Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association最新文献

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Association between residential greenness and the risk of inflammatory bowel disease in patients with COVID-19: A Korean nationwide cohort study. 住宅绿化与COVID-19患者炎症性肠病风险之间的关系:一项韩国全国性队列研究
IF 2
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association Pub Date : 2026-07-01 Epub Date: 2026-04-30 DOI: 10.4103/sjg.sjg_430_25
Dongjin Yeo, Kyeongeun Kim, Juyeong Kim, Sooji Lee, Hayeon Lee, Francesco Branda, Masoud Rahmati, Sunyoung Kim, Ho Geol Woo, Selin Woo, Yerin Hwang, Dong Keon Yon
{"title":"Association between residential greenness and the risk of inflammatory bowel disease in patients with COVID-19: A Korean nationwide cohort study.","authors":"Dongjin Yeo, Kyeongeun Kim, Juyeong Kim, Sooji Lee, Hayeon Lee, Francesco Branda, Masoud Rahmati, Sunyoung Kim, Ho Geol Woo, Selin Woo, Yerin Hwang, Dong Keon Yon","doi":"10.4103/sjg.sjg_430_25","DOIUrl":"10.4103/sjg.sjg_430_25","url":null,"abstract":"","PeriodicalId":520774,"journal":{"name":"Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association","volume":" ","pages":"349-358"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13441247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148304627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of tumor detection capability for pancreatic ductal adenocarcinoma concomitant with intraductal papillary mucinous neoplasm in each MRI sequence. 胰腺导管腺癌合并导管内乳头状黏液性肿瘤各MRI序列的肿瘤检测能力评价。
IF 2
Yasuhisa Jimbo, Ko Tomishima, Katsuhiro Sano, Akiyoshi Suzuki, Hiroyuki Kiko, Shin Arii, Takumi Okuaki, Haruka Hagiwara, Yusuke Yamaguchi, Ippei Ikoma, Muneo Ikemura, Hiroto Ota, Daishi Kabemura, Taito Fukuma, Mako Ushio, Sho Takahashi, Yusuke Takasaki, Fumi Kurata, Shigeto Ishii, Toshio Fujisawa, Hiroyuki Isayama
{"title":"Evaluation of tumor detection capability for pancreatic ductal adenocarcinoma concomitant with intraductal papillary mucinous neoplasm in each MRI sequence.","authors":"Yasuhisa Jimbo, Ko Tomishima, Katsuhiro Sano, Akiyoshi Suzuki, Hiroyuki Kiko, Shin Arii, Takumi Okuaki, Haruka Hagiwara, Yusuke Yamaguchi, Ippei Ikoma, Muneo Ikemura, Hiroto Ota, Daishi Kabemura, Taito Fukuma, Mako Ushio, Sho Takahashi, Yusuke Takasaki, Fumi Kurata, Shigeto Ishii, Toshio Fujisawa, Hiroyuki Isayama","doi":"10.4103/sjg.sjg_91_26","DOIUrl":"https://doi.org/10.4103/sjg.sjg_91_26","url":null,"abstract":"<p><strong>Background: </strong>During follow-up of IPMN, attention should be paid to both IPMN-derived carcinoma and PDAC concomitant with IPMN (concomitant PDAC). Concomitant PDAC lacks clear risk factors and is often detected late. This study evaluated non-contrast MRI performance for early detection and identification of optimal imaging sequences.</p><p><strong>Methods: </strong>Patients histologically diagnosed with PDAC between May 2012 and March 2024 who underwent MRI at diagnosis were retrospectively included. PDAC located ≥5 mm from an IPMN was defined as concomitant PDAC. Cases of IPMC and main-duct IPMN were excluded. MRI sequences (T1WI, T2WI, MRCP, and DWI with ADC maps) were reviewed. Tumor detection was defined as (1) mass identification on T1WI/T2WI, (2) Main pancreatic duct (MPD) stricture or poor visualization with upstream dilatation on MRCP, or (3) hyperintense mass on DWI. Two radiologists independently evaluated all images.</p><p><strong>Results: </strong>Sixty-four cases (28 females; median tumor diameter, 21 mm) were analyzed. The median age at diagnosis was 74.5 years (interquartile range: 68-80 years), Blood test values showed median CA19-9 levels of 78 U/mL. The detection sensitivities by radiologists A and B were T1WI, 76.7%/68.3% (κ0.71); T2WI, 31.3%/29.7% (κ0.71); DWI, 71.4%/71.4% (κ0.87); and MRCP, 43.4%/35.8% (κ0.84). Combined sensitivities were 89.1%/82.8% for \"T1WI and DWI\" and 92.2%/85.9% for \"T1WI, DWI and MRCP\".