Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association最新文献

{"title":"Relationship between gastroesophageal reflux and chronic kidney disease: A meta-analysis of 4 million patients.","authors":"Andres Chaponan-Lavalle, Ambar Godoy, Jose M Estrada-Grossmann, Eduardo S Acosta, Yolanda Chaponan-Lavalle, Luis G Azañedo-Garcia, Karina Ordaya-Gonzales, Manuel Gonzales-Palomo, Fortunato S Príncipe-Meneses, Arjunmohan Mohan, Renato Beas, Jose Arriola-Montenegro","doi":"10.4103/sjg.sjg_133_25","DOIUrl":"https://doi.org/10.4103/sjg.sjg_133_25","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) has been associated with higher risk of gastrointestinal disorders, particularly Gastroesophageal reflux disease (GERD). However, the magnitude of this association and the underlying mechanisms remains unclear.</p><p><strong>Methods: </strong>A systematic search was conducted across major databases from inception to November 2024. We included cross-sectional and case-control studies evaluating the relationship between CKD and GERD. Data were extracted and analyzed using a random-effects model to calculate pooled odds ratios (ORs) and prevalence rates. Study quality was assessed using the Newcastle-Ottawa Scale, and heterogeneity was evaluated using the Cochran's Q test and I² statistic.</p><p><strong>Results: </strong>Nine studies involving 4,650,709 participants were included. The pooled prevalence of GERD among CKD patients was 18% (95% CI: 0.10-0.26, I² =93.64%). The pooled crude OR for the association between CKD and GERD was 2.53 (95% CI: 1.30-4.92) and adjusted OR was 1.48 (95% CI: 1.05-2.08).</p><p><strong>Conclusion: </strong>This meta-analysis reveals a marginally significant association between CKD and GERD, highlighting higher prevalence of GERD among individuals with CKD. Furthers studies are needed to elucidate the underlying pathophysiological mechanisms and potential clinical implications.</p>","PeriodicalId":520774,"journal":{"name":"Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical outcomes of curative intent management in emergency vs. elective colon cancer: A retrospective single center study.","authors":"Noura S Alhassan, Thamer A Bin Traiki, Sulaiman A Alshammari, Mohaned Makkawi, Yazeed A Alkhayyal, Mohammed A Alswayyed, Maha-Hamadien Abdulla, Ahmad M Zubaidi, Omar A Al-Obeed, Reem A Alharbi, Khayal A AlKhayal","doi":"10.4103/sjg.sjg_101_25","DOIUrl":"https://doi.org/10.4103/sjg.sjg_101_25","url":null,"abstract":"<p><strong>Background: </strong>Presentation affects several surgical parameters and post-operative outcomes. This study compares emergency versus elective colon cancer outcomes and prognostic factors associated with postoperative complications.</p><p><strong>Methods: </strong>All colon cancer patients who underwent curative resection between July 2015 and December 2019 were retrospectively reviewed and analyzed. Patients were divided into emergency and elective groups based on their presentation.</p><p><strong>Results: </strong>A total of 215 patients were included; 70 patients (32.6%) in the emergency group. Of them, 61 patients presented with obstruction, and nine with free perforation. The elective group had a higher laparoscopic approach (82.8%) with primary anastomosis (90.3%) compared to the emergency group (57.1% and 68.6%, respectively, P < 0.001). Postoperative complications were clinically higher in the emergency group (30% vs. 20.7%, P = 0.171). ICU/HDU admission was higher in the emergency group (40% vs. 17.2%, P < 0.001), and had a longer hospital stay (15 vs. 10 days, P < 0.003). Regression analysis revealed increased risk of complications among patients with comorbidities (OR 3.21; 95% CI, P = 0.002), albumin levels <30g/dl (OR 2.20; 95% CI, P = 0.01), complete obstruction (OR 2.42; 95% CI, P = 0.017), perforation (OR 9.98; 95% CI, P < 0.001), and open surgery (OR 4.84; 95% CI, P < 0.001).