Revista internacional de andrologia最新文献

{"title":"Diagnostic value of basal sex hormone levels and pelvic B-mode ultrasound in central precocious puberty among female children.","authors":"Weimin Jin, Miangen Zhang, Jun Xiang, Zhishu Li","doi":"10.22514/j.androl.2024.032","DOIUrl":"https://doi.org/10.22514/j.androl.2024.032","url":null,"abstract":"<p><strong>Background: </strong>This study aims to explore the diagnostic significance of basal sex hormone levels and pelvic B-mode ultrasound in the context of central precocious puberty (CPP) in female children.</p><p><strong>Methods: </strong>A cohort study was conducted at the Third Affiliated Hospital of Wenzhou Medical University from January 2014 to January 2024. The study enrolled female children exhibiting early breast development before the age of 8 and subjected them to gonadotropin-releasing hormone (GnRH) stimulation tests. Subsequently, the participants were categorized into a CPP cohort and a non- CPP cohort, each comprising 75 individuals. Comparative analysis was performed on the basal luteinizing hormone (LH) levels, uterine length and ovarian volume between the two cohorts.</p><p><strong>Results: </strong>The results show no significant differences were observed in age and body mass index (BMI) between the CPP and non-CPP groups (both <i>p</i> > 0.05). However, basal LH levels, uterine length, and ovarian volume were significantly higher in the CPP group compared to the non-CPP group (all <i>p</i> < 0.05). Binary logistic regression analysis revealed that basal LH levels, uterine length, and ovarian volume were independent risk factors for CPP in female children (all <i>p</i> < 0.05). Receiver Operating Characteristic (ROC) curve analysis showed that the area under the curve (AUC) for basal LH, ovarian volume, and uterine length were 0.823, 0.752 and 0.730, respectively. The combined diagnosis of these three factors significantly improved diagnostic performance, with an AUC of 0.931 (95% confidence interval (CI) : 0.891-0.972), a sensitivity of 88.00%, and a specificity of 86.70%.</p><p><strong>Conclusions: </strong>The integration of basal levels of sex hormones and pelvic B-mode ultrasound holds considerable importance in the diagnosis of CPP in young girls, offering a non-invasive, accessible and cost-effective method for clinical assessment. Therefore, its utilization is highly recommended.</p>","PeriodicalId":519907,"journal":{"name":"Revista internacional de andrologia","volume":"22 4","pages":"68-74"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual experience under the influence of alcohol and cannabis consumption.","authors":"Andrea Blanc, Ana Galindo, Laura Tascón","doi":"10.22514/j.androl.2024.014","DOIUrl":"10.22514/j.androl.2024.014","url":null,"abstract":"<p><p>Substance use affects different areas of life, including the sexual sphere. Drugs and specifically the use of alcohol and cannabis, can influence sexual experience. However, there has been little research and to date none has been carried out in Spain that compares the effect of alcohol and cannabis consumption in the same people on their sexual experience. Therefore, the objective of the study was to analyze and compare the effect of alcohol and cannabis in the same people on their sexual experience. The sample consisted of 483 people who had ever consumed alcohol and cannabis. Participants answered an online questionnaire about alcohol and cannabis use and sexual experience. The results show that despite the fact that when people consume alcohol, they feel more attractive, they feel more attraction towards other people, they are more extroverted, their desire increases and they have longer sexual relations than when they consume cannabis, people who frequently consume when consume cannabis, they have more sensitivity and they are more sexually satisfied than when they consume alcohol. Regarding the sexual experience, although they prefer not to use drugs when they have sex, people who frequently consume prefer to consume more cannabis than alcohol. Therefore, it is concluded that, although alcohol facilitates the sexual encounter, with cannabis people feel more sexually satisfied.</p>","PeriodicalId":519907,"journal":{"name":"Revista internacional de andrologia","volume":"22 3","pages":"40-47"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating discordance between embryologists and histopathologists: analysis of multiple factors in mTESE sperm retrieval outcomes.","authors":"Mehmet Sahin, Osman Can, Emin Taha Keskin, Yigit Can Filtekin, Halil Lutfi Canat","doi":"10.22514/j.androl.2024.020","DOIUrl":"10.22514/j.androl.2024.020","url":null,"abstract":"<p><p>The objective of the study is to primarily highlight the consistency between the embryologist and the histopathologist in microdissection testicular sperm extraction and to explore the factors affecting sperm retrieval. The research included 91 patients, aged 20 to 47, who