Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association最新文献

{"title":"Predictors of morbidity and mortality post emergency abdominal surgery: A national study.","authors":"Afnan Altamimi,&nbsp;Mazen Hassanain,&nbsp;Thamer Nouh,&nbsp;Khawlah Ateeq,&nbsp;Murad Aljiffry,&nbsp;Abrar Nawawi,&nbsp;Ghaith Al Saied,&nbsp;Mohammed Riaz,&nbsp;Huda Alanbar,&nbsp;Abdullah Altamimi,&nbsp;Saeed Alsareii,&nbsp;Mashael Al-Mousa,&nbsp;Abeer Al-Shammari,&nbsp;Saleh Alnuqaydan,&nbsp;Amal Ghzwany","doi":"10.4103/sjg.SJG_11_18","DOIUrl":"https://doi.org/10.4103/sjg.SJG_11_18","url":null,"abstract":"<p><strong>Background/aim: </strong>Emergency surgeries have increased in Saudi Arabia. This study examines these surgeries and associated complications.</p><p><strong>Patients and methods: </strong>This was a prospective multicenter cohort study of patients undergoing emergency intraperitoneal surgery from the eight health sectors of Saudi Arabia. Patients' data were collected over 14 days.</p><p><strong>Results: </strong>In total, 283 patients were included (163 men [54.06%]). The majority of cases were open surgery (204 vs. 79). The 24 h and 30-day mortality rates for the cohort were 0.7 and 2.47%, respectively. Twenty-nine patients (10.24%) required re-intervention, while 19 (8.12%) needed critical care admission. The median length of hospital stay was 3 days. Multivariate analysis showed American Society of Anesthesiologist (ASA) classification score (P = 0.0003), diagnosis (P < 0.0001), stoma formation (P = 0.0123), and anastomotic leak (P = 0.0015) to correlate significantly with 30-day mortality.</p><p><strong>Conclusion: </strong>American Society of Anesthesiologist score, diagnosis, stoma formation and anastomotic leak are associated with 30-day mortality after emergency surgery in Saudi Arabia.</p>","PeriodicalId":520774,"journal":{"name":"Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association","volume":" ","pages":"282-288"},"PeriodicalIF":2.7,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9f/7f/SJG-24-282.PMC6151994.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36027126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic susceptibility for celiac disease is highly prevalent in the Saudi population.","authors":"Abdulrahman Al-Hussaini,&nbsp;Hanan Alharthi,&nbsp;Awad Osman,&nbsp;Nezar Eltayeb-Elsheikh,&nbsp;Aziz Chentoufi","doi":"10.4103/sjg.SJG_551_17","DOIUrl":"https://doi.org/10.4103/sjg.SJG_551_17","url":null,"abstract":"<p><strong>Background/aim: </strong>To determine the frequency of celiac disease (CD)-predisposing human leukocyte antigen (HLA)-DQ genotypes in the Saudi population, where the prevalence of CD is 1.5% as recently reported in a mass screening study.</p><p><strong>Patients and methods: </strong>In a cross-sectional population-based study, a total of 192 randomly selected healthy school children (97 females, mean age 10.5 ± 2.2 years, all negative for tissue transglutaminase-IgA) were typed for D QA1 and D QB1 genes by polymerase chain reaction sequence-specific oligonucleotide probes.</p><p><strong>Results: </strong>Of the 192 children, 52.7% carried the high-risk CD-associated HLA-DQ molecules: homozygous DQ2.5 ( 2.6%), DQ2.5/DQ2.2 ( 4.7%), heterozygous DQ2.5 ( 28.15%), homozygous DQ8 ( 4.2%), DQ8/DQ2.2 ( 3.6%), and double dose DQ2.2 ( 9.4%). Low-risk CD-associated HLA-DQ molecules (single dose DQ2.2 and heterozygous DQ8) constituted 3.6% and 9.4%, respectively. Among the very low-risk groups, individuals lacking alleles that contribute to DQ2/DQ8 variants (33.5%), 13.5% carried only one of the alleles of the high-risk HLA-DQ2.5 heterodimer called \"half-heterodimer\" (HLA-DQA1*05 in 12% and HLA-DQB1* 02 in 1.5%), and 20.8% lacked all the susceptible alleles (DQX.x). Gender distribution was not significantly different among the CD-risk groups.</p><p><strong>Conclusion: </strong>We report one of the highest frequencies of CD-predisposing HLA-DQ genotypes among healthy general populations (52.7%) worldwide, which might partly explain the high prevalence of CD in the Saudi community.</p>","PeriodicalId":520774,"journal":{"name":"Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association","volume":" ","pages":"268-273"},"PeriodicalIF":2.7,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/64/f2/SJG-24-268.PMC6152002.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36269780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraintestinal manifestations of pediatric inflammatory bowel disease in Saudi Arabia.","authors":"Mahmood D Al-Mendalawi","doi":"10.4103/sjg.SJG_300_18","DOIUrl":"https://doi.org/10.4103/sjg.SJG_300_18","url":null,"abstract":"I refer to the interesting study by Alreheili et al.