Cancer causes & control : CCC最新文献

{"title":"Risk factors for esophageal cancer in a high-incidence area of Malawi.","authors":"Anja L Geßner,&nbsp;Angelika Borkowetz,&nbsp;Torsten J Wilhelm,&nbsp;Enock Ludzu,&nbsp;Michael Baier,&nbsp;Yamikani Mastala,&nbsp;Saulos Nyirenda,&nbsp;Henning Mothes","doi":"10.1007/s10552-021-01482-6","DOIUrl":"https://doi.org/10.1007/s10552-021-01482-6","url":null,"abstract":"<p><strong>Purpose: </strong>To explore associations of nutritional, infectious, and lifestyle factors with esophageal cancer (EC) occurrence in a high-risk area of Malawi.</p><p><strong>Methods: </strong>This case-control study was performed with 227 patients undergoing endoscopy for dysphagia or other upper gastrointestinal complaints. Data on clinicopathological characteristics and risk factors were collected using a questionnaire developed for this study specifically. Ninety-eight blood samples were collected and the prevalence of antibodies against human immunodeficiency virus, herpes simplex virus, cytomegalovirus, Epstein-Barr virus, varicella-zoster virus, and Helicobacter pylori were determined serologically.</p><p><strong>Results: </strong>The tumor and control groups comprised 157 (69.2%) and 70 (31.8%) patients, respectively. Patients with tumors were significantly older than controls (55.5 vs. 43.5 years, p < 0.001). The male/female ratio did not differ between groups (59% and 54% male, respectively; p = 0.469). EC was associated with smoking (p < 0.001), and alcohol consumption (p = 0.020), but 43% of patients with tumors did not smoke or drink. EC was associated with the consumption of hot food and tea (p = 0.003) and smoked fish (p = 0.011). EC was not associated with any serologically investigated infectious agents. In an age adjusted binary logistic regression analysis of all nutritive factors, only locally made alcohol was significant [odds ratio (OR), 9.252; 95% confidence interval (CI), 1.455-58.822; p = 0.018].</p><p><strong>Conclusions: </strong>Apart from alcohol consumption and smoking, the consumption of hot food or tea and smoked fish are associated with EC. Locally distilled alcohol consumption increases the EC risk in Malawi.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":" ","pages":"1347-1354"},"PeriodicalIF":2.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39271139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary changes and food habits: social and clinical determinants in a cohort of women diagnosed with breast cancer in Barcelona (DAMA cohort).","authors":"C Clotas,&nbsp;G Serral,&nbsp;E Vidal Garcia,&nbsp;R Puigpinós-Riera","doi":"10.1007/s10552-021-01483-5","DOIUrl":"https://doi.org/10.1007/s10552-021-01483-5","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to analyze the influence of social determinants on changes in dietary habits before and after diagnosis of breast cancer in women (Barcelona, 2003-2013).</p><p><strong>Methods: </strong>We performed a cohort study with 2,235 women diagnosed with breast cancer. The information was obtained from an ad hoc questionnaire based on recommendations from the Spanish Society of Community Nutrition. We conducted a descriptive bivariate analysis and fit logistic regression models. The dependent variable was the change in dietary habits (food groups) and the independent variables were a selection of social and clinical variables (age, social class, cohabitation, years since diagnosis, history of replaces, and treatment with chemotherapy).</p><p><strong>Results: </strong>While 5.8% of women followed a healthy diet (consumption of vegetables, fruits, farinaceous, lean meat, and seafood) before diagnosis, 9.5% did so after diagnosis. We observed statistically significant changes in consumption of all food groups (p < 0.001) after diagnosis. The greatest change in consumption patterns was observed in women aged < 50 years and those from non-manual classes (high classes) [e.g., legume consumption: OR_{<50 years/>65 years} = 2.9 (95% CI 1.78-4.81); OR_{non-manual/manual} = 2.5 (95% CI 1.38-4.36)]. The occurrence of relapses and chemotherapy was associated with greater changes in dietary habits.</p><p><strong>Conclusion: </strong>Women with breast cancer change their eating habits after diagnosis, and these changes are conditioned by social and clinical determinants.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":" ","pages":"1355-1364"},"PeriodicalIF":2.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39383201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptomatic presentation of cervical cancer in emergency departments in California.","authors":"Frances B Maguire,&nbsp;Julianne J P Cooley,&nbsp;Cyllene R Morris,&nbsp;Arti Parikh-Patel,&nbsp;Vanessa A Kennedy,&nbsp;Theresa H M Keegan","doi":"10.1007/s10552-021-01489-z","DOIUrl":"https://doi.org/10.1007/s10552-021-01489-z","url":null,"abstract":"<p><strong>Purpose: </strong>Through screening and HPV vaccination, cervical cancer can mostly be prevented or detected very early, before symptoms develop. However, cervical cancer persists, and many women are diagnosed at advanced stages. Little is known about the degree to which U.S. women may begin their diagnostic workup for cervical cancer in Emergency Departments (ED). We sought to quantify the proportion of women presenting symptomatically in the ED prior to their diagnosis with cervical cancer and to describe their characteristics and outcomes.