Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology最新文献

{"title":"The Impact of Edema on Skeletal Muscle Changes among Patients with Pancreatic Ductal Adenocarcinoma.","authors":"Evan W Davis, Margaret A Park, Toni L Basinski, J Pablo Arnoletti, Mark Bloomston, Tiffany L Carson, TIago Biachi De Castria, Dung-Tsa Chen, Elena M Cortizas, Sylvia L Crowder, Maria Genilo-Delgado, Wade G Douglas, Kevin L Huguet, Kun Jiang, Pamela J Hodul, Aleksandra Karolak, Dae Won Kim, John M Koomen, Anjana A Menon, Qianxing Mo, Shaffer R Mok, Manuel A Molina-Vega, Lina Moreno-Urazan, Sabeen Ahmed, Nathan H Parker, Jose M Pimiento, Ghluam Rasool, Lauren M Sparks, Paul A Stewart, Alexandra F Tassielli, Jamie K Teer, Jose G Trevino, Vic Velanovich, Xuefeng Wang, Christopher J Whelan, Sarah M Judge, Andrew R Judge, Jason B Fleming, Mokenge P Malafa, Daniel Jeong, Jennifer B Permuth","doi":"10.1158/1055-9965.EPI-25-0237","DOIUrl":"10.1158/1055-9965.EPI-25-0237","url":null,"abstract":"<p><strong>Background: </strong>Muscle loss influences pancreatic ductal adenocarcinoma (PDAC) outcomes, but treatment-related edema may cause overestimation of total skeletal muscle area (tSMA) confounding our understanding of muscle changes. However, no studies have quantified the impact of edema on tSMA and psoas skeletal muscle area (pSMA) changes. Thus, we sought to i) assess the impact of edema on tSMA and pSMA change between diagnosis and follow-up and ii) explore the utility of pSMA as a clinically relevant measure of muscle and muscle loss among PDAC patients.</p><p><strong>Methods: </strong>Body composition was measured using computed tomography scans at diagnosis and follow-up from ninety-five patients enrolled in the Florida Pancreas Collaborative cohort study. Edema was assessed by opacifications in subcutaneous fat, and tSMA and pSMA change were expressed as percent change between diagnosis and follow-up. We used multivariable generalized linear models to estimate mean tSMA and pSMA change overall and by edema status. Spearman correlation was used to measure interrelationships of tSMA and pSMA.</p><p><strong>Results: </strong>tSMA increased between diagnosis and follow-up (Δ=0.66) but only in patients with edema (Δ=3.35) while non-edematous patients lost tSMA (Δ=-2.03). Conversely, pSMA decreased regardless of edema status. Further, tSMA and pSMA were strongly correlated overall (r=0.75) and in non-edematous patients (r=0.83).</p><p><strong>Conclusions: </strong>Edema inflated estimates of tSMA at follow-up in PDAC patients, but pSMA was impervious to edema and may represent a suitable proxy for tSMA.</p><p><strong>Impact: </strong>pSMA is a reliable measure of muscle and muscle loss and should be considered in future studies assessing muscle loss in PDAC patients.</p>","PeriodicalId":520580,"journal":{"name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atopy improves survival and decreases risk of brain metastasis in cutaneous melanoma.","authors":"Corey Neff, Mackenzie Price, Christine Ann Pittman Ballard, Gino Cioffi, Zhen Liu, Rabina Walsh, Jill S Barnholtz-Sloan, Kyle M Walsh, April K S Salama, Carey K Anders, Peter E Fecci, Quinn T Ostrom","doi":"10.1158/1055-9965.EPI-24-1212","DOIUrl":"10.1158/1055-9965.EPI-24-1212","url":null,"abstract":"<p><strong>Background: </strong>Development of new melanoma therapies has increased survival, and more patients are living to develop brain metastasis (BrM). Identifying those at increased risk of BrM is of significant public health importance, and our objective was to assess the relationship between atopy and survival or reduced BrM cumulative incidence (CI) in melanoma.</p><p><strong>Methods: </strong>This retrospective study was conducted in individuals (≥65 years) in linked Surveillance, Epidemiology and End Results and Medicare data. History of atopy diagnosed prior to melanoma was ascertained using ICD-9/ICD-10 codes. Associations between atopy, CI of BrM and overall survival were assessed using cox proportional hazards models to estimate hazard ratios (HR) and p-values.</p><p><strong>Results: </strong>A total of 23,508 cutaneous melanoma cases were identified. Overall, 6.1% developed BrM, and 38% had history of atopy. Atopy was associated with a 18% decrease in death (p<0.001). Among those without metastasis at diagnosis, atopy decreased BrM CI by 16% (p=0.006). Among those with metastasis at diagnosis (any site), only those who received checkpoint inhibitors had a suggestive but non-significant survival with atopy.