</p><p><strong>Conclusions: </strong>Among single sequences, T1WI demonstrated the highest sensitivity. The combination of \"T1WI, DWI, and MRCP\" showed the highest sensitivity, although the differences were not statistically significant and should be interpreted cautiously for detecting PDAC concomitant with IPMN.</p>","PeriodicalId":520774,"journal":{"name":"Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148261345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Denominator bias in MENA MASLD epidemiology: A call for decision-grade surveillance. 中东和北非MASLD流行病学的分母偏倚:呼吁进行决策级监测。
IF 2
Mohamed El-Kassas, Khalid M AlNaamani, Faisal M Sanai, Yusuf Yilmaz, Asma Labidi, Mohammed O Mohammed, Mortada H F El-Shabrawi, Maen Almattooq, Nabil Debzi, Ali Tumi, Mehdi Ksiaa, Cesar Yaghi, Mohamed Elbadry, Nawel Afredj, Mahmoud S Desoky, Khaled Matar, Imam Waked, Gamal Esmat, Abdel-Naser Elzouki, Khalid A Alswat
{"title":"Denominator bias in MENA MASLD epidemiology: A call for decision-grade surveillance.","authors":"Mohamed El-Kassas, Khalid M AlNaamani, Faisal M Sanai, Yusuf Yilmaz, Asma Labidi, Mohammed O Mohammed, Mortada H F El-Shabrawi, Maen Almattooq, Nabil Debzi, Ali Tumi, Mehdi Ksiaa, Cesar Yaghi, Mohamed Elbadry, Nawel Afredj, Mahmoud S Desoky, Khaled Matar, Imam Waked, Gamal Esmat, Abdel-Naser Elzouki, Khalid A Alswat","doi":"10.4103/sjg.sjg_87_26","DOIUrl":"10.4103/sjg.sjg_87_26","url":null,"abstract":"<p><strong>Abstract: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent in the Middle East and North Africa (MENA) region, yet published estimates of prevalence and outcomes remain uncertain because the underlying denominators are inconsistently defined. This perspective argues that MENA MASLD epidemiology is systematically biased by three interacting mechanisms: distorted sampling frames, referral pathway selection, and structural undercapture of rural and displaced populations. Much of the current evidence is derived from convenience cohorts concentrated in urban, tertiary care settings where diagnostic availability and follow-up are greater than in the general population, leading to directional rather than random error. In parallel, risk stratification pathways that rely on two-step testing can funnel case detection toward specialty rich settings, overrepresenting advanced disease while missing earlier stages managed outside hepatology services. MASLD nomenclature change and incomplete alignment of coding and clinical documentation may further introduce artefactual inflection points that complicate trend interpretation. We highlight how underdiagnosis and under-recording in primary care propagate bias across downstream estimates and how validation of administrative algorithms and text-based ascertainment can quantify hidden disease reservoirs within routine data systems. Building on regional priority settings, we propose denominator-focused actions: probability-based sampling embedded in noncommunicable disease surveys; purposeful inclusion of rural and displaced groups; linkable data across primary care, laboratories, hospitals, and mortality registries; and harmonized coding and terminology. By decision-grade denominators, we refer to population denominators that are sufficiently representative, transparent, and linkable to support national surveillance, resource allocation, and trial-readiness decisions.</p>","PeriodicalId":520774,"journal":{"name":"Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148207629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and etiology of abnormal liver function tests in a tertiary inflammatory bowel disease cohort in the United Arab Emirates: A cross-sectional study. 在阿拉伯联合酋长国的三级炎症性肠病队列中,肝功能检查异常的患病率和病因:一项横断面研究。
IF 2
Heba Abualkas, Maitha Al Hosani, Ahmed Al-Rifai, Mohammed N Quraishi
