European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery最新文献

{"title":"Validation of the prognostic model \"oncologiq palliative\" for head and neck cancer patients.","authors":"B N van den Besselaar, D van Klaveren, D Berzenji, A Hoesseini, J C Jansen, J A Hardillo, R J Baatenburg de Jong, M P J Offerman, A Sewnaik","doi":"10.1007/s00405-025-09462-1","DOIUrl":"https://doi.org/10.1007/s00405-025-09462-1","url":null,"abstract":"<p><strong>Purpose: </strong>Patients diagnosed with incurable head and neck squamous cell carcinoma (HNSCC) have a poor prognosis, with a median survival of approximately five months. Physicians often struggle to predict prognosis accurately and tend to overestimate survival. Timely sharing of validated accurate individual information on life expectancy could aid in facilitating better patient counseling. However, this knowledge is lacking. Therefore, the aim of this study is to conduct temporal and external validation of the prognostic model OncologIQ Palliative to assess its accuracy and generalizability.</p><p><strong>Methods: </strong>The validation procedure involved temporal assessment in a retrospective cohort of 355 palliative HNSCC patients from Erasmus MC (2017-2020), followed by external validation in a retrospective cohort of 44 patients from Leiden University Medical Center (2019-2021).The discriminative ability of OncologIQ Palliative was assessed using the C-index and calibration was evaluated through graphical assessment, intercept, and slope.</p><p><strong>Results: </strong>The temporal cohort had a median follow-up of 115 days, and the external cohort 143 days. The model showed moderate discriminative ability in temporal validation (C-index 0.66) and better discrimination in external validation (C-index 0.71). Reasonable agreement was observed between predicted and observed 6-month and 1-year survival rates, with some deviations from the perfect calibration line.</p><p><strong>Conclusion: </strong>The validation methods conducted in this study underscored the reliability of OncologIQ Palliative. They showed adequate calibration and discrimination in both validation procedures, thereby facilitating the provision of more accurate prognostic counselling for head and neck cancer patients in the palliative phase.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymph node metastasis development in external ear squamous cell carcinoma follow-up: the role of T stage, tumor grade, and anatomical subsites.","authors":"Sante De Santis, Stefania Galassi, Luca Feci, Andrea Nosiglia, Jacopo Cambi","doi":"10.1007/s00405-025-09463-0","DOIUrl":"https://doi.org/10.1007/s00405-025-09463-0","url":null,"abstract":"<p><strong>Purpose: </strong>Lymph node metastasis (LNM) significantly impacts prognosis in external ear squamous cell carcinoma (SCC). Identifying high-risk patients remains a challenge due to the lack of standardized criteria for elective neck dissection (END). This study aims to evaluate predictive factors for LNM in external ear SCC.</p><p><strong>Methods: </strong>a retrospective analysis of 176 patients with T1-T3, N0 external ear SCC who underwent surgical excision between 2015 and 2019 was conducted. Patients were stratified by tumour subsite (auricle, external auditory canal, retroauricular, and preauricular regions). Histopathological parameters, including tumor size (T), depth of invasion (DOI), perineural invasion (PNI), perivascular invasion (PVI), cartilage invasion, and tumor grade, were analysed for association with LNM. Statistical analyses included univariate and multivariate logistic regression models.</p><p><strong>Results: </strong>LNM occurred in 5.7% (n = 10) of patients, with metastases appearing within an average of 7.1 months post-surgery. T3 tumours had a significantly higher LNM rate (p < 0.05). The preauricular region was the most frequent metastatic subsite (p = 0.001). Poorly differentiated tumours (G3/G4) were strongly associated with LNM (p = 0.001). DOI and cartilage invasion were not independent predictors. The Brigham and Women's Hospital (BWH) classification system demonstrated superior risk stratification compared to NCCN and AJCC-8.</p><p><strong>Conclusion: </strong>T3 stage, preauricular location, and high tumour grade are significant predictors of LNM in external ear SCC. The findings support the need for individualised risk stratification, with consideration of END in high-risk cases. Future studies should incorporate molecular markers to refine metastatic risk assessment.