</p><p><strong>Methods: </strong>We identified women diagnosed from 2006 to 2017 with cervical cancer in the California Cancer Registry. We linked this cohort to statewide ED discharge records to determine ED use and symptoms present at the encounter. Multivariable logistic regression models examined associations with ED use and multivariable Cox proportional hazards regression models examined associations with survival.</p><p><strong>Results: </strong>Of the more than 16,000 women with cervical cancer in the study cohort, 28% presented symptomatically in the ED prior to diagnosis. Those presenting symptomatically were more likely to have public (odds ratio [OR] 1.16; 95% confidence interval [CI] 1.06-1.27) or no insurance (OR 4.81; CI 4.06-5.71) (vs. private), low socioeconomic status (SES) (OR 1.76; CI 1.52-2.04), late-stage disease (OR 5.29; CI 4.70-5.96), and had a 37% increased risk of death (CI 1.28-1.46).</p><p><strong>Conclusion: </strong>Nearly a third of women with cervical cancer presented symptomatically, outside of a primary care setting, suggesting that many women, especially those with low SES, may not be benefiting from screening or healthcare following abnormal results.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":" ","pages":"1411-1421"},"PeriodicalIF":2.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10552-021-01489-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39339116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transportation noise and risk for colorectal cancer: a nationwide study covering Denmark.","authors":"Mette Sørensen,&nbsp;Aslak Harbo Poulsen,&nbsp;Jesse Thacher,&nbsp;Ulla Arthur Hvidtfeldt,&nbsp;Matthias Ketzel,&nbsp;Camilla Geels,&nbsp;Steen Solvang Jensen,&nbsp;Victor H Valencia,&nbsp;Ole Raaschou-Nielsen","doi":"10.1007/s10552-021-01492-4","DOIUrl":"https://doi.org/10.1007/s10552-021-01492-4","url":null,"abstract":"<p><strong>Purpose: </strong>Few studies have suggested that traffic noise is a risk factor for cancer, but evidence is inconclusive. We aimed to investigate whether road traffic and railway noise are associated with risk of colorectal cancer.</p><p><strong>Methods: </strong>We obtained address history for all 3.5 million people above 40 years of age and living in Denmark for the period 1990-2017 and estimated road traffic and railway noise (L_den) at the most and least exposed facades of all addresses as well as air pollution (PM_2.5). During follow-up (2000-2017), 35,881 persons developed colon cancer and 19,755 developed rectal cancer. Information on individual and area-level demographic and socioeconomic variables was collected from Danish registries. We analyzed data using Cox proportional hazards models, including traffic noise as time-varying 10-year average exposure.</p><p><strong>Results: </strong>Exposure to road traffic noise at the most exposed façade was associated with an incidence rate ratio and 95% confidence interval for proximal colon cancer of 1.018 (0.999-1.038) per 10 dB higher noise. We observed no associations for road traffic noise at the least exposed façade or for railway noise in relation to proximal colon cancer. Also, we found no association between road traffic or railway noise and risk for distal colon cancer or rectal cancer.</p><p><strong>Conclusion: </strong>Traffic noise did not seem associated with higher risk for colorectal cancer, although the suggestion of a slightly higher risk of proximal colon cancer following exposure to road traffic noise warrants further research.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":" ","pages":"1447-1455"},"PeriodicalIF":2.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39372290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Statins to mitigate cardiotoxicity in cancer patients treated with anthracyclines and/or trastuzumab: a systematic review and meta‑analysis.","authors":"Mary Obasi,&nbsp;Arielle Abovich,&nbsp;Jacqueline B Vo,&nbsp;Yawen Gao,&nbsp;Stefania I Papatheodorou,&nbsp;Anju Nohria,&nbsp;Aarti Asnani,&nbsp;Ann H Partridge","doi":"10.1007/s10552-021-01495-1","DOIUrl":"https://doi.org/10.1007/s10552-021-01495-1","url":null,"abstract":"","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":" ","pages":"1407-1409"},"PeriodicalIF":2.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9172661/pdf/10552_2021_Article_1495.