Alzheimer disease and associated disorders最新文献_第9页

Recruiting Dementia Caregivers Into Clinical Trials: Lessons Learnt From the Australian TRANSCENDENT Trial. 招募痴呆护理人员进入临床试验:从澳大利亚TRANSCENDENT试验中吸取的教训。

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2016-10-01 DOI: 10.1097/WAD.0000000000000149

Matthew J Leach, Tahereh Ziaian, Andrew Francis, Tamara Agnew

{"title":"Recruiting Dementia Caregivers Into Clinical Trials: Lessons Learnt From the Australian TRANSCENDENT Trial.","authors":"Matthew J Leach, Tahereh Ziaian, Andrew Francis, Tamara Agnew","doi":"10.1097/WAD.0000000000000149","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000149","url":null,"abstract":"The burden on those caring for a person with dementia is substantial. Although quality research assists in addressing the needs of these caregivers, recruiting caregivers into clinical studies is often problematic. This investigation explores the difficulties and successes in recruiting dementia caregivers into community-based clinical research by reporting the findings of a mixed-method substudy of a multicenter randomized controlled trial involving 40 community-dwelling dementia caregivers living in Adelaide, South Australia. Data for the substudy were derived from standardized trial monitoring documentation and structured telephone interviews. From a total of 16 distinct methods used across a 12-month recruitment campaign, the most cost-effective strategy was the distribution of flyers through a single study site. This approach generated the greatest number of enrollments of all methods used, achieving a 67% recruitment yield. The least cost-effective strategy, with a 0% recruitment yield, was the publication of a newspaper advertisement. Themes that emerged from the interviews pointed toward 5 key facilitators and 3 barriers to future trial recruitment. This study has generated new insights into the effective recruitment of dementia caregivers into clinical trials. We anticipate that these lessons learnt will assist in shaping the recruitment strategies of future studies of dementia caregivers.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":"338-344"},"PeriodicalIF":2.1,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/WAD.0000000000000149","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34585364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Diffusion Tensor Changes According to Age at Onset and Apolipoprotein E Genotype in Alzheimer Disease. 阿尔茨海默病弥散张量随发病年龄和载脂蛋白E基因型的变化

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2016-10-01 DOI: 10.1097/WAD.0000000000000155

Min-Jeong Kim, Sang Won Seo, Sung Tae Kim, Jong-Min Lee, Duk L Na

{"title":"Diffusion Tensor Changes According to Age at Onset and Apolipoprotein E Genotype in Alzheimer Disease.","authors":"Min-Jeong Kim, Sang Won Seo, Sung Tae Kim, Jong-Min Lee, Duk L Na","doi":"10.1097/WAD.0000000000000155","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000155","url":null,"abstract":"Age at onset is one of the most important factors that affects the clinical course in Alzheimer disease (AD), whereas other factors such as apolipoprotein E (apoE) genotype may also play a major role. In this study, we aimed to investigate the effect of age at onset and apoE genotype on white-matter changes in AD using diffusion tensor imaging. About 213 patients with AD and 66 normal individuals underwent diffusion tensor imaging, and apoE genotype was obtained in all AD patients and in 24 normal individuals. When multiple regression analysis was conducted, a younger age at onset was associated with lower fractional anisotropy in both deep-located long-range limbic and association fibers and superficial-located short-range association fibers in the frontal, the temporal, and the parietal lobes, and with a higher mean diffusivity in deep-located fibers and the bilateral medial thalamus. When analyzed separately in apoE e4 carriers and noncarriers, e4 carriers showed an association between a younger age at onset and lower fractional anisotropy, mainly in deep-located fibers, whereas noncarriers showed this association in both deep-located and superficial-located fibers. There was no difference in the spatial distribution between carriers and noncarriers in the association between the age at onset and mean diffusivity. Our results suggest that the topographical distribution of white-matter changes in AD is significantly affected by the interaction between age at onset and apoE genotype.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":"297-304"},"PeriodicalIF":2.1,"publicationDate":"2016-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/WAD.0000000000000155","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34585366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Divergent processing of monetary and social reward in behavioral variant frontotemporal dementia and Alzheimer disease. 行为变异额颞叶痴呆和阿尔茨海默病中货币和社会奖励的分化加工。

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2015-04-01 DOI: 10.1097/WAD.0000000000000012

David C Perry, Virginia E Sturm, Kristie A Wood, Bruce L Miller, Joel H Kramer

引用次数: 29

How Preserved is Emotion Recognition in Alzheimer Disease Compared With Behavioral Variant Frontotemporal Dementia? 与行为变异性额颞叶痴呆相比，阿尔茨海默病患者的情绪识别如何保存?

