Sovremennye tekhnologii v meditsine最新文献

{"title":"L-Boronphenylalanine Biodistribution Dynamics in the Organs of Mice with Subcutaneous Tumor Xenograft is a Model to Assess Neuron Sources Efficiency in Boron Neutron Capture Therapy.","authors":"I N Druzkova, A A Pakhomova, N I Ignatova, A R Suleymanova, A V Maslennikova","doi":"10.17691/stm2023.15.6.02","DOIUrl":"10.17691/stm2023.15.6.02","url":null,"abstract":"<p><p>Boron neutron capture therapy (BNCT), due to its high biological efficiency, is one of the most promising methods of radiation therapy for malignant tumors. Currently, research in this area has received momentum due to the emergence of fundamentally new compact neutron sources suitable for clinical use. <b>The aim of the investigation</b> was to study L-boronphenylalanine (L-BPA) biodistribution in the organs of experimental animals with subcutaneous tumor xenografts, and evaluate the application of the experimental model to assess the effectiveness of new neutron sources.</p><p><strong>Materials and methods: </strong>The experiments were carried out on BALB/c mice with subcutaneous xenograft of mouse adenocarcinoma CT26. L-boronphenylalanine in a molar excess of fructose was administered intravenously at a dose of 350 mg/kg, the organs under study were taken 1.5, 3, 6, and 24 h after drug administration. The content of the ¹⁰B isotope was analyzed using inductively coupled plasma mass spectroscopy (ICP-MS). The absence of toxic effects was verified pathomorphologically.</p><p><strong>Results: </strong>The maximum L-BPA content in the tumor was 142.0±4.41 μg/g 1.5 h after drug administration. The minimum therapeutic concentration of L-BPA in the tumor persists up to 5.4 h after drug administration. Among normal organs, the maximum content was observed in the kidneys, it is most likely being associated with the structural and functional features of the organ rather than the true content of L-BPA in the tissues. Histological studies revealed no structural disorders and dystrophic changes in tissues against the background of L-BPA introduction.</p><p><strong>Conclusion: </strong>The results of the study demonstrate the feasibility of the studied tumor model to evaluate the efficiency of new neutron sources for BNCT. The L-borophenylalanine content in the tumor and the time of maintaining the minimum therapeutic concentration appeared to be sufficient for effective BNCT. The high contrast of ¹⁰B accumulation relative to non-pathological tissues minimizes the possible side effects of BNCT.</p>","PeriodicalId":520289,"journal":{"name":"Sovremennye tekhnologii v meditsine","volume":"15 6","pages":"14-20"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valve Formation during Colostomy by Means of Spherical Implants Based on Titanium Nickelide Both Wrapping and Non-Wrapping the Serous-Muscular Layer of the Intestine.","authors":"V I Korobeinikova, G Ts Dambaev, S G Anikeev, V N Khodorenko, O A Kaydash, M V Bukterov, A A Ufandeev, D V Vasilchenko, E A Avdoshina, M M Soloviev, N E Kurtseitov, V E Gunter","doi":"10.17691/stm2023.15.6.06","DOIUrl":"10.17691/stm2023.15.6.06","url":null,"abstract":"<p><p>Imposition of a classic colostomy does not allow to control the passage of intestinal discharge. This shortcoming provides rationale for development of new materials for implants, as well as new techniques for valve formation. <b>The aim of the study</b> is to assess the possibility of using spherical implants based on titanium nickelide both wrapping and non-wrapping the serous-muscular layer of the intestine for valve formation during colostomy.</p><p><strong>Materials and methods: </strong>Experiments were performed on 45 male Wistar rats with the average body weight of 587±10 g. Depending on the type of surgical intervention, all animals were divided into three groups. In the control group (n=15), a classic end colostomy was formed without spherical implants. In test group 1 (n=15), colostomy was formed using spherical implants made of titanium nickelide with wrapping the serous-muscular layer of the intestine; in test group 2 (n=15), the same procedure was performed without wrapping the serous-muscular layer. To assess the clinical condition of the animals, the authors monitored the body weight dynamics, food and water consumption, signs of discharge from the stoma, and recorded complications. The animals were euthanized on day 7, day 30, and day 60 of the experiment. During necropsy, the condition of the abdominal organs was assessed macroscopically with a special attention to the signs of adhesions. The severity of the inflammatory process in the area of surgical intervention was assessed histologically.