Journal of clinical hypertension (Greenwich, Conn.)最新文献

Single-pill combination of cilnidipine, an l-/n-type calcium channel blocker, and valsartan reduces the day-by-day variability of morning home systolic blood pressure in patients with treated hypertension: A sub-analysis of the HOPE-combi survey. 西尼地平、l /n型钙通道阻滞剂和缬沙坦单片联合用药可降低高血压治疗患者家中早晨收缩压的逐日变异性:HOPE-combi调查的亚分析。

IF 2.8

Journal of clinical hypertension (Greenwich, Conn.) Pub Date : 2021-02-01 Epub Date: 2021-01-17 DOI: 10.1111/jch.14178

Kazuomi Kario, Saori Matsuda, Shinobu Nagahama, Yoshiki Kurose, Hitoshi Sugii, Tsukasa Teshima, Noriyuki Suzuki

{"title":"Single-pill combination of cilnidipine, an l-/n-type calcium channel blocker, and valsartan reduces the day-by-day variability of morning home systolic blood pressure in patients with treated hypertension: A sub-analysis of the HOPE-combi survey.","authors":"Kazuomi Kario, Saori Matsuda, Shinobu Nagahama, Yoshiki Kurose, Hitoshi Sugii, Tsukasa Teshima, Noriyuki Suzuki","doi":"10.1111/jch.14178","DOIUrl":"https://doi.org/10.1111/jch.14178","url":null,"abstract":"We examined the effects of a fixed-dose single-pill combination of cilnidipine (10 mg), an L-/N-type calcium channel blocker, and valsartan (80 mg) (SPC of Cil/Val) on the day-by-day variability of morning home systolic blood pressure (MHSBP) in 616 patients with treated hypertension for 12 months as a sub-analysis of the HOPE-Combi survey, multicentral, post-marketing, and prospective observational survey. The SPC of Cil/Val was administrated once a day in the morning. The SPC of Cil/Val decreased the standard deviation (SD, from 6.3 ± 4.8 to 5.1 ± 3.8 mmHg, p < .01), coefficient of variation (from 4.3 ± 3.2 to 3.8 ± 2.9%, p < .05), average real variability (ARV, from 7.9 ± 6.6 to 6.3 ± 5.1 mmHg, p < .01), and the difference between maximum and minimum (MMD, from 11.9 ± 9.2 to 9.7 ± 7.2 mmHg, p < .01) of MHSBP. The variability of MHSBP increased with age; however, this was not increased in patients ≥70 years at the baseline. In elderly patients (≥70 years, N = 283), the SPC of Cil/Val decreased the SD (from 6.9 ± 5.6 to 5.6 ± 4.4 mmHg, p < .01), ARV (from 8.6 ± 7.7 to 6.9 ± 5.7 mmHg, p < .05), and MMD (from 13.2 ± 10.7 to 10.7 ± 8.3 mmHg, p < .01) of MHSBP at 12 months; the reduction in these MHSBP variability parameters was comparable to that in adults <70 years. These results suggest that the SPC of Cil/Val is effective in reducing day-by-day variability of MHSBP in elderly patients.","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":" ","pages":"392-397"},"PeriodicalIF":2.8,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jch.14178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38830418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Microvascular changes at different stages of chronic kidney disease. 慢性肾脏疾病不同阶段的微血管变化。

IF 2.8

Journal of clinical hypertension (Greenwich, Conn.) Pub Date : 2021-02-01 Epub Date: 2020-12-19 DOI: 10.1111/jch.14138

Dennis Kannenkeril, Shaun Frost, Janis M Nolde, Márcio Galindo Kiuchi, Revathy Carnagarin, Leslie Marisol Lugo-Gavidia, Justine Chan, Anu Joyson, Vance B Matthews, Lakshini Y Herat, Omar Azzam, Maryam Mehdizadeh, Janardhan Vignarajan, Yogesan Kanagasingam, Markus P Schlaich