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surgical treatment of otogenic vertigo.","authors":"Tian Yu, Xiaohong Chen","doi":"10.1007/s00405-025-09467-w","DOIUrl":"https://doi.org/10.1007/s00405-025-09467-w","url":null,"abstract":"<p><strong>Objective: </strong>To provide a comprehensive review of surgical strategies for vestibular dysfunction-induced vertigo (VDIV), including indications, contraindications, and comparative efficacy analyses of mainstream procedures, and to critically evaluate contemporary controversies and emerging directions based on recent advancements.</p><p><strong>Background: </strong>Vestibular dysfunction-induced vertigo (VDIV), a balance disorder caused by inner ear pathology, significantly impacts patients' quality of life and often requires surgical intervention when conservative treatments fail. While pharmacological management and vestibular rehabilitation alleviate symptoms in most cases, approximately 10-20% of patients progress to refractory VDIV due to failed conservative treatment, necessitating surgical intervention.</p><p><strong>Methods: </strong>This article provides a comprehensive review of surgical strategies for VDIV, including indications, contraindications, and comparative efficacy analyses of mainstream procedures (e.g., endolymphatic sac decompression, semicircular canal occlusion, vestibular neurectomy).</p><p><strong>Results: </strong>Current evidence suggests that ESD offers symptom control in 62.1%-80.36% of patients with minimal invasiveness, while transcanal semicircular canal plugging (TSCP) achieves higher success rates (96.7%-100%) at the cost of potential hearing loss. For patients in the advanced stage of the disease, combined surgical procedures (such as ESD+TSCP) can achieve a balance between vertigo control (100%) and hearing preservation (with a hearing loss rate of 33.3%).  CONCLUSION: The selection of surgical methods should be based on a comprehensive consideration of the patient's specific condition, including the severity of vertigo, hearing level, and overall health status. Future research should focus on exploring more effective and less invasive surgical techniques to improve the prognosis of patients. Additionally, in-depth studies on the long-term outcomes and quality of life of patients after different surgical procedures are necessary to provide more scientific and reliable evidence for clinical decision making.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144130027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating hyperbaric oxygen therapy as an adjunct to corticosteroids in sudden sensorineural hearing loss: a systematic review and meta-analysis.","authors":"Khaled Moghib, Ali L Abbas Dawoud, Gergis Altalab, Mohamed Salah Syed, Izere Salomon, Halima Abdirashid Y Musse, Ossama Ahmed Mohamed Doubie, Ahmed I Elsekhary, Raneem Awni Al-Dalaeen, Gamal El-Din Hady Kandil","doi":"10.1007/s00405-025-09372-2","DOIUrl":"https://doi.org/10.1007/s00405-025-09372-2","url":null,"abstract":"<p><strong>Background: </strong>Sudden sensorineural hearing loss (SSNHL) is a medical emergency characterized by unexplained hearing loss, usually one-sided, of at least 30 dB across three or more contiguous frequencies within 72 h. This condition significantly impairs daily communication and has serious consequences for mental health, social relationships, and the overall quality of life. Hyperbaric oxygen therapy (HBOT) is being investigated as a potential adjuvant treatment for SSNHL alongside systemic steroids.</p><p><strong>Objectives: </strong>This systematic review and meta-analysis aimed to evaluate the efficacy of HBOT combined with systemic corticosteroids compared with corticosteroids alone in patients with SSNHL.</p><p><strong>Method: </strong>We searched PubMed, Cochrane, Scopus, Web of Science, and Google Scholar to identify 14 studies that matched our inclusion criteria of randomized controlled trials (RCTs) published in English, which evaluated HBOT alone or with corticosteroids in adults (≥ 18 years) diagnosed with SSNHL based on the AAO-HNS criteria, reporting pure-tone audiometry (PTA)-based outcomes. The analysis included 794 participants and evaluated outcomes such as improvements in Pure Tone Audiometry (PTA) thresholds, rates of hearing recovery, and adverse events.</p><p><strong>Results: </strong>Results indicated that the combined therapy of HBOT and systemic corticosteroids significantly improved low-frequency hearing thresholds (SMD: 0.83, 95% CI: 0.66-1.00, p < 0.0001) and increased the odds of complete recovery (OR: 2.05, 95% CI: 1.41-2.98, p = 0.0002). However, significant heterogeneity (I² = 96.7%) and variations in the treatment protocols were observed. Adverse events, including vertigo, have been reported but are generally mild.