{"title":"Prevalence and etiology of abnormal liver function tests in a tertiary inflammatory bowel disease cohort in the United Arab Emirates: A cross-sectional study.","authors":"Heba Abualkas, Maitha Al Hosani, Ahmed Al-Rifai, Mohammed N Quraishi","doi":"10.4103/sjg.sjg_131_26","DOIUrl":"https://doi.org/10.4103/sjg.sjg_131_26","url":null,"abstract":"<p><strong>Background: </strong>Abnormal liver function tests (LFTs) are common in inflammatory bowel disease (IBD), yet data from the Middle East are lacking. We aimed to determine the prevalence, etiological spectrum, and risk factors for abnormal LFTs in a tertiary IBD cohort in the United Arab Emirates.</p><p><strong>Methods: </strong>In this retrospective cohort study with cross-sectional and longitudinal components, all adult IBD patients in a tertiary institutional registry were screened for abnormal LFTs. Etiologies were assigned across predefined categories, and logistic regression identified associated factors.</p><p><strong>Results: </strong>Persistent abnormal LFTs (per the operational definition) were identified in 72 of 510 patients (14.1%, 95% CI 11.4-17.4%). The most common etiology was metabolic dysfunction-associated steatotic liver disease (MASLD, 22.2%), followed by infection-related causes (11.1%), drug-induced liver injury (11.1%), and IBD activity-related causes (4.2%). Viral hepatitis screening was performed in ≥86% of cases; autoimmune markers were tested in 36-56%, and FibroScan in 24%. After adjustment for concomitant primary sclerosing cholangitis (PSC-IBD) as a clinically important confounder, cumulative advanced therapy exposure remained associated with abnormal LFTs (adjusted OR 1.20, 95% CI 1.00-1.42, P = 0.041); PSC-IBD itself was strongly associated with abnormal LFTs in the model (adjusted OR 8.69, 95% CI 3.11-25.24, P < 0.001), as expected. LFTs normalized in 30.0% and improved in 20.0% of patients during follow-up.</p><p><strong>Conclusions: </strong>Abnormal LFTs affected one in seven IBD patients in this UAE cohort, with MASLD as the leading cause. These findings suggest potential value in integrating structured liver investigation algorithms into routine IBD care.</p>","PeriodicalId":520774,"journal":{"name":"Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148166820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A multicenter comparative study of clinical and nursing outcomes: Percutaneous endoscopic versus radiologic gastrostomy. 一项多中心临床和护理结果的比较研究:经皮内镜与放射胃造口术。
IF 2
Qin-Qin Yin, Shuang-Lin Lu, Jian Mao, Zhen-Nan Dong
{"title":"A multicenter comparative study of clinical and nursing outcomes: Percutaneous endoscopic versus radiologic gastrostomy.","authors":"Qin-Qin Yin, Shuang-Lin Lu, Jian Mao, Zhen-Nan Dong","doi":"10.4103/sjg.sjg_77_26","DOIUrl":"https://doi.org/10.4103/sjg.sjg_77_26","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous endoscopic gastrostomy (PEG) and percutaneous radiologic gastrostomy (PRG) are established routes for long-term enteral nutrition. Comparative studies commonly emphasize technical success and complications, while downstream care intensity and caregiver burden are less well quantified.</p><p><strong>Methods: </strong>We conducted a retrospective comparative cohort study of patients who underwent PEG versus PRG at three tertiary care centers, between January 2021 and January 2025. Propensity score matching (1:1) was used to reduce selection bias, and the primary comparative analyses were performed in the matched cohort. Outcomes included technical success, procedure duration, 30-day complications, nutritional recovery, tube-care nursing interventions within 30 days, caregiver burden (Zarit Burden Interview, ZBI), and caregiver satisfaction (5-point Likert scale).