JPEN. Journal of parenteral and enteral nutrition最新文献_第2页

Prognostic evaluation of GLIM-defined severe malnutrition via skeletal muscle mass index in critically ill adults: A comparative analysis. 通过骨骼肌质量指数对危重症成人的严重营养不良进行预后评估：一项比较分析。

JPEN. Journal of parenteral and enteral nutrition Pub Date : 2025-06-22 DOI: 10.1002/jpen.2789

Tomoka Miyagi, Minoru Yoshida, Shinya Suganuma, Kensuke Nakamura, Shunsuke Takaki

{"title":"Prognostic evaluation of GLIM-defined severe malnutrition via skeletal muscle mass index in critically ill adults: A comparative analysis.","authors":"Tomoka Miyagi, Minoru Yoshida, Shinya Suganuma, Kensuke Nakamura, Shunsuke Takaki","doi":"10.1002/jpen.2789","DOIUrl":"https://doi.org/10.1002/jpen.2789","url":null,"abstract":"Background: The Global Leadership Initiative on Malnutrition (GLIM) criteria are recommended by major academic societies; however, their application to critically ill patients is limited because of the difficulties associated with assessing muscle mass and the lack of standardized methods and cutoff values. We herein applied GLIM criteria to intensive care unit (ICU) patients by accurately assessing total skeletal muscle volume using computed tomography (CT) with sarcopenia diagnostic cutoff values.Methods: We included consecutive adult patients admitted to our ICU who underwent CT of the trunk. Total skeletal muscle area at the third lumbar vertebra was measured, and the skeletal muscle index was calculated. Reduced muscle mass was defined with Iritani criteria. A positive result in any of the phenotypic criteria was regarded as severe malnutrition. The primary outcome was in-hospital mortality. We also examined the agreement with the Subjective Global Assessment (SGA) using Cohen kappa coefficient.Results: Among 147 patients, 38 had weight loss, 39 had a low body mass index (BMI), and 41 had reduced muscle mass. In-hospital mortality was associated with reduced muscle mass (13.2% vs 43.9%, P < 0.001) and low BMI (15.7% vs 38.5%, P = 0.003). The concordance of individual and sole phenotypic criteria with SGA was low, whereas concordance was the highest at κ = 0.70 when all three criteria were combined.Conclusions: GLIM criteria with accurate muscle mass evaluation using sarcopenia diagnostic cutoffs by CT may facilitate the identification of ICU patients with malnutrition whose prognosis is poor.","PeriodicalId":520701,"journal":{"name":"JPEN. Journal of parenteral and enteral nutrition","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence of catheter-related bloodstream infections with sodium citrate lock therapy in adult patients receiving home parenteral nutrition: A descriptive cohort study. 接受家庭肠外营养的成人患者应用柠檬酸钠锁栓治疗后导管相关血流感染的发生率：一项描述性队列研究。

JPEN. Journal of parenteral and enteral nutrition Pub Date : 2025-06-22 DOI: 10.1002/jpen.2788

Rachel Leong, Nisha J Dave, Daniel P Griffith, Anna Guo, Kirk A Easley, John R Galloway, Thomas R Ziegler, Vivian M Zhao

