Journal of clinical hypertension (Greenwich, Conn.)最新文献

{"title":"Associations of Biological Age and Heart Age Accelerations With New-Onset Stroke in Individuals With Cardiovascular-Kidney-Metabolic Syndrome Stages 0-3: Evidence From a Chinese Longitudinal Study.","authors":"Hao Zhu, Hannah Lui, Li He, Jing Zhang, Zhi Jin","doi":"10.1111/jch.70256","DOIUrl":"10.1111/jch.70256","url":null,"abstract":"<p><p>Individuals with cardiovascular-kidney-metabolic (CKM) syndrome face an elevated risk of stroke, yet effective risk stratification indicators remain limited. This prospective study aims to investigate the associations of biological age acceleration (BioAge-gap) and heart age acceleration (HeartAge-gap) with new-onset stroke in individuals with CKM syndrome Stages 0-3, utilizing data from the China Health and Retirement Longitudinal Study (CHARLS) collected between 2015 and 2020. Baseline BioAge-gap and HeartAge-gap were calculated via the Klemera-Doubal method (KDM) and Framingham risk score (FRS), respectively. The primary outcome was self-reported physician-diagnosed stroke identified during the 2018 and 2020 follow-ups. Analysis of 7283 eligible participants aged 45-75 years revealed a positive association between BioAge-gap and new-onset stroke (odds ratio [OR] = 1.05, p < 0.01). Furthermore, compared to participants with a non-positive HeartAge-gap, those with HeartAge-gaps of 0-5 years and ≥5 years exhibited significantly increased risks of stroke by 74% and 141%, respectively. Subgroup analyses and interaction tests identified a significant gender interaction in the association between HeartAge-gap and stroke, indicating that men with accelerated heart age represent a vulnerable subgroup. Restricted cubic splines (RCSs) confirmed a linear association, and sensitivity analyses validated the robustness of these findings. Integrating these intuitive indicators into clinical practice could facilitate primary stroke prevention and mitigate CKM syndrome progression.</p>","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":"28 4","pages":"e70256"},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: \"Reducing the Risk of Developing Diabetes: The Role of Angiotensin Receptor Blockers and Angiotensin Converting Enzyme Inhibitors in Patients With Hypertension Combined Prediabetes\".","authors":"Sabika Ayesha, Sundas Ishtiaq, Mohammad Ibtihaj Ali, Noor Ul Huda","doi":"10.1111/jch.70121","DOIUrl":"10.1111/jch.70121","url":null,"abstract":"","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":"27 8","pages":"e70121"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144802447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact Factors for Trajectories of Medication and Healthy Lifestyle Adherence in Young Adults With Hypertension: A Mixed Methods Study.","authors":"Xiang Fang, Yu Jia, Yiheng Zhou, Ziyu Yang, Ru Guo, Yu Cheng, Yonglang Cheng, Rui Zeng, Zhi Wan, Qian Zhao, Dongze Li, Bo Yuan, Rong Yang, Can Shen, Xiaoyang Liao","doi":"10.1111/jch.70107","DOIUrl":"10.1111/jch.70107","url":null,"abstract":"<p><p>Treatment adherence is a cornerstone of effective hypertension management. However, the dynamic patterns of adherence and their influencing factors among young Chinese adults with hypertension remain insufficiently understood. This study aimed to explore the trajectories of medication adherence and healthy lifestyle behaviors, as well as the associated influencing factors, in this population. A mixed methods design was employed. First, a prospective cohort of 89 young hypertensive patients was established. Adherence was assessed using guideline-recommended questionnaires from the 2018 Chinese Hypertension Guidelines at the 3rd and 6th months of follow-up. Medication adherence was categorized as low, moderate, or high. The healthy lifestyle adherence score encompassed six dimensions: diet, salt intake, alcohol consumption, smoking status, physical activity, and weight control. Second, semi-structured interviews based on the Health Belief Model were conducted to identify factors influencing adherence. Qualitative data were coded accordingly. During follow-up, 28.07% of participants exhibited a