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2015-04-01 DOI: 10.1097/WAD.0000000000000023

Maxime Bertoux, Leonardo C de Souza, Marie Sarazin, Aurélie Funkiewiez, Bruno Dubois, Michael Hornberger

{"title":"How Preserved is Emotion Recognition in Alzheimer Disease Compared With Behavioral Variant Frontotemporal Dementia?","authors":"Maxime Bertoux, Leonardo C de Souza, Marie Sarazin, Aurélie Funkiewiez, Bruno Dubois, Michael Hornberger","doi":"10.1097/WAD.0000000000000023","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000023","url":null,"abstract":"Background: Emotion deficits are a recognised biomarker for behavioural variant frontotemporal dementia (bvFTD), but recent studies have reported emotion deficits also in Alzheimer’s disease (AD). Methods: A hundred and twenty-three participants (33 AD, 60 bvFTD, 30 controls) were administered a facial emotion recognition test, to investigate the clinical factors influencing the diagnostic distinction on this measure. Binomial regression analysis revealed that facial emotion recognition in AD was influenced by disease duration and MMSE, whereas the same was not true for bvFTD. Based on this information, we median-split the AD group on disease duration (3 years) or MMSE (24) and compared the facial emotion recognition performance of mild-AD, moderate-AD, bvFTD patients and controls. Results: Results showed that very mild-AD performed consistently at control levels for all emotions. By contrast, mild/moderate-AD and bvFTD were impaired compared to controls on most emotions. Interestingly, mild/moderate-AD were significantly impaired compared to very mild-AD on total score, anger and sadness subscores. Logistic regression analyses corroborated these findings with ~94% of very mild-AD being successfully distinguished from bvFTD at presentation, while this distinction was reduced to ~78% for mild/moderate-AD. Conclusions: Facial emotion recognition in AD is influenced by disease progression, with very mild-AD being virtually intact for emotion performance. Mild/moderate-AD and bvFTD show consistent impairment in emotion recognition, with bvFTD being worse. A disease progression of over 3 years or a MMSE lower than 24 should warrant caution to put too much emphasis on emotion recognition performance in the diagnostic distinction of AD and bvFTD.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":"154-7"},"PeriodicalIF":2.1,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/WAD.0000000000000023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40298400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 55

Erythrocyte membrane stability to hydrogen peroxide is decreased in Alzheimer disease. 阿兹海默症患者红细胞膜对过氧化氢的稳定性降低。

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2014-10-01 DOI: 10.1097/WAD.0000000000000026

Marilena Gilca, Daniela Lixandru, Laura Gaman, Bogdana Vîrgolici, Valeriu Atanasiu, Irina Stoian

{"title":"Erythrocyte membrane stability to hydrogen peroxide is decreased in Alzheimer disease.","authors":"Marilena Gilca, Daniela Lixandru, Laura Gaman, Bogdana Vîrgolici, Valeriu Atanasiu, Irina Stoian","doi":"10.1097/WAD.0000000000000026","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000026","url":null,"abstract":"The brain and erythrocytes have similar susceptibility toward free radicals. Therefore, erythrocyte abnormalities might indicate the progression of the oxidative damage in Alzheimer disease (AD). The aim of this study was to investigate erythrocyte membrane stability and plasma antioxidant status in AD. Fasting blood samples (from 17 patients with AD and 14 healthy controls) were obtained and erythrocyte membrane stability against hydrogen peroxide and 2,2'-azobis-(2-amidinopropane) dihydrochloride (AAPH), serum Trolox equivalent antioxidant capacity (TEAC), residual antioxidant activity or gap (GAP), erythrocyte catalase activity (CAT), erythrocyte superoxide dismutase (SOD) activity, erythrocyte nonproteic thiols, and total plasma thiols were determined. A significant decrease in erythrocyte membrane stability to hydrogen peroxide was found in AD patients when compared with controls (P<0.05). On the contrary, CAT activity (P<0.0001) and total plasma thiols (P<0.05) were increased in patients with AD compared with controls. Our results indicate that the most satisfactory measurement of the oxidative stress level in the blood of patients with AD is the erythrocyte membrane stability to hydrogen peroxide. Reduced erythrocyte membrane stability may be further evaluated as a potential peripheral marker for oxidative damage in AD. ","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":"358-63"},"PeriodicalIF":2.1,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/WAD.0000000000000026","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40298395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Deficient symbol processing in Alzheimer disease. 阿尔茨海默病的符号加工缺陷。