{"title":"Incidence of catheter-related bloodstream infections with sodium citrate lock therapy in adult patients receiving home parenteral nutrition: A descriptive cohort study.","authors":"Rachel Leong, Nisha J Dave, Daniel P Griffith, Anna Guo, Kirk A Easley, John R Galloway, Thomas R Ziegler, Vivian M Zhao","doi":"10.1002/jpen.2788","DOIUrl":"https://doi.org/10.1002/jpen.2788","url":null,"abstract":"Background: We determined the incidence of catheter-related bloodstream infections in adult patients requiring home parenteral nutrition (HPN) while receiving sodium citrate locks.Methods: We conducted a single-center descriptive cohort study involving 38 adults who required HPN from January 1, 2020, to August 31, 2022. The exact method, assuming a Poisson distribution, was used to estimate the incidence rate of catheter-related bloodstream infections per 1000 catheter days among patients receiving sodium citrate locks. Univariate and multivariate analyses using Poisson regression and frailty models were employed to evaluate predictive factors.Results: Thirty-eight patients received sodium citrate locks, with 65.8% women (mean age, 50.2 ± 14.5 years). The average length of HPN was 3.6 years. Forty-six catheter-related bloodstream infections occurred during 20,085 catheter days, demonstrating an incidence rate of 2.3 (95% confidence interval, 1.7-3.1) per 1000 catheter days. Peripheral-inserted central catheters had a higher incidence rate (3.9 per 1000 catheter days) than Hickman catheters (2.2 per 1000 catheter days), with a hazard ratio of 1.27, indicating a 27% increased risk of catheter-related bloodstream infections. Univariate and multivariate Poisson regression analyses revealed that for every 1-h increase in HPN infusion duration (h/day), the incidence rate of catheter-related bloodstream infections is expected to increase by 10%.Conclusion: Catheter-related bloodstream infections are common in adult patients requiring HPN. Sodium citrate locks may help prevent these infections. Recognizing predictive factors, such as the duration of parenteral infusion, can help healthcare providers develop more effective prevention strategies.","PeriodicalId":520701,"journal":{"name":"JPEN. Journal of parenteral and enteral nutrition","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Essential fatty acid deficiency in children treated with long-term 100% fish-oil lipid injectable emulsion: A longitudinal descriptive cohort study. 长期100%鱼油脂类注射乳剂治疗儿童必需脂肪酸缺乏症：一项纵向描述性队列研究。

JPEN. Journal of parenteral and enteral nutrition Pub Date : 2025-06-19 DOI: 10.1002/jpen.2785

Kathleen M Gura, Muralidhar H Premkumar, Kara L Calkins, Mark Puder

{"title":"Essential fatty acid deficiency in children treated with long-term 100% fish-oil lipid injectable emulsion: A longitudinal descriptive cohort study.","authors":"Kathleen M Gura, Muralidhar H Premkumar, Kara L Calkins, Mark Puder","doi":"10.1002/jpen.2785","DOIUrl":"10.1002/jpen.2785","url":null,"abstract":"Background: To assess severity and risk of an essential fatty acid deficiency in children <2 years with parenteral nutrition-associated cholestasis on long-term 100% fish-oil lipid injectable emulsion.Methods: This longitudinal descriptive cohort study included patients receiving fish-oil lipid injectable emulsion (1 g/kg/day). Triene: tetraene ratios were monitored for up to 4 years and classified as mildly elevated (≥0.05 and <0.2) or essential fatty acid deficiency (≥0.2).Results: One hundred and twenty-seven patients with a baseline median age of 14 weeks were included. Serum docosahexaenoic acid and eicosapentaenoic acid levels markedly increased, whereas arachidonic acid, linoleic acid, and α-linolenic acid levels decreased before stabilizing. Median triene: tetraene ratios peaked at 0.027 at week 8 and then stabilized within a range of 0.015 and 0.020 from week 16 until the end of the study. Seven patients had mildly elevated triene: tetraene ratio at the end of the study. Three infants had an essential fatty acid deficiency, but none demonstrated clinical signs consistent with this deficiency. One deficiency was attributed to a laboratory error; two were associated with adverse events. All patients resolved with the continuation of fish-oil lipid injectable emulsion.Conclusion: Children with parenteral nutrition-associated cholestasis on long-term fish-oil lipid injectable emulsion are at low risk for a clinical or biochemical essential fatty acid deficiency. These findings indicate that despite its low content of linoleic acid and α-linolenic acid, long-term 1 g/kg/day of 100% fish-oil lipid injectable emulsion is not associated with an essential fatty acid deficiency.","PeriodicalId":520701,"journal":{"name":"JPEN. Journal of parenteral and enteral nutrition","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parenteral nutrition weaning in pediatric intestinal failure patients enrolled in remote patient monitoring: A descriptive study. 参与远程患者监测的儿童肠衰竭患者肠外营养断奶：一项描述性研究。

JPEN. Journal of parenteral and enteral nutrition Pub Date : 2025-06-15 DOI: 10.1002/jpen.2784

Stephanie B Oliveira, Julia D Thomas, Conrad Cole, Michael Helmrath, Samuel Kocoshis, Paul W Wales

