Journal of clinical hypertension (Greenwich, Conn.)最新文献

{"title":"Associations of Neprilysin and Its Coding Gene Variation With Hypertension in Chinese Adults.","authors":"Junting Hu, Jing Duan, Jiexiang Jing, Qiu Zhang, Xianfeng Yu, Rongyan Zhang, Yuting Jia, Mingzhe Du, Penghao Wang, Xueyang Zhang, Yibing Jin, Xiangdong Yang, Mingzhi Zhang, Hao Peng, Yun Shen","doi":"10.1111/jch.70260","DOIUrl":"10.1111/jch.70260","url":null,"abstract":"<p><p>Neprilysin (NEP) degrades several vasoactive peptides and may contribute to blood pressure maintenance. This study aims to examine the associations between serum NEP levels and variants at its coding gene and hypertension in a general Chinese population. Leveraging the baseline blood specimens of the Gusu cohort, serum NEP was assayed, and 14 single-nucleotide polymorphisms (SNPs) in the MME gene were genotyped (10 passed the Hardy-Weinberg equilibrium test) by MassArray for 2286 participants (mean age 52 years, 61.4% females). The associations of serum NEP and SNPs with hypertension were examined by logistic regression. Major conventional risk factors, including lifestyle and metabolic factors, were adjusted for. We found that participants with a higher level of serum NEP were more likely to have prevalent hypertension (OR = 1.07, 95%CI: 1.02-1.13, p = 0.006 for log2-transformed NEP). The SNP rs9864287 was associated with hypertension susceptibility (P < 0.05), but this association was not significant after correction for multiple comparisons. These results suggested that there was a weak association between serum NEP and hypertension in Chinese adults, independent of conventional risk factors. The role of NEP in hypertension remains to be elucidated.</p>","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":"28 4","pages":"e70260"},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13091957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147719345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertensive Urgency: Which Patient Will be Fine in a Quiet Room?","authors":"Goran Koracevic, Milovan Stojanovic","doi":"10.1111/jch.70258","DOIUrl":"10.1111/jch.70258","url":null,"abstract":"","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":"28 4","pages":"e70258"},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13082211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Incidence of Abdominal Obesity and Cardiometabolic Risk in Early Adolescence.","authors":"Augusto César F De Moraes, Tiago A Oliveira, John Virostko, Marcus V Nascimento-Ferreira, Ethan T Hunt","doi":"10.1111/jch.70254","DOIUrl":"10.1111/jch.70254","url":null,"abstract":"<p><p>Abdominal obesity and related cardiometabolic risk (CMR) factors frequently begin in adolescence and contribute to long‑term health burden, yet longitudinal trajectories in U.S. youth are poorly characterized. This study quantifies the prevalence and 2‑ and 4‑year incidence of emerging CMR, with emphasis on excess adiposity, in a diverse adolescent cohort. We analyzed longitudinal data from the Adolescent Brain Cognitive Development Study, collected at three time points: 2018-2020 (mean age, 12.1 years), 2020-2022 (mean age, 14.2 years), and 2022-2024 (mean age, 16.1 years). Adolescents (n = 4788 to 3313) with anthropometric and laboratory data were included. Abdominal obesity was defined as a waist-to-height ratio > 0.5. Additional CMR factors included elevated total cholesterol (≥ 145 mg/dL), glycated hemoglobin (HbA1c ≥ 5.7%), and high blood pressure (≥ 95th percentile for age, sex, and height). Weighted prevalence and 2- and 4-year incidence were calculated. At baseline, abdominal obesity affected 38.4% (95% CI: 36.4%-40.4%), followed by elevated cholesterol (17.6%), HbA1c (8.7%), and blood pressure (3.0%). Over a four-year period, new-onset abdominal obesity occurred in 10.5% of individuals, compared with 15.4% for cholesterol, 4.7% for HbA1c, and 3.1% for blood pressure. The steepest CMR progression was observed for lipid and adiposity markers. Abdominal obesity is highly prevalent by early adolescence, and new cardiometabolic risk develops rapidly, particularly for adiposity and dyslipidemia. These results highlight the need for early obesity screening and interventions to mitigate long‑term cardiometabolic risk in youth.