Cancer causes & control : CCC最新文献

{"title":"Precision greenness exposure is associated with lung cancer risk in medicare beneficiaries.","authors":"Padideh Lovan, Ma Ruixuan, Sara Fleszar-Pavlovic, Julius R Dewald, Joanna Lombard, Frank J Penedo, Yalda Zarnegarnia, William Aitken, Yannine Estrada, Scott C Brown, José Szapocznik","doi":"10.1007/s10552-026-02227-z","DOIUrl":"10.1007/s10552-026-02227-z","url":null,"abstract":"<p><strong>Purpose: </strong>This study examines whether lung cancer risk is influenced by block-level greenness, controlling for age, sex, race/ethnicity, area deprivation index (ADI), and walkability in older adults, and whether age, sex, race/ethnicity, ADI, or walkability plays a moderating role in this relationship.</p><p><strong>Methods: </strong>Data from US Medicare beneficiaries aged 65 years and older were included for the years 2011 and 2016. Beneficiaries included in this study received a lung cancer diagnosis for the first time between 2012 and 2016. All resided in Miami-Dade County, Florida (M_age = 74.31 ± 6.95, 58.69% females, 20.24% White, 68.12% Hispanic, 11.63% Black). Greenness was measured using normalized difference vegetation index. Greenness in 2011 was used to predict lung cancer risk in 2012-2016. Generalized estimating equation (GEE) analyses were performed.</p><p><strong>Results: </strong>Results indicated that 754 out of 234,360 individuals (0.32%) were diagnosed with lung cancer in 2012-2016. Higher neighborhood greenness in 2011 was associated with lower lung cancer risk from 2012 to 2016 after adjustment for age, sex, race/ethnicity, ADI, and walkability, with each 0.1-unit increase in NDVI corresponding to an approximately 9% lower lung cancer risk (OR = 0.91, 95% CI: 0.85-0.98, p = .008). In the best-fit model, walkability moderated the associations between greenness and lung cancer risk, with the beneficiaries living in non-car dependent neighborhoods experiencing a lower risk. In stratified analyses, inverse associations were observed among beneficiaries younger than 75 years, men, Hispanic beneficiaries, and non-car dependent neighborhoods.</p><p><strong>Conclusion: </strong>Our findings suggest that higher greenness at the Census block level may be associated with reduced lung cancer risk in older adults. This underscores the critical role of environmental factors, particularly access to green spaces, in cancer prevention strategies. Future research should further explore the interplay among biological, behavioral, or social factors that may shape the association between greenness and lung cancer risk.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":"37 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13452843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age and sex differences in the global cancer burden.","authors":"Taylor Hughes, Malak Ibrahim, Hyuna Sung, Sophie Pilleron, Miranda Fidler-Benaoudia","doi":"10.1007/s10552-026-02224-2","DOIUrl":"10.1007/s10552-026-02224-2","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to describe the 2022 cancer burden by sex and age group globally, as well as by world region.</p><p><strong>Methods: </strong>We utilized GLOBOCAN 2022 estimates to quantify overall and cancer-specific incidence and mortality using counts and age-standardized rates (ASRs; per 100,000) simultaneously stratified by sex and age bands (0-14, 15-29, 30-39, 40-49, 50-59, 60-69, 70-79, and 80 + years), globally and by world region.</p><p><strong>Results: </strong>In 2022, an estimated 18.7 million cases (excluding nonmelanoma skin cancer) and 9.7 million cancer-related deaths occurred globally, of which 51 and 56%, respectively, occurred in males. Cases increased with age, peaking at 60-69, while cancer-related deaths peaked at 70-79. Females had higher burdens in age bands spanning 30-59, driven by female-specific cancers, whereas males dominated in older age groups primarily due to lung and prostate cancers. Regional patterns varied considerably. In parts of Africa and Asia, nearly half of female cases occurred before age 50, contrasting with Europe, North America, and Australia/New Zealand, where cases were concentrated at older ages. Mortality patterns often mirrored incidence but were disproportionately high in transitioning regions and younger age bands, indicating a greater adverse impact of limited access to early detection and treatment. Finally, regional cancer hotspots were identified and discussed.</p><p><strong>Conclusion: </strong>These findings serve as a reference for the global cancer community to guide future research and inform cancer control initiatives, highlighting the need for age- and sex-specific, and regionally tailored strategies.