</p><p><strong>Results: </strong>After matching, 84 patients (42 per group) were analyzed. Technical success was comparable (PEG 98.7% vs. PRG 95.2%, P = 0.341), while procedure duration was shorter with PRG (22.1 ± 5.8 vs. 28.4 ± 6.5 min, P < 0.001). Thirty-day complications (16.7% vs. 21.4%, P = 0.541) and nutritional recovery (albumin at 1 month: 3.4 ± 0.4 vs. 3.3 ± 0.5 g/dL, P = 0.472; 4-week weight gain: 1.9 kg [1.0-2.7] vs. 1.8 kg [1.2-2.5], P = 0.715) were similar. PRG required more nursing interventions (6.1 ± 2.0 vs. 4.2 ± 1.3, P < 0.001). Caregiver burden was lower with PEG (ZBI 21.6 ± 5.2 vs. 26.4 ± 6.8, P = 0.002), and satisfaction scores were higher (mean ± standard deviation: 4.2 ± 0.9 vs. 3.4 ± 1.1, P = 0.001).</p><p><strong>Conclusion: </strong>PEG and PRG are both effective options for long-term enteral nutrition. Although PRG offers shorter procedure duration, PEG is associated with lower postprocedure care intensity and better caregiver-reported outcomes. Findings for complication rates are exploratory and hypothesis-generating and require confirmation in larger prospective studies.</p>","PeriodicalId":520774,"journal":{"name":"Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148166827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Awareness, barriers, and uptake of colorectal cancer screening among first-degree relatives: A cross-sectional study. 一级亲属对结直肠癌筛查的认识、障碍和吸收:一项横断面研究。
IF 2
Ammar Alotaibi, Razan Alhamidi, Abdulaziz Altamimi, Abdullah Althunayan, Muhammad F Mubarak, Saad Alkhowaiter, Ghazi Alotaibi, Noura Alhassan, Resheed Alkhiari, Majid Almadi
{"title":"Awareness, barriers, and uptake of colorectal cancer screening among first-degree relatives: A cross-sectional study.","authors":"Ammar Alotaibi, Razan Alhamidi, Abdulaziz Altamimi, Abdullah Althunayan, Muhammad F Mubarak, Saad Alkhowaiter, Ghazi Alotaibi, Noura Alhassan, Resheed Alkhiari, Majid Almadi","doi":"10.4103/sjg.sjg_108_26","DOIUrl":"https://doi.org/10.4103/sjg.sjg_108_26","url":null,"abstract":"<p><strong>Background: </strong>First-degree relatives (FDRs) of colorectal cancer (CRC) patients are at increased risk for CRC. Colonoscopy is the recommended screening modality, yet uptake in this high-risk group remains poorly characterized, particularly in Saudi Arabia.</p><p><strong>Methods: </strong>We conducted a cross-sectional study of FDR of patients diagnosed with CRC at a tertiary academic center. They completed a structured questionnaire assessing awareness of CRC screening, previous screening practice, and perceived barriers to undergoing a colonoscopy.</p><p><strong>Results: </strong>Among 346 FDRs, 122 (35.3%) were aware of CRC screening recommendations and 78 (22.5%) had undergone colonoscopy. Among participants who had not undergone colonoscopy and provided complete barrier-response data ( n = 268), the most commonly reported barrier was lack of information or inadequate counseling (51.9%, n = 139), followed by psychological fear (17.9%, n = 48) and financial barriers (16.4%, n = 44). Colonoscopy uptake did not differ by gender (23.4% vs. 19.7%, P = 0.423) but was higher among those with higher educational attainment and medical backgrounds ( P = 0.001).</p><p><strong>Conclusion: </strong>CRC screening awareness and colonoscopy uptake among FDRs of CRC patients are suboptimal. Family-centered counseling at diagnosis, structured patient navigation, and tailored education programs are needed to improve screening participation in this at-risk population.</p>","PeriodicalId":520774,"journal":{"name":"Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148166845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of early-onset and average-onset colorectal cancer in Saudi Arabia: A multicenter retrospective cohort study. 沙特阿拉伯早发和平均发结直肠癌的比较:一项多中心回顾性队列研究。
IF 2
