Cancer causes & control : CCC最新文献

{"title":"Association between dietary intake and urinary concentrations of caffeine and caffeine metabolites and elevated serum prostate-specific antigen (PSA) among men at risk for prostate cancer.","authors":"Hongke Wu, Ming Wang, Alicia C McDonald","doi":"10.1007/s10552-025-02015-1","DOIUrl":"https://doi.org/10.1007/s10552-025-02015-1","url":null,"abstract":"<p><strong>Purpose: </strong>Prostatic chronic inflammation has been found to be associated with prostate cancer risk. Caffeine intake has shown to exhibit anti-inflammatory properties. The relationship between caffeine and prostatic inflammation remains not known. We examined whether dietary intake and urinary concentration of caffeine and its metabolites are associated with serum prostate-specific antigen (PSA) levels, a surrogate marker of prostatic inflammation, among prostate cancer-free men.</p><p><strong>Methods: </strong>Cancer-free men, aged ≥ 40 years, with dietary caffeine intake and serum PSA results were identified from the 2001-2010 National Health and Nutrition Examination Survey. Elevated serum PSA was based on age- and race-specific definitions. Weighted logistic regression analysis with survey sample weights was used to examine the association between dietary intake and urinary concentration of caffeine and its metabolites and elevated serum PSA.</p><p><strong>Results: </strong>There were 5,456 men included. Approximately 6.4% of them had an elevated serum PSA. Men with an elevated serum PSA (geometric mean: 63.4 mg) had statistically significantly lower dietary caffeine intake compared to men with a normal serum PSA (geometric mean: 80.9 mg) (p value < 0.01). After adjusting for confounders, dietary caffeine intake and urinary caffeine and its metabolites concentrations were not statistically significantly associated with elevated serum PSA.</p><p><strong>Conclusion: </strong>Men with elevated serum PSA had lower dietary caffeine intake compared to men with a normal serum PSA. However, dietary caffeine intake and urinary caffeine concentration were not associated with elevated serum PSA, after adjusting for confounders. Prospective studies that investigate relationships among caffeine intake and prostatic inflammation are warranted.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sitting time and risk of cancer incidence and cancer mortality in postmenopausal women: the Women's Health Accelerometry Collaboration.","authors":"Eric T Hyde, Kelly R Evenson, Annie Green Howard, Humberto Parada, Chongzhi Di, Michael J LaMonte, John Bellettiere, Carmen C Cuthbertson, I-Min Lee, Andrea Z LaCroix","doi":"10.1007/s10552-025-02024-0","DOIUrl":"https://doi.org/10.1007/s10552-025-02024-0","url":null,"abstract":"<p><strong>Purpose: </strong>Few studies have explored whether accelerometer-measured sedentary behavior increases cancer risk. We examined the associations of accelerometer-measured daily sitting time and mean sitting bout duration classified by the Convolutional Neural Network Hip Accelerometer Posture (CHAP) machine-learned algorithm with incidence of any cancer, incidence of 13 physical activity-related cancers, and cancer mortality among postmenopausal women.</p><p><strong>Methods: </strong>We used data from 22,097 women (mean age = 73.3 years, standard deviation [SD] = 6.7) in the Women's Health Accelerometry Collaboration, a consortium of two US-based cohort studies of postmenopausal women: the Women's Health Study and the Women's Health Initiative Objective Physical Activity and Cardiovascular Health Study. Women who completed hip-worn triaxial accelerometry for ≥ 4 of 7 consecutive days were included. Associations between sedentary behaviors and physician-adjudicated invasive cancer incidence and mortality were tested using Cox regression.</p><p><strong>Results: </strong>Women were followed on average 8.0 years to identify cancer cases (n = 1,861) and deaths (n = 601). Overall, mean sitting time was 567 (SD = 113) min/day and mean sitting bout duration was 12.8 (SD = 4) min/bout. In covariate-adjusted models, one-SD increment higher in sitting time was associated with a 6% increased risk of incident cancer (hazard ratio [HR] = 1.06, 95% CI: 1.01-1.11); associations were similar for bout duration (HR = 1.05, 95% CI: 1.00-1.10). Estimates were similar for the 13 physical activity-related cancers (sitting time: HR = 1.10, 95% CI: 1.04-1.17; bout duration: HR = 1.08, 95% CI: 1.02-1.14) and for cancer mortality (sitting time: 1.06, 95% CI: 0.98-1.16; bout duration: HR = 1.05, 95% CI: 0.97-1.13).</p><p><strong>Conclusion: </strong>Among postmenopausal women, sedentary behavior was associated with increased cancer risk, particularly for physical activity-related cancers and cancer mortality.