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":"37 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A real-world workplace-based screening for Helicobacter pylori infection: the HPOS study.","authors":"Giulia Collatuzzo, Giulia Fiorini, Matteo Pavoni, Maria Vittoria Costanzucci Paolino, Andrei Cosmin Siea, Maria Zafeiratou, Laura Astolfi, Luca Magni, Tommaso Renieri, Silvia Mangiaterra, Marika D'Agostini, Nataliia Danilevskaia, Dino Vaira, Paolo Boffetta","doi":"10.1007/s10552-026-02189-2","DOIUrl":"10.1007/s10552-026-02189-2","url":null,"abstract":"<p><strong>Objectives: </strong>Helicobacter pylori (H.pylori) eradication contributes to gastric cancer (GC) prevention, yet many subjects are unaware of their infection status. We implemented a workplace-based H.pylori screening.</p><p><strong>Design: </strong>We implemented a cross-sectional screening with short-term follow-up among hospital workers (HWs), enrolled during occupational health surveillance (OHS). A stool antigen test (SAT) was adopted for H.pylori diagnosis. H.pylori-positive HWs were referred to their general practitioner (GP) or a gastroenterologist and were followed up at three months. Participation, prevalence of infection, participants' experience, and treatment rates were investigated through descriptive and multivariable analyses.</p><p><strong>Setting: </strong>The study was carried out between 2023 and 2025 at S.Orsola University Hospital in Bologna, Italy.</p><p><strong>Participants: </strong>The study targeted HWs aged 40-65 employed at S.Orsola University Hospital.</p><p><strong>Results: </strong>Of 744 eligible HWs contacted, 550 were enrolled (73.9%), including 399 through OHS and 151 volunteers; the largest proportion of participants were women (74.7%) and nurses (40.2%). Dropout rate was 15.5% (n = 115), leaving 435 HWs with a SAT result. H.pylori prevalence was 16.6%. Men were less likely to participate than women (OR = 0.68, 95% CI = 0.47-0.99). Education was negatively associated with H. pylori infection (OR = 0.41, 95% CI = 0.18-0.93 for the highest educational level vs the lowest). No specific pattern was observed in relation to contact with a physician and treatment prescription. 58/72 H. pylori-positive HWs (80.6%) contacted a physician, 53 (73.6%) being prescribed a treatment and 13 (18.1%) undergoing upper endoscopy. Confirmatory test rate after treatment was suboptimal, while eradication rate was 97.3% when considering those with confirmatory test result (36/37 HWs). Across followed up HWs, the average quality of experience was 8.9/10; 13 had a family member tested following this intervention.</p><p><strong>Conclusions: </strong>The intervention integrated into OHS was well received and extended to family members of the participants, suggesting that a workplace-based H.pylori screening might contribute to GC prevention. Replications in other workplaces are warranted.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":"37 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13424376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148623710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and burden of colon and rectum cancer attributable to low physical activity in China: a comprehensive analysis from 1990 to 2021.","authors":"Zhouwei Zhan, Bijuan Chen, Xiamei Chen, Ning Ma, Sijing Zhou, Jingjie Xu, Chunkang Yang, Zengqing Guo","doi":"10.1007/s10552-026-02222-4","DOIUrl":"10.1007/s10552-026-02222-4","url":null,"abstract":"<p><strong>Background: </strong>Colon and rectum cancer (CRC) is an increasing public health concern in China due to rising incidence and disability, particularly among aging populations. Despite medical advancements, low physical activity remains a major modifiable risk factor. This study evaluates CRC burden trends from 1990 to 2021, focusing on demographic and temporal effects.</p><p><strong>Methods: </strong>Using age-standardized rates for mortality, disability-adjusted life years (DALYs), years lived with disability (YLDs), and years of life lost (YLLs), this retrospective analysis employed Joinpoint regression, decomposition, and age-period-cohort modeling to explore temporal changes and demographic drivers of CRC outcomes. Data were segmented by gender and age groups to assess trends and contributing factors.</p><p><strong>Results: </strong>CRC mortality and DALYs have demonstrated divergent trends over the past three decades. While mortality rates initially declined, recent years have shown an uptick, particularly among males. In contrast, YLD rates have risen consistently, reflecting an increasing burden of non-fatal outcomes, especially in older adults. Age-period-cohort analysis revealed reduced mortality and DALY rates in recent cohorts and periods, highlighting the impact of improved healthcare and public health interventions. However, decomposition analysis identified aging as the most significant driver of the increasing burden, with population growth and epidemiological changes also contributing. Notably, younger cohorts (25-45 years) in recent periods exhibited a rising burden of DALYs, indicating emerging public health challenges.</p><p><strong>Conclusions: </strong>The burden of CRC attributable to low physical activity in China reflects a complex interplay of demographic and epidemiological factors. Addressing this burden requires targeted public health strategies that promote physical activity, mitigate disability, and prioritize interventions for vulnerable groups, particularly the elderly and younger at-risk cohorts.