Learning & memory (Cold Spring Harbor, N.Y.)最新文献_第2页

IF 2.2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2026-05-08 Print Date: 2026-05-01 DOI: 10.1101/lm.054162.125

Christopher N Wahlheim, Lauren L Richmond

{"title":"Memory-based similar lure rejections promote subsequent memory for relative recency.","authors":"Christopher N Wahlheim, Lauren L Richmond","doi":"10.1101/lm.054162.125","DOIUrl":"10.1101/lm.054162.125","url":null,"abstract":"Memory updating requires detecting changes between similar events and preserving information about their relative order. Two experiments examined whether memory-based rejection of similar lures in the Mnemonic Similarity Task supports subsequent temporal memory. Participants studied objects, completed a modified recognition test including repeated targets, similar lures, and novel foils, and then performed a relative recency test in which they selected which of two versions of the same object appeared during the previous recognition test. Recency judgments for lures were most accurate when they were correctly rejected as \"similar,\" suggesting that retrieval-based comparison processes during recognition supported subsequent memory updating. Conditional analyses showed that this benefit was enhanced when participants also reported the subjective experience of remembering that both objects had appeared in the experiment, indexing memory for change. Subjective reports of retrieving studied objects before seeing lures were associated with more accurate lure decisions, and clearer subjective retrieval was associated with more frequent reports indicating memory for change. Together, these findings suggest that retrieval and comparison processes engaged during mnemonic discrimination encode information that supports distinguishing earlier and later events. This study provides a step toward integrating cognitive accounts of temporal memory with complementary neural accounts of episodic memory updating.","PeriodicalId":520703,"journal":{"name":"Learning & memory (Cold Spring Harbor, N.Y.)","volume":"33 5","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147857940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic stress enhances threat responding and impacts fear extinction. 慢性压力增强威胁反应，影响恐惧消退。

IF 2.2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2026-04-13 Print Date: 2026-04-01 DOI: 10.1101/lm.054214.126

Yingchu He, Camila Demaestri, Pantelis Antonoudiou, Jamie L Maguire

{"title":"Chronic stress enhances threat responding and impacts fear extinction.","authors":"Yingchu He, Camila Demaestri, Pantelis Antonoudiou, Jamie L Maguire","doi":"10.1101/lm.054214.126","DOIUrl":"10.1101/lm.054214.126","url":null,"abstract":"Chronic stress is a major risk factor for psychiatric disorders. Previous work from our laboratory has demonstrated that chronic stress exposure disrupted network activity in the basolateral amygdala (BLA) and altered the activity of projection-specific neurons in the BLA to bias information processing to favor negative valence processing. Although the BLA is well established as a critical hub for fear memory encoding and retrieval, it remains unclear how chronic stress alters ensemble recruitment within the BLA and its downstream circuit dynamics to shape fear and extinction learning. To answer this question, we used retrograde tracing combined with immunohistochemistry in adult male mice to examine how chronic unpredictable stress (CUS) during adulthood alters the activity of the BLA and its projections to the nucleus accumbens (NAc) or bed nucleus of the (BNST) following fear extinction. Here we demonstrate that CUS produced a shift toward persistent threat responding and alters extinction learning, accompanied by reduced recruitment within the lateral nucleus of the BLA (LA) and in BLA-NAc projecting neurons. These findings provide circuit-level evidence for how chronic stress disrupts information flow from BLA, biasing valence processing toward extinction-resistant fear states and potentially contributing to the persistence of maladaptive fear in stress-related psychiatric disorders.","PeriodicalId":520703,"journal":{"name":"Learning & memory (Cold Spring Harbor, N.Y.)","volume":"33 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13082538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal- and sex-specific changes in proteasome-dependent and independent polyubiquitination in the amygdala during fear memory formation. 恐惧记忆形成过程中杏仁核中蛋白酶体依赖和独立多泛素化的时间和性别特异性变化。