</p><p><strong>Conclusion: </strong>This meta-analysis suggests that combining systemic corticosteroids with HBOT may improve hearing recovery in ISSNHL, particularly at lower frequencies within the first three months. However, high heterogeneity and the lack of statistical significance in the random-effects model call for cautious interpretation. Well-designed RCTs with standardized protocols and clear patient selection criteria are needed to confirm these findings. Future research should focus on identifying subgroups most likely to benefit and optimizing treatment protocols.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144130022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Endolymphatic hydrops impairs inner ear uptake and distribution of intratympanically injected gadolinium mixed with dexamethasone in patients with Meniere's disease.","authors":"Jing Zou, Hongbin Li, Minhui Zhu, Luguang Chen, Zhen Wang, Tianhao Lu, Yukun Chen, Jianping Lu, Ilmari Pyykkö","doi":"10.1007/s00405-025-09383-z","DOIUrl":"https://doi.org/10.1007/s00405-025-09383-z","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144130021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solitary fibrous tumor in the pterygopalatine fossa: a rare case report and literature review.","authors":"Jian-Sheng Zhou, Hui Yuan, Jiu-Qiang Chen, Lei Shen","doi":"10.1007/s00405-025-09440-7","DOIUrl":"https://doi.org/10.1007/s00405-025-09440-7","url":null,"abstract":"<p><strong>Introduction: </strong>Solitary fibrous tumor is a rare spindle cell tumor that may occur in various parts of the body. No documented case of solitary fibrous tumor has been reported in pterygopalatine fossa.</p><p><strong>Case report: </strong>A 25-year-old male complained of right facial numbness for 20 days. Computed tomography of the paranasal sinuses demonstrated a well-circumscribed lesion centered in the right pterygopalatine fossa. On magnetic resonance imaging the lesion was homogenously isointense to muscle on T1 weighted imaging (T1WI) and slightly hyperintense to muscle on T2 weighted (T2WI). The intro-operative frozen pathology reveals a benign spindle cell tumor. The tumor was removed successfully via transnasal combined with Caldwell-Luc approach without complications. However, the final pathology combined with immunohistochemistry confirmed the diagnosis of solitary fibrous tumor. No further radiotherapy is performed post-operation. After half a year follow up, there is no recurrence.</p><p><strong>Conclusion: </strong>For the tumor in the pterygopalatine fossa, the possibility of solitary fibrous tumor should be considered and radical endoscopic resection should be the preferred treatment approach.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144130025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rehabilitation of facial nerve palsy combining neuromuscular retraining and botulinum toxin A injection: a tertiary referral centre experience and a new working protocol proposal.","authors":"Bonali Marco, Calvaruso Federico, Andrea Tozzi, Del Giovane Cinzia, Nizzoli Federica, Reggiani Elena, Lo Manto Alfredo, Silvestri Martina, Marchioni Daniele, Ferrulli Giuseppe, Melchiorri Claudio","doi":"10.1007/s00405-025-09465-y","DOIUrl":"https://doi.org/10.1007/s00405-025-09465-y","url":null,"abstract":"<p><strong>Purpose: </strong>Neuromuscular retraining (NMR) is the primary treatment for synkinesis in facial nerve palsy (FNP) patients, with botulinum toxin type A (BTX-A) enhancing rehabilitation outcomes. This study aims to assess the functional outcomes of combining BTX-A infiltration and NMR in treating synkinesis in peripheral FNP patients.</p><p><strong>Materials and methods: </strong>This retrospective study, conducted at the University Hospital of Modena (2020-2023), included patients with chronic peripheral FNP treated with NMR and at least two BTX-A injections for synkinesis. The degree of paralysis was assessed using the Sunnybrook classification system before and after BTX-A injections.</p><p><strong>Results: </strong>The study included 140 patients, with FNP causes categorized as iatrogenic (46%), idiopathic (38%), infective (10%), and post-traumatic (5.3%). The median time between paralysis onset and first BTX-A injection was 19.3 months, with an average of 15.68 IU per injection session. The most commonly treated muscles for synkinesis were the platysma, mentalis, orbicularis oculi, orbicularis oris, and levator labii superioris alaeque nasi on the affected side. For facial symmetry, the frontalis, zygomatic, depressor labii inferioris, and depressor anguli oris muscles on the healthy side were treated. Following two BTX-A injections, the Sunnybrook score improved by a mean of 11.76 points, and the synkinesis score decreased by 4.78 points (both statistically significant, p < 0.05).