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":"37 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148623697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Second primary cancers among females with a first primary cervical, uterine and ovarian cancer: a population-based study in North Portugal.","authors":"Elisabete Gonçalves, Filipa Fontes, Jéssica Rocha Rodrigues, Rita Calisto, Maria José Bento, Nuno Lunet, Samantha Morais","doi":"10.1007/s10552-026-02191-8","DOIUrl":"10.1007/s10552-026-02191-8","url":null,"abstract":"<p><strong>Purpose: </strong>To estimate the incidence rates of second primary cancers (SCPs) [diagnosed > 2 months after a first primary cancer (FPC)], and cumulative incidence and mortality of metachronous SPCs in patients with a cervical, uterine, or ovarian FPC, and to compare the incidence of SPCs with that expected in the general female population.</p><p><strong>Methods: </strong>A cohort of patients with cervical, uterine, or ovarian FPC from the North Region Cancer Registry of Portugal, diagnosed in 2000-2010 (n = 5846) was followed until 31/12/2015 for synchronous and metachronous SPCs. Cumulative incidence of metachronous SPCs considering death as a competing event, and incidence rates and standardized incidence ratios (SIR) of SPCs were estimated.</p><p><strong>Results: </strong>Diagnosis of an SPC occurred in 541 (9.3%) patients at a median age of 60 years. SPCs were more frequent among patients with uterine cancers. Colon, breast, and corpus uteri were the most common sites for an SPC among patients with a gynecological FPC. A higher incidence of all and individual SPCs compared to the general female population was found (SIR = 1.96, 95% CI 1.79-2.12) with the most relevant sites being cancers of the colon (SIR = 2.32, 95% CI 1.82-2.89), lung (SIR = 2.70, 95% CI 1.88, 3.66), cervix (SIR = 4.87, 95% CI 3.43, 6.56), corpus uteri (SIR = 5.37, 95% CI 4.16, 6.73) and ovary (SIR = 6.06, 95% CI 4.12-8.37). The 10-year cumulative incidence of a metachronous SPC and death for patients with a gynecological FPC was 7.4% and 39.2%, respectively.</p><p><strong>Conclusion: </strong>In Portugal, patients with a gynecological FPC have a higher incidence of SPCs compared to the general female population, particularly elderly females. Increased surveillance and counselling among these patients are needed.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":"37 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148612243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How did exposure to critical access hospitals change Medicare's effect on cancer survival?","authors":"Jason Semprini","doi":"10.1007/s10552-026-02220-6","DOIUrl":"10.1007/s10552-026-02220-6","url":null,"abstract":"<p><strong>Introduction: </strong>Upon turning 65, cancer patients experience the \"Medicare Effect' of better outcomes relative to patients nearly 65. Context likely mediates this effect, but so might differential access to care. In response to over 400 rural hospital closures in the 1980s-90 s, in 1997 the US federal government created a Critical Access Hospital (CAH) designation and funding to maintain access to care in rural communities. Despite the intrinsic relationship between CAH and Medicare, it is unknown whether the CAH destinations mitigated or exacerbated the observed disparities in cancer outcomes between patients newly eligible and not yet eligible for Medicare.</p><p><strong>Methods: </strong>Population-based data for this study was obtained from the Surveillance, Epidemiology, and End Results (SEER) program's SEER-13 data (1993-2010). The two primary outcomes measure distant staging at diagnosis and two-year patient survival. We construct a Difference-in-Discontinuities framework test if this \"Medicare Effect\" on distant staging and survival varies in counties with and without a Critical Access Hospital (CAH), before and after CAH conversion.</p><p><strong>Results: </strong>Consistent with prior literature, gaining Medicare was associated with reduced probability of distant stage diagnosis and improved two-year survival. Exposure to CAHs did not change Medicare's effect on staging, but did increase Medicare's effect on all-cause survival for males with prostate cancer (Est. =  + 0.019, se = 0.005), and females with lung (+ 0.046, se = 0.021) and colorectal cancer (Est. =  + 0.076, se = 0.026).</p><p><strong>Conclusion: </strong>Policies improving cancer survival remain warranted for both men and women with, and without Medicare. Sustaining the availability of CAH services remains essential for ensuring equitable access to cancer care.