{"title":"Parenteral nutrition weaning in pediatric intestinal failure patients enrolled in remote patient monitoring: A descriptive study.","authors":"Stephanie B Oliveira, Julia D Thomas, Conrad Cole, Michael Helmrath, Samuel Kocoshis, Paul W Wales","doi":"10.1002/jpen.2784","DOIUrl":"https://doi.org/10.1002/jpen.2784","url":null,"abstract":"Background: Remote patient monitoring (RPM) enhances patient surveillance. This study describes our initial experience with RPM in pediatric intestinal failure patients and its preliminary impact on parenteral nutrition (PN) reduction in an outpatient setting.Methods: We performed a descriptive cohort study on pediatric patients with intestinal failure receiving home PN and enrolled in an RPM program managed by our intestinal rehabilitation team. Initiated in March 2021, the study compared PN energy and volume reduction rates before and after RPM implementation. We calculated the rate of PN decrease per day and the time to achieve a 20% reduction in PN volume. Paired t tests were used for comparisons. Statistical significance was set at P < 0.05. The study received institutional review board approval.Results: Seventeen patients were included (52% male; mean age: 44 months). The most common etiology of short bowel syndrome was necrotizing enterocolitis (NEC), with a mean residual small bowel length of 15.5% ± 12.5%. Post-RPM, there was a greater reduction in PN energy and volume (0.22 ± 0.28 and 0.17 ± 0.24) compared with pre-RPM (0.08 ± 0.10 and 0.07 ± 0.08), though not statistically significant (P = 0.11 and P = 0.17). Time to achieve a 20% reduction in PN was shorter post RPM but not statistically significant (P = 0.06 and P = 0.20 for energy and volume, respectively).Conclusion: Remote patient monitoring appears safe for pediatric intestinal failure patients, with potential for higher PN reduction and shorter time to achieve it. Further research is needed to fully assess RPM's impact on this population.","PeriodicalId":520701,"journal":{"name":"JPEN. Journal of parenteral and enteral nutrition","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Teduglutide in adults with short bowel syndrome and intestinal failure: A descriptive cohort study. Teduglutide治疗短肠综合征和肠衰竭：一项描述性队列研究。

JPEN. Journal of parenteral and enteral nutrition Pub Date : 2025-06-14 DOI: 10.1002/jpen.2786

Elizabeth S L Low, Kathryn Burrell, Katrina Tan, Brooke Chapman, Adam Testro, Darren Wong

{"title":"Teduglutide in adults with short bowel syndrome and intestinal failure: A descriptive cohort study.","authors":"Elizabeth S L Low, Kathryn Burrell, Katrina Tan, Brooke Chapman, Adam Testro, Darren Wong","doi":"10.1002/jpen.2786","DOIUrl":"https://doi.org/10.1002/jpen.2786","url":null,"abstract":"Background: International evidence supports the efficacy of teduglutide in reducing parenteral support requirements, or achieving enteral autonomy, in patients with short bowel syndrome-intestinal failure. This is a multicenter observational study presenting the real-world experience with teduglutide in Australia.Materials and methods: 11 of 12 Australian intestinal rehabilitation units submitted data for 19 adult patients with short bowel syndrome-intestinal failure prescribed teduglutide from November 2020 to August 2023. Patient and clinical characteristics, including teduglutide dosing and parenteral support prescriptions, were collected at 3-month intervals for 12 months from teduglutide initiation and finally at study termination. Univariate analysis was conducted and results presented as medians with interquartile ranges (IQRs).Results: Seventy-four percent of the cohort (median age 58 [IQR 44-67] years) were female. The median residual small bowel length was 85 cm (IQR 60-118), with 53% having colon in continuity. Prior to teduglutide commencement, median parenteral support duration was 3.8 (IQR 1.1-11.0) years, with weekly parenteral support volumes of 11.5 (IQR 6.2-15.3) L/week. Seven patients (37%) achieved enteral autonomy, with five weaned off by 12 months and the remaining between 12-42 months from teduglutide initiation. 79% achieved ≥20% parenteral support volume reductions, with overall median parenteral support volume reductions of 28% after 12 months. Baseline quality-of-life assessments suggested that sexual function, travel ability, and sleep patterns were areas of greatest disease burden.Conclusion: Within an Australian cohort, teduglutide is effective at reducing parenteral support requirements in patients with short bowel syndrome-intestinal failure, although the effect onset and range remains heterogenous.","PeriodicalId":520701,"journal":{"name":"JPEN. Journal of parenteral and enteral nutrition","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Donor human milk storage and gastrointestinal morbidities in preterm infants: A case-control study. 供体母乳储存与早产儿胃肠道发病率：一项病例对照研究。