{"title":"Microvascular changes at different stages of chronic kidney disease.","authors":"Dennis Kannenkeril, Shaun Frost, Janis M Nolde, Márcio Galindo Kiuchi, Revathy Carnagarin, Leslie Marisol Lugo-Gavidia, Justine Chan, Anu Joyson, Vance B Matthews, Lakshini Y Herat, Omar Azzam, Maryam Mehdizadeh, Janardhan Vignarajan, Yogesan Kanagasingam, Markus P Schlaich","doi":"10.1111/jch.14138","DOIUrl":"https://doi.org/10.1111/jch.14138","url":null,"abstract":"Patients with progressing chronic kidney disease (CKD) are more likely to experience cardio- and cerebrovascular events than progressing to end-stage renal disease. The authors explored whether retinal microvascular calibers differed with the degree of renal impairment and between the standard and extended optic disk and may serve as a simple additional tool for risk stratification in this highly vulnerable patient cohort. The authors analyzed central retinal arteriolar and venular equivalent calibers (CRAE, CRVE) at different retinal zones (zone B&C) using digital retinal imaging in hypertensive patients with stage 2 (n = 66) or stage 3 CKD (n = 30). Results were adjusted for age, sex, HbA1c, and 24-hour diastolic blood pressure. Mean eGFR was 77.7 ± 8.9 and 48.8 ± 7.9 ml/min/1.73 m2 for stage 2 and 3 CKD, respectively. CRAE and CRVE in zones B and C were significantly lower in patients with stage 3 CKD compared to patients with stage 2 CKD (CRAE-B:141.1 ± 21.4 vs. 130.5 ± 18.9 µm, p = .030; CRAE-C:137.4 ± 19.4 vs 129.2 ± 18.2 µm, p = .049; CRVE-B:220.8 ± 33.0 vs. 206.0 ± 28.4 µm, p = .004; and CRVE-C:215.9 ± 33.0 vs. 201.2 ± 25.1µm, p = .003). In patients with stage 2 CKD, CRAE-B was higher than CRAE-C (141.1 ± 21.4 vs. 137.4 ± 19.4µm, p < .001). In contrast, such a difference was not found in patients with stage 3 CKD. CRAE of both retinal zones correlated with eGFR for the entire cohort. In patients with stage 3 CKD, retinal narrowing is more pronounced compared to patients with stage 2 CKD. Whether the novel observation of difference in arteriolar caliber between zones B and C in stage 2 CKD could serve as an early marker of CKD progression warrants further investigation.","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":" ","pages":"309-316"},"PeriodicalIF":2.8,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jch.14138","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38727991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Relaxing music reduces blood pressure and heart rate among pre-hypertensive young adults: A randomized control trial. 放松的音乐降低高血压前期年轻人的血压和心率:一项随机对照试验。

IF 2.8

Journal of clinical hypertension (Greenwich, Conn.) Pub Date : 2021-02-01 Epub Date: 2020-12-21 DOI: 10.1111/jch.14126

Imtiyaz Ali Mir, Moniruddin Chowdhury, Rabiul Md Islam, Goh Yee Ling, Alauddin A B M Chowdhury, Zobaer Md Hasan, Yukihito Higashi