</p>","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":"28 4","pages":"e70254"},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147795065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe Hypertension and Hematologic Abnormalities in Pseudoxanthoma Elasticum: A Pediatric Case Report.","authors":"Hana Flogelova, Dagmar Pospisilova, Lenka Bakaj-Zbrozkova, Lucie Sochorcova, Jirina Manakova, Eva Kriegova, Pavla Koralkova, Katarina Hlusickova Kapralova, Monika Horvathova","doi":"10.1111/jch.70249","DOIUrl":"10.1111/jch.70249","url":null,"abstract":"<p><p>Pseudoxanthoma elasticum (PXE) is a rare autosomal recessive disorder caused by pathogenic variants in ABCC6, leading to progressive calcification of elastic fibers. Although PXE typically presents in adolescence with dermatologic or ocular manifestations, early vascular involvement, including pediatric hypertension, is increasingly recognized. We report a 3-year-old boy referred for evaluation of persistent erythrocytosis of unclear etiology. Clinical, biochemical, and hematologic assessments revealed intermittent reticulocytosis, normal oxygen saturation, and suppressed/normal erythropoietin levels. Long-term zinc supplementation initiated in infancy for suspected dermatitis enteropathica preceded the onset of erythrocytosis. At age eight, severe systemic hypertension was diagnosed together with medullary nephrocalcinosis and splenic and pancreatic calcifications. Imaging excluded renal artery stenosis. Whole-exome sequencing identified compound heterozygous pathogenic ABCC6 variants, establishing the diagnosis of PXE. Ophthalmologic examination revealed peau d'orange. Blood pressure control required combination antihypertensive therapy and was associated with partial normalization of red blood cell (RBC) parameters and a marked increase in plasma renin activity. RBC enzymatic profiling demonstrated metabolic adaptations consistent with oxidative stress. This case illustrates an unusual clinical presentation of PXE in early childhood. We propose that erythrocytosis, potentially promoted by zinc supplementation, may have contributed to early vascular stress and hypertension. Later, renal microvascular calcification and renin-angiotensin-aldosterone system activation may have contributed to the persistence of elevated RBC counts despite low erythropoietin. These observations suggest that PXE may be considered in the differential diagnosis of children with unexplained hypertension, particularly when additional systemic findings are present.</p>","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":"28 4","pages":"e70249"},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13082210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A National Hypertension Awareness and Early Screening Initiative: \"Act at 30 - It's Time for Heart Check\".","authors":"Uday M Jadhav, Tiny Nair, Jabir Abdullakutty, Rajeev Garg, T Govindan Unni, Smit Shrivastava, Rajeev Agarwala, P P Mohanan, Sandip Mitra","doi":"10.1111/jch.70203","DOIUrl":"10.1111/jch.70203","url":null,"abstract":"<p><p>India is witnessing a growing burden of early-onset hypertension and cardiovascular disease, particularly among adults under the age of 40. Despite this trend, current national screening programs predominantly target individuals over 40, resulting in a significant gap in early detection and prevention efforts. This white paper addresses this gap by drawing on a mixed-methods approach that combines an extensive review of national and international literature, health surveys, and hypertension guidelines with qualitative insights from 25 expert consultations. These consultations included cardiologists, endocrinologists, and public health specialists, and were conducted through structured one-on-one interviews and focused group discussions. The findings revealed that nearly 25% of Indian adults aged 30-39 are already hypertensive or pre-hypertensive, with lifestyle-related risk factors such as chronic stress, unhealthy diets, physical inactivity, and obesity contributing to early cardiovascular risk. Experts unanimously emphasized the widespread underdiagnosis and lack of awareness in this age group, highlighting missed opportunities for early intervention. A strong consensus emerged around the urgent need to lower the current screening threshold to age 30 and introduce first-time cardiovascular assessments, including blood pressure, glucose, lipid profiles, and obesity metrics at this stage. The paper argues that implementing early screening through existing health infrastructure, workplace wellness initiatives, and digital health platforms is both epidemiologically sound and economically viable. A national policy shift in this direction could significantly improve early detection, reduce disease burden, and enhance long-term health outcomes for the Indian population.