</p><p><strong>Conclusion: </strong>Emergency presentation rate was high among our patients with less-favorable surgical outcomes. Open surgery and stoma creation were more prevalent in the emergency group. Complete obstruction, perforation, open surgery, hypo-albuminemia, and presence of comorbidities were independent risk factors for complications.</p>","PeriodicalId":520774,"journal":{"name":"Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between serum total bile acid and nonalcoholic fatty liver disease: A cross-sectional study.","authors":"Yingying Chen,&nbsp;Huang Su,&nbsp;Haibo Xue,&nbsp;Tingting Wang,&nbsp;Ting Qian,&nbsp;Chengwei Liao,&nbsp;Jinming Wu","doi":"10.4103/sjg.sjg_512_21","DOIUrl":"https://doi.org/10.4103/sjg.sjg_512_21","url":null,"abstract":"<p><strong>Background: </strong>Nonalcoholic fatty liver disease (NAFLD) is a common component of chronic liver disease. Total bile acid (TBA) may influence the NAFLD progression through its signaling pathways. We attempted to find out if there is a correlation between TBA and NAFLD.</p><p><strong>Methods: </strong>427,507 subjects were enrolled in health examinations conducted by The First Affiliated Hospital of Wenzhou Medical University. Among them, only 67616 met the inclusion criteria. Demographic, clinical, and laboratory data were gathered from all subjects. We used multivariate logistic regression model to find the correlation between serum TBA and NAFLD after adjusting for acknowledged risk factors for NAFLD.</p><p><strong>Results: </strong>A negative correlation was found between the TBA and NAFLD after adjusting for confounders in the multivariate logistic regression model (OR: 0.80; 95% CI: 0.72, 0.88, P < 0.001). After subgroup analysis, we found the interaction between NAFLD and diabetes was significant (P = 0.043). In patients with NAFLD without diabetes, TBA showed a protective effect in NAFLD (OR: 0.75; 95% CI: 0.67, 0.85).</p><p><strong>Conclusion: </strong>TBA is protective for NAFLD, but not in patients with NAFLD and diabetes. Further studies are urgently required to completely explore the underlying mechanisms of TBA in the pathogenesis of NAFLD.</p>","PeriodicalId":520774,"journal":{"name":"Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association","volume":" ","pages":"304-311"},"PeriodicalIF":2.7,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/31/e0/SJG-28-304.PMC9408735.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39803972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of safety and efficacy of intragastric botulinum toxin-A versus gastric balloon.","authors":"Raed M Tayyem,&nbsp;Haitham G Qandeel,&nbsp;Hamzeh I Al-Balas,&nbsp;Farah R Tayyem,&nbsp;Jehad Z Fataftah,&nbsp;Mahmoud I Al-Balas","doi":"10.4103/sjg.sjg_534_21","DOIUrl":"https://doi.org/10.4103/sjg.sjg_534_21","url":null,"abstract":"<p><strong>Background: </strong>A prospective case-matched study was conducted to compare the safety and efficacy of endoscopic intragastric botulinum toxin-A (EIBT) versus endoscopically planned gastric balloon (EPGB), as a treatment for obesity.</p><p><strong>Methods: </strong>A total of 176 patients (matched for age and sex) were equally divided to undergo EIBT (n = 88) or EPGB (n = 88). Patients who received EIBT were restricted to a body mass index (BMI) of 25 to 35 kg/m², whereas a BMI >25 kg/m² was allowed in the EPGB group. The main measured outcomes were weight loss, procedure duration, complications, early satiety, and quality of life (QoL).</p><p><strong>Results: </strong>The patients were followed up for a mean of 6 months. The mean weight loss was greater in the EPGB group than in the EIBT group (15.6 kg vs. 9.3 kg, P < 0.001). However, the percentage excess weight loss and the satiety score were greater in the EIBT group (59.1% vs. 42.2%, P < 0.001; and 3.5 vs. 2.3, P < 0.001) respectively. The procedure duration was shorter for EIBT patients (10 min vs. 15 min, P < 0.001). The postoperative complication rate recorded in the EPGB group was significantly higher (30% vs. 9%, P = 0.001). Adverse symptoms lasted longer in EPGB (5.2 days vs. 0.7 days, P < 0.001). Both groups enjoyed similar improvements in QoL.