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community engagement in the context of cancer: scoping review of definitions and measures to inform program-level analysis.","authors":"Heidi J Keeler, Regina Idoate, Brooke J Fitzpatrick, Emma Hymel, Josiane Kabayundo, Krishtee Napit, Cynthia M Schmidt, Shinobu Watanabe-Galloway","doi":"10.1007/s10552-025-02026-y","DOIUrl":"https://doi.org/10.1007/s10552-025-02026-y","url":null,"abstract":"<p><strong>Purpose: </strong>The objective of this research is to determine how community-engaged activities, and their resulting impact, are currently being measured by cancer centers. To accomplish this, the various definitions of community engagement as used by cancer center community outreach and engagement programs are identified and analyzed, and the frameworks and metrics employed in assessing community outreach and engagement programming are explored. This work can help to inform how to better determine community engagement impact and its overall return on investment, as well as compare impact across cancer centers.</p><p><strong>Methods: </strong>Between August 29 and September 1, 2022, MEDLINE, CINAHL, PsycINFO, EMBASE, and Google Scholar were searched for articles including the \"community engagement\" and \"cancer\" search concepts. After removal of duplicate records, a title abstract screen was conducted to identify those articles that (1) were conducted within the USA, (2) focused on cancer, (3) undertaken by a cancer center, (4) pertained to community engagement, and (5) published in the English language. The review excluded conference abstracts, editorials, and book chapters.</p><p><strong>Results: </strong>Analysis of definitions identified within the included literature revealed the following four overarching core components of community engagement specific to cancer centers: defined stakeholders, resource exchange, collaborative relationships, and mutually beneficial outcomes. The most common frameworks/models were community-based research models, followed by social and behavioral focused. Measures to assess all essential aspects of community engagement were infrequently included in community projects.</p><p><strong>Conclusion: </strong>The results of this scoping review and analysis propose a common definition and model of community engagement for cancer-related activities conducted by cancer centers. These are important as common measures can be incorporated into all aspects of community engagement work. This can assist cancer centers in determining collective impact using both project and process outcomes. Common measures can help cancer centers include time and resources needed for community engagement within budgets and impact reporting.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The behavioral and social drivers of HPV vaccination among parents and young people in Indonesia: a scoping review.","authors":"Aisya Athifa, Yasmin Mohamed, Isabella Overmars, Margie Danchin, Jessica Kaufman","doi":"10.1007/s10552-025-02027-x","DOIUrl":"https://doi.org/10.1007/s10552-025-02027-x","url":null,"abstract":"<p><strong>Purpose: </strong>The Indonesian Government launched the national human papillomavirus (HPV) vaccination program in August 2023, reaching 90% coverage for both doses. This scoping review explored the behavioral and social drivers of HPV vaccination among parents and young people in Indonesia.</p><p><strong>Methods: </strong>We searched four databases for primary quantitative, qualitative, and mixed-method studies in English or Bahasa Indonesia assessing behavioral and social drivers of HPV vaccination in Indonesia. Participants were parents and young people under 24. The quality was appraised with the Mixed Methods Appraisal Tool. Narrative synthesis was conducted to summarize findings according to the World Health Organization's Behavioral and Social Drivers (BeSD) of vaccination framework.</p><p><strong>Results: </strong>Eighteen studies were included. Drivers were mapped across the BeSD domains: thinking and feeling, social process, motivation, and practical issues. The majority were related to what people think and feel including low knowledge and awareness of HPV disease and vaccines despite high motivation to vaccinate. This review identifies the importance of HPV vaccines' halal-haram status. Spouses and teachers were the most cited influencers in vaccine decision-making not healthcare providers. Puskesmas was the preferred vaccination location and concerns about vaccine costs were frequently mentioned.</p><p><strong>Conclusion: </strong>This review identifies the main drivers of HPV vaccination among parents and young people in Indonesia to optimize HPV vaccine uptake as the national rollout is expanded. Clear communication about the halal-haram status of HPV vaccines, involvement of parents, family, teachers, and trusted community members to communicate about HPV vaccines and ensuring HPV vaccine accessibility outside schools are needed.