</p>","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":"28 4","pages":"e70203"},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147795077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Biological Age and Heart Age Accelerations With New-Onset Stroke in Individuals With Cardiovascular-Kidney-Metabolic Syndrome Stages 0-3: Evidence From a Chinese Longitudinal Study.","authors":"Hao Zhu, Hannah Lui, Li He, Jing Zhang, Zhi Jin","doi":"10.1111/jch.70256","DOIUrl":"10.1111/jch.70256","url":null,"abstract":"<p><p>Individuals with cardiovascular-kidney-metabolic (CKM) syndrome face an elevated risk of stroke, yet effective risk stratification indicators remain limited. This prospective study aims to investigate the associations of biological age acceleration (BioAge-gap) and heart age acceleration (HeartAge-gap) with new-onset stroke in individuals with CKM syndrome Stages 0-3, utilizing data from the China Health and Retirement Longitudinal Study (CHARLS) collected between 2015 and 2020. Baseline BioAge-gap and HeartAge-gap were calculated via the Klemera-Doubal method (KDM) and Framingham risk score (FRS), respectively. The primary outcome was self-reported physician-diagnosed stroke identified during the 2018 and 2020 follow-ups. Analysis of 7283 eligible participants aged 45-75 years revealed a positive association between BioAge-gap and new-onset stroke (odds ratio [OR] = 1.05, p < 0.01). Furthermore, compared to participants with a non-positive HeartAge-gap, those with HeartAge-gaps of 0-5 years and ≥5 years exhibited significantly increased risks of stroke by 74% and 141%, respectively. Subgroup analyses and interaction tests identified a significant gender interaction in the association between HeartAge-gap and stroke, indicating that men with accelerated heart age represent a vulnerable subgroup. Restricted cubic splines (RCSs) confirmed a linear association, and sensitivity analyses validated the robustness of these findings. Integrating these intuitive indicators into clinical practice could facilitate primary stroke prevention and mitigate CKM syndrome progression.</p>","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":"28 4","pages":"e70256"},"PeriodicalIF":2.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147725489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: \"Reducing the Risk of Developing Diabetes: The Role of Angiotensin Receptor Blockers and Angiotensin Converting Enzyme Inhibitors in Patients With Hypertension Combined Prediabetes\".","authors":"Sabika Ayesha, Sundas Ishtiaq, Mohammad Ibtihaj Ali, Noor Ul Huda","doi":"10.1111/jch.70121","DOIUrl":"10.1111/jch.70121","url":null,"abstract":"","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":"27 8","pages":"e70121"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331878/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144802447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact Factors for Trajectories of Medication and Healthy Lifestyle Adherence in Young Adults With Hypertension: A Mixed Methods Study.","authors":"Xiang Fang, Yu Jia, Yiheng Zhou, Ziyu Yang, Ru Guo, Yu Cheng, Yonglang Cheng, Rui Zeng, Zhi Wan, Qian Zhao, Dongze Li, Bo Yuan, Rong Yang, Can Shen, Xiaoyang Liao","doi":"10.1111/jch.70107","DOIUrl":"10.1111/jch.70107","url":null,"abstract":"<p><p>Treatment adherence is a cornerstone of effective hypertension management. However, the dynamic patterns of adherence and their influencing factors among young Chinese adults with hypertension remain insufficiently understood. This study aimed to explore the trajectories of medication adherence and healthy lifestyle behaviors, as well as the associated influencing factors, in this population. A mixed methods design was employed. First, a prospective cohort of 89 young hypertensive patients was established. Adherence was assessed using guideline-recommended questionnaires from the 2018 Chinese Hypertension Guidelines at the 3rd and 6th months of follow-up. Medication adherence was categorized as low, moderate, or high. The healthy lifestyle adherence score encompassed six dimensions: diet, salt intake, alcohol consumption, smoking status, physical activity, and weight control. Second, semi-structured interviews based on the Health Belief Model were conducted to identify factors influencing adherence. Qualitative data were coded accordingly. During follow-up, 28.07% of participants exhibited a decline in medication adherence, whereas 19.30% showed improvement. For healthy lifestyle adherence, 46.07% declined and 22.47% improved. Baseline characteristics did not differ significantly across different adherence trajectory groups (p > 0.05). A total of 27 and 36 individuals participated in interviews regarding medication and lifestyle adherence, yielding 553 and 878 codes, respectively. Social, environmental, and patient-related factors accounted for 73% and 85% of these codes, respectively. The most frequently reported influencing factors included reminders and encouragement from family members, childcare responsibilities, occupational demands, social obligations, and awareness of hypertension. In conclusion, young adults with hypertension commonly experience fluctuations in both medication and lifestyle adherence. These variations are predominantly influenced by a combination of social, environmental, and individual-level factors. Trial Registration: Chinese Clinical Trial Registry (https://www.chictr.org.cn/): ChiCTR2000033434.