decline in medication adherence, whereas 19.30% showed improvement. For healthy lifestyle adherence, 46.07% declined and 22.47% improved. Baseline characteristics did not differ significantly across different adherence trajectory groups (p > 0.05). A total of 27 and 36 individuals participated in interviews regarding medication and lifestyle adherence, yielding 553 and 878 codes, respectively. Social, environmental, and patient-related factors accounted for 73% and 85% of these codes, respectively. The most frequently reported influencing factors included reminders and encouragement from family members, childcare responsibilities, occupational demands, social obligations, and awareness of hypertension. In conclusion, young adults with hypertension commonly experience fluctuations in both medication and lifestyle adherence. These variations are predominantly influenced by a combination of social, environmental, and individual-level factors. Trial Registration: Chinese Clinical Trial Registry (https://www.chictr.org.cn/): ChiCTR2000033434.</p>","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":"27 8","pages":"e70107"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144802446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Pressure and Hypertension in Adolescents and Young Adults: Results From a Nationwide Screening Program.","authors":"Wesley Teck Wee Loo, Wilbert Hsien Hao Ho, Daniel Yan Zheng Lim, Nishanth Thiagarajan, Wee Kiat Ang, Jonathan Yong Jun Han, Shen Goy, Gerald Gui Ren Sng, Lian Kiat Lim, Huai Yang Lim","doi":"10.1111/jch.70075","DOIUrl":"10.1111/jch.70075","url":null,"abstract":"<p><p>Literature on blood pressure (BP) norms in the adolescent and young adult (AYA) population remains sparse compared to adults. This study aims to describe the BP norms, prevalence of undiagnosed hypertension, and associations with demographic and anthropometric data among asymptomatic Asian AYA males. We studied retrospective cross-sectional data from individuals attending a national centralized BP screening program for enlistment over 30 months. Each individual's initial office BP reading was used to determine the cohort's BP norms. Individuals with a high reading, defined as systolic ≥140 mmHg and/or diastolic ≥90 mmHg, repeated office BP at a separate office visit. Those demonstrating two high readings underwent 24-h ambulatory BP (ABP) measurement. 49 033 males of median age 18.1 years were studied. The median, 75th centile, and 95th centile initial visit office BP readings were 121/74, 130/81, and 139/89 mmHg. 302 (0.62%; 95% CI, 0.55-0.69) were diagnosed with hypertension by office BP criteria. 270 underwent ABP measurement-180 (0.37%; 95% CI, 0.31-0.42) and 239 (0.49%; 95% CI, 0.43-0.55) had hypertension by ESC/ESH and ACC/AHA criteria, respectively. Higher weight, body mass index (BMI), and body fat percentage were associated with hypertension. The prevalence of undiagnosed hypertension among Asian AYA males is <1%. Norm-based cut-offs for high BP yielded absolute-value cut-offs similar to those recommended by adult guidelines; the 95th centile corresponded closely to 140/90 mmHg. Given similar diagnostic cut-offs with both norm-based and absolute-value approaches, both methods may be adopted. Focused screening of subgroups at higher risk of hypertension, such as obese individuals, may be considered in resource-limited settings.</p>","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":"27 8","pages":"e70075"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144802445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-pill combination of cilnidipine, an l-/n-type calcium channel blocker, and valsartan reduces the day-by-day variability of morning home systolic blood pressure in patients with treated hypertension: A sub-analysis of the HOPE-combi survey.","authors":"Kazuomi Kario,&nbsp;Saori Matsuda,&nbsp;Shinobu Nagahama,&nbsp;Yoshiki Kurose,&nbsp;Hitoshi Sugii,&nbsp;Tsukasa Teshima,&nbsp;Noriyuki Suzuki","doi":"10.1111/jch.14178","DOIUrl":"https://doi.org/10.1111/jch.14178","url":null,"abstract":"<p><p>We examined the effects of a fixed-dose single-pill combination of cilnidipine (10 mg), an