Saleh Alessy, Badr Al-Bawardy, Abeer Alabdullah, Duna Barakeh, Mayar Alatout, Sara Khan, Osamah Altamimi, Shams A AlBader, Aljohara S Alasheikh, Mohammad Alhassoun, Layan A Alsubki, Basmah B Khoja, Abdulmohsen Alshammari, Nawaf AlEnaz, Saleh Alorainy, Norah Bin Sulaiman, Ahmad Alharbi, Waleed Alomaim, Manal Bukhary, Saleh A Alqahtani
{"title":"Comparison of early-onset and average-onset colorectal cancer in Saudi Arabia: A multicenter retrospective cohort study.","authors":"Saleh Alessy, Badr Al-Bawardy, Abeer Alabdullah, Duna Barakeh, Mayar Alatout, Sara Khan, Osamah Altamimi, Shams A AlBader, Aljohara S Alasheikh, Mohammad Alhassoun, Layan A Alsubki, Basmah B Khoja, Abdulmohsen Alshammari, Nawaf AlEnaz, Saleh Alorainy, Norah Bin Sulaiman, Ahmad Alharbi, Waleed Alomaim, Manal Bukhary, Saleh A Alqahtani","doi":"10.4103/sjg.sjg_51_26","DOIUrl":"https://doi.org/10.4103/sjg.sjg_51_26","url":null,"abstract":"<p><strong>Background: </strong>Although overall colorectal cancer (CRC) incidence has stabilized or declined in some regions, early-onset CRC (EO-CRC) is increasing in many countries. We aimed to compare EO-CRC with average-onset CRC (AO-CRC) to inform screening and care policies in Saudi Arabia.</p><p><strong>Methods: </strong>This retrospective study included patients with newly diagnosed CRC from, January 2017 to December 2023, at two referral centers in Saudi Arabia. We compared patient and tumor characteristics between EO-CRC and AO-CRC. Kaplan-Meier curve with log-rank test was used to compare overall survival up to 36 months after diagnosis.</p><p><strong>Results: </strong>Of 1365 patients with confirmed CRC, 406 (29.7%) had EO-CRC and 959 (70.3%) had AO-CRC, with more males in both groups (56% in EO-CRC and 53% in AO-CRC; P = 0.373). Hypertension and type 2 diabetes were more common in AO-CRC (both P < 0.001), while smoking history was more frequently documented in EO-CRC (16.7% vs. 12.0%; P = 0.054), although this difference did not reach statistical significance. Late-stage diagnosis was more frequent in EO-CRC (stage IV: 53.0% vs. 42.3%; P = 0.009), while tumor location was similar across groups, predominantly left-sided (87% vs. 89%; P = 0.391). Symptom profiles were broadly comparable between groups. Abdominal pain was more common in EO-CRC (60.3% vs. 53.6%; P = 0.015), whereas rectal bleeding occurred at similar frequencies in both groups (45.3% vs. 46.7%; P = 0.860). At 36 months, estimated survival probabilities were 0.75 for EO-CRC and 0.78 for AO-CRC, with no significant difference between groups on unadjusted analysis (log-rank P = 0.40). In multivariable Cox regression adjusting for sex and stage, EO-CRC was not associated with a difference in hazard of death than AO-CRC (adjusted hazard ratio 1.04, 95% confidence interval 0.80-1.37).</p><p><strong>Conclusion: </strong>EO-CRC comprised approximately one-third of CRC diagnoses in our cohort. Patients with EO-CRC had higher rates of late-stage diagnosis and more commonly presented with abdominal pain, whereas rectal bleeding, a well-recognized alarm symptom, occurred at similar frequencies in both groups. Despite later-stage presentation, short-term survival up to 36 months was similar between EO-CRC and AO-CRC. These findings highlight the need for tailored screening and early detection in younger populations.</p>","PeriodicalId":520774,"journal":{"name":"Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148166824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The unfinished success of hepatitis B control in Saudi Arabia: Concentrated burden in adult males and geographic notification hotspots in the post-vaccination era, 2019-2023. 沙特阿拉伯乙型肝炎控制未完成的成功:2019-2023年疫苗接种后时代成年男性集中负担和地理通报热点
IF 2
Nizar A Khamjan