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":"37 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148612200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparities in colonoscopy adherence and neoplasia detection after positive fecal immunochemical test: a retrospective matched cohort study.","authors":"Stephanie Chaparro, Mostafa Eysha, Islam Hamza Zaki, Mona A Ali, Hend A Elsaka, Alejandro Robles, Marc J Zuckerman, Sherif E Elhanafi","doi":"10.1007/s10552-026-02221-5","DOIUrl":"10.1007/s10552-026-02221-5","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;The fecal immunochemical test (FIT) is widely used as a first-line, noninvasive colorectal cancer (CRC) screening tool due to its convenience, affordability, and high patient adherence. However, its effectiveness depends on timely follow-up colonoscopy, and failure to complete diagnostic colonoscopy after a positive FIT can result in missed or delayed detection of precancerous lesions or CRC. It remains unclear whether FIT-based screening and subsequent follow-up are equally effective across age groups and racial and ethnic populations. This study evaluates real-world differences in colonoscopy adherence and diagnostic yield following a positive FIT and examines their implications for disparities in CRC outcomes and all-cause mortality.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective cohort study was conducted using de-identified patient data from the TriNetX research network. Adult patients aged ≥ 45 years who underwent colorectal cancer screening were identified using ICD-10 codes, and positive FIT results were identified using LOINC code 29,771-3. Patients were stratified into two cohorts based on whether they had a diagnostic colonoscopy performed within 1 year of the positive FIT. The study population was further stratified into three age-based cohorts (45-50, 51-64, and 65-85 years), two ethnicity-based cohorts (Hispanic and non-Hispanic), and five race-based cohorts (White, Black, Asian, Native Hawaiian or Other Pacific Islander, and American Indian or Alaska Native). To reduce selection bias and account for potential confounders, 1:1 propensity score matching was performed using demographic characteristics and relevant comorbidities. Matched cohorts were compared using odds ratios (ORs) for colonoscopy adherence, polyp detection, and colorectal cancer detection at both the 1-year and 10-year follow-up intervals. All-cause mortality was compared between matched cohorts using hazard ratios (HRs) at the same 1-year and 10-year follow-up intervals.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The study included 45,598 adults with a positive FIT, of whom 17,727 completed colonoscopy within 1 year and 27,871 did not. After propensity score matching, 17,101 patients remained in each group. Patients who completed colonoscopy had higher CRC detection at 1 year (OR 2.401, 95% CI 1.771-3.257) and 10 years (OR 1.501, 95% CI 1.189-1.895), as well as higher polyp detection at 1 year (OR 17.610, 95% CI 16.534-18.756) and 10 years (OR 14.331, 95% CI 13.577-15.126). Colonoscopy completion was associated with lower all-cause mortality at 1 year (HR 0.604, 95% CI 0.516-0.707) and 10 years (HR 0.799, 95% CI 0.744-0.859). Adults aged 45-50 had higher colonoscopy adherence than those aged 51-64 (OR 1.214, 95% CI 1.111-1.326), while adults aged 51-64 had higher adherence than those aged 65-85 (OR 1.248, 95% CI 1.195-1.304). Hispanic patients demonstrated higher adherence than non-Hispanic patients (OR 1.686, 95% CI 1.537-1.848). Polyp detec","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":"37 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148612216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heme iron intake and the risk of colorectal cancer: a prospective analysis of the modifying role of calcium.","authors":"Waverly Shi, Peilu Wang, Edward L Giovannucci","doi":"10.1007/s10552-026-02195-4","DOIUrl":"10.1007/s10552-026-02195-4","url":null,"abstract":"<p><strong>Purpose: </strong>Although red meat and processed meat are well-established risk factors of colorectal cancer (CRC), the mechanisms underlying this association are less clear. Heme iron, abundant in red and processed meats, is one plausible etiologic factor. In addition, calcium, a well-established independent protective factor against CRC, may prevent heme-induced colorectal carcinogenesis by binding to heme iron in the gut.</p><p><strong>Methods: </strong>We prospectively examined the association between heme iron and CRC risk and whether these associations differed by calcium intake in the Nurses' Health Study, Nurses' Health Study II and Health Professionals Follow-Up Study. We used Cox proportional hazards regression analyses to calculate cohort-specific hazard ratios (HRs) and pooled results using a fixed-effect model.</p><p><strong>Results: </strong>We analyzed data from 211,851 participants and documented 2983 incident CRC cases during up to 36 years of follow-up. Comparing the highest to lowest quintile, the pooled multivariable HRs (95% CIs) for CRC were 1.03 (0.91, 1.17) for total heme iron intake, 1.02 (0.91, 1.16) for heme iron from red and processed meat, and 1.02 (0.90, 1.15) for heme iron from non-red and non-processed meat sources. Total heme iron intake, heme iron from red and processed meat, and heme iron from non-red meat and non-processed meat sources were largely not associated with CRC risk. Moreover, the association between heme iron and CRC did not appear to differ by calcium status.