Revista internacional de andrologia最新文献_第5页

Long term follow-up on young adults that underwent hypospadias repair through urethral advancement in childhood. 对儿童时期通过尿道前移术进行尿道下裂修复的年轻成人进行长期随访。

Revista internacional de andrologia Pub Date : 2024-03-01 Epub Date: 2024-03-30 DOI: 10.22514/j.androl.2024.004

Sharmila Devi Ramnarine, Alberto Parente, Veronica Vargas, Alvaro Escassi, Rosa María Paredes

{"title":"Long term follow-up on young adults that underwent hypospadias repair through urethral advancement in childhood.","authors":"Sharmila Devi Ramnarine, Alberto Parente, Veronica Vargas, Alvaro Escassi, Rosa María Paredes","doi":"10.22514/j.androl.2024.004","DOIUrl":"10.22514/j.androl.2024.004","url":null,"abstract":"Assess the long-term outcome on cosmetic appearance, voiding, sexual function, and psychological impact of young adults operated by urethral advance (UA) technique in childhood. Patients over 14 years old, who underwent UA hypospadias repair in our centre (2000-2010) were evaluated. All patients presented mid-distal hypospadias with subcoronal or penile meatus and curvature lower than 20°. The cosmetic appearance, urinary and sexual function, body perception and overall satisfaction were assessed through 5 questionnaires. From 2000 to 2010, 143 children underwent UA hypospadias repair. 36 patients between 14 and 27 years were evaluated. The Hypospadias Objective Penile Evaluation (HOPE) showed an average of 8.75 (+/- 0.97), which indicates a good aesthetic result. Voiding dysfunction symptoms were assessed through the American Urological Association Symptom Index (AUASI) where 80.6% had none or mild symptoms and 19.4% had moderate symptoms. Only 11/36 patients were sexually active, according to the International Index of Erectile Function (IIEF-15) scale, none had erectile dysfunction, and their relationships were satisfactory. Assessment of the body perception through the Genital Perception Scale (GPS) was positive or very positive in 88.9% of the patients. However, the perception of their genitals was positive or very positive in 77.8%, there is a negative correlation between the perception of their body and genitals in 13.9% of the patients. Our results indicate that UA technique for hypospadias repair might be a valid option for the correction of mid-distal hypospadias when indicated.","PeriodicalId":519907,"journal":{"name":"Revista internacional de andrologia","volume":"22 1","pages":"23-28"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140912876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zinc alleviates high fat diet-induced spermatogenic dysfunction in Wistar rats: role of oxidative stress, HMGB1 and inflammasome. 锌能缓解高脂饮食诱导的 Wistar 大鼠生精功能障碍：氧化应激、HMGB1 和炎症小体的作用。

Revista internacional de andrologia Pub Date : 2024-03-01 Epub Date: 2024-03-30 DOI: 10.22514/j.androl.2024.007

Eman Hamed Elmorsy, Rania Gaber Aly, Noha Mohamed Badae, Mona Mohamed Aboghazala, Salma Samir Omar

{"title":"Zinc alleviates high fat diet-induced spermatogenic dysfunction in Wistar rats: role of oxidative stress, HMGB1 and inflammasome.","authors":"Eman Hamed Elmorsy, Rania Gaber Aly, Noha Mohamed Badae, Mona Mohamed Aboghazala, Salma Samir Omar","doi":"10.22514/j.androl.2024.007","DOIUrl":"10.22514/j.androl.2024.007","url":null,"abstract":"Whether chronic inflammation in the genital tract induced by obesity shares in spermatogenic dysfunction is not clearly known. We aimed to study the effect of high fat diet (HFD) on spermatogenesis, seminal oxidative stress (malondialdehyde (MDA)) and inflammatory markers (high mobility group box 1 (HMGB1), nucleotide-binding oligomerization domain, leucine rich repeat and pyrin-3 domain containing (NLRP3)) in the rat testes and the role of zinc on testicular dysfunction and chronic inflammation in high fat diet (HFD) fed rat testes. This parallel group comparative experimental study included 36 male wistar rats divided into 3 groups: group A (fed on normal control diet); group B (fed on high fat diet (HFD) only); and group C (fed on HFD with zinc supplementation 3.2 mg/kg/day orally). At the end of the 12th week, sperm count, viability and motility were assessed by computer-assisted seemen analysis (CASA), seminal malondialdehyde measured by calorimetry and histopathological examination of testicular sections was done. Immunohistochemical staining was done for HMGB1 and NLRP3 evaluation. Sperm count was lowest in group B. Groups A and C showed statistically significant higher mean sperm vitality, total and progressive motility scores (p < 0.001), while no difference was found between the groups A and C (p > 0.05). Seminal malondialdehyde level was significantly highest in group B. Tubular diameter, epithelial height and Johnsen score were significantly lowest in group B. Significantly higher HMGB1 and NLRP3 levels were demonstrated in group B (p < 0.001). Obesity is associated with testicular dysfunction, testicular oxidative stress and increased testicular HMGB1 and NLRP3. We suggest a beneficial effect of zinc on testicular function in HFD-rats.","PeriodicalId":519907,"journal":{"name":"Revista internacional de andrologia","volume":"22 1","pages":"44-52"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gallic acid attenuates torsion/detorsion-induced testicular injury in rats through suppressing of HMGB1/NF-κB axis and endoplasmic reticulum stress. 没食子酸通过抑制HMGB1/NF-κB轴和内质网应激减轻扭转/扭转诱导的大鼠睾丸损伤