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical risk factors for hepatocellular carcinoma in Southeast Louisiana: a matched case-control study.","authors":"Gabrielle V Gonzalez, Denise M Danos, Tekeda F Ferguson, George Therapondos, Mei-Chin Hsieh, Claudia Leonardi","doi":"10.1007/s10552-025-02021-3","DOIUrl":"https://doi.org/10.1007/s10552-025-02021-3","url":null,"abstract":"<p><strong>Purpose: </strong>Hepatocellular carcinoma (HCC) incidence rates have risen in the past 30 years, and it is vital to understand the risk factors that contribute to the disease. Notably, Louisiana is experiencing higher than average rates of hepatitis C (HCV), obesity, alcohol use disorder (AUD), and poverty which are all possible risk factors for HCC. Thus, the primary objective was to assess the prevalence and effects of prominent HCC risk factors in Louisiana to support strategies for prevention and treatment in high-risk populations.</p><p><strong>Methods: </strong>This matched 1:1 case-control study used cancer registry records and electronic health records obtained from the Louisiana Tumor Registry and Louisiana Public Health Institute's Research Action for Health Network to identify cases of invasive HCC and disease-free controls. A total of 1,389 HCC cases were matched to HCC-free controls on age, sex, race, and health system. Clinical diagnoses of risk factors were identified using International Classification of Disease diagnosis codes in the medical record for both cases and controls. Conditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI), including a model of two-way interactions.</p><p><strong>Results: </strong>HCV was the most prominent risk factor among cases (63.4%), followed by type 2 diabetes (39.3%), alcohol use disorder (26.4%), metabolic dysfunction-associated steatotic liver disease (MASLD, 17.5%), and hepatitis B virus (8.9%). HCV was associated with an increased risk of HCC (OR = 192.0; 95% CI: 64.3-570), as were hepatitis B (OR = 94.1; 95% CI: 11.4-776), AUD (OR = 33.2; 95% CI: 11.4-96.7), MASLD (OR = 6.5; 95% CI: 3.2-13.2), and type 2 diabetes (OR = 2.0; 95% CI: 1.4-2.8). A significant antagonistic interaction was observed between HCV and MASLD (p = 0.002).</p><p><strong>Conclusion: </strong>This study identified highly prominent risk factors for HCC among Louisiana high-risk populations. Unfortunately, Louisiana faces several challenges regarding HCC trends and risk factors, particularly viral hepatitis, metabolic dysfunction, and alcohol use. This calls for new and innovative strategies to address risk factors and support the prevention, control, and treatment of HCC. Further insight on the novel antagonistic relationship between HCV and MASLD is necessary to understand the complex biological pathway between the two risk factors.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144513046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparities in human papillomavirus vaccination uptake across the intersection of disability and sexual orientation.","authors":"Amarachukwu F Orji, Gilbert Gimm, Tarang Parekh, Rodman Turpin, Carolyn Drews-Botsch","doi":"10.1007/s10552-025-02025-z","DOIUrl":"https://doi.org/10.1007/s10552-025-02025-z","url":null,"abstract":"<p><strong>Purpose: </strong>Although human papillomavirus (HPV) vaccination provides effective primary prevention against cervical cancer, HPV vaccination rates remain low in the U.S. It is unknown whether women with disabilities and/or LGB + women are likely to experience disparities in HPV vaccination uptake.</p><p><strong>Methods: </strong>We used data from the 2014-2022 Behavioral Risk Factor Surveillance System (N = 40,401) to estimate HPV vaccination rates among women aged 18-44 years. Adjusted prevalence ratios (aPRs) were estimated using modified Poisson regression models for four subgroups defined by disability status and LGB + status. Analyses were further stratified by age (18-26 years; 27-44 years).</p><p><strong>Results: </strong>Overall, only 19% of eligible women had received at least one dose of the HPV vaccine, and 12% had completed the full series. Younger women were more likely than older women to have been vaccinated. Compared with heterosexual women without disabilities, heterosexual women with disabilities, had lower vaccination uptake (heterosexual with disabilities: aPR = 0.95; 95% CI 0.93-0.97; LGB + with disabilities: aPR = 0.97; 95% CI 0.96-0.98), and were 12% less likely to complete the series (heterosexual with disabilities: aPR = 0.88; 95% CI 0.83-0.93).</p><p><strong>Conclusion: </strong>HPV vaccination rates remain low, representing missed opportunities for primary prevention. Women with disabilities had lower vaccination rates than women without disabilities and were less likely to complete the vaccine series. These findings, combined with age-stratified results, highlight the need for stronger catch-up campaigns and targeted efforts to address structural barriers related to disability, ultimately improving HPV vaccination coverage and reducing the burden of cervical cancer.