{"title":"Relaxing music reduces blood pressure and heart rate among pre-hypertensive young adults: A randomized control trial.","authors":"Imtiyaz Ali Mir, Moniruddin Chowdhury, Rabiul Md Islam, Goh Yee Ling, Alauddin A B M Chowdhury, Zobaer Md Hasan, Yukihito Higashi","doi":"10.1111/jch.14126","DOIUrl":"https://doi.org/10.1111/jch.14126","url":null,"abstract":"Prevalence of pre-hypertension is higher among young adults and may increase the risk for hypertension and cardiovascular morbidity. Music therapy has been investigated to reduce the blood pressure in the hypertensive population; however, its efficacy on blood pressure in pre-hypertensive young adults is not known. Thirty pre-hypertensive (systolic blood pressure [SBP] = 120-139 mmHg and diastolic blood pressure [DBP] = 80-89 mmHg) young adults were recruited and randomly assigned into two groups. Music group (N = 15) received music therapy by passive listening to music for 30 minutes/day, 5 days/week for 4 weeks, along with Dietary Approaches to Stop Hypertension (DASH) eating plan (a diet rich in fruits and vegetables, low-fat dairy or unsaturated fat) and limit the daily sodium intake less than 100 mmol/day. The control group (N = 15) practiced only DASH eating plan and sodium restriction. The SBP, DBP, and heart rate (HR) were measured before and after 4 weeks of intervention. There was a significant reduction in SBP (8.73 mmHg, p < .001) and HR (6.42 beats/minute, p = .002); however, the reduction in DBP (1.44 mmHg, p = .101) was not statistically significant in the music group. Control group did not exhibit any significant reduction in SBP (0.21 mmHg, p < .836), DBP (0.81 mmHg, p < .395) and HR (0.09 beats/minute, p < .935). In conclusion, music therapy reduced significantly SBP and HR suggesting that it could be a promising tool to prevent the progression of pre-hypertension toward hypertension among young adults.","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":" ","pages":"317-322"},"PeriodicalIF":2.8,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jch.14126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38734353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Correlation between small and dense low-density lipoprotein cholesterol and cardiovascular events in Beijing community population. 北京社区人群低密度脂蛋白胆固醇与心血管事件的相关性研究

IF 2.8

Journal of clinical hypertension (Greenwich, Conn.) Pub Date : 2021-02-01 Epub Date: 2021-01-22 DOI: 10.1111/jch.14150

Xiaona Wang, Liang Wang, Ruihua Cao, Xu Yang, Wenkai Xiao, Yun Zhang, Ping Ye

{"title":"Correlation between small and dense low-density lipoprotein cholesterol and cardiovascular events in Beijing community population.","authors":"Xiaona Wang, Liang Wang, Ruihua Cao, Xu Yang, Wenkai Xiao, Yun Zhang, Ping Ye","doi":"10.1111/jch.14150","DOIUrl":"https://doi.org/10.1111/jch.14150","url":null,"abstract":"The relationship between small dense low-density lipoprotein cholesterol (sdLDL-C) and different cardiovascular events has been observed in several large community studies, and the results have been controversial. However, there is currently no cross-sectional or longitudinal follow-up study on sdLDL-C in the Chinese hypertension population. We analyzed the association of plasma sdLDL-C levels with major adverse cardiovascular events in 1325 subjects from a longitudinal follow-up community-based population in Beijing, China. During the follow-up period, a total of 191 subjects had MACEs. Cox regression analysis showed that sdLDL-C is a major risk factor for MACEs independent of sex, age, BMI, hypertension, diabetes, smoking, SBP, DBP, FBG, eGFR in the general community population (1.013 (1.001 -1.025, P < .05)), but the correlation disappeared after adjusting for TC and HDL-C in Model 3. Cox analysis showed that hypertension combined with high level of sdLDL-C was still the risk factor for MACEs ((2.079 (1.039-4.148)). Our findings in the Chinese cohort support that sdLDL-C is a risk factor for major adverse cardiovascular events in hypertension subjects.","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":" ","pages":"345-351"},"PeriodicalIF":2.8,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jch.14150","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38848142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Association between aspirin use and cardiovascular outcomes in ALLHAT participants with and without chronic kidney disease: A post hoc analysis. 有或无慢性肾脏疾病的ALLHAT参与者阿司匹林使用与心血管结局的关系:事后分析

IF 2.8

Journal of clinical hypertension (Greenwich, Conn.) Pub Date : 2021-02-01 Epub Date: 2020-12-19 DOI: 10.1111/jch.14091

