonga, O G Onduru, L F Mwita

{"title":"Improving childhood TB case notification through intensified clinical services.","authors":"E N Mgeyi, C A Swai, P A Luge, I Kavishe, J J Gwimile, L B Komba, B T Kasambala, K P Mckenzie, E W Ketang'enyi, N E Kipiki, R Balama, G Sililo, R Kisonga, O G Onduru, L F Mwita","doi":"10.5588/ijtld.26.0053","DOIUrl":"https://doi.org/10.5588/ijtld.26.0053","url":null,"abstract":"<sec><title>BACKGROUND</title>Childhood TB is a major cause of morbidity and mortality among children under 15, with diagnosis challenged by non-specific symptoms and paucibacillary disease. This study analysed the impact of intensified clinical interventions on childhood TB notification and treatment outcomes in four high-burden regions of Tanzania.</sec><sec><title>METHODS</title>The study used a retrospective pre-post intervention design, analysing childhood TB data (2018-2023) across four regions (Katavi, Kigoma, Rukwa, and Songwe) to assess the impact of health care worker training and intensified clinical services. Childhood TB data were extracted from the national electronic TB and leprosy system and analysed using χ² tests at a 0.05 significance level.</sec><sec><title>RESULTS</title>4,178 childhood TB cases were notified across regions. A statistically significant increase was observed post-intervention (P < 0.001). The proportion of districts that attained the national notification target (≥15%) significantly rose from 18.2% to 81.8%. Treatment outcomes improved significantly across all regions (χ² = 23.91, P < 0.001), with treatment completion rising from 82.1% to 87.5% and mortality decreasing from 6.0% to 3.4%.</sec><sec><title>CONCLUSION</title>Implemented interventions in the regions led to significant improvements in childhood TB case management. Their effectiveness was demonstrated by increased use of childhood TB diagnostic methods, improved treatment outcomes, and reduced childhood TB mortality.</sec>.","PeriodicalId":520801,"journal":{"name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","volume":"30 10","pages":"436-441"},"PeriodicalIF":3.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149123051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Results of the FAST-TB end-users' survey align with priority research questions on new TB treatment regimens. FAST-TB最终用户调查的结果与新的结核病治疗方案的重点研究问题一致。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-09-30 DOI: 10.5588/ijtld.26.0442

A Bellavia, T A Refera, D R Silva, Y Kherabi, N Singla, Y Permata, R C Teixeira, E Pontali, G Fumagalli, L Lagrutta, M Munoz-Torrico, M Rifat, M B Souleymane, S Villa, C Lienhardt, R Centis, L D'Ambrosio, M C Raviglione, G B Migliori

{"title":"Results of the FAST-TB end-users' survey align with priority research questions on new TB treatment regimens.","authors":"A Bellavia, T A Refera, D R Silva, Y Kherabi, N Singla, Y Permata, R C Teixeira, E Pontali, G Fumagalli, L Lagrutta, M Munoz-Torrico, M Rifat, M B Souleymane, S Villa, C Lienhardt, R Centis, L D'Ambrosio, M C Raviglione, G B Migliori","doi":"10.5588/ijtld.26.0442","DOIUrl":"https://doi.org/10.5588/ijtld.26.0442","url":null,"abstract":"<sec><title>BACKGROUND</title>Rapid adoption and scale-up of new anti-TB regimens requires evidence on efficacy and safety, but also on end-user preferences, implementation barriers, regulatory hurdles, and local conditions. The aim of this study is to describe the extent to which the questions included in a global end-user survey address priority research questions identified through a Delphi process.</sec><sec><title>METHODS</title>We used a methodological mapping approach to examine the extent to which questions included in a TB survey and interviews to patients, health care workers, and experts align with seven research questions identified through a recent Delphi process. The content of the survey and interviews was systematically compared and matched against the priority research questions to assess its analytical capacity.</sec><sec><title>RESULTS</title>The survey contains data relevant to all seven research questions: three with full analytical capacity; three with substantial but incomplete capacity; and one with partial capacity.</sec><sec><title>CONCLUSION</title>Mapping and matching exercise indicates that the FAST-TB survey and structured interviews can help identify where additional qualitative, economic, or policy research will be needed to support new regimen development, adoption, and scale-up.</sec>.","PeriodicalId":520801,"journal":{"name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","volume":"30 10","pages":"427-435"},"PeriodicalIF":3.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149123054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetes prevalence and factors associated with newly detected diabetes in elderly TB patients. 老年结核病患者糖尿病患病率及与新发现糖尿病相关的因素

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-09-30 DOI: 10.5588/ijtld.26.0206

M A Habib, S S Efa, K Afrin, N Islam, M D Hossain

{"title":"Diabetes prevalence and factors associated with newly detected diabetes in elderly TB patients.","authors":"M A Habib, S S Efa, K Afrin, N Islam, M D Hossain","doi":"10.5588/ijtld.26.0206","DOIUrl":"https://doi.org/10.5588/ijtld.26.0206","url":null,"abstract":"<sec><title>BACKGROUND</title>TB and diabetes mellitus (DM) frequently coexist, particularly in low- and middle-income countries. Evidence on their coexistence among the elderly in Bangladesh is limited. This study assessed prevalence of diabetes and associated factors with newly detected diabetes in elderly TB patients.</sec><sec><title>METHODS</title>This cross-sectional study was conducted in 2025 across eight tertiary care hospitals in Bangladesh. A total of 656 TB patients aged ≥60 years were included. Diabetes status was determined using prior diagnosis and oral glucose tolerance testing after 2 weeks of TB treatment initiation. Data were collected by face-to-face interview using semi-structured questionnaire. Informed written consent was taken and ethical issues were maintained. Data were analysed by IBM SPSS software. Multivariable logistic regression identified factors associated with newly detected diabetes.</sec><sec><title>RESULTS</title>Prevalence of diabetes was 30.3%, including 16.8% known and 16.3% newly detected. Newly detected diabetes was associated with age 65-69 years (adjusted odds ratio [AOR] = 3.81) and ≥70 years (AOR = 4.95), physical inactivity (AOR = 5.23), overweight/obesity (AOR = 7.73), family history of diabetes (AOR = 9.14), and pulmonary TB (AOR = 4.49). Dietary risk lost significance in adjusted analysis.</sec><sec><title>CONCLUSIONS</title>Due to high burden of diabetes in elderly TB patients, routine diabetes screening and TB-DM management, particularly targeting high-risk groups, are essential to improve outcomes.</sec>.","PeriodicalId":520801,"journal":{"name":"The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease","volume":"30 10","pages":"454-459"},"PeriodicalIF":3.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149123064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rifapentine access in Europe: a persistent regulatory gap. 利福喷丁在欧洲的使用：一个持续的监管缺口。

IF 3.1

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Pub Date : 2026-08-28 DOI: 10.5588/ijtld.26.0354

A Noguera-Julian, C Latre, Á Flores, J Manzano, J A Caylà

引用次数: 0