L-/N-type calcium channel blocker, and valsartan (80 mg) (SPC of Cil/Val) on the day-by-day variability of morning home systolic blood pressure (MHSBP) in 616 patients with treated hypertension for 12 months as a sub-analysis of the HOPE-Combi survey, multicentral, post-marketing, and prospective observational survey. The SPC of Cil/Val was administrated once a day in the morning. The SPC of Cil/Val decreased the standard deviation (SD, from 6.3 ± 4.8 to 5.1 ± 3.8 mmHg, p < .01), coefficient of variation (from 4.3 ± 3.2 to 3.8 ± 2.9%, p < .05), average real variability (ARV, from 7.9 ± 6.6 to 6.3 ± 5.1 mmHg, p < .01), and the difference between maximum and minimum (MMD, from 11.9 ± 9.2 to 9.7 ± 7.2 mmHg, p < .01) of MHSBP. The variability of MHSBP increased with age; however, this was not increased in patients ≥70 years at the baseline. In elderly patients (≥70 years, N = 283), the SPC of Cil/Val decreased the SD (from 6.9 ± 5.6 to 5.6 ± 4.4 mmHg, p < .01), ARV (from 8.6 ± 7.7 to 6.9 ± 5.7 mmHg, p < .05), and MMD (from 13.2 ± 10.7 to 10.7 ± 8.3 mmHg, p < .01) of MHSBP at 12 months; the reduction in these MHSBP variability parameters was comparable to that in adults <70 years. These results suggest that the SPC of Cil/Val is effective in reducing day-by-day variability of MHSBP in elderly patients.</p>","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":" ","pages":"392-397"},"PeriodicalIF":2.8,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jch.14178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38830418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microvascular changes at different stages of chronic kidney disease.","authors":"Dennis Kannenkeril,&nbsp;Shaun Frost,&nbsp;Janis M Nolde,&nbsp;Márcio Galindo Kiuchi,&nbsp;Revathy Carnagarin,&nbsp;Leslie Marisol Lugo-Gavidia,&nbsp;Justine Chan,&nbsp;Anu Joyson,&nbsp;Vance B Matthews,&nbsp;Lakshini Y Herat,&nbsp;Omar Azzam,&nbsp;Maryam Mehdizadeh,&nbsp;Janardhan Vignarajan,&nbsp;Yogesan Kanagasingam,&nbsp;Markus P Schlaich","doi":"10.1111/jch.14138","DOIUrl":"https://doi.org/10.1111/jch.14138","url":null,"abstract":"<p><p>Patients with progressing chronic kidney disease (CKD) are more likely to experience cardio- and cerebrovascular events than progressing to end-stage renal disease. The authors explored whether retinal microvascular calibers differed with the degree of renal impairment and between the standard and extended optic disk and may serve as a simple additional tool for risk stratification in this highly vulnerable patient cohort. The authors analyzed central retinal arteriolar and venular equivalent calibers (CRAE, CRVE) at different retinal zones (zone B&C) using digital retinal imaging in hypertensive patients with stage 2 (n = 66) or stage 3 CKD (n = 30). Results were adjusted for age, sex, HbA1c, and 24-hour diastolic blood pressure. Mean eGFR was 77.7 ± 8.9 and 48.8 ± 7.9 ml/min/1.73 m² for stage 2 and 3 CKD, respectively. CRAE and CRVE in zones B and C were significantly lower in patients with stage 3 CKD compared to patients with stage 2 CKD (CRAE-B:141.1 ± 21.4 vs. 130.5 ± 18.9 µm, p = .030; CRAE-C:137.4 ± 19.4 vs 129.2 ± 18.2 µm, p = .049; CRVE-B:220.8 ± 33.0 vs. 206.0 ± 28.4 µm, p = .004; and CRVE-C:215.9 ± 33.0 vs. 201.2 ± 25.1µm, p = .003). In patients with stage 2 CKD, CRAE-B was higher than CRAE-C (141.1 ± 21.4 vs. 137.4 ± 19.4µm, p < .001). In contrast, such a difference was not found in patients with stage 3 CKD. CRAE of both retinal zones correlated with eGFR for the entire cohort. In patients with stage 3 CKD, retinal narrowing is more pronounced compared to patients with stage 2 CKD. Whether the novel observation of difference in arteriolar caliber between zones B and C in stage 2 CKD could serve as an early marker of CKD progression warrants further investigation.