</p><p><strong>Conclusions: </strong>Atopy confers improved survival and decreased BrM CI. History of atopy in the elderly may identify those with more robust immune function that may be more responsive to treatment.</p><p><strong>Impact: </strong>Elderly individuals with prior diagnosis of atopy had significantly improved survival and decreased incidence of BrM as compared to individuals without atopy. This suggests that history of atopy may identify a subgroup within melanoma with improved response to treatment and a more robust immune system.</p>","PeriodicalId":520580,"journal":{"name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Night shift work and risk of melanoma: a prospective cohort study among 59,384 female nurses in the Netherlands.","authors":"Linske de Bruijn, Henriëtte M van Duijne, Roel C H Vermeulen, Jelle J Vlaanderen, Hans Kromhout, Katarzyna Jóźwiak, Flora E van Leeuwen, Nina E Berentzen, Michael Schaapveld","doi":"10.1158/1055-9965.EPI-25-0301","DOIUrl":"10.1158/1055-9965.EPI-25-0301","url":null,"abstract":"<p><strong>Background: </strong>Night shift work may be a risk factor for melanoma, potentially due to suppressed melatonin and decreased vitamin D levels. We examine the potential association between night shift work and melanoma risk using detailed, lifetime information on night shift work in a large cohort of Dutch nurses.</p><p><strong>Methods: </strong>We used questionnaire data from the Nightingale Study obtained from 59,384 (former) female nurses aged 19-65 (median: 48.7 years; interquartile range: 39.6-55.3). Hazard ratios (HR) and 95% confidence intervals (95%CI) for melanoma risk in relation to various lifetime night shift work exposure variables were estimated.</p><p><strong>Results: </strong>During 10 years of follow-up, 307 women developed melanoma. Melanoma risk did not differ between women who worked night shifts and those who never worked night shifts (age-adjusted HR=0.98; 95%CI=0.73-1.30). No statistically significantly increased risks were found for a longer night shift work duration, a higher cumulative number of nights worked, a higher number of consecutive nights worked per month, or a shorter time since quitting night shift work.</p><p><strong>Conclusion: </strong>We found no association between night shift work exposure and melanoma risk.</p><p><strong>Impact: </strong>This study should reassure nurses that working night shifts is not associated with an increased risk of melanoma.</p>","PeriodicalId":520580,"journal":{"name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7617932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer incidence and prevalence in relation to proximity to a nuclear power plant in Gyeongju, Republic of Korea.","authors":"Kyoung-Nam Kim, Sung-Chan Kang, Youlim Kim, Kyungsik Kim, Youjin Hong, Sangjun Lee, Soseul Sung, Woojin Lim, Kwan Lee, Ji-Hyuk Park, Seok-Ju Yoo, Hyunchul Park, Keon Wook Kang, Sangjun Han, Jae-Wook Choi, Kyung-Hee Kim, Sue K Park","doi":"10.1158/1055-9965.EPI-24-1876","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-24-1876","url":null,"abstract":"<p><strong>Background: </strong>Previous studies on cancer risk near nuclear power plants (NPPs) have reported inconsistent results. This study aimed to estimate the standardized incidence ratios (SIRs) and standardized prevalence ratios (SPRs) of cancer near a NPP in Korea.</p><p><strong>Methods: </strong>Claims data from the National Health Insurance Service (2006-2020) were used to calculate the SIRs and SPRs for all cancers and 17 radiation-related cancer types. Proximity to the Wolsong NPP in Gyeongju, Korea, was categorized into < 5 km (Region I), 5-9.9 km (Region II), 10-20 km (Region III), and 60-100 km (Region IV).</p><p><strong>Results: </strong>The SIRs for all cancers were 1.12 (95% confidence interval: 0.83, 1.41), 1.50 (1.16, 1.85), 0.87 (0.76, 0.97), and 1.04 (0.91, 1.16) in Regions I, II, III, and IV, respectively. The SPRs for all cancers were 0.67 (0.59, 0.75), 0.78 (0.70, 0.87), 0.68 (0.65, 0.71), and 0.76 (0.72, 0.80) in Regions I, II, III, and IV, respectively. In the analyses combining Regions I and II, the SIRs for all cancers and stomach cancer, as well as the SPRs for esophageal cancer and lung cancer, were increased in regions located within 10 km from the NPP.</p><p><strong>Conclusions: </strong>Elevated, but statistically non-significant, point estimates of the SIR and SPR, with wide confidence intervals, were observed for several outcomes within 5 km of the NPP.