</p><p><strong>Conclusion: </strong>EIBT is a safe and effective treatment for mild obesity. Although the weight loss was greater in the EPGB group, the percentage excess weight loss, procedure duration, postoperative complications, and symptom duration were significantly better in the EIBT group. QoL improvement was comparable between the two groups.</p>","PeriodicalId":520774,"journal":{"name":"Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association","volume":" ","pages":"276-281"},"PeriodicalIF":2.7,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2c/4c/SJG-28-276.PMC9408739.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39725295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short versus long esophageal myotomy during peroral endoscopic myotomy: A systematic review and meta-analysis of comparative trials.","authors":"Zaheer Nabi,&nbsp;Rupjyoti Talukdar,&nbsp;Harshal Mandavdhare,&nbsp;D Nageshwar Reddy","doi":"10.4103/sjg.sjg_438_21","DOIUrl":"https://doi.org/10.4103/sjg.sjg_438_21","url":null,"abstract":"<p><strong>Background: </strong>: Peroral endoscopic myotomy (POEM) is an established modality of treatment for achalasia cardia. Considerable variations exist in the technique of POEM with respect to the length and orientation of the myotomy. In this systematic review and meta-analysis, we compared the outcomes of short versus long myotomy during POEM.</p><p><strong>Methods: </strong>: We searched multiple databases from January 2010 to March 2021 to identify studies reporting on POEM. We selected studies that reported on comparative outcomes of POEM using short versus long myotomy. We performed a comparative analysis of clinical success, procedural duration, gastroesophageal reflux disease (GERD), and adverse events with short and long myotomy in POEM by meta-analysis.</p><p><strong>Results: </strong>: A total of 521 patients from five studies in which 241 patients were treated with short and 280 patients with long myotomy approaches were analyzed. The pooled rate for clinical success gave an odds ratio (OR) of 1.27 (95% confidence interval [CI] 0.50-3.26; I² = 0; P = 0.62); for hospital stay OR 0.22 (95% CI - 0.03 to 0.46; I² = 0; P = 0.08); for GERD by esophagogastroduodenoscopy (EGD) OR 0.58 (95% CI 0.31-1.07; I² = 0; P = 0.08), and for adverse events OR 0.67 (95% CI 0.29-1.53; I² = 51; P = 0.34). Abnormal esophageal acid exposure was less frequent with OR 0.45 (95% CI 0.22-0.90; P = 0.02; I² = 0) and the procedure duration was significantly shorter in the short myotomy group with OR - 0.76 (95% CI - 1.00 to - 0.52; I² = 43; P =0.001).</p><p><strong>Conclusion: </strong>: Short myotomy and long myotomy in POEM seem comparable with each other in terms of clinical success and adverse events. Short myotomy is associated with significantly shorter procedural duration and possibly reduced esophageal acid exposure compared with long myotomy.</p>","PeriodicalId":520774,"journal":{"name":"Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association","volume":" ","pages":"261-267"},"PeriodicalIF":2.7,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ba/de/SJG-28-261.PMC9408737.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39913257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum levels of soluble HLA-G correlate with disease activity in pediatric patients with Crohn's disease.","authors":"Murat Cansever,&nbsp;Mehmet Akif Göktaş,&nbsp;Duran Arslan,&nbsp;Türkan Patiroğlu","doi":"10.4103/sjg.sjg_327_21","DOIUrl":"https://doi.org/10.4103/sjg.sjg_327_21","url":null,"abstract":"<p><strong>Background: </strong>Human leukocyte antigen (HLA)-G, a member of the HLA family, is crucial for fetomaternal tolerance. Transmembrane or circulating/soluble HLA-G (sHLA-G) is elevated in autoimmune conditions and the tumor microenvironment. Circulating sHLA-G levels and their association with disease activity have not yet been assessed in pediatric patients with inflammatory bowel disease (IBD). This study aimed to quantify the serum sHLA-G levels of pediatric patients with IBD and assess the association of serum sHLA-G with disease activity.