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2014-10-01 DOI: 10.1097/WAD.0000000000000035

Max Toepper, Carolin Steuwe, Thomas Beblo, Eva Bauer, Sebastian Boedeker, Christine Thomas, Hans J Markowitsch, Martin Driessen, Gebhard Sammer

{"title":"Deficient symbol processing in Alzheimer disease.","authors":"Max Toepper, Carolin Steuwe, Thomas Beblo, Eva Bauer, Sebastian Boedeker, Christine Thomas, Hans J Markowitsch, Martin Driessen, Gebhard Sammer","doi":"10.1097/WAD.0000000000000035","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000035","url":null,"abstract":"Symbols and signs have been suggested to improve the orientation of patients suffering from Alzheimer disease (AD). However, there are hardly any studies that confirm whether AD patients benefit from signs or symbols and which symbol characteristics might improve or impede their symbol comprehension. To address these issues, 30 AD patients and 30 matched healthy controls performed a symbol processing task (SPT) with 4 different item categories. A repeated-measures analysis of variance was run to identify impact of different item categories on performance accuracy in both the experimental groups. Moreover, SPT scores were correlated with neuropsychological test scores in a broad range of other cognitive domains. Finally, diagnostic accuracy of the SPT was calculated by a receiver-operating characteristic curve analysis. Results revealed a global symbol processing dysfunction in AD that was associated with semantic memory and executive deficits. Moreover, AD patients showed a disproportional performance decline at SPT items with visual distraction. Finally, the SPT total score showed high sensitivity and specificity in differentiating between AD patients and healthy controls. The present findings suggest that specific symbol features impede symbol processing in AD and argue for a diagnostic benefit of the SPT in neuropsychological assessment. ","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":"340-6"},"PeriodicalIF":2.1,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/WAD.0000000000000035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40296821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Feasibility and validity of the self-administered computerized assessment of mild cognitive impairment with older primary care patients. 老年初级保健患者自我管理的轻度认知障碍计算机评估的可行性和有效性。

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2014-10-01 DOI: 10.1097/WAD.0000000000000036

Mary C Tierney, Gary Naglie, Ross Upshur, Rahim Moineddin, Jocelyn Charles, R Liisa Jaakkimainen

{"title":"Feasibility and validity of the self-administered computerized assessment of mild cognitive impairment with older primary care patients.","authors":"Mary C Tierney, Gary Naglie, Ross Upshur, Rahim Moineddin, Jocelyn Charles, R Liisa Jaakkimainen","doi":"10.1097/WAD.0000000000000036","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000036","url":null,"abstract":"We investigated whether a validated computerized cognitive test, the Computerized Assessment of Mild Cognitive Impairment (CAMCI), could be independently completed by older primary care patients. We also determined the optimal cut-off for the CAMCI global risk score for mild cognitive impairment against an independent neuropsychological reference standard. All eligible patients aged 65 years and older, seen consecutively over 2 months by 1 family practice of 13 primary care physicians, were invited to participate. Patients with a diagnosis or previous work-up for dementia were excluded. Primary care physicians indicated whether they, the patient, or family had concerns about each patient's cognition. A total of 130 patients with cognitive concerns and a matched sample of 133 without cognitive concerns were enrolled. The CAMCI was individually administered after instructions to work independently. Comments were recorded verbatim. A total of 259 (98.5%) completed the entire CAMCI. Two hundred and forty-one (91.6%) completed it without any questions or after simple acknowledgment of their question. Lack of computer experience was the only patient characteristic that decreased the odds of independent CAMCI completion. These results support the feasibility of using self-administered computerized cognitive tests with older primary care patients, given the increasing reliance on computers by people of all ages. The optimal cut-off score had a sensitivity of 80% and specificity of 74%. ","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":"311-9"},"PeriodicalIF":2.1,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/WAD.0000000000000036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40296824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Is bilingualism associated with a lower risk of dementia in community-living older adults? Cross-sectional and prospective analyses. 在社区生活的老年人中，双语与较低的痴呆风险有关吗?横断面和前瞻性分析。

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2014-10-01 DOI: 10.1097/WAD.0000000000000019