</p><p><strong>Conclusion: </strong>BTX-A is an effective treatment for reducing synkinesis and improving facial function in chronic FNP. When combined with consistent rehabilitation, it supports the resumption of voluntary movement. NMR proves to be an essential adjunctive therapy in enhancing the outcomes of BTX-A treatment.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144130023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the efficacy of hypertonic nasal spray with algae in rhinosinusitis.","authors":"Benyamin Alam, Amir Reza Akbari","doi":"10.1007/s00405-025-09403-y","DOIUrl":"10.1007/s00405-025-09403-y","url":null,"abstract":"","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144130020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fanconi anemia patients with head and neck squamous cell carcinoma - a multi-center study.","authors":"Nir Tsur, Anner Moskovitz, Yehuda Zadik, Ehud Even-Or, Narin Nard Carmel Neiderman, Elchanan Zloczower, Omry Frig, Orna Steinberg-Shemer, Hannah Tamary, Noga Kurman, Inna Ospovat, Eyal Yosefof","doi":"10.1007/s00405-025-09466-x","DOIUrl":"https://doi.org/10.1007/s00405-025-09466-x","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the presentation, treatment, and outcomes of head and neck squamous cell carcinoma (HNSCC) in patients with Fanconi anemia (FA), a rare genetic disorder characterized by increased cancer risk and treatment complications.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of 11 FA patients diagnosed with HNSCC across five XXX medical centers from 2014 to 2023. Data on patient demographics, tumor characteristics, treatment modalities, complications, recurrences, and survival outcomes were analyzed using descriptive and survival statistics.</p><p><strong>Results: </strong>FA patients developed HNSCC at a median age of 31.5 years, primarily in the oral cavity. Surgical treatment was the primary treatment modality; however adjunct radiotherapy resulted in severe complications, such as high-grade mucositis in 75% of cases. Median overall survival was 28.7 months, with 36.4% of patients succumbing within 12 months of diagnosis. Recurrences were noted in three patients, split equally between local and distant sites, and 36% developed secondary malignancies up to 17 years post-initial diagnosis.</p><p><strong>Conclusions: </strong>HNSCC in FA patients presents distinct challenges, including a younger onset age, high rates of severe treatment complications, and poor survival outcomes. Tailoring treatment strategies to minimize radiotherapy exposure and implementing rigorous, long-term surveillance for second malignancies are essential for managing these high-risk patients.</p><p><strong>Level of evidence: </strong>Level IV.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Localized laryngeal amyloidosis: an unusual diagnosis in pediatric patients. Case report.","authors":"Javiera Pardo Jadue, Camila Ramírez Pelayo, Andrés Lanas Volz","doi":"10.1007/s00405-025-09444-3","DOIUrl":"https://doi.org/10.1007/s00405-025-09444-3","url":null,"abstract":"<p><strong>Purpose: </strong>The primary objective of this study was to present a rare case of localized laryngeal amyloidosis in a pediatric patient, a condition with only 18 documented cases worldwide in individuals under eighteen years of age. Furthermore, it compares the diagnostic approach and management of this case with those outlined in the limited existing literature.</p><p><strong>Methods: </strong>A 10-year-old male patient presented with progressively worsening dysphonia. Clinical evaluation included nasofibroscopy, contrast-enhanced CT imaging, and histopathological examination of resected tissue. The histological diagnosis was confirmed using Congo red staining. Additional tests were conducted to rule out systemic amyloidosis, including serum biochemistry and echocardiogram. The patient was followed for three years postoperatively.</p><p><strong>Results: </strong>The patient was diagnosed with localized laryngeal amyloidosis, confirmed through histopathological analysis. Surgical management included a partial excision using cold dissection, followed by complete macroscopic resection with CO2 laser. Postoperative recovery showed minimal dysphonia with no dyspnea. Follow-up evaluations, including nasofibroscopy, revealed no significant recurrence of disease after three years, with only a small right posterior leukoplakia, interpreted as an impact-related lesion.</p><p><strong>Conclusion: </strong>Localized laryngeal amyloidosis is an rare condition in pediatric patients. Early diagnosis is critical, and surgical management via transoral endoscopic resection is effective in improving symptoms. Regular follow-up is necessary due to the high likelihood of recurrence, especially within the first five years.</p>","PeriodicalId":520614,"journal":{"name":"European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}