</p><p><strong>Methods: </strong>: We enrolled 24 pediatric IBD patients Crohn's disease (CD) and ulcerative colitis (UC), n = 12 each] and 24 healthy controls. Based on the disease activity index, five and seven of the CD patients had mild and moderate/severe disease, respectively, whereas six of the UC patients were in remission and six had mild disease. Serum was collected and sHLA-G levels were determined by enzyme-linked immunosorbent assay (ELISA).</p><p><strong>Results: </strong>: Pediatric patients with CD had significantly higher sHLA-G levels compared with patients with UC and healthy controls. Notably, serum sHLA-G levels were significantly higher in patients with moderate/severe CD than in those with mild CD.</p><p><strong>Conclusions: </strong>: Serum sHLA-G levels correlate with disease activity in pediatric patients with CD and are higher in CD patients than in UC patients. Thus, sHLA-G is a potential biomarker for disease activity in CD.</p>","PeriodicalId":520774,"journal":{"name":"Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association","volume":" ","pages":"233-238"},"PeriodicalIF":2.7,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/35/6e/SJG-28-233.PMC9212116.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39943922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early discontinuation of biological therapy among inflammatory bowel disease patients in Bahrain: Real world experience.","authors":"Maheeba Abdulla,&nbsp;Jehad AlQamish,&nbsp;Nafeesa Mohammed,&nbsp;Mahmood Al Saeed,&nbsp;Hasan Jawad Al Aali,&nbsp;Aysha Al Khaja,&nbsp;Zahra Abdulla Isa Yusuf Hasan,&nbsp;Fatema Yusuf Haider,&nbsp;Sayed Dhiyaa Noor Ebrahim,&nbsp;Zahra Sayed Alawi Mahfoodh,&nbsp;Mahmood Ali Hasan Hubail,&nbsp;Isa Alhajri,&nbsp;Fatema Al-Matrook,&nbsp;Ahmed Tork","doi":"10.4103/sjg.sjg_336_21","DOIUrl":"https://doi.org/10.4103/sjg.sjg_336_21","url":null,"abstract":"<p><strong>Background: </strong>Despite the effectiveness of several biological agents in the treatment of inflammatory bowel disease (IBD), some patients respond better than others. Such discrepancies are often evident early in the treatment course. The aim of this study is to identify the risks and assess the rate of early biological discontinuation (BD) among IBD patients.</p><p><strong>Methods: </strong>In this retrospective cohort study conducted in Bahrain all IBD patients who were administered biological agents between June 2009 and June 2019 were included. Medical records were reviewed to collect study data and confirm IBD diagnoses. Early discontinuation of biological agents was defined by discontinuation of a biological agent (within 6 months from administration). Montreal classification was used to classify Crohn's disease and ulcerative colitis (UC) according to location and extension, respectively.</p><p><strong>Results: </strong>Ineffectiveness was the most common reason for early BD. Early BD was not related to the type of IBD, biological agent used, or to most patient-related factors (such as gender and family history). Patient age at index biological initiation was the only independent significant predictor of early BD (P = 0.045, adjusted odds ratios (95% CI): 1.06 (1.001-1.116)] even after correction of two significant factors: comorbid diabetes and marked weight loss at diagnosis.</p><p><strong>Conclusion: </strong>The older the IBD patient at the time of biological therapy initiation, the higher the incidence of early BD. Therefore, caution and close follow-up are required for biological therapy among elderly patients to assess effectiveness and adverse drug reactions.