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39425609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing prevalence of metastatic castration-resistant prostate cancer in a managed care population in the United States.","authors":"Katrine L Wallace,&nbsp;Adrienne Landsteiner,&nbsp;Scott H Bunner,&nbsp;Nicole M Engel-Nitz,&nbsp;Amy N Luckenbaugh","doi":"10.1007/s10552-021-01484-4","DOIUrl":"https://doi.org/10.1007/s10552-021-01484-4","url":null,"abstract":"<p><strong>Purpose: </strong>Numerous treatment breakthroughs for patients with metastatic castration-resistant prostate cancer (mCRPC) have been demonstrated in clinical trials in the past 15 years. However, real-world evidence on the changing epidemiology and longevity of this population has not been demonstrated. This study assessed prevalence trends for mCRPC over eight years in a large managed care population.</p><p><strong>Methods: </strong>In a claims database, adult male patients were included with ≥ 1 claim for prostate cancer, pharmacologic/surgical castration, and metastatic disease during the identification period. The index mCRPC date was the first metastatic claim; six months of continuous enrollment before and after was required. Patients with metastatic disease at baseline were excluded. Patients were followed until death, end of study, or disenrollment, whichever was earliest. Total, mCRPC per-prostate cancer, and age-specific prevalence rates were calculated cross-sectionally for each year under study (2010-2017).</p><p><strong>Results: </strong>Of 343,089 patients identified with a claim for prostate cancer, 3690 mCRPC cases (1.1%) were identified. Incidence (new cases per year) remained relatively constant over the study period while prevalence of mCRPC (total cases per year) increased. mCRPC prevalence increased with increasing age. Total and mCRPC per-prostate cancer prevalence rates increased in monotonic, year-over-year trends from 2010 to 2017, while incidence (new cases per year) of mCRPC remained relatively stable.</p><p><strong>Conclusion: </strong>This study found increasing prevalence of mCRPC in an insured patient population during the 8-year period, coupled with stable incidence, validating that patients with the disease are living longer. With the addition of androgen receptor-directed therapies and poly(ADP-ribose) polymerase inhibitors in recent years, this trend will likely continue.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":" ","pages":"1365-1374"},"PeriodicalIF":2.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10552-021-01484-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39307032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Cannabis use is associated with patient and clinical factors in a population-based sample of colorectal cancer survivors.","authors":"P A Newcomb,&nbsp;M Ton,&nbsp;R C Malen,&nbsp;J L Heffner,&nbsp;J Labadie,&nbsp;A I Phipps,&nbsp;A N Burnett-Hartman","doi":"10.1007/s10552-021-01499-x","DOIUrl":"https://doi.org/10.1007/s10552-021-01499-x","url":null,"abstract":"","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":" ","pages":"1329-1331"},"PeriodicalIF":2.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39533283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in the relationship between diabetes and prostate cancer among Black and White non-Hispanic men.","authors":"Eric A Miller,&nbsp;Paul F Pinsky,&nbsp;Dudith Pierre-Victor","doi":"10.1007/s10552-021-01486-2","DOIUrl":"https://doi.org/10.1007/s10552-021-01486-2","url":null,"abstract":"<p><strong>Purpose: </strong>Studies finding lower incidence rates of prostate cancer among men with diabetes have been primarily conducted in White non-Hispanic (WNH) populations. The purpose of this analysis is to compare the relationship between diabetes and prostate cancer among Black (BNH) and White non-Hispanic men.</p><p><strong>Methods: </strong>We used Surveillance, Epidemiology, and End Results (SEER)-Medicare data from 2011 to 2015 to compare incidence rates and tumor characteristics between BNH and WNH men by diabetes status. Age-adjusted incidence rates and corresponding rate ratios (RR) by diabetes status were calculated overall and by tumor grade, stage, and PSA level separately for BNH and WNH men. We used multivariable logistic regression to compare tumor characteristics among men with prostate cancer in the numerator, both within and across race/ethnic groups.</p><p><strong>Results: </strong>Overall age-adjusted incidence rates were significantly lower in men with diabetes compared to those without among WNH men [RR = 0.88 95% Confidence Interval (CI) 0.86-0.90] but there was no difference in rates by diabetes status among BNH men (RR = 1.01 95% CI 0.96-1.07). Men with diabetes were less likely to be diagnosed with distant-staged tumors compared to those without diabetes in both race/ethnic groups but the magnitude of difference by diabetes status was greater in BNH [Odds Ratio (OR) = 0.52 95% CI 0.42-0.64] than WNH (OR = 0.88 95% CI 0.81-0.95) men (p-value for interaction < 0.001).