visited our Reproductive Technology center from July 2020 to June 2023. Patient data were collected retrospectively, including demographics, physical exams, lab tests, radiological assessments, genetic analyses, medical histories and histopathological results. Using the Johnsen scoring system for evaluation, the histopathologist identified mature spermatozoa in the specimen in some patients (Johnsen score 8-10); however, the embryologist only declared successful sperm retrieval in 66.6% of them. Overall sperm retrieval rates were lower than expected at 40%. Significant factors influencing sperm retrieval rates included Follicle Stimulating Hormone (<i>p</i> = 0.001), Luteinizing Hormone (<i>p</i> = 0.007), testicular volume (<i>p</i> < 0.001), histopathology (<i>p</i> < 0.001), and alcohol consumption (<i>p</i> = 0.007). A logistic regression model was used to identify the independent predictors of successful sperm retrieval. FSH (<i>p</i> = 0.038), testicular volume (<i>p</i> < 0.001), histopathology (<i>p</i> < 0.001), and alcohol consumption (<i>p</i> = 0.013) emerged as significant predictive factors for the outcome of sperm retrieval. As a result, in addition to patient-related factors, the consistency between the pathologist and embryologist also affects sperm retrieval rates.</p>","PeriodicalId":519907,"journal":{"name":"Revista internacional de andrologia","volume":"22 3","pages":"32-39"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of imaging in patients with corporal fibrosis undergoing penile prosthesis placement: a narrative review.","authors":"Esther García Rojo, Lisa Kollitsch, Borja García Gómez, Manuel Alonso Isa, Javier Romero Otero, Ignacio Moncada, Daniar Osmonov","doi":"10.22514/j.androl.2024.016","DOIUrl":"10.22514/j.androl.2024.016","url":null,"abstract":"<p><p>Penile prosthesis implantation (PPI) is a definitive solution for severe erectile dysfunction unresponsive to conventional therapies. However, in patients with corporal fibrosis (CF), the procedure presents significant challenges and higher complication risks. This narrative review explores the crucial role of imaging techniques, such as ultrasound and magnetic resonance imaging, in preoperative planning for PPI in patients with CF. Through a comprehensive literature search, we analyzed studies focusing on the efficacy of these imaging modalities in assessing fibrosis severity and guiding surgical strategies. Our findings highlight that advanced imaging provides essential insights into fibrosis extent, thereby optimizing surgical outcomes and reducing potential complications. The review underscores the importance of meticulous preoperative imaging in improving patient management and surgical precision in this complex clinical scenario.</p>","PeriodicalId":519907,"journal":{"name":"Revista internacional de andrologia","volume":"22 3","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulation of STAT3 and NF-κB signaling pathways by <i>trans</i>-Anethole in testicular ischemia-reperfusion injury and its gonadoprotective effect.","authors":"Ugur Seker, Yasin Gökçe, Bulent Kati, Meral Yuksel, Baris Can Guzel, Majid Shokoohi","doi":"10.22514/j.androl.2024.015","DOIUrl":"10.22514/j.androl.2024.015","url":null,"abstract":"<p><p>Testicular ischemia reperfusion (I/R) injury is a significant urological problem where clinical interventions may be inadequate, and the antioxidants might be potential co-treatment modalities. This study examined the gonadoprotective effect of <i>trans</i>-Anethole in testicular I/R injury. Twenty-eight male rats were divided into four groups. Rats in the I/R, I/R + <i>t</i>100, I/R + <i>t</i>200 groups underwent bilateral testicular I/R injury. The I/R + <i>t</i>100 and I/R + <i>t</i>200 groups received 100 or 200 mg/kg <i>trans</i>-Anethole at the 2nd hour of ischemia. Microscopic evaluations demonstrated that testicular I/R injury leads to severe testicular degeneration. Tissue oxidative stress, pro-apoptotic Bcl-2 associated X (Bax) and Caspase 3, pro-inflammatory Tumor necrosis factor-alpha (TNF-α), Interleukin-1 beta (IL-1β) and Interleukin 6 (IL-6) cytokines levels were significantly (<i>p</i> < 0.05) upregulated when compared to the Control group. Additionally, transcription factors Signal transducer and activator of transcription 3 (STAT3) and Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) levels increased significantly (<i>p</i> < 0.05) compared to the Control group. Tissue disrupted parameters in the I/R + <i>t</i>200 group were significantly different (<i>p <</i> 0.05) from the I/R group, contrasting with the slight improvement in the I/R + <i>t</i>100 group. The STAT3 and NF-κB expression levels in the I/R + <i>t</i>200 group were significantly suppressed (<i>p</i> < 0.05) compared to the I/R group. In conclusion, our study indicates that <i>trans</i>-Anethole could enhance gonadoprotective activity in testicular I/R injury, potentially involving transcription factors STAT3 and NF-κB. However, before the consumption of <i>trans</i>-Anethole-containing natural or manufactured goods, the potential benefits and side effects should be carefully evaluated.