Niraj Desai, Brigid Wilson, Michael Bond, Alexander Conant, Mahboob Rahman

{"title":"Association between aspirin use and cardiovascular outcomes in ALLHAT participants with and without chronic kidney disease: A post hoc analysis.","authors":"Niraj Desai, Brigid Wilson, Michael Bond, Alexander Conant, Mahboob Rahman","doi":"10.1111/jch.14091","DOIUrl":"https://doi.org/10.1111/jch.14091","url":null,"abstract":"It is unclear whether aspirin is beneficial for prevention of CVD in patients with CKD. We performed a secondary analysis of the ALLHAT trial to assess the effect of baseline aspirin use on nonfatal myocardial infarction (MI) or fatal coronary heart disease (CHD), all-cause mortality, and stroke. Baseline characteristics of aspirin users and nonusers were used to generate propensity-matched cohorts. Using conditional Cox proportional hazard regression models, we examined the effect of aspirin on the outcomes in the cohort at large and across 3 levels of kidney function (eGFR ≥90, 60-89, and <60). 11 250 ALLHAT participants reported using aspirin at baseline. The propensity-matched dataset included 6894 nonusers matched with replacement to achieve a balanced analysis population (n = 22 500). Risk of fatal CHD or nonfatal MI (HR = 0.94, 95% CI 0.86-1.02) and stroke (HR = 1.01, 95% CI 0.89-1.15) was not significantly different between groups. Aspirin users were at significantly lower risk of all-cause mortality compared to nonusers (HR = 0.82, 95% CI 0.76-0.88). Aspirin use was not associated with incidence of fatal CAD or nonfatal MI in patients with CVD (HR = 0.93, CI 0.84-1.04) or without CVD at baseline (HR = 1.04, CI 0.82-1.32). Results were consistent across strata of GFR (interaction p value NS). In hypertensive patients at high cardiovascular risk, aspirin use is not associated with risk of nonfatal MI, fatal CHD, or stroke; however, aspirin use is associated with lower risk of all-cause mortality. These results are consistent across baseline eGFR.","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":" ","pages":"352-362"},"PeriodicalIF":2.8,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jch.14091","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38728629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Association of thyroid hormones with blood pressure and arterial stiffness in the general population: The Dali study. 甲状腺激素与普通人群血压和动脉僵硬的关系:达利研究。

IF 2.8

Journal of clinical hypertension (Greenwich, Conn.) Pub Date : 2021-02-01 Epub Date: 2020-12-27 DOI: 10.1111/jch.14154

Md Tasneem Jamal, Qing-Lu Li, Qi-Yan Li, Wan-Ying Liang, Li-Hong Wang, Jian-Hang Wei, Quan Liang, Nai-Qing Hu, Li-Hua Li

{"title":"Association of thyroid hormones with blood pressure and arterial stiffness in the general population: The Dali study.","authors":"Md Tasneem Jamal, Qing-Lu Li, Qi-Yan Li, Wan-Ying Liang, Li-Hong Wang, Jian-Hang Wei, Quan Liang, Nai-Qing Hu, Li-Hua Li","doi":"10.1111/jch.14154","DOIUrl":"https://doi.org/10.1111/jch.14154","url":null,"abstract":"Thyroid dysfunction plays a role in blood pressure (BP) regulation. However, the associations between thyroid function and BP and arterial stiffness in the general Chinese population without thyroid disease are unknown. This population-based cross-sectional study aimed to investigate the association between thyroid function and peripheral and central BP and arterial stiffness in Chinese individuals. After excluding those who had thyroid diseases or incomplete clinical measurements, this study included 691 participants. Of the participants, 444 (64.2%) were women and 215 (31.1%) had hypertension. After adjustment for covariates, serum FT3 was significantly associated with a higher pulse rate in both sexes. In men, each 2.72-fold increase in serum FT4 levels was associated with higher peripheral systolic BP (+10.82 mmHg, p = .005) and pulse pressure (+5.71 mmHg, p = .03). Each 2.72-fold increase in serum FT4 levels was associated with higher central systolic BP (+8.03 mmHg, p = .03) and pulse pressure (+3.89 mmHg, p = .05). In women, serum FT4 was only associated with a higher central pulse pressure (+2.96 mmHg, p = .04). After adjustment for covariates, serum FT4 was significantly associated with a faster cfPWV exclusively in men. Our study showed that serum FT4 is associated with higher peripheral and central BP and faster cfPWV in men, whereas serum FT3 is positively associated with a higher pulse rate in both sexes, indicating that the effects of thyroid function on BP and arterial stiffness are more significant in men than in women.","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":" ","pages":"363-372"},"PeriodicalIF":2.8,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jch.14154","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38757284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Thyroid hormones regulate both cardiovascular and renal mechanisms underlying hypertension. 甲状腺激素调节高血压的心血管和肾脏机制。