</p><p><strong>Conclusion: </strong>The relationship between diabetes and prostate cancer differed between BNH and WNH men. The differences could have implications in evaluating the effectiveness of prostate cancer screening in men with diabetes across racial/ethnic subgroups.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":" ","pages":"1385-1393"},"PeriodicalIF":2.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10552-021-01486-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39299207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis use is associated with patient and clinical factors in a population-based sample of colorectal cancer survivors.","authors":"P A Newcomb,&nbsp;M Ton,&nbsp;R C Malen,&nbsp;J L Heffner,&nbsp;J Labadie,&nbsp;A I Phipps,&nbsp;A N Burnett-Hartman","doi":"10.1007/s10552-021-01468-4","DOIUrl":"https://doi.org/10.1007/s10552-021-01468-4","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to characterize patient and clinical factors associated with cannabis (marijuana) use among patients diagnosed with colorectal cancer (CRC).</p><p><strong>Methods: </strong>We identified CRC patients, diagnosed from 2016 to 2018, using the Seattle-Puget Sound Surveillance, Epidemiology, and End Results (SEER) cancer registry. CRC patients were recruited via mail and telephone, and participants completed a questionnaire eliciting information on medical history, demographics, and lifestyle factors, including cannabis use. Cancer stage was obtained from SEER registry data.</p><p><strong>Results: </strong>Of 1,433 survey respondents, 339 (24%) were current cannabis users. Current cannabis use was associated with younger age at diagnosis, lower BMI, and a higher prevalence of cigarette smoking and alcohol consumption (p-value < 0.05). Cannabis use was also associated with lower quality of life scores (FACT-C) and advanced-stage cancer (p-value < 0.05).</p><p><strong>Conclusion: </strong>Cannabis use among CRC patients was common. Patients with more advanced disease were more likely to report cannabis use. Use also varied by some personal factors, consistent with patterns in the general population. Given the high prevalence of cannabis use among CRC patients, research is needed to determine the benefits and harms of cannabis use for symptom management in cancer patients.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":" ","pages":"1321-1327"},"PeriodicalIF":2.3,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10552-021-01468-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39185157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for early-onset colorectal cancer: a population-based case-control study in Ontario, Canada.","authors":"Vicky C Chang,&nbsp;Michelle Cotterchio,&nbsp;Prithwish De,&nbsp;Jill Tinmouth","doi":"10.1007/s10552-021-01456-8","DOIUrl":"https://doi.org/10.1007/s10552-021-01456-8","url":null,"abstract":"<p><strong>Purpose: </strong>There has been an alarming increase in colorectal cancer (CRC) incidence among young adults aged < 50 years, and factors driving this upward trend are unknown. This study investigated associations between various medical, lifestyle, and dietary factors and risk of early-onset CRC (EO-CRC).</p><p><strong>Methods: </strong>A population-based case-control study was conducted in Ontario, Canada during 2018-2019. EO-CRC cases aged 20-49 years (n = 175) were identified from the Ontario Cancer Registry; sex- and age group-matched controls (n = 253) were recruited through random digit dialing. Data on potential a priori risk factors were collected using a web-based self-reported questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable logistic regression.</p><p><strong>Results: </strong>Family history of CRC in a first- or second-degree relative (OR 2.37; 95% CI 1.47-3.84), longer sedentary time (≥ 10 vs. < 5 h/day, OR 1.93; 95% CI 1.02-3.65), greater consumption of sugary drinks (≥ 7 vs. < 1 drinks/week, OR 2.99; 95% CI 1.57-5.68), and a more Westernized dietary pattern (quartile 4 vs. 1, OR 1.92; 95% CI 1.01-3.66) were each associated with an increased risk of EO-CRC. Conversely, calcium supplement use (OR 0.53; 95% CI 0.31-0.92), history of allergy or asthma (OR 0.62; 95% CI 0.39-0.98), and greater parity in females (≥ 3 vs. nulliparity, OR 0.29; 95% CI 0.11-0.76) were each associated with a reduced risk.</p><p><strong>Conclusion: </strong>Modifiable factors, particularly sedentary behavior and unhealthy diet including sugary drink consumption, may be associated with EO-CRC risk. Our findings, if replicated, may help inform prevention strategies targeted at younger persons.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":" ","pages":"1063-1083"},"PeriodicalIF":2.3,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s10552-021-01456-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39088925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}