</p>","PeriodicalId":519907,"journal":{"name":"Revista internacional de andrologia","volume":"22 3","pages":"57-67"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An integrative prediction model of successful sperm retrieval for men with non-obstructive azoospermia.","authors":"Zhanpeng Liu, Xinchi Xu, Yichun Wang, Chao Yang, Wei Wang, Chao Qin","doi":"10.22514/j.androl.2024.021","DOIUrl":"10.22514/j.androl.2024.021","url":null,"abstract":"<p><p>Microdissection testicular sperm extraction (micro-TESE) is an efficient method for obtaining spermatozoa from patients with non-obstructive azoospermia, but the overall success rate of this surgery is only approximately one-third. This study aimed to construct an integrative prediction model for andrologists to assess the preoperative success retrieval rate. A total of 217 patients diagnosed with non-obstructive azoospermia at the First Affiliated Hospital of Nanjing Medical University were included, in whom sperm was successfully retrieved in 71 patients. We retrospectively analyzed their clinical characteristics and pathological features. Single factor analysis and logistic regression analysis were utilized to validate the predictive performance, and the area under the curve (AUC) analysis was conducted to further assess the clinical diagnostic value of the model. The results showed that a history of Klinefelter syndrome or cryptorchidism, FSH (Follicle Stimulating Hormone) levels, and testicular pathology contributed differently to the nomogram prediction model. Relatively normal FSH levels, a history of Klinefelter syndrome or cryptorchidism, and favorable testicular pathological types were assigned higher scores, with higher scores often accompanying a preferable success rate of sperm retrieval. The integrated model showed good prediction performance, with an AUC (Area Under the Curve) of 0.781 (95% CI (confidence interval) 0.713-0.849). Overall, our integrative model demonstrates excellent prediction performance and may assist andrologists in balancing the benefits of surgery preoperatively.</p>","PeriodicalId":519907,"journal":{"name":"Revista internacional de andrologia","volume":"22 3","pages":"48-56"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on the treatment of premature ejaculation by integrated traditional Chinese and Western medicine.","authors":"Peng Xu, Jingkai Wang, Hailuo Wang, Ruoran Zhang, Kun Pang","doi":"10.22514/j.androl.2024.019","DOIUrl":"10.22514/j.androl.2024.019","url":null,"abstract":"<p><p>Premature ejaculation (PE) is a common condition that troubles men in today's society, which significantly influences men's mental health and the relationship between spouses. Both traditional Chinese medicine (TCM) and Western medicine are currently the preferred treatment options for PE. When treating PE with both traditional Chinese and Western medicine, two sets of treatment plans are briefly introduced: internal treatment and external treatment. In the internal treatment method, the popular TCM formulas in recent years were introduced, their therapeutic effects and principles on PE were described, and the results of analyzing the effective ingredients of TCM monomers from the perspective of molecular biology in recent years were also presented. Then the mechanism of their treatment of PE was explained and their efficacy and safety was compared with Western medicine in treating PE; in terms of external treatment, the current mainstream treatment schemes were introduced, such as acupuncture and moxibustion, liquid medicine external application, massage desensitization and behavioral psychotherapy, and their advantages and disadvantages were elaborated. Finally, the theoretical treatment of PE was put into practice through rational criticism and analysis to improve men's physical health and promote the development of the TCM culture.</p>","PeriodicalId":519907,"journal":{"name":"Revista internacional de andrologia","volume":"22 3","pages":"24-31"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic use of platelet-rich plasma for the treatment of male infertility.","authors":"Paula Alonso-Frías, Marga Esbert","doi":"10.22514/j.androl.2024.018","DOIUrl":"10.22514/j.androl.2024.018","url":null,"abstract":"<p><p>Platelet-Rich Plasma (PRP) is a regenerative therapy that has gained interest in recent years, being the subject of various studies and applications. In the field of human reproduction specifically, there are growth factors (GFs) present in PRP that have shown an impact on sperm quality and function. The main objective of this article is to conduct a literature review on the use of PRP for the treatment of male infertility. To achieve this, a bibliographic search of articles and reviews