IF 2.8

Journal of clinical hypertension (Greenwich, Conn.) Pub Date : 2021-02-01 Epub Date: 2020-12-29 DOI: 10.1111/jch.14152

Stanislovas S Jankauskas, Marco B Morelli, Jessica Gambardella, Angela Lombardi, Gaetano Santulli

引用次数: 4

Comparative effects of topiroxostat and febuxostat on arterial properties in hypertensive patients with hyperuricemia. 托吡司他与非布司他对高血压合并高尿酸血症患者动脉特性的影响比较。

IF 2.8

Journal of clinical hypertension (Greenwich, Conn.) Pub Date : 2021-02-01 Epub Date: 2021-01-05 DOI: 10.1111/jch.14153

Kazuomi Kario, Masafumi Nishizawa, Mari Kiuchi, Arihiro Kiyosue, Fumishi Tomita, Hiroshi Ohtani, Yasuhisa Abe, Hideyo Kuga, Satoshi Miyazaki, Takatoshi Kasai, Makiko Hongou, Takanori Yasu, Jin Kuramochi, Yoshihiro Fukumoto, Satoshi Hoshide, Ichiro Hisatome

{"title":"Comparative effects of topiroxostat and febuxostat on arterial properties in hypertensive patients with hyperuricemia.","authors":"Kazuomi Kario, Masafumi Nishizawa, Mari Kiuchi, Arihiro Kiyosue, Fumishi Tomita, Hiroshi Ohtani, Yasuhisa Abe, Hideyo Kuga, Satoshi Miyazaki, Takatoshi Kasai, Makiko Hongou, Takanori Yasu, Jin Kuramochi, Yoshihiro Fukumoto, Satoshi Hoshide, Ichiro Hisatome","doi":"10.1111/jch.14153","DOIUrl":"https://doi.org/10.1111/jch.14153","url":null,"abstract":"Elevated serum uric acid is a cardiovascular risk factor in patients with hypertension, even when blood pressure (BP) is well controlled. Xanthine oxidoreductase inhibitors (XORi) reduce serum uric acid levels and have several other potential effects. This multicenter, randomized, open-label study compared the effects of two XORi, topiroxostat and febuxostat, on arterial stiffness, uric acid levels, and BP in hypertensive patients with hyperuricemia. Patients received topiroxostat 40-160 mg/day or febuxostat 10-60 mg/day, titrated to maintain serum uric acid <6 mg/dl, for 24 weeks. The primary endpoint was change in the cardio-ankle vascular index (CAVI) from baseline to 24 weeks. There were no significant changes in CAVI from baseline to 24 weeks (from 9.13 to 9.16 [feboxustat] and 8.98 to 9.01 [topiroxostat]). Compared with baseline, there were significant reductions in serum uric acid (-2.9 and -2.5 mg/dl; both p < 0.001) and morning home systolic BP (-3.6 and -5.1 mm Hg; both p < 0.01) after 24 weeks' treatment with febuxostat and topiroxostat. BP decreased to the greatest extent in the subgroup of patients with uncontrolled blood pressure at baseline. Topiroxostat, but not febuxostat, significantly decreased plasma xanthine oxidoreductase activity versus baseline. The urinary albumin-creatinine ratio (UACR) decreased significantly from baseline to 24 weeks with topiroxostat (-20.8%; p = 0.021), but not febuxostat (-8.8%; p = 0.362). In conclusion, neither topiroxostat nor febuxostat had any significant effects on arterial stiffness over 24 weeks' treatment.","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":" ","pages":"334-344"},"PeriodicalIF":2.8,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jch.14153","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38783220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Variations in blood pressure control by medical comorbidities prior to sudden death. 猝死前医学合并症对血压控制的影响