Caleb M Yeung, Philip D St John, Verena Menec, Suzanne L Tyas

{"title":"Is bilingualism associated with a lower risk of dementia in community-living older adults? Cross-sectional and prospective analyses.","authors":"Caleb M Yeung, Philip D St John, Verena Menec, Suzanne L Tyas","doi":"10.1097/WAD.0000000000000019","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000019","url":null,"abstract":"Objective: The aim of this study was to determine whether bilingualism is associated with dementia in cross-sectional or prospective analyses of older adults.Methods: In 1991, 1616 community-living older adults were assessed and were followed 5 years later. Measures included age, sex, education, subjective memory loss (SML), and the modified Mini-mental State Examination (3MS). Dementia was determined by clinical examination in those who scored below the cut point on the 3MS. Language status was categorized based upon self-report into 3 groups: English as a first language (monolingual English, bilingual English) and English as a Second Language (ESL).Results: The ESL category had lower education, lower 3MS scores, more SML, and were more likely to be diagnosed with cognitive impairment, no dementia at both time 1 and time 2 compared with those speaking English as a first language. There was no association between being bilingual (ESL and bilingual English vs. monolingual) and having dementia at time 1 in bivariate or multivariate analyses. In those who were cognitively intact at time 1, there was no association between being bilingual and having dementia at time 2 in bivariate or multivariate analyses.Conclusions: We did not find any association between speaking >1 language and dementia.","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":"326-32"},"PeriodicalIF":2.1,"publicationDate":"2014-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1097/WAD.0000000000000019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40298393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 75

Association between neuropathology and brain volume in the Framingham Heart Study. 弗雷明汉心脏研究中神经病理学与脑容量的关系。

Alzheimer disease and associated disorders Pub Date : 2014-07-01 DOI: 10.1097/WAD.0000000000000032

Berneet Kaur, Jayandra J Himali, Sudha Seshadri, Alexa S Beiser, Rhoda Au, Ann C McKee, Sanford Auerbach, Philip A Wolf, Charles S DeCarli

{"title":"Association between neuropathology and brain volume in the Framingham Heart Study.","authors":"Berneet Kaur, Jayandra J Himali, Sudha Seshadri, Alexa S Beiser, Rhoda Au, Ann C McKee, Sanford Auerbach, Philip A Wolf, Charles S DeCarli","doi":"10.1097/WAD.0000000000000032","DOIUrl":"10.1097/WAD.0000000000000032","url":null,"abstract":"Studies of clinical and community cohorts have shown that antemortem imaging measures of hippocampal volume have correlated with postmortem Alzheimer pathology. Fewer studies have examined the relationship between both Alzheimer and cerebrovascular pathology, and antemortem brain imaging. The aim of this study was to correlate antemortem brain magnetic resonance imaging (MRI) volumes with postmortem brain pathology (both Alzheimer-related and cerebrovascular) in a community-derived cohort from the Framingham Heart Study. Participants (n=59) from the Framingham Heart Study were included if they were enrolled in the brain autopsy program and underwent antemortem clinical evaluation, neuropsychological testing, and brain MRI. Cortical neurofibrillary tangle pathology correlated with lower total cerebral brain (β±SE=-0.04±0.01, P=0.004) and hippocampal volumes (β±SE=-0.03±0.02, P=0.044) and larger temporal horns (log-transformed, β±SE=0.05±0.01, P=0.001). Similar findings were seen between total/cortical neuritic plaques and total cerebral brain and temporal horn volume. White matter hyperintensities (also log-transformed) were best predicted by the presence of deep nuclei microinfarcts (β±SE=0.53±0.21, P=0.016), whereas hippocampal volume was significantly decreased in the presence of hippocampal sclerosis (β±SE=-1.23±0.30, P<0.001). This study showed that volumetric MRI measures correlated with postmortem Alzheimer-related and cerebrovascular neuropathology in this community-derived cohort, confirming that these MRI measures are important antemortem surrogates for these dementia-related pathologies. ","PeriodicalId":520551,"journal":{"name":"Alzheimer disease and associated disorders","volume":" ","pages":"219-25"},"PeriodicalIF":0.0,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139422/pdf/nihms563127.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40298392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive behavioral group intervention for Alzheimer caregivers. 阿尔茨海默病护理人员的认知行为群体干预。

IF 2.1

Alzheimer disease and associated disorders Pub Date : 2014-07-01 DOI: 10.1097/WAD.0000000000000033

Serena Passoni, Loretta Moroni, Alessio Toraldo, Manuela T Mazzà, Giorgio Bertolotti, Nicola Vanacore, Gabriella Bottini

引用次数: 25