Revista internacional de andrologia Pub Date : 2024-03-01 Epub Date: 2024-03-30 DOI: 10.22514/j.androl.2024.001

Selim Demir, Ilke Onur Kazaz, Gokcen Kerimoglu, Nihal Turkmen Alemdar, Fatih Colak, Tugba Arici, Ahmet Mentese, Yuksel Aliyazicioglu

{"title":"Gallic acid attenuates torsion/detorsion-induced testicular injury in rats through suppressing of HMGB1/NF-κB axis and endoplasmic reticulum stress.","authors":"Selim Demir, Ilke Onur Kazaz, Gokcen Kerimoglu, Nihal Turkmen Alemdar, Fatih Colak, Tugba Arici, Ahmet Mentese, Yuksel Aliyazicioglu","doi":"10.22514/j.androl.2024.001","DOIUrl":"10.22514/j.androl.2024.001","url":null,"abstract":"It was aimed to evaluate whether gallic acid (GA) have a beneficial effect in the testicular ischemia/reperfusion injury (IRI) model in rats for the first time. Testicular malondialdehyde, 8-hydroxy-2'-deoxyguanosine, superoxide dismutase, catalase, high mobility group box 1 protein, nuclear factor kappa B, tumor necrosis factoralpha, interleukin-6, myeloperoxidase, 78-kDa glucose-regulated protein, activating transcription factor 6, CCAAT-enhancer-binding protein homologous protein and caspase-3 levels were determined using colorimetric methods. The oxidative stress, inflammation, endoplasmic reticulum stress and apoptosis levels increased statistically significantly in the IRI group compared with the sham operated group (p < 0.05). GA application improved these damage significantly (p < 0.05). Moreover, it was found that the results of histological examinations supported the biochemical results to a statistically significant extent. Our findings suggested that GA may be evaluated as a protective agent against testicular IRI.","PeriodicalId":519907,"journal":{"name":"Revista internacional de andrologia","volume":"22 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140912893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective effect of astaxanthin on testis torsion/detorsion injury through modulation of autophagy. 虾青素通过调节自噬对睾丸扭转/扭转损伤的保护作用

Revista internacional de andrologia Pub Date : 2024-03-01 Epub Date: 2024-03-30 DOI: 10.22514/j.androl.2024.005

Nesibe Yilmaz, Azibe Yildiz, Kevser Tanbek, Aysegul Kisaoglu, Umit Yilmaz, Evren Kose

{"title":"Protective effect of astaxanthin on testis torsion/detorsion injury through modulation of autophagy.","authors":"Nesibe Yilmaz, Azibe Yildiz, Kevser Tanbek, Aysegul Kisaoglu, Umit Yilmaz, Evren Kose","doi":"10.22514/j.androl.2024.005","DOIUrl":"10.22514/j.androl.2024.005","url":null,"abstract":"A significant clinical condition known as testicular torsion leads to permanent ischemic damage to the testicular tissue and consequent loss of function in the testicles. In this study, it was aimed to evaluate the protective effects of Astaxanthin (ASTX) on testicular damage in rats with testicular torsion/detorsion in the light of biochemical and histopathological data. Spraque Dawley rats of 21 were randomly divided into three groups; sham, testicular torsion/detorsion (TTD) and astaxanthin + testicular torsion/detorsion (ASTX + TTD). TTD and ASTX + TTD groups underwent testicular torsion for 2 hours and then detorsion for 4 hours. Rats in the ASTX + TTD group were given 1 mg/kg/day astaxanthin by oral gavage for 7 days before torsion. Following the detorsion process, oxidative stress parameters and histopathological changes in testicular tissue were evaluated. Malondialdehyde (MDA) and total oxidant status (TOS) levels were significantly decreased