</p>","PeriodicalId":520774,"journal":{"name":"Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association","volume":" ","pages":"193-200"},"PeriodicalIF":2.7,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e1/b7/SJG-28-193.PMC9212118.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39725291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of Elbasvir/Grazoprevir fixed-dose combination for 8 weeks in HCV treatment and health-related quality of life (HRQoL) in treatment-naïve, non-cirrhotic, genotype 4-infected patients (ELEGANT-4): A single-center, single-arm, open-label, phase 3 trial.","authors":"Ahmad AlEid,&nbsp;Areej Al Balkhi,&nbsp;Adel Qutub,&nbsp;Shahem Abbarh,&nbsp;Abed AlLehibi,&nbsp;Abdullah Almtawa,&nbsp;Nawwaf Al Otaibi,&nbsp;Ahmed AlGhamdi,&nbsp;Adel AlGhamdi,&nbsp;Abdulrahman Alamr,&nbsp;Shameem Ahmad,&nbsp;Khalid Al Sayari,&nbsp;Bashaar Al Ibrahim,&nbsp;Abdullah AlKhathlan","doi":"10.4103/sjg.sjg_374_21","DOIUrl":"https://doi.org/10.4103/sjg.sjg_374_21","url":null,"abstract":"<p><strong>Background: </strong>Cost, adverse events, and long treatment duration can be significant obstacles in treating hepatitis C virus (HCV)-infected individuals. Shortening the treatment regimen can minimize these barriers, thereby enhancing adherence and increasing medication availability to more patients.</p><p><strong>Methods: </strong>This is a single-centre, single-arm, open-label, phase 3 clinical trial on treatment naïve, non-cirrhotic, HCV genotype 4 patients. The study aimed to evaluate an 8-week course of Elbasvir (ELB)/Grazoprevir (GZR) in this population. The primary endpoint was sustained virologic response at 12 weeks after the end of treatment (SVR-12). The secondary endpoints were SVR-4, adverse events, and changes in health- and hepatitis-related quality of life (HRQoL).</p><p><strong>Results: </strong>Of the 30 patients who were enrolled, 29 (97%) achieved SVR-12 and SVR-4 (95% CI: 90-100%). No patients experienced serious or life-threatening adverse events (AEs), but mild/moderate AEs were reported by 16 (53%). The most commonly reported AEs were itching/skin rash (20%), headache (16.7%), abdominal/epigastric pain and decreased appetite (13.3% each), and nausea/vomiting (10%). Marked improvements in HRQoL were reported between the first (baseline) and third (SVR-12) timepoints. HRQoL score improvements involved the physical, mental, and hepatitis-specific indices, and ranged between 6 and 42 points (out of 100, P ≤0.003).</p><p><strong>Conclusion: </strong>The trial provides empirical evidence that HCV genotype 4-infected patients can achieve viral eradication with an 8-week-regimen of ELB/GZR. Further, this course of treatment is associated with a minimal adverse event profile and potentially significant improvements in quality of life. (ClinicalTrials.gov number, NCT03578640).</p>","PeriodicalId":520774,"journal":{"name":"Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association","volume":" ","pages":"225-232"},"PeriodicalIF":2.7,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cd/bd/SJG-28-225.PMC9212120.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39782431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal manifestations of COVID-19 in a single center in the Eastern Province of Saudi Arabia.","authors":"Reem J Al Argan,&nbsp;Mona H Ismail,&nbsp;Dania M Alkhafaji,&nbsp;Raed M Alsulaiman,&nbsp;Fatimah E Ismaeel,&nbsp;Reem S AlSulaiman,&nbsp;Ali N Almajid,&nbsp;Lameyaa Alsheekh,&nbsp;Tariq S Alsaif,&nbsp;Alaa A Alzaki,&nbsp;Safi G Alqatari,&nbsp;Abrar J Alwaheed,&nbsp;Abir H Al Said,&nbsp;Marwan J Al Wazzeh,&nbsp;Abdulaziz A AlQurain","doi":"10.4103/sjg.sjg_547_21","DOIUrl":"https://doi.org/10.4103/sjg.sjg_547_21","url":null,"abstract":"<p><strong>Background: </strong>Several gastrointestinal (GI) symptoms have been associated with novel coronavirus disease-2019 (COVID-19). Their prevalence and relation to the severity and hospital outcome of COVID-19 have not been well reported in the Middle East and Saudi Arabia. We aimed to examine the GI manifestations of COVID-19 and their association with the severity and hospital outcome of COVID-19 infection.