</p><p><strong>Results: </strong>The survival rate in three groups was 100%. In the group with the formation of a colostomy non-wrapping the serous-muscular layer, a good effect of regeneration in the stoma area was shown, the connection of the skin flap and the intestinal wall was complete. Macroscopically, adhesions and inflammatory processes of the peritoneum in the control and two test groups were minimal.</p><p><strong>Conclusion: </strong>The present study shows the advantage of experimental modeling of colostomy using spherical titanium nickelide implants non-wrapping the serous-muscular layer of the colon compared to classical formation of colostomy. At that, wrapping the serous-muscular layer of the colon using spherical titanium nickelide implants is behind classical formation of a colostomy.</p>","PeriodicalId":520289,"journal":{"name":"Sovremennye tekhnologii v meditsine","volume":"15 6","pages":"49-60"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser Soldering of Cartilage Tissue to Collagenous Biomaterial (an <i>in vitro</i> Study).","authors":"N Yu Ignatieva, O L Zakharkina, A P Sviridov","doi":"10.17691/stm2023.15.6.04","DOIUrl":"10.17691/stm2023.15.6.04","url":null,"abstract":"<p><p><b>The aim of the study</b> was to assess the effectiveness of laser soldering of biological tissues and materials for bulk heating of albumin solder on the joints of the intact and chemically modified cartilage of the porcine nasal septum.</p><p><strong>Materials and methods: </strong>The materials for soldering were double-trypsinized and glyceraldehyde-treated plates made from cartilage of the porcine nasal septum, and intact cartilage. A 25% albumin solution was used as a solder. The junction was heated by laser radiation with the wavelengths of 1.56 and 1.68 μm through an optical fiber. The process was monitored using a digital USB microscope. After the materials were soldered, mechanical tests of the samples were conducted, and the fraction of intact collagen in the areas adjacent to the solder was determined. A thermal imager was used to record the dynamics of the temperature field in the area of laser exposure.</p><p><strong>Results: </strong>The effective soldering of cartilage tissue with collagenous biomaterial occurs with sequential application and laser heating of two/three layers of solder for radiation with wavelengths of 1.68/1.56 μm, respectively. The laser power densities for the solder layers were 0.7/0.8 W/mm² (the average surface temperature ~85°C) for λ=1.68 μm and 1.77/1.34/0.96 W/mm² (the average surface temperature ~100°C) for λ=1.56 μm. The tensile strength of the soldered samples reached ~12% for λ=1.56 μm and ~15% for λ=1.68 μm of the tensile strength of intact cartilage. In the tissue areas adjacent to the first layer of albumin, at a thickness of ~300 μm, most of the collagen network was destroyed. In other areas, collagen was predominantly preserved.</p><p><strong>Conclusion: </strong>Laser soldering of chemically modified and intact cartilages can be effectively conducted using radiation of λ=1.56 μm and λ=1.68 μm, absorbed not only by the solder, but also by the tissue. However, to minimize the area of degradation, it is necessary to match the diameter of the laser spot and the size of the solder-filled cavity between the construction and the intact cartilage.</p>","PeriodicalId":520289,"journal":{"name":"Sovremennye tekhnologii v meditsine","volume":"15 6","pages":"31-37"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Sandblasting and Plasma Electrolytic Oxidation on Surface Quality of Dental Implants.","authors":"L I Zaynullina, R G Farrakhov, I A Ramazanov, R Z Khamatdinov, V S Dyuryagin, E V Parfenov","doi":"10.17691/stm2023.15.6.05","DOIUrl":"10.17691/stm2023.15.6.05","url":null,"abstract":"<p><p>Titanium alloys have high biocompatibility, and, therefore, they are widely used in the production of implantable medical devices. Implants, in turn, must have certain surface properties for a positive osseointegration. To improve biocompatibility, as well as cell viability, numerous implant surface modifications have been proposed in order to improve topography, roughness parameters, and surface layer chemical and phase compositions. The most common type of surface treatment for dental implants involves sandblasting with aluminum oxide Al₂O₃ (corundum). However, aluminum is not a biocompatible element, and it can contribute to development of various diseases. Currently, the method of plasma electrolytic oxidation is being actively developed to ensure formation of a biocompatible TiO₂-based oxide coating on the surface of titanium implants. <b>The aim of the study</b> was to establish the residual aluminum content in the surface layer of dental implants after sandblasting and subsequent plasma electrolytic oxidation to justify the effective process sequence in serial production of dental implants.