IF 2.8

Journal of clinical hypertension (Greenwich, Conn.) Pub Date : 2021-02-01 Epub Date: 2021-01-02 DOI: 10.1111/jch.14164

Susan K Keen, Albert Chang, Suhani Gupta, Feng-Chang Lin, Ross J Simpson

引用次数: 0

Different age-related impacts of lean and obesity on cardiovascular prognosis in Japanese patients with cardiovascular risks: The J-HOP (Japan Morning Surge-Home Blood Pressure) Study. 日本有心血管风险的患者中，不同年龄相关的瘦和肥胖对心血管预后的影响:J-HOP(日本晨间手术-家庭血压)研究

IF 2.8

Journal of clinical hypertension (Greenwich, Conn.) Pub Date : 2021-02-01 Epub Date: 2021-01-02 DOI: 10.1111/jch.14161

Shinichi Toriumi, Tomoyuki Kabutoya, Satoshi Hoshide, Kazuomi Kario

{"title":"Different age-related impacts of lean and obesity on cardiovascular prognosis in Japanese patients with cardiovascular risks: The J-HOP (Japan Morning Surge-Home Blood Pressure) Study.","authors":"Shinichi Toriumi, Tomoyuki Kabutoya, Satoshi Hoshide, Kazuomi Kario","doi":"10.1111/jch.14161","DOIUrl":"https://doi.org/10.1111/jch.14161","url":null,"abstract":"The relationship between lean and cardiovascular events has been shown to vary with age, but the relationship between age-related lean and cardiovascular events in Asia has not been established. We divided patients enrolled in the J-HOP (Japan Morning Surge-Home Blood Pressure) study with one or more cardiovascular disease risks into three groups based on their body mass index (BMI): lean (BMI < 21), normal-weight (21 ≤ BMI <27), and obese (BMI ≥ 27). We stratified the risk of cardiovascular events of lean and obesity compared to normal weight into the patients < 65 years old and those aged ≥ 65 years. A total of 286 cardiovascular disease events were observed during the follow-up period (73 ± 46 months). Regarding the relationship between BMI and cardiovascular disease risk, both lean and obesity were independent prognostic factors: lean: hazard ratio (HR) 1.43, 95% confidence interval (CI): 1.02-2.01, p = .040; obesity: HR 1.55, 95%CI: 1.13-2.12, p = .006. In patients < 65 years old, the risk of cardiovascular disease of the lean patients was lower than that of the normal-weight patients (HR 0.39, 95%CI: 0.12-1.29, p = .124) and the risk of obesity patients was significantly higher (HR 1.77, 95%CI: 1.08-2.92, p = .024). In the patients aged ≥ 65 years, lean was a significant independent factor of cardiovascular events compared to normal-weight (lean: HR 1.70, 95%CI: 1.18-2.47, p = .005). In conclusion, lean was an independent predictor of cardiovascular events in patients aged ≥ 65 years.","PeriodicalId":520663,"journal":{"name":"Journal of clinical hypertension (Greenwich, Conn.)","volume":" ","pages":"382-388"},"PeriodicalIF":2.8,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1111/jch.14161","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39109641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0