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Medicaid expansion with colon cancer care: treatment patterns and survival in non-metastatic cases from state registry-claims data.","authors":"Kirsten Y Eom, Weichuan Dong, Richard S Hoehn, Jeffrey M Albert, Uriel Kim, Gregory Cooper, Johnie Rose, Jennifer Tsui, Siran M Koroukian","doi":"10.1007/s10552-025-01983-8","DOIUrl":"https://doi.org/10.1007/s10552-025-01983-8","url":null,"abstract":"<p><strong>Purpose: </strong>Despite growing research on Medicaid expansion's impact on cancer outcomes, there remains a critical need for a more nuanced understanding of how expansion affects cancer care and survival. This study assesses whether Medicaid expansion was associated with improved receipt of standard treatment, timely treatment initiation, and overall survival among colon cancer patients, while examining the specific factors influencing these outcomes.</p><p><strong>Methods: </strong>Using Ohio's state cancer registry linked with Medicaid records, we analyzed 688 Medicaid-enrolled patients with non-metastatic colon cancer diagnosed between May 2011 and December 2017. We employed multivariable Poisson and Cox proportional hazard regression analyses to evaluate the impact of Medicaid expansion on treatment and survival outcomes, controlling for individual- and area-level factors.</p><p><strong>Results: </strong>We observed no significant changes in the likelihood of receipt of standard treatment or timely treatment initiation post-expansion vs. pre-expansion, and no significant differences in these outcomes by Medicaid eligibility criteria post-expansion. However, we observed significantly improved survival (hazard ratio, HR 0.49 [0.28, 0.88]) among patients who became newly eligible for Medicaid under the ACA vs. pre-expansion. Patients enrolled emergently (shortly after/upon diagnosis) were more likely to receive standard treatment (risk ratio, RR 1.14 [1.02, 1.27]).</p><p><strong>Conclusions: </strong>Our findings provide nuanced insights into Medicaid expansion's impact on colon cancer care, showing that while expansion did not affect treatment measures, it improved survival among newly eligible patients. Higher standard treatment likelihood among emergently enrolled patients suggests complex post-expansion care dynamics. Further research should investigate mechanisms underlying improved survival and develop interventions to enhance treatment quality alongside observed survival benefits.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between human papillomavirus (HPV) knowledge and HPV vaccine acceptance among women and affecting factors in Türkiye.","authors":"Halime Abay, Betül Çakmak, Feride Mualla Alagöz, Özlem Uzunlar","doi":"10.1007/s10552-025-02023-1","DOIUrl":"10.1007/s10552-025-02023-1","url":null,"abstract":"<p><strong>Purpose: </strong>The most effective method for preventing cervical cancer is the human papillomavirus (HPV) vaccine, but the vaccine is not included in the national immunization program. This study aimed to investigate the relationship between HPV knowledge and attitudes, intentions and behaviors toward HPV vaccination among Turkish women.</p><p><strong>Methods: </strong>This analytical cross-sectional study was conducted in with 320 women aged 18-49 years in Türkiye. Data were collected using the Human Papillomavirus Knowledge Scale (HPV-KS) and the Carolina HPV Immunization Attitudes and Beliefs Scale (CHIAS). Data were analyzed using Mann-Whitney U test, Kruskal-Wallis test, and Bonferroni correction the effects of independent variables (sociodemographic characteristics, vaccination intentions, etc.) on scale scores. Spearman's correlation coefficient was used to investigate the relationship between all total and subscale scores. The backward logistic regression analysis was performed to investigate the effects of all total and subscale scores on HPV vaccination behaviors.</p><p><strong>Results: </strong>Of the participants, 51.2% had knowledge about the HPV vaccine, 90.9% had not been vaccinated against HPV, and 65.9% intended to receive the HPV vaccine. A negative correlation was found between the HPV-KS subscale mean scores and CHIAS subscale mean scores (p < 0.05). As attitudes that perceived HPV vaccine as harmful increased, vaccination behaviors decreased (Z = - 2.326; p = 0.020). Backward logistic regression analysis showed that for every 1-unit increase in \"Uncertainty\" subscale scores, the uptake of the HPV vaccine decreased by by 54.3% (OR = 0.457; 95% CI 1.015-1.152). Backward logistic regression analysis showed that for every 1-unit increase in \"Ineffectiveness\" subscale scores, the uptake of the HPV vaccine for yourself/children if it is free decreased by 35.8% (OR = 0.642; 95% CI 0.449-0.197).</p><p><strong>Conclusion: </strong>Women's HPV knowledge and acceptance of vaccination were low. There was a positive correlation between women's HPV knowledge levels and their attitudes and behaviors toward HPV vaccination. HPV awareness should be increased in the community, and HPV vaccines should be integrated into the national immunization program.