</p>","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":"27 8","pages":"e70107"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144802446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Pressure and Hypertension in Adolescents and Young Adults: Results From a Nationwide Screening Program.","authors":"Wesley Teck Wee Loo, Wilbert Hsien Hao Ho, Daniel Yan Zheng Lim, Nishanth Thiagarajan, Wee Kiat Ang, Jonathan Yong Jun Han, Shen Goy, Gerald Gui Ren Sng, Lian Kiat Lim, Huai Yang Lim","doi":"10.1111/jch.70075","DOIUrl":"10.1111/jch.70075","url":null,"abstract":"<p><p>Literature on blood pressure (BP) norms in the adolescent and young adult (AYA) population remains sparse compared to adults. This study aims to describe the BP norms, prevalence of undiagnosed hypertension, and associations with demographic and anthropometric data among asymptomatic Asian AYA males. We studied retrospective cross-sectional data from individuals attending a national centralized BP screening program for enlistment over 30 months. Each individual's initial office BP reading was used to determine the cohort's BP norms. Individuals with a high reading, defined as systolic ≥140 mmHg and/or diastolic ≥90 mmHg, repeated office BP at a separate office visit. Those demonstrating two high readings underwent 24-h ambulatory BP (ABP) measurement. 49 033 males of median age 18.1 years were studied. The median, 75th centile, and 95th centile initial visit office BP readings were 121/74, 130/81, and 139/89 mmHg. 302 (0.62%; 95% CI, 0.55-0.69) were diagnosed with hypertension by office BP criteria. 270 underwent ABP measurement-180 (0.37%; 95% CI, 0.31-0.42) and 239 (0.49%; 95% CI, 0.43-0.55) had hypertension by ESC/ESH and ACC/AHA criteria, respectively. Higher weight, body mass index (BMI), and body fat percentage were associated with hypertension. The prevalence of undiagnosed hypertension among Asian AYA males is <1%. Norm-based cut-offs for high BP yielded absolute-value cut-offs similar to those recommended by adult guidelines; the 95th centile corresponded closely to 140/90 mmHg. Given similar diagnostic cut-offs with both norm-based and absolute-value approaches, both methods may be adopted. Focused screening of subgroups at higher risk of hypertension, such as obese individuals, may be considered in resource-limited settings.</p>","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":"27 8","pages":"e70075"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144802445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-pill combination of cilnidipine, an l-/n-type calcium channel blocker, and valsartan reduces the day-by-day variability of morning home systolic blood pressure in patients with treated hypertension: A sub-analysis of the HOPE-combi survey.","authors":"Kazuomi Kario,&nbsp;Saori Matsuda,&nbsp;Shinobu Nagahama,&nbsp;Yoshiki Kurose,&nbsp;Hitoshi Sugii,&nbsp;Tsukasa Teshima,&nbsp;Noriyuki Suzuki","doi":"10.1111/jch.14178","DOIUrl":"https://doi.org/10.1111/jch.14178","url":null,"abstract":"<p><p>We examined the effects of a fixed-dose single-pill combination of cilnidipine (10 mg), an L-/N-type calcium channel blocker, and valsartan (80 mg) (SPC of Cil/Val) on the day-by-day variability of morning home systolic blood pressure (MHSBP) in 616 patients with treated hypertension for 12 months as a sub-analysis of the HOPE-Combi survey, multicentral, post-marketing, and prospective observational survey. The SPC of Cil/Val was administrated once a day in the morning. The SPC of Cil/Val decreased the standard deviation (SD, from 6.3 ± 4.8 to 5.1 ± 3.8 mmHg, p < .01), coefficient of variation (from 4.3 ± 3.2 to 3.8 ± 2.9%, p < .05), average real variability (ARV, from 7.9 ± 6.6 to 6.3 ± 5.1 mmHg, p < .01), and the difference between maximum and minimum (MMD, from 11.9 ± 9.2 to 9.7 ± 7.2 mmHg, p < .01) of MHSBP. The variability of MHSBP increased with age; however, this was not increased in patients ≥70 years at the baseline. In elderly patients (≥70 years, N = 283), the SPC of Cil/Val decreased the SD (from 6.9 ± 5.6 to 5.6 ± 4.4 mmHg, p < .01), ARV (from 8.6 ± 7.7 to 6.9 ± 5.7 mmHg, p < .05), and MMD (from 13.2 ± 10.7 to 10.7 ± 8.3 mmHg, p < .01) of MHSBP at 12 months; the reduction in these MHSBP variability parameters was comparable to that in adults <70 years. These results suggest that the SPC of Cil/Val is effective in reducing day-by-day variability of MHSBP in elderly patients.</p>","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":" ","pages":"392-397"},"PeriodicalIF":2.8,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jch.14178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38830418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}