IF 2.2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2026-03-31 Print Date: 2026-04-01 DOI: 10.1101/lm.054203.125

Brieann Brown, Natalie Preveza, Gaurav Jones, Meagan Turner, W Keith Ray, Timothy J Jarome

{"title":"Temporal- and sex-specific changes in proteasome-dependent and independent polyubiquitination in the amygdala during fear memory formation.","authors":"Brieann Brown, Natalie Preveza, Gaurav Jones, Meagan Turner, W Keith Ray, Timothy J Jarome","doi":"10.1101/lm.054203.125","DOIUrl":"10.1101/lm.054203.125","url":null,"abstract":"Strong evidence has emerged over the last two decades implicating proteasome-dependent and independent protein polyubiquitination in the memory consolidation process. Recently, it was shown that multiple forms of polyubiquitination, including proteasome-dependent K48 and proteasome-independent M1 polyubiquitination, regulate fear memory formation in a sex-dependent manner in the amygdala. However, prior work focused on single time points during the postlearning period, leaving questions about whether these are true sex differences in polyubiquitin modifications that persist throughout the extended consolidation process. Here, using unbiased polyubiquitin-type specific proteomics, we identified the protein targets of K48 and M1 polyubiquitination in the amygdala 2 and 4 h after contextual fear conditioning. Notably, we found that while the sex differences in the targeting of proteins with these polyubiquitin modifications persist for several hours after fear conditioning, the temporal dynamics of these changes vary across males and females. Further, while target protein pathways vary significantly across sexes at every time point examined, there are several notable overlaps between males and females. Together, these data provide the first comprehensive analysis of sex differences in proteasome-dependent and independent protein polyubiquitination in fear memory formation and significantly advance our understanding of the potential sex-specific roles of diverse polyubiquitin modifications in the memory consolidation process.","PeriodicalId":520703,"journal":{"name":"Learning & memory (Cold Spring Harbor, N.Y.)","volume":"33 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13082537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The lateral habenula as a link between negative outcomes and adaptive strategy switching. 侧链是负面结果和适应性策略转换之间的联系。

IF 2.2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2026-03-31 Print Date: 2026-04-01 DOI: 10.1101/lm.054186.125

Victoria I Hones, Maeve C Bottoms, Jesse T Miles, Sheri J Y Mizumori

{"title":"The lateral habenula as a link between negative outcomes and adaptive strategy switching.","authors":"Victoria I Hones, Maeve C Bottoms, Jesse T Miles, Sheri J Y Mizumori","doi":"10.1101/lm.054186.125","DOIUrl":"10.1101/lm.054186.125","url":null,"abstract":"Flexible strategy use relies on the concerted effort of multiple cognitive processes. Originally appreciated for its role in aversive conditioning (for review, see Mondoloni et al., Transl Psychiatry 12: 86 [2022]), the lateral habenula (LHb) has recently been linked to flexible behavior more broadly (Baker et al., Front Behav Neurosci 9: 1-22 [2015]; Baker et al., Front Mol Neurosci 12: 1-15 [2019]; Mizumori and Baker, Trends Neurosci 40: 481-493 [2017]; Hones and Mizumori, Front Behav Neurosci 16: 852235 [2022]; Ahmadlou et al., Nature 641: 151-161 [2025]), prompting the question as to whether its encoding of negative outcomes contributes specifically to adaptive strategy switching. To address this gap in knowledge, the present study investigated how LHb inactivation with muscimol affects distinct aspects of flexible decision-making that depend on an understanding of negative outcomes when using a spatial set-shifting task. LHb inactivation resulted in a decreased ability to efficiently acquire new strategies after changes in reward contingencies but did not affect the exploitation of adopted strategies. A measure of choice flexibility confirmed that, without an intact LHb, rats fail to appropriately adapt to new strategies following errors. This effect suggests that the LHb contributes to the appropriate use of negative choice outcomes to inform future decisions. Therefore, aversive signaling in the LHb may play a broad role beyond purely aversive contexts, such as in guiding behavioral adaptation.","PeriodicalId":520703,"journal":{"name":"Learning & memory (Cold Spring Harbor, N.Y.)","volume":"33 4","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rhythmic modulation of the dorsal hippocampus during specific within-trial segments links to future behavior. 在特定的试验中，海马背侧的节律调节与未来的行为有关。