</p><p><strong>Impact: </strong>This exploratory study provides information to design further longitudinal studies with individual-level data and more accurate exposure assessment to understand cancer risks near NPPs.</p>","PeriodicalId":520580,"journal":{"name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gravida and birth outcomes prior to and after diagnosis of early age onset colorectal cancer among female patients: Population-based epidemiologic studies.","authors":"Niki Oveisi, Eric C Sayre, Sharlene Gill, Vicki Cheng, Vienna Cheng, Lori A Brotto, Stuart Peacock, Helen McTaggart-Cowan, Gillian E Hanley, Amirrtha Srikanthan, Mary A De Vera","doi":"10.1158/1055-9965.EPI-25-0442","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-25-0442","url":null,"abstract":"<p><strong>Background: </strong>Early age-onset colorectal cancer (EAO-CRC) strikes during the reproductive years, yet pregnancies before and after diagnosis have not been thoroughly studied. Our objective was to comprehensively examine: 1) the relationship between gravida and EAO-CRC; and 2) the relationship between EAO-CRC and births post cancer diagnosis.</p><p><strong>Methods: </strong>We conducted a case-control and a cohort study using administrative health data from British Columbia, Canada, of females diagnosed with EAO-CRC from 2005 to 2017, and age and sex matched cancer-free controls. Multivariable logistic regression models were used to evaluate: 1) the association between gravida assessed over the 5-year prodrome period before cancer diagnosis and EAO-CRC; and 2) the association between EAO-CRC and births assessed over a 5-year period following cancer diagnosis.</p><p><strong>Results: </strong>The study sample consisted of 865 females (age at EAO-CRC diagnosis 42.5 +/- 6.1 years) with EAO-CRC and 8,291 controls (42.4 +/- 6.3 years). Females with a gravida of ≥2 in the 5-year prodrome period had 1.82 times the odds of EAO-CRC compared to those with gravida of 0 (odds ratio [OR] 1.82; 95% confidence interval (CI) 1.19, 2.78). Post cancer diagnosis, females with EAO-CRC had significantly lower odds of giving birth within five years (OR 0.23; 95% CI 0.15, 0.37). Older age, lower income, rural residence, and greater healthcare utilization were associated with lower odds of post-diagnosis births.</p><p><strong>Conclusions: </strong>Our study highlights the complex relationship between reproductive health and EAO-CRC.</p><p><strong>Impact: </strong>Findings indicate a need for comprehensive psychosocial support addressing family planning for female EAO-CRC patients.</p>","PeriodicalId":520580,"journal":{"name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in physical activity and risk of cancer, findings from the UK Biobank study.","authors":"Andrew Harper, Christine M Friedenreich, Momtafin Khan, Darren R Brenner, Brigid M Lynch, Lin Yang","doi":"10.1158/1055-9965.EPI-25-0227","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-25-0227","url":null,"abstract":"<p><p>Background Most studies investigating physical activity and cancer risk used a single-time measure of physical activity. The present analysis investigates whether changes in physical activity during midlife influence cancer risk. Methods A prospective cohort of adults ≥40 years from the UK Biobank who provided self-reported physical activity data via the IPAQ at both baseline (2007-2010) and follow-up (2012-2013) were analyzed. Changes in physical activity were classified as decreased, maintained, or increased between these two timepoints. Incident cancers were ascertained to 13 May 2022. Multivariable Cox regressions were used to examine the associations between changes in physical activity and the risk of cancer overall, by sex, by obesity versus non-obesity related cancers, and for breast and prostate cancers, respectively. Results A total of 16,792 participants (mean [SD] age, 56.8 [7.4], 8421 [50.2%] females) provided repeated data on physical activity. During a median follow-up of 8.3-years, 1,397 incident cancer cases occurred. No statistically significant associations between changes in physical activity and overall cancer risk were found. Increasing physical activity from low to higher levels was associated with lowered risk of obesity-related cancer (HR=0.72, 95% CI=0.54-0.95), particularly for the risk of breast cancer (HR=0.61, 95% CI: 0.36-1.04). Females who decreased their physical activity from high to lower levels had an elevated cancer risk (HR=1.47, 95% CI: 1.02-2.11). Conclusion Increasing physical activity over time was associated with lower risk of developing obesity-related cancers, particularly breast cancer. Impact Our findings suggest that behavioural changes to increase physical activity in midlife may help reduce cancer risk.