in scientific journals about the possible use of PRP for the treatment of male factor published between 2018 and 2023 has been carried out. Nine publications were identified, proposing the application of PRP in the following areas: sperm cryopreservation, oxidative stress, culture of spermatogonial stem cells, and secretory azoospermia. According to the literature, supplementing the cryopreservation medium with PRP improves sperm parameters, and samples incubated with PRP show an increase in their antioxidant capacity. Finally, PRP can increase the proliferation and vitality of spermatogonial stem cells and sperm recovery in cases of non-obstructive azoospermia. PRP shows therapeutic potential in various aspects of the male factor. Further research with a larger sample size is needed to define both its protocols and its clinical efficacy.</p>","PeriodicalId":519907,"journal":{"name":"Revista internacional de andrologia","volume":"22 3","pages":"16-23"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of average penis length and the thoughts of Turkish men and partners. Is surgery necessary?","authors":"Eray Hasirci, Ilke Onur Kazaz, Okan Alkis, Anil Eker, Mehmet Hamza Gultekin, Mehmet Vehbi Kayra, Kagan Turker Akbaba, Mesut Berkan Duran, Sakir Ongun, Tuncay Toprak, Gokhan Ceker, Hasan Deliktas, Tufan Cicek, Erman Ceyhan, Ugur Akgun, Meric Yavuz Colak, Tahsin Turunc","doi":"10.22514/j.androl.2024.023","DOIUrl":"10.22514/j.androl.2024.023","url":null,"abstract":"<p><p>The purpose of this study was to determine the average penis length and girth among the Turkish population, and to analyse the perspectives of couples. A total of 1703 males and 139 female partners participated in this study. All the participants completed a questionnaire and the flaccid and stretched penis length and girth were recorded. The results showed that the average flaccid penis length was 8.44 ± 2.28 cm and 12.27 ± 2.91 cm stretched, with girth of 8.23 ± 2.07 cm. Regarding the importance of penis size for a satisfying sexual experience, 18.5% of men thought penis length mattered, 9.9% considered thickness important, and 71.6% thought both were significant. A majority of participants, 67.8% of males and 76% of females, expressed that erect penis length was crucial for sexual pleasure. For a healthy sexual intercourse, 19.4% of the female partners emphasized the significance of penis length, 23.7% highlighted thickness, and 56.8% emphasized both factors for a fulfilling sexual relationship. A comparison between men's stretched penis length and the ideal length for partner satisfaction revealed no statistically significant difference (13 (4.8-21) cm <i>vs.</i> 12 (8-20) cm, <i>p</i> = 0.078). The average penis length and girth of Turkish males were found to be similar to the data in studies of this subject in literature. Both the males and their partners thought that erect penis length and girth were important for sexual intercourse. The males considering penis lengthening and thickening procedures should know whether or not their own penis is close to the average values, to avoid undergoing unnecessary surgeries.</p>","PeriodicalId":519907,"journal":{"name":"Revista internacional de andrologia","volume":"22 3","pages":"74-81"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of sperm morphological parameters in the selection of fertilization methods.","authors":"Donghong Li, Yunhao Wang, Longling Han, Dan Gao, Chao Yang, Weijing Wang, Mingjun Lei, Bingru Luo, Xiaoqiong Zeng","doi":"10.22514/j.androl.2024.022","DOIUrl":"10.22514/j.androl.2024.022","url":null,"abstract":"<p><p>To investigate the role of <i>in-vitro</i> fertilization (IVF) or intracytoplasmic sperm injection (ICSI) in cases with isolated teratozoospermia, and to provide reference for infertile patients to choose a reasonable insemination program. From January 2018 to December 2022, 433 couples received assisted reproductive assistance in the Department of Reproductive Medicine of our hospital. Among them, 81 patients presented isolated teratozoospermia (other sperm parameters were normal). These underwent IVF/ICSI, and differences in embryological data were compared between groups. 60 patients with moderate teratozoospermia went IVF, 11 needed rescue ICSI (R-ICSI, 18.33%), and 49 developed up to the blastocyst stage. 14 patients with severe teratozoospermia went IVF, 2 needed R-ICSI (14.29%), and 12 developed up to the blastocyst stage. There were no statistically significant differences in the proportion of R-ICSI between the two groups. Embryological outcomes were not significantly different between groups. The present results suggest that patients with moderate and severe teratozoospermia can be effectively treated with IVF, being R-ICSI performed when necessary.</p>","PeriodicalId":519907,"journal":{"name":"Revista internacional de andrologia","volume":"22 3","pages":"68-73"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}