Gareth Robert Barker, Liang Fong Wong, James B Uney, Elizabeth C Warburton
{"title":"内侧前额叶皮层的CREB转录调节长期联想识别记忆的形成。","authors":"Gareth Robert Barker, Liang Fong Wong, James B Uney, Elizabeth C Warburton","doi":"10.1101/lm.050021.119","DOIUrl":null,"url":null,"abstract":"<p><p>The medial prefrontal cortex (mPFC) is known to be critical for specific forms of long-term recognition memory, however the cellular mechanisms in the mPFC that underpin memory maintenance have not been well characterized. This study examined the importance of phosphorylation of cAMP responsive element binding protein (CREB) in the mPFC for different forms of long-term recognition memory in the rat. Adenoviral transduction of the mPFC with a dominant-negative inhibitor of CREB impaired object-in-place memory following a 6 or 24 h retention delay, but no impairment was observed following delays of 5 min or 3 h. Long-term object temporal order memory and spatial temporal order memory was also impaired. In contrast, there were no impairments in novel object recognition or object location memory. These results establish, for the first time, the importance of CREB phosphorylation within the mPFC for memory of associative and temporal information crucial to recognition.</p>","PeriodicalId":520703,"journal":{"name":"Learning & memory (Cold Spring Harbor, N.Y.)","volume":" ","pages":"45-51"},"PeriodicalIF":2.2000,"publicationDate":"2020-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1101/lm.050021.119","citationCount":"8","resultStr":"{\"title\":\"CREB transcription in the medial prefrontal cortex regulates the formation of long-term associative recognition memory.\",\"authors\":\"Gareth Robert Barker, Liang Fong Wong, James B Uney, Elizabeth C Warburton\",\"doi\":\"10.1101/lm.050021.119\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The medial prefrontal cortex (mPFC) is known to be critical for specific forms of long-term recognition memory, however the cellular mechanisms in the mPFC that underpin memory maintenance have not been well characterized. This study examined the importance of phosphorylation of cAMP responsive element binding protein (CREB) in the mPFC for different forms of long-term recognition memory in the rat. Adenoviral transduction of the mPFC with a dominant-negative inhibitor of CREB impaired object-in-place memory following a 6 or 24 h retention delay, but no impairment was observed following delays of 5 min or 3 h. Long-term object temporal order memory and spatial temporal order memory was also impaired. In contrast, there were no impairments in novel object recognition or object location memory. These results establish, for the first time, the importance of CREB phosphorylation within the mPFC for memory of associative and temporal information crucial to recognition.</p>\",\"PeriodicalId\":520703,\"journal\":{\"name\":\"Learning & memory (Cold Spring Harbor, N.Y.)\",\"volume\":\" \",\"pages\":\"45-51\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2020-01-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1101/lm.050021.119\",\"citationCount\":\"8\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Learning & memory (Cold Spring Harbor, N.Y.)\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1101/lm.050021.119\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2020/2/1 0:00:00\",\"PubModel\":\"Print\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Learning & memory (Cold Spring Harbor, N.Y.)","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1101/lm.050021.119","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/2/1 0:00:00","PubModel":"Print","JCR":"","JCRName":"","Score":null,"Total":0}
CREB transcription in the medial prefrontal cortex regulates the formation of long-term associative recognition memory.
The medial prefrontal cortex (mPFC) is known to be critical for specific forms of long-term recognition memory, however the cellular mechanisms in the mPFC that underpin memory maintenance have not been well characterized. This study examined the importance of phosphorylation of cAMP responsive element binding protein (CREB) in the mPFC for different forms of long-term recognition memory in the rat. Adenoviral transduction of the mPFC with a dominant-negative inhibitor of CREB impaired object-in-place memory following a 6 or 24 h retention delay, but no impairment was observed following delays of 5 min or 3 h. Long-term object temporal order memory and spatial temporal order memory was also impaired. In contrast, there were no impairments in novel object recognition or object location memory. These results establish, for the first time, the importance of CREB phosphorylation within the mPFC for memory of associative and temporal information crucial to recognition.