</p>","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":" ","pages":"309-316"},"PeriodicalIF":2.8,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jch.14138","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38727991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relaxing music reduces blood pressure and heart rate among pre-hypertensive young adults: A randomized control trial.","authors":"Imtiyaz Ali Mir,&nbsp;Moniruddin Chowdhury,&nbsp;Rabiul Md Islam,&nbsp;Goh Yee Ling,&nbsp;Alauddin A B M Chowdhury,&nbsp;Zobaer Md Hasan,&nbsp;Yukihito Higashi","doi":"10.1111/jch.14126","DOIUrl":"https://doi.org/10.1111/jch.14126","url":null,"abstract":"<p><p>Prevalence of pre-hypertension is higher among young adults and may increase the risk for hypertension and cardiovascular morbidity. Music therapy has been investigated to reduce the blood pressure in the hypertensive population; however, its efficacy on blood pressure in pre-hypertensive young adults is not known. Thirty pre-hypertensive (systolic blood pressure [SBP] = 120-139 mmHg and diastolic blood pressure [DBP] = 80-89 mmHg) young adults were recruited and randomly assigned into two groups. Music group (N = 15) received music therapy by passive listening to music for 30 minutes/day, 5 days/week for 4 weeks, along with Dietary Approaches to Stop Hypertension (DASH) eating plan (a diet rich in fruits and vegetables, low-fat dairy or unsaturated fat) and limit the daily sodium intake less than 100 mmol/day. The control group (N = 15) practiced only DASH eating plan and sodium restriction. The SBP, DBP, and heart rate (HR) were measured before and after 4 weeks of intervention. There was a significant reduction in SBP (8.73 mmHg, p < .001) and HR (6.42 beats/minute, p = .002); however, the reduction in DBP (1.44 mmHg, p = .101) was not statistically significant in the music group. Control group did not exhibit any significant reduction in SBP (0.21 mmHg, p < .836), DBP (0.81 mmHg, p < .395) and HR (0.09 beats/minute, p < .935). In conclusion, music therapy reduced significantly SBP and HR suggesting that it could be a promising tool to prevent the progression of pre-hypertension toward hypertension among young adults.</p>","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":" ","pages":"317-322"},"PeriodicalIF":2.8,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jch.14126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38734353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between small and dense low-density lipoprotein cholesterol and cardiovascular events in Beijing community population.","authors":"Xiaona Wang,&nbsp;Liang Wang,&nbsp;Ruihua Cao,&nbsp;Xu Yang,&nbsp;Wenkai Xiao,&nbsp;Yun Zhang,&nbsp;Ping Ye","doi":"10.1111/jch.14150","DOIUrl":"https://doi.org/10.1111/jch.14150","url":null,"abstract":"<p><p>The relationship between small dense low-density lipoprotein cholesterol (sdLDL-C) and different cardiovascular events has been observed in several large community studies, and the results have been controversial. However, there is currently no cross-sectional or longitudinal follow-up study on sdLDL-C in the Chinese hypertension population. We analyzed the association of plasma sdLDL-C levels with major adverse cardiovascular events in 1325 subjects from a longitudinal follow-up community-based population in Beijing, China. During the follow-up period, a total of 191 subjects had MACEs. Cox regression analysis showed that sdLDL-C is a major risk factor for MACEs independent of sex, age, BMI, hypertension, diabetes, smoking, SBP, DBP, FBG, eGFR in the general community population (1.013 (1.001 -1.025, P < .05)), but the correlation disappeared after adjusting for TC and HDL-C in Model 3. Cox analysis showed that hypertension combined with high level of sdLDL-C was still the risk factor for MACEs ((2.079 (1.039-4.148)). Our findings in the Chinese cohort support that sdLDL-C is a risk factor for major adverse cardiovascular events in hypertension subjects.