内侧前额叶皮层的CREB转录调节长期联想识别记忆的形成。

IF 2.2
Learning & memory (Cold Spring Harbor, N.Y.) Pub Date : 2020-01-16 Print Date: 2020-02-01 DOI:10.1101/lm.050021.119
Gareth Robert Barker, Liang Fong Wong, James B Uney, Elizabeth C Warburton
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引用次数: 8

摘要

众所周知,内侧前额叶皮层(mPFC)对特定形式的长期识别记忆至关重要,然而,mPFC中支撑记忆维持的细胞机制尚未得到很好的表征。本研究探讨了大鼠mPFC中cAMP反应元件结合蛋白(CREB)磷酸化对不同形式的长期识别记忆的重要性。用CREB显性阴性抑制剂介导mPFC的腺病毒转导会在6或24小时的滞留延迟后损害物体在位记忆,但在5分钟或3小时的滞留延迟后未观察到损害。长期物体时间顺序记忆和空间时间顺序记忆也会受损。相比之下,在新物体识别和物体定位记忆方面没有损伤。这些结果首次确立了mPFC中CREB磷酸化对记忆的重要性,这些记忆对识别至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

CREB transcription in the medial prefrontal cortex regulates the formation of long-term associative recognition memory.

CREB transcription in the medial prefrontal cortex regulates the formation of long-term associative recognition memory.

CREB transcription in the medial prefrontal cortex regulates the formation of long-term associative recognition memory.

CREB transcription in the medial prefrontal cortex regulates the formation of long-term associative recognition memory.

The medial prefrontal cortex (mPFC) is known to be critical for specific forms of long-term recognition memory, however the cellular mechanisms in the mPFC that underpin memory maintenance have not been well characterized. This study examined the importance of phosphorylation of cAMP responsive element binding protein (CREB) in the mPFC for different forms of long-term recognition memory in the rat. Adenoviral transduction of the mPFC with a dominant-negative inhibitor of CREB impaired object-in-place memory following a 6 or 24 h retention delay, but no impairment was observed following delays of 5 min or 3 h. Long-term object temporal order memory and spatial temporal order memory was also impaired. In contrast, there were no impairments in novel object recognition or object location memory. These results establish, for the first time, the importance of CREB phosphorylation within the mPFC for memory of associative and temporal information crucial to recognition.

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