[1] published in this Journal. It is well‐known that inflammatory bowel disease (IBD) is associated with a variety of extraintestinal manifestations (EIMs) that could produce greater morbidity than the underlying intestinal disease and might even be the initial presentation of IBD. The authors mentioned that during the 10‐year study period (2001–2011) in a single‐center in the Kingdom of Saudi Arabia (KSA), EIMs were reported in 21 (31.8%) of 66 patients.[1] These included osteoporosis/osteopenia (n = 11), peripheral joint inflammation (n = 9), primary sclerosing cholangitis (n = 5), erythema nodosum (n = 2), sacroiliitis (n = 2), ankylosing spondylitis (n = 2), pyoderma gangrenosum (n = 1), and uveitis/episcleritis (n = 1).[1] Interestingly, this reported prevalence of EIMs appeared higher than that previously reported in KSA. For instance, Hasosah et al.[2] reported that during the 7‐year study period (2005–2012) in a single center, only one child (8%) with skin involvement (pyoderma gangrenosum) was observed among 12 pediatric IBD patients. AlSaleem et al.[3] noted that during the 9‐year study period (2003–2012) involving 188 pediatric IBD patients from 15 medical centers from different regions in KSA, EIMs were reported in only 6 (4%) patients, namely arthritis (n = 3) and skin rash (n = 3). I presume that the differences in the reported prevalence and pattern of EIMs in the study by Alreheili et al.[1] and that reported in other Saudi studies[2,3] could be plausibly explained by a number of factors.","PeriodicalId":520774,"journal":{"name":"Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association","volume":" ","pages":"307"},"PeriodicalIF":2.7,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9a/b5/SJG-24-307.PMC6151996.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36404850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastric adenocarcinoma expressing human epidermal growth factor receptor in South Asian population.","authors":"Asma Shabbir,&nbsp;Muhammad Asif Qureshi,&nbsp;Abdullah Bin Khalid,&nbsp;Talat Mirza,&nbsp;Asma Shaikh,&nbsp;Syed Mehmood Hasan","doi":"10.4103/sjg.SJG_23_18","DOIUrl":"https://doi.org/10.4103/sjg.SJG_23_18","url":null,"abstract":"<p><strong>Background/aim: </strong>Gastric cancer is the third leading cause of cancer mortality worldwide. Human epidermal growth factor (Her-2/neu) has shown strong therapeutic implication in breast cancer. Although the prevalence of Her-2/neu over-expression in gastric cancer has been reported across the world, it is still unknown from South Asia. The aim of this study is to evaluate Her-2/neu expression in gastric adenocarcinomas and to correlate with various clinicopathological variables.</p><p><strong>Patients and methods: </strong>A total of 95 consecutive patients undergoing endoscopic biopsy or gastrectomy were recruited in this study. Clinicopathological parameters of all patients were recorded and hematoxylin and eosin (H and E) staining was performed. Over-expression of Her-2/neu was investigated by immunohistochemistry using α-Her-2 antibody. To quantify Her-2/neu over-expression, the Hofmann validation scoring system was used and further its association was seen with age, gender, histopathological type, grade, and stage of the tumor. Data were entered and analyzed using SPSS version 21. A P value of <0.05 was considered as significant.</p><p><strong>Results: </strong>Overall, 21 (22.1%) cases were positive for Her-2/neu overexpression from the total of 95 gastric adenocarcinomas. Her-2/neu was significantly expressed in low-grade gastric cancer (grade I = 50%, grade II = 34.5%, grade III = 14.5%; P = 0.030). Although there was insignificant difference between Her-2/neu over expression and other variables, Her-2/neu score 3+ was predominantly seen in females, age >60 years, Laurens intestinal type, and IIIC stage tumors.</p><p><strong>Conclusion: </strong>Her-2/neu is over-expressed in a limited group of gastric cancer patients in our population and indicates a significant strong association with low grades of gastric cancer.</p>","PeriodicalId":520774,"journal":{"name":"Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association","volume":" ","pages":"289-293"},"PeriodicalIF":2.7,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/79/a5/SJG-24-289.PMC6151997.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36136880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}