JPEN. Journal of parenteral and enteral nutrition Pub Date : 2025-06-08 DOI: 10.1002/jpen.2780

Terence James M Camilon, Mary Galemmo, Whitney Savino, Allison Rohrer, Mathew J Gregoski, Aaron P Lesher, Katherine E Chetta

{"title":"Donor human milk storage and gastrointestinal morbidities in preterm infants: A case-control study.","authors":"Terence James M Camilon, Mary Galemmo, Whitney Savino, Allison Rohrer, Mathew J Gregoski, Aaron P Lesher, Katherine E Chetta","doi":"10.1002/jpen.2780","DOIUrl":"https://doi.org/10.1002/jpen.2780","url":null,"abstract":"Background: Prolonged storage of donor human milk may alter its bioactive components, potentially affecting preterm infant outcomes. No prior studies have examined the impact of donor human milk storage duration on necrotizing enterocolitis or spontaneous intestinal perforation.Methods: In a retrospective case-control study (February 2022 to January 2024) at a single neonatal intensive care unit, we evaluated preterm infants (<32 weeks' gestational age or birth weight <1700 g) receiving donor human milk. Cases (n = 36) had necrotizing enterocolitis (Bell stage ≥2A) or spontaneous intestinal perforation; controls (n = 226) were disease free. Donor human milk storage duration (days from expression to consumption) was calculated using lot expiration dates. Logistic regression assessed associations, adjusting for gestational age, birth weight, and other confounders.Results: Of 262 infants, 36 developed necrotizing enterocolitis (n = 28) or spontaneous intestinal perforation (n = 8). Mean donor human milk storage duration was 258.6 (SD, 29.9) days in cases and 244.5 (SD, 21.7) days in controls (P = 0.01). Each additional storage day increased the adjusted odds of necrotizing enterocolitis or spontaneous intestinal perforation by 3.6% (95% confidence interval, 1.17-5.5; P < 0.001), after accounting for maternal and infant comorbidities.Conclusions: Prolonged donor human milk storage is associated with necrotizing enterocolitis and spontaneous intestinal perforation in preterm infants, particularly those <750 g. These findings suggest a need to reevaluate donor human milk storage guidelines for high-risk neonates, pending multicenter validation.","PeriodicalId":520701,"journal":{"name":"JPEN. Journal of parenteral and enteral nutrition","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between parenteral nutrition and length of stay in late preterm and term infants: A retrospective cohort study. 肠外营养与晚期早产儿和足月婴儿住院时间的关系：一项回顾性队列研究。

JPEN. Journal of parenteral and enteral nutrition Pub Date : 2025-06-06 DOI: 10.1002/jpen.2781

Katrina A Savioli, Carl E Hunt, Anwar E Ahmed, Cara H Olsen, Reese H Clark, Nicole R Dobson

{"title":"Association between parenteral nutrition and length of stay in late preterm and term infants: A retrospective cohort study.","authors":"Katrina A Savioli, Carl E Hunt, Anwar E Ahmed, Cara H Olsen, Reese H Clark, Nicole R Dobson","doi":"10.1002/jpen.2781","DOIUrl":"https://doi.org/10.1002/jpen.2781","url":null,"abstract":"Background: We aimed to determine how the use of parenteral nutrition in late preterm and term infants admitted to the neonatal intensive care unit (NICU) affects outcomes, specifically length of stay.Methods: This is a retrospective cohort study that included infants ≥35 weeks gestation admitted to a Pediatrix Medical Group-affiliated NICU on day of life 0-2 in 2009-2019. Propensity score matching was used to control for demographics, delivery characteristics, and severity of illness. Infants were excluded if they received comfort or palliative care in the delivery room or transferred before discharge home. The primary outcome was length of stay. Secondary outcomes were duration of conventional and high-frequency ventilation, late-onset sepsis, and mortality.Results: The total cohort had 470,433 neonates; of the 259,495 infants who met inclusion criteria and survived to discharge, 97,577 (37.6%) received parenteral nutrition. Of 59,580 propensity-matched neonates comparing parenteral nutrition vs no parenteral nutrition, those receiving parenteral nutrition (n = 29,790) had a longer median length of stay (10 vs 9 days, P < 0.0001). Analysis of secondary outcomes revealed a higher mean number of conventional ventilation days, higher odds of late-onset sepsis, and higher odds of mortality in neonates receiving parenteral nutrition vs no parenteral nutrition.Conclusion: Parenteral nutrition in late preterm and term neonates is associated with increased length of stay, duration of conventional ventilation, and odds of late-onset sepsis and mortality. Prospective clinical trials are needed to better understand the optimal use and timing of parenteral nutrition and associated morbidities in this population.","PeriodicalId":520701,"journal":{"name":"JPEN. Journal of parenteral and enteral nutrition","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between multioil intravenous lipid emulsion and cholestasis in infants with gastrointestinal disorders: A retrospective cohort study. 多油静脉注射脂质乳剂与胃肠道疾病婴儿胆汁淤积的关系：一项回顾性队列研究。