</p>","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":" ","pages":"345-351"},"PeriodicalIF":2.8,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jch.14150","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38848142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between aspirin use and cardiovascular outcomes in ALLHAT participants with and without chronic kidney disease: A post hoc analysis.","authors":"Niraj Desai,&nbsp;Brigid Wilson,&nbsp;Michael Bond,&nbsp;Alexander Conant,&nbsp;Mahboob Rahman","doi":"10.1111/jch.14091","DOIUrl":"https://doi.org/10.1111/jch.14091","url":null,"abstract":"<p><p>It is unclear whether aspirin is beneficial for prevention of CVD in patients with CKD. We performed a secondary analysis of the ALLHAT trial to assess the effect of baseline aspirin use on nonfatal myocardial infarction (MI) or fatal coronary heart disease (CHD), all-cause mortality, and stroke. Baseline characteristics of aspirin users and nonusers were used to generate propensity-matched cohorts. Using conditional Cox proportional hazard regression models, we examined the effect of aspirin on the outcomes in the cohort at large and across 3 levels of kidney function (eGFR ≥90, 60-89, and <60). 11 250 ALLHAT participants reported using aspirin at baseline. The propensity-matched dataset included 6894 nonusers matched with replacement to achieve a balanced analysis population (n = 22 500). Risk of fatal CHD or nonfatal MI (HR = 0.94, 95% CI 0.86-1.02) and stroke (HR = 1.01, 95% CI 0.89-1.15) was not significantly different between groups. Aspirin users were at significantly lower risk of all-cause mortality compared to nonusers (HR = 0.82, 95% CI 0.76-0.88). Aspirin use was not associated with incidence of fatal CAD or nonfatal MI in patients with CVD (HR = 0.93, CI 0.84-1.04) or without CVD at baseline (HR = 1.04, CI 0.82-1.32). Results were consistent across strata of GFR (interaction p value NS). In hypertensive patients at high cardiovascular risk, aspirin use is not associated with risk of nonfatal MI, fatal CHD, or stroke; however, aspirin use is associated with lower risk of all-cause mortality. These results are consistent across baseline eGFR.</p>","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":" ","pages":"352-362"},"PeriodicalIF":2.8,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jch.14091","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38728629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of thyroid hormones with blood pressure and arterial stiffness in the general population: The Dali study.","authors":"Md Tasneem Jamal,&nbsp;Qing-Lu Li,&nbsp;Qi-Yan Li,&nbsp;Wan-Ying Liang,&nbsp;Li-Hong Wang,&nbsp;Jian-Hang Wei,&nbsp;Quan Liang,&nbsp;Nai-Qing Hu,&nbsp;Li-Hua Li","doi":"10.1111/jch.14154","DOIUrl":"https://doi.org/10.1111/jch.14154","url":null,"abstract":"<p><p>Thyroid dysfunction plays a role in blood pressure (BP) regulation. However, the associations between thyroid function and BP and arterial stiffness in the general Chinese population without thyroid disease are unknown. This population-based cross-sectional study aimed to investigate the association between thyroid function and peripheral and central BP and arterial stiffness in Chinese individuals. After excluding those who had thyroid diseases or incomplete clinical measurements, this study included 691 participants. Of the participants, 444 (64.2%) were women and 215 (31.1%) had hypertension. After adjustment for covariates, serum FT3 was significantly associated with a higher pulse rate in both sexes. In men, each 2.72-fold increase in serum FT4 levels was associated with higher peripheral systolic BP (+10.82 mmHg, p = .005) and pulse pressure (+5.71 mmHg, p = .03). Each 2.72-fold increase in serum FT4 levels was associated with higher central systolic BP (+8.03 mmHg, p = .03) and pulse pressure (+3.89 mmHg, p = .05). In women, serum FT4 was only associated with a higher central pulse pressure (+2.96 mmHg, p = .04). After adjustment for covariates, serum FT4 was significantly associated with a faster cfPWV exclusively in men. Our study showed that serum FT4 is associated with higher peripheral and central BP and faster cfPWV in men, whereas serum FT3 is positively associated with a higher pulse rate in both sexes, indicating that the effects of thyroid function on BP and arterial stiffness are more significant in men than in women.</p>","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":" ","pages":"363-372"},"PeriodicalIF":2.8,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jch.14154","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38757284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}