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Land use, zoning, and breast cancer incidence in California: an ecological study.","authors":"Valerie Stahl, Rainbow Rubin, Pujeeta Chowdhary, Humberto Parada","doi":"10.1007/s10552-025-02020-4","DOIUrl":"10.1007/s10552-025-02020-4","url":null,"abstract":"<p><strong>Background: </strong>The relationship between land use and zoning and breast cancer (BC) incidence is understudied, despite the potential for the built environment to result in exposure to mammary carcinogens. We examined associations between land use and zoning and BC incidence rates in California (CA).</p><p><strong>Methods: </strong>We obtained 10-year (2012-2021) age-adjusted BC incidence rates (aIRs) of female BC by the 542 medical service study areas (MSSAs) from CA Health Maps and 2021 zoning data for 535 jurisdictions from CA's Office of Planning and Research Statewide Zoning Database. Land use and zoning was calculated as a percentage of total MSSA area using GIS. We used multiple linear regression to examine the associations (βs and 95% confidence intervals, CIs) between the percentages of non-residential land use (per 10% increases) including %agricultural, %high-intensity commercial, %industrial, %park or open space, and %mixed-use in MSSAs and aIRs overall and by race/ethnicity.</p><p><strong>Results: </strong>BC aIRs increased with increasing %high-intensity commercial zoning (β = 8.32, 95% CI = 0.06, 16.57) among all women. BC aIRs increased with increasing %agricultural zoning (β = 3.11, 95% CI = 1.06, 5.15) among Black women, and decreased with increasing %park or open space zoning (β = - 0.85, 95% CI = - 1.54, - 0.17) among non-Hispanic White women (NHW).</p><p><strong>Conclusions: </strong>Land use and zoning are associated with BC incidence rates among women in CA. Breast cancer prevention strategies can establish healthier communities through zoning modifications that prioritize open, public spaces, and recreational uses.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144340786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspective of females from a rural community in India toward the knowledge, screening, and treatment of breast and cervical cancer and preventive vaccination.","authors":"Deepak Sundriyal, Yogesh Bahurupi, Shalini Rajaram, Mahendra Singh, Pradeep Aggarwal, Preeti Antil, Sweety Gupta, Amit Sehrawat","doi":"10.1007/s10552-025-02018-y","DOIUrl":"https://doi.org/10.1007/s10552-025-02018-y","url":null,"abstract":"<p><strong>Purpose: </strong>The success of a preventive oncology program depends upon the general population's awareness of the disease, its magnitude, and the screening and prevention process. Our study aimed to analyze the situational awareness of a rural community population toward the most common cancers in females.</p><p><strong>Methods: </strong>We conducted a cross-sectional study in the rural Indian community of Uttarakhand, recruiting 589 participants from Pauri Garhwal. We developed a questionnaire comprising sociodemographic information, knowledge of the disease, early detection, and the attitude toward breast and cervical cancer treatment. We also registered the participant's knowledge and enthusiasm toward vaccination against cervical cancer. Local non-governmental organization (Uttarakhand Manav Seva Samiti, Delhi) collaborated to conduct door-to-door interviews.</p><p><strong>Results: </strong>Among the participants, 38% and 79% had never heard about breast and cervical cancer, respectively. A limited understanding of various signs and symptoms of breast cancer varying from 14% to 50% was noted. Only 36.1% (132) and 11.5% (42) of the participants had heard about breast cancer and were aware of breast examination and mammography, including its utility in diagnosing early breast cancer. Similarly, the knowledge about various signs and symptoms of cervical cancer varied from 11 to 55% among the participants. Only 6.5% of them have heard about preventive vaccination. Encouraging results of the study were that nearly 57% and 56% of the participants expressed eagerness to participate in cancer screening programs. Participants who were Younger (< 40 years) and had more years of education had significantly higher levels of knowledge about and positive attitudes toward breast and cervical cancers.</p><p><strong>Conclusion: </strong>A grim lack of awareness in the rural community has been observed regarding breast and cervical cancers and preventive vaccination. Strengthening educational activities in the rural community against these cancers seems to be an indispensable step toward a preventive oncology program.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144277971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}