JPEN. Journal of parenteral and enteral nutrition Pub Date : 2025-06-03 DOI: 10.1002/jpen.2776

Lauren J Lee, Esther S Kim, Tahmineh Romero, Kara L Calkins

{"title":"Association between multioil intravenous lipid emulsion and cholestasis in infants with gastrointestinal disorders: A retrospective cohort study.","authors":"Lauren J Lee, Esther S Kim, Tahmineh Romero, Kara L Calkins","doi":"10.1002/jpen.2776","DOIUrl":"https://doi.org/10.1002/jpen.2776","url":null,"abstract":"Background: Infants with gastrointestinal (GI) disorders are at risk for parenteral nutrition-associated cholestasis. A multioil intravenous lipid emulsion (MO ILE) contains less phytosterols and more arachidonic and docosahexaenoic acid (DHA) than 100% soybean oil lipid emulsion (SO ILE). This study compares parenteral nutrition-associated cholestasis, growth, and fatty acids in infants with GI disorders who received MO ILE or SO ILE.Methods: This retrospective cohort study included 48 infants with GI disorders born between 2014 and 2022 who received an intravenous lipid emulsion for ≥14 days. Cholestasis was defined as serum conjugated bilirubin ≥2 mg/dl; growth was assessed by z score changes. Gas chromatography and mass spectrometry was used to measure fatty acid content in the erythrocyte cell membrane.Results: The incidence of parenteral nutrition-associated cholestasis was similar (MO ILE 30% vs SO ILE 29%, P > 0.99). However, compared with infants who received parenteral nutrition >28 days and SO ILE, infants who received parenteral nutrition >28 days and MO ILE experienced a slower rise in conjugated bilirubin (0.1 ± 0.03 vs 0.26 ± 0.38 mg/dl, P interaction < 0.001). Weight z score decline (discharge to birth) was less in the MO ILE group vs SO ILE group (-1.0 [-2.0, -0.4] vs -0.4 [-0.9, 0], P = 0.04). Although the MO ILE group demonstrated improved DHA status at weeks 1-3 (P < 0.05 for all), arachidonic acid and DHA decreased over time in both groups and there was no difference in the rate of change (P interaction > 0.3 for both).Conclusion: In infants with GI disorders, MO ILE was associated with improved growth. MO ILE was well tolerated and hepatoprotective in infants who required prolonged parenteral nutrition.","PeriodicalId":520701,"journal":{"name":"JPEN. Journal of parenteral and enteral nutrition","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between heparin addition to parenteral nutrition and catheter-related complications in very preterm infants: A retrospective cohort study. 肝素加肠外营养与极早产儿导管相关并发症之间的关系：一项回顾性队列研究。

JPEN. Journal of parenteral and enteral nutrition Pub Date : 2025-05-27 DOI: 10.1002/jpen.2779

Jiao Li, Jing Shi, Xiaohong Li, Xiaoyan Yang, Jing Zhao, Tingting Zhu, Haiting Liu, Yanling Hu, Jun Tang, Dapeng Chen, Dezhi Mu