IF 2.2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2026-02-03 Print Date: 2026-02-01 DOI: 10.1101/lm.054175.125

Maeve C Bottoms, Jesse T Miles, Sheri J Y Mizumori

引用次数: 0

Meta-analytic evidence for fast mapping in healthy adults. 健康成人快速定位的meta分析证据。

IF 2.2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2026-02-03 Print Date: 2026-02-01 DOI: 10.1101/lm.054168.125

Marc N Coutanche

引用次数: 0

The influence of social content on episodic memory retrieval. 社会内容对情景记忆提取的影响。

IF 2.2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2026-02-03 Print Date: 2026-02-01 DOI: 10.1101/lm.054180.125

Ameer Ghouse, Raphael Kaplan

引用次数: 0

Instrumental learning enhances the intrinsic excitability of basal amygdala projection neurons. 工具学习增强基底杏仁核投射神经元的内在兴奋性。

IF 2.2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2025-12-23 Print Date: 2026-01-01 DOI: 10.1101/lm.054161.125

Eddie T Wise, Philip Jean-Richard-Dit-Bressel, Joanna O-Y Yau, Gavan P McNally, John M Power

引用次数: 0

Agency alters memory organization during free recall. 在自由回忆过程中，代理改变了记忆组织。

IF 2.2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2025-12-23 Print Date: 2026-01-01 DOI: 10.1101/lm.054121.125

Lindsay I Rait, Elizabeth A Horwath, Sarah DuBrow, Vishnu P Murty

引用次数: 0

Sex differences in extinction of Pavlovian food cues. 巴甫洛夫食物线索消失中的性别差异。

IF 2.2

Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2025-12-23 Print Date: 2026-01-01 DOI: 10.1101/lm.054164.125

Danielle S Lafferty, W Shelby Parsons, Amanda M K Madden, Rebecca Shteyn, Gorica D Petrovich

{"title":"Sex differences in extinction of Pavlovian food cues.","authors":"Danielle S Lafferty, W Shelby Parsons, Amanda M K Madden, Rebecca Shteyn, Gorica D Petrovich","doi":"10.1101/lm.054164.125","DOIUrl":"10.1101/lm.054164.125","url":null,"abstract":"Food-associated memories are fundamental to our survival. Learned food cues guide food-seeking and eating behaviors. How long these memories persist varies across individuals. In some people, enduring food memories become maladaptive and cause sustained cravings and disordered eating. Women are more susceptible than men to obesity, eating disorders, and addiction, and yet, memory and extinction of food cues have not been systematically examined in both sexes. Here, we compared adult male and female rats during cue-food acquisition, extinction, and renewal or reacquisition in three experiments with Pavlovian conditioning. Extinction is context-specific, and there are sex differences in context-dependent renewal of responding after extinction. The first two experiments tested whether pretraining habituation to the learning and extinction contexts (with or without food reward) would improve renewal in both sexes. Habituation did not improve renewal in either experiment. Unexpectedly, females showed impaired extinction. The third experiment utilized a test of extinction resistance: the partial reinforcement extinction effect. In this task, females showed pronounced resistance to extinction compared to males, especially when learning and extinction occurred in the same context. These findings point to differences in extinction as the potential cause of individual differences in persistent cue-driven food cravings and the inability to alter eating behaviors.","PeriodicalId":520703,"journal":{"name":"Learning & memory (Cold Spring Harbor, N.Y.)","volume":"33 1","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12735318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145822608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0