</p><p><strong>Materials and methods: </strong>The research was conducted to establish the residual content of aluminum in the surface layer of the NCTi implant subjected to two surface treatment methods: sandblasting and plasma electrolytic oxidation following the sandblasting.</p><p><strong>Results: </strong>Sandblasting with Al₂O₃ particles leads to fixation of such particles with Al weight fraction of 2.67±0.79% in the surface layer of the implant. Treatment of a dental implant using plasma electrolytic oxidation helps to reduce the Al weight fraction in the surface layer to 0.33±0.08% and significantly improves the implant corrosion resistance with a decrease in corrosion currents by an order of magnitude.</p>","PeriodicalId":520289,"journal":{"name":"Sovremennye tekhnologii v meditsine","volume":"15 6","pages":"40-46"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GIS Software Package \"Epidemiological Atlas of Russia\" on Current Infectious Diseases.","authors":"S A Sarskov, M V Vyushkov, A V Polyanina, S L Slavin, N N Zaitseva","doi":"10.17691/stm2023.15.6.03","DOIUrl":"https://doi.org/10.17691/stm2023.15.6.03","url":null,"abstract":"<p><p><b>The aim of the study</b> is to develop a GIS software package \"Epidemiological Atlas of Russia\" on topical infectious and parasitic diseases in the Russian Federation to create an open and publicly accessible information resource allowing to improve the quality of morbidity epidemiological monitoring and analysis.</p><p><strong>Materials and methods: </strong>The GIS software package \"Epidemiological Atlas of Russia\" was designed for data monitoring, epidemiological analysis, and cartographic visualization and was implemented as a web resource consisting of a web application, a package administration module, and a database management system. The following development tools were used to create the package: JavaScript, PHP, additional mapping libraries (Leaflet, OpenStreetMap), MySQL database management systems, Visual Basic .NET. The primary information for the database was taken from official federal statistical observation forms No.1 and No.2 \"Information on infectious and parasitic diseases\".</p><p><strong>Results: </strong>Analytical methods and GIS technologies used in epidemiological practice were evaluated, optimal technical solutions based on the experience of developing the \"Epidemiological Atlas of the Volga Federal District\" were selected. A versatile database structure was designed and developed to create an array of input and output statistical values of an epidemiological nature. Original algorithms were created to obtain and evaluate epidemiological indicators. Web application \"Epidemiological Atlas of Russia\" was developed to present, analyze, and visualize information on infectious and parasitic diseases in the subjects of a district, federal districts, and the Russian Federation as a whole. It allows to work with report forms of the Ministry of Health to organize federal statistical monitoring in the field of health protection and with laboratory studies results to create thematic modules providing detailed information on individual nosologies. Initial data were temporally broken down by months, and spatially, by Russian Federation subjects. All visualization results were dynamically updated and generated based on user's interactive request.</p><p><strong>Conclusion: </strong>GIS software package \"Epidemiological Atlas of Russia\" was developed as an open and publicly accessible information resource and is designed to improve the quality of epidemiological monitoring, operational and retrospective epidemiological analysis of the incidence of current infectious and parasitic diseases in the Russian Federation. The package is intended for use in federal executive authorities, in supervisory authorities and institutions of Rospotrebnadzor, in medical organizations of the Ministry of Health of the Russian Federation and is in line with the state policy aimed to introduce modern technologies into practice.</p>","PeriodicalId":520289,"journal":{"name":"Sovremennye tekhnologii v meditsine","volume":"15 6","pages":"22-27"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}