{"title":"Association between heparin addition to parenteral nutrition and catheter-related complications in very preterm infants: A retrospective cohort study.","authors":"Jiao Li, Jing Shi, Xiaohong Li, Xiaoyan Yang, Jing Zhao, Tingting Zhu, Haiting Liu, Yanling Hu, Jun Tang, Dapeng Chen, Dezhi Mu","doi":"10.1002/jpen.2779","DOIUrl":"https://doi.org/10.1002/jpen.2779","url":null,"abstract":"Background: This study aimed to assess the necessity of adding heparin to parenteral nutrition for continuous infusion through a peripherally inserted central catheter in very preterm infants.Methods: This retrospective cohort study was conducted between January 1, 2019, and January 1, 2023. Preterm infants with gestational age <32 weeks requiring a peripherally inserted central catheter for parenteral nutrition were included. The heparin group received parenteral nutrition with 0.5 IU/ml heparin added for infusion through a peripherally inserted central catheter, whereas the nonheparin group did not receive heparin. Propensity score matching was used to balance baseline variables between the two groups. The primary outcome was the incidence of catheter-related complications. A noninferiority margin of 10% was chosen. Nonelective catheter removal, heparin-related side effects, and catheter dwell time were compared between the two groups.Results: A total of 1089 very preterm infants were included. After propensity score matching, 432 infants from each group were analyzed. The incidence of catheter-related complications was 22.9% in the heparin group and 21.8% in the nonheparin group, with an absolute difference of -1.16% (95% CI: -6.71% to 4.40%). The upper bound was below 10% (P for noninferiority < 0.001), confirming noninferiority. In addition, no significant difference was found between the two groups in the incidence of nonelective catheter removal or heparin-related side effects.Conclusion: Parenteral nutrition without heparin was noninferior to the addition of heparin during infusion through peripherally inserted central catheter on the risk of catheter-related complications in very preterm infants.","PeriodicalId":520701,"journal":{"name":"JPEN. Journal of parenteral and enteral nutrition","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between epigenetic clock acceleration and malnutrition among adults in the United States: A cross-sectional study. 美国成年人表观遗传时钟加速与营养不良之间的关系：一项横断面研究。

JPEN. Journal of parenteral and enteral nutrition Pub Date : 2025-05-27 DOI: 10.1002/jpen.2778

An Zhou, Qun Ye, Yonghui Wei, Wei-Dong Li

{"title":"Association between epigenetic clock acceleration and malnutrition among adults in the United States: A cross-sectional study.","authors":"An Zhou, Qun Ye, Yonghui Wei, Wei-Dong Li","doi":"10.1002/jpen.2778","DOIUrl":"https://doi.org/10.1002/jpen.2778","url":null,"abstract":"Background: We investigated relationships between nutrition assessment tools (Controlling Nutritional Status [CONUT], Geriatric Nutritional Risk Index [GNRI], and Naples Prognostic Score [NPS]) and epigenetic clocks, evaluating malnutrition's impact on biological aging.Methods: Using National Health and Nutrition Examination Survey database (1999-2002), 2532 participants aged ≥50 years were assessed with three nutrition tools and analyzed against 12 epigenetic clocks using multiple linear regression models adjusted for confounding factors.Results: Malnutrition prevalence rates were 13.5% (CONUT), 4.2% (GNRI), and 46.8% (NPS). Compared with no-risk groups, moderate-to-severe malnutrition showed significant epigenetic age acceleration, particularly in NPS assessment. GrimAge2Mort demonstrated up to 4.19 years acceleration (in NPS model 3, P < 0.01), DunedinPoAm showed significant increase (in NPS model 3, β = 0.083, P < 0.01), and YangCell significantly decreased (in NPS model 3, β = -0.019, P < 0.01). These associations remained significant after adjusting for confounding factors. A clear dose-response relationship existed between malnutrition and epigenetic age acceleration.Conclusion: This study provides first systematic evidence of significant associations between malnutrition and epigenetic age acceleration, particularly in moderate-to-severe malnutrition, leading to substantial biological aging acceleration. GrimAge2Mort, DunedinPoAm, and YangCell emerged as stable indicators for assessing nutrition-related biological aging. These findings provide new insights into malnutrition's impact on aging and offer important references for clinical nutrition intervention strategies.","PeriodicalId":520701,"journal":{"name":"JPEN. Journal of parenteral and enteral nutrition","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0