</p><p><strong>Methods: </strong>We conducted a retrospective observational study of hospitalized COVID-19 patients who had a positive SARS-COV2 PCR test and were admitted at a university hospital in Saudi Arabia, from March to September 2020. The primary objective of the study was to describe the GI manifestations of COVID-19. The secondary objective was to investigate the association of GI manifestations with severity and outcome of COVID-19 infection.</p><p><strong>Results: </strong>We included 390 patients, of which 111 (28.5%) presented with GI manifestations. The most common presentation was diarrhea followed by nausea, vomiting, and abdominal pain. Patients without GI manifestations had a higher risk of severe-critical COVID-19 infection evident by the development of lung infiltration in more than 50% of lung fields within 24-48 h, acute respiratory distress syndrome, altered mental status, multiorgan failure, and cytokine storm syndrome (P < 0.05). These patients had a higher mortality rate compared to patients with GI manifestations (P = 0.01). A lower odds of death was seen among patients with GI symptoms (AOR 0.36; 95% CI, 0.158-0.82; P = 0.01).</p><p><strong>Conclusion: </strong>COVID-19 infection presents commonly with GI manifestations. Patients with GI manifestations have less severe COVID-19 disease and lower mortality rates.</p>","PeriodicalId":520774,"journal":{"name":"Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association","volume":" ","pages":"218-224"},"PeriodicalIF":2.7,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/93/01/SJG-28-218.PMC9212119.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39830018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic resonance enterography and bowel ultrasonography in Saudi Arabian patients with Crohn's disease: A correlation study.","authors":"Rani Ahmad,&nbsp;Ahmed Abduljabbar,&nbsp;Mohammad Wazzan,&nbsp;Rawan Thabit,&nbsp;Mahmoud Mosli,&nbsp;Omar I Saadah","doi":"10.4103/sjg.sjg_261_21","DOIUrl":"https://doi.org/10.4103/sjg.sjg_261_21","url":null,"abstract":"<p><strong>Background: </strong>Crohn's disease (CD) is a complex autoimmune disease that results in chronic inflammation of the gastrointestinal tract. CD activity is determined through clinical, laboratory, endoscopic, and radiological evaluations. Studies that examine the data of radiological modalities of evaluation are lacking, particularly in Saudi Arabia. This study compares magnetic resonance enterography (MRE) and ultrasonography (US) findings among patients diagnosed with CD, to uncover a possible correlation between these techniques.</p><p><strong>Methods: </strong>All patients were assessed for disease activity using MRE and US.</p><p><strong>Results: </strong>A total of 376 patients with CD were recruited. The mean age was 14.9 ± 4.3 years (range, 8-27 years), and males constituted 64% (n = 239) of the cohort. Overall, a strong positive correlation was found between US and MRE evaluations of disease activity (r = 0.83, P < 0.001). US activity correlated positively with MRE findings of enlarged lymph nodes (P < 0.001), bowel wall enhancement (P < 0.001), distal jejunal thickness (P < 0.001), and distal ileal thickness (P < 0.001). The mean difference in wall thickness was significant based on gender (P < 0.001), age in proximal jejunal thickness (P < 0.001), and distal ileal thickness (P = 0.011).</p><p><strong>Conclusions: </strong>MRE and US correlate significantly as imaging techniques for the assessment of CD activity.</p>","PeriodicalId":520774,"journal":{"name":"Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association","volume":" ","pages":"186-192"},"PeriodicalIF":2.7,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/69/bf/SJG-28-186.PMC9212113.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39302432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}