</p><p><strong>Conclusion: </strong>Overall, our study does not support a strong role of heme iron intake in CRC risk and suggests that the protective association of calcium intake on CRC risk does not depend on heme iron.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":"37 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13495568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148582022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of neighborhood racial and ethnic, economical, and educational segregation with breast cancer risk: The Multiethnic ohort Study.","authors":"Ugonna Ihenacho, Jenna Khan-Gates, Katherine Lin, Janine V Abe, Pushkar P Inamdar, Juan Yang, Yuqing Li, Meera Sangaramoorthy, Christopher A Haiman, Loïc Le Marchand, Lynne R Wilkens, Scarlett Lin Gomez, Salma Shariff-Marco, Anna H Wu, Iona Cheng","doi":"10.1007/s10552-026-02187-4","DOIUrl":"10.1007/s10552-026-02187-4","url":null,"abstract":"<p><strong>Purpose: </strong>Residential segregation is recognized as an upstream driver of poor health, yet few studies have evaluated its impact on breast cancer incidence at a local level. We examined associations of neighborhood residential segregation with breast cancer (BC) incidence in the Multiethnic Cohort Study (MEC).</p><p><strong>Methods: </strong>Measures of Index of Concentration at the Extremes were developed to assess residential segregation by income, education, race and ethnicity, and racialized income. A prospective study (1993-1996 through December 2019) was conducted to examine associations of these measures and breast cancer incidence for 101,785 African American, Japanese American, Latina, Native Hawaiian, and White female participants in the MEC, aged 45-75 years at baseline and residing in California and Hawai'i. Multivariable Cox regression was conducted to evaluate the associations of several residential segregation measures with breast cancer incidence (cases = 7,381) adjusting for demographic, lifestyle, and reproductive factors.</p><p><strong>Results: </strong>In California, BC risk was higher for females residing in neighborhoods with the highest compared to lowest concentration of privilege by income segregation (quintile 5 [Q5] vs. Q1: hazard ratio [HR] 1.12, 95% confidence interval [CI] 1.00-1.25, P_trend = 0.001) and education segregation (Q5 vs. Q1: HR 1.15, 95% CI 1.01-1.31; P_trend = 0.01). For Latina females, risks increased with increasing privilege for measures of income, education, race and ethnicity, and racialized income residential segregation (P_trends < 0.05). No associations were observed in Hawai'i.</p><p><strong>Conclusion: </strong>In California, residential economic privilege was independently associated with increased BC risk. Future studies should examine neighborhood- and individual-level pathways placing females residing in privileged areas at greater risk.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":"37 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13400465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lessons learned: drivers of non-response in a large population-based cohort study of Black women.","authors":"Jeuneviette E Bontemps-Jones, Lauren E McCullough, Elizabeth G Kirkland, Lauren R Teras, Maddison L Hall, Peter J Briggs, Daniela M Dudas, Maria Moore, Jamal Winn, Alpa V Patel","doi":"10.1007/s10552-026-02217-1","DOIUrl":"10.1007/s10552-026-02217-1","url":null,"abstract":"<p><strong>Purpose: </strong>To identify barriers and facilitators for survey completion in the VOICES of Black Women (VOICES) study and to determine which communication methods encouraged survey completion.</p><p><strong>Methods: </strong>In 2023, the American Cancer Society piloted VOICES, an online study to better understand cancer and other health conditions among Black women. Approximately 2/3 of the 243 women who registered and consented did not complete the baseline survey (n = 140). In 2024, we sequentially employed four methods of communication to contact non-responders: email, mailed postcard, text message, and phone. At each touchpoint, we requested participants answer three questions about why they had not completed the survey.</p><p><strong>Results: </strong>Thirty women (22%) completed the non-responder survey. Time was the most common issue for non-completion (n = 18). Some participants indicated that adjustments to communication, survey design, and survey navigation could facilitate completion. Emailing produced the highest number of responses to the non-responder survey (15/138; 11%) and subsequent baseline survey completion (5/15, 33%).</p><p><strong>Conclusion: </strong>Despite a lack of time among other barriers, VOICES non-responders were willing to complete the baseline survey and provide feedback on the survey process.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":"37 9","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148581959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}