</p>","PeriodicalId":520580,"journal":{"name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"History of breastfeeding in relation to circulating inflammatory and metabolic biomarkers.","authors":"Nan Lin, Allison F Vitonis, Jennifer M Mongiovi, Leslie V Farland, Tianyi Huang, Kathryn L Terry, A Heather Eliassen, Mary K Townsend, Cuilin Zhang, Frank B Hu, Naoko Sasamoto","doi":"10.1158/1055-9965.EPI-25-0034","DOIUrl":"10.1158/1055-9965.EPI-25-0034","url":null,"abstract":"<p><strong>Background: </strong>Breastfeeding history has been associated with reduced risk of chronic diseases, although the underlying biological link is unclear.</p><p><strong>Methods: </strong>The study included 16,165 parous women in the Nurses' Health Studies who reported lactation history and biomarkers measured using plasma samples collected at mid-life. We calculated multivariable-adjusted geometric means of ten inflammatory biomarkers [high sensitivity C-reactive protein(hsCRP), interleukin-6 (IL6), IL8, IL10, insulin-like growth factor-1 (IGF1), soluble tumor necrosis factor α receptor 2 (sTNFR2), B-cell activating factor, C-X-C motif chemokine ligand 13 (CXCL13), sIL2-receptor-α (Rα), sIL6Rα] and eight metabolic biomarkers[triglyceride, total cholesterol, high- and low-density lipoprotein (HDL and LDL), leptin, soluble leptin receptor, adiponectin, retinol-binding protein 4] by self-reported history of breastfeeding prior to blood collection. False discovery rate (FDR) was used for multiple testing corrections.</p><p><strong>Results: </strong>Average age at blood collection was 52.6 years. Ever breastfeeding was associated with higher IGF1 (149.22 vs. 143.76 ng/mL, p-value=0.0002/FDR=0.004) compared with never breastfeeding. Longer breastfeeding duration was associated with lower IL10 (p-trend=0.001/FDR=0.01) and higher IGF1 (p-trend=0.0005/FDR=0.01). No significant associations were observed for other biomarkers. Longer breastfeeding duration was associated with higher IGF1 among premenopausal women but not among postmenopausal women (p-interaction=0.02). Longer breastfeeding duration was associated with lower soluble leptin receptor levels among those with BMI≥25kg/m2 (p-trend=0.01/FDR=0.09) but not among those with BMI<25 kg/m2 (p-interaction=0.0002).</p><p><strong>Conclusion: </strong>Ever breastfeeding and longer breastfeeding duration was associated with higher IGF1 levels measured in mid-life.</p><p><strong>Impact: </strong>Our results support the potential long-term systemic impact of breastfeeding on circulating IGF1 levels, which may influence future chronic disease risk.</p>","PeriodicalId":520580,"journal":{"name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct Sources of Social Adversity, Stress, and Coping Mechanisms Among Breast Cancer Patients to Identify Areas for Intervention.","authors":"Chloe J Taub, Alexandra E Hernandez, Peter A Borowsky, Molly Ream, Rachel Plotke, Maya Lubarsky, Elizabeth Reguero, Susan B Kesmodel, Michael H Antoni, Neha Goel","doi":"10.1158/1055-9965.EPI-24-1790","DOIUrl":"10.1158/1055-9965.EPI-24-1790","url":null,"abstract":"<p><strong>Background: </strong>Social adversity from neighborhood disadvantage (ND), objectively measured using the Area Deprivation Index [ADI], is a known factor contributing to breast cancer (BC) disparities and has been associated with heightened psychophysiologic stress response processes, more aggressive tumor biology, and worse disease outcomes. While many aspects of ND may be less accessible for modification, some subjective experiences of ND may be modifiable through psychosocial intervention. This study investigates a critical gap in the literature regarding the link between objective ND and potentially modifiable subjective perceptions of ND.</p><p><strong>Methods: </strong>From 2020-2024, 610 adult patients (English, Spanish, Creole-speaking) receiving care for BC at a South Florida National Cancer Institute-designated cancer center and sister safety-net hospital enrolled in a cohort study and completed measures for neighborhood-level adversity (Neighborhood Social Environment Adversity Survey [NSEAS]) and individual-level (Perceived Stress Scale [PSS], Impact of Event Scale-Intrusions [IES-I]) perceived stress as well as coping mechanisms (John Henryism Active Coping Scale [JHAC], Social Provisions Scale [SPS], Management of Current Stress [MOCS]). ADI was derived from residential addresses.</p><p><strong>Results: </strong>Multiple regression analyses found 1) women living in areas of higher objective ND reported greater levels of perceived ND [NSEAS], 2) greater subjective ND related to greater general [PSS] but not cancer-specific stress [IES-I], and 3) women with greater coping mechanisms [JHAC, SPS, MOCS] reported lower levels of subjective ND (ps<.05).</p><p><strong>Conclusions: </strong>This study clarified relationships among sources of social adversity, stress, and coping mechanisms.</p><p><strong>Impact: </strong>These findings may help inform intervention design for BC patients living in social adversity.</p>","PeriodicalId":520580,"journal":{"name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144288125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Climate change and cancer risk: connections with physical activity, diet, and adiposity.","authors":"Colleen B McGrath, Hannah E Guard, Sydney Yearley, Miriam Marlink, Katherine M Kutzer, Ethan Ecsedy, James Dun Rappaport, Eric B Rimm, Jaime E Hart, Francine Laden, Walter C Willett, Jane B Vaselkiv, Lorelei A Mucci","doi":"10.1158/1055-9965.EPI-25-0501","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-25-0501","url":null,"abstract":"<p><p>Climate change and its environmental consequences have broadly influenced human health, including the direct effects of climate related-environmental exposures increasing cancer risk. In this review, we summarize evidence and make inferences on the indirect impact of climate change on cancer etiology through three interrelated cancer risk factors-physical activity, diet, and adiposity, and how these, in turn, may have downstream effects on cancer risk. Moreover, we highlight ways in which climate change will likely exacerbate existing cancer disparities through these three cancer risk factors.</p>","PeriodicalId":520580,"journal":{"name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144288124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body mass index, IGF1-related polymorphisms and risk of familial breast cancer in women with no BRCA1 or BRCA2 pathogenic variant.","authors":"Barbara Fritsch-Humblet, Yue Jiao, Séverine Eon-Marchais, Marie-Gabrielle Dondon, Dorothée Le Gal, Juana Beauvallet, Dominique Stoppa-Lyonnet, Nadine Andrieu, Fabienne Lesueur","doi":"10.1158/1055-9965.EPI-24-1860","DOIUrl":"https://doi.org/10.1158/1055-9965.EPI-24-1860","url":null,"abstract":"<p><strong>Background: </strong>Body mass index (BMI) and some single-nucleotide polymorphisms (SNPs) associated with IGF1 metabolism are risk factors for breast cancer (BC) in the general population. No investigation has been performed in women presenting a familial predisposition to BC, except in women carrying a pathogenic variant in BRCA1 or BRCA2 (BRCA1/2). We investigated the effect of BMI and IGF1-related SNPs in high-risk women with no BRCA1/2 pathogenic variant.</p><p><strong>Methods: </strong>We conducted a case-control study in the GENESIS study (1556 cases and 1546 controls). We assessed association between 639,424 SNPs associated with circulating IGF1 level or located in genes of KEGG pathways involving IGF1 and BC using logistic regression models.</p><p><strong>Results: </strong>A reduced risk of estrogen receptor (ER)-positive tumors was observed for premenopausal women with a BMI above 25 (OR=0.52, 95%CI:0.34-0.81). None of the SNPs were associated with BC except rs117292219 in STAT5A and associated with a reduced risk of ER-negative tumors (OR=0.41, 95%CI:0.26-0.66). No interaction between BMI and any of the analyzed SNPs was observed.</p><p><strong>Conclusions: </strong>Our findings on BMI effect were consistent with that reported in the general population and in BRCA1/2 pathogenic variant carriers: overweight women have a reduced risk of BC before menopause, but no increased risk after menopause. We found few associations between IGF1-related SNPs and familial BC, even if variants at STAT5A locus warrant further investigation.</p><p><strong>Impact: </strong>This large case-control study does not support a major role of the genetic variability of IGF1 metabolism in familial BC risk in women with no BRCA1/2 pathogenic variant.</p>","PeriodicalId":520580,"journal":{"name":"Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}