{"title":"The unfinished success of hepatitis B control in Saudi Arabia: Concentrated burden in adult males and geographic notification hotspots in the post-vaccination era, 2019-2023.","authors":"Nizar A Khamjan","doi":"10.4103/sjg.sjg_74_26","DOIUrl":"https://doi.org/10.4103/sjg.sjg_74_26","url":null,"abstract":"<p><strong>Background: </strong>Following the 1989 universal infant vaccination mandate, Saudi Arabia achieved significant reductions in Hepatitis B Virus (HBV) prevalence. The spatiotemporal dynamics of HBV notifications were performed to identify the \"unfinished success\" of the national elimination program.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of national HBV notification data (2019-2023). Gini coefficients measured inequality while Pareto analysis identified high-concentration foci. Vaccination program impact (VPI) was estimated by comparing pediatric (0-14 years) to adult notification rates (NR). Population attributable fraction (PAF) and VPI modeled the leverage of targeted versus universal screening strategies.</p><p><strong>Results: </strong>A 75.6-fold higher NR in adults (30.24/100,000) than children (0.40/100,000; P < 0.001) was observed, with a Gini of 0.43 indicating high age-based inequality. PAF showed 98.2% of the national burden is concentrated in adults (15+ years). VPI was 98.7% [95% CI: 98.1%-99.1%], preventing an estimated 2,507 pediatric cases in 2023. The national NR exhibited a V-shaped trajectory: a 50.7% decline during the COVID-19 pandemic followed by a complete rebound by 2023, identifying the decline as a surveillance artifact. Saudi males had a 1.5-fold higher NR than females (58.45 vs. 37.93/100,000; NR Ratio = 1.54; P < 0.001). Geographically, Pareto analysis confirmed 78.5% of the burden concentrated in four regions, with Jazan as the primary hotspot (NR: 72.53).</p><p><strong>Conclusion: </strong>While infant vaccination has reached diminishing returns against the adult reservoir, we propose pivoting to a \"Precision Public Health\" approach, prioritizing targeted screening and linkage-to-care for Saudi adult males within identified geographic hotspots.</p>","PeriodicalId":520774,"journal":{"name":"Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148304664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Favorable outcomes in patients over 65 years of age with hepatocellular carcinoma undergoing liver transplantation. 65岁以上肝癌患者行肝移植的良好结果。
IF 2
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association Pub Date : 2026-05-01 Epub Date: 2026-01-05 DOI: 10.4103/sjg.sjg_396_25
Saad Alghamdi, Dimitri Aristotle Raptis, Lina Aljurf, Mona Aljefri, Saleh A Alqahtani, Waleed Al-Hamoudi, Bandar Aljudaibi, Fuat H Saner, Dieter C Broering, Massimo Malago
{"title":"Favorable outcomes in patients over 65 years of age with hepatocellular carcinoma undergoing liver transplantation.","authors":"Saad Alghamdi, Dimitri Aristotle Raptis, Lina Aljurf, Mona Aljefri, Saleh A Alqahtani, Waleed Al-Hamoudi, Bandar Aljudaibi, Fuat H Saner, Dieter C Broering, Massimo Malago","doi":"10.4103/sjg.sjg_396_25","DOIUrl":"10.4103/sjg.sjg_396_25","url":null,"abstract":"","PeriodicalId":520774,"journal":{"name":"Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association","volume":" ","pages":"222-227"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13263033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145902199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An interpretable machine learning model for predicting the risk of post-endoscopic retrograde cholangiopancreatography complications in elderly patients with choledocholithiasis. 一个可解释的机器学习模型用于预测老年胆总管结石患者内镜后逆行胆管造影并发症的风险。
IF 2
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association Pub Date : 2026-05-01 Epub Date: 2026-01-06 DOI: 10.4103/sjg.sjg_400_25
Guanjun Zhang, Ke Meng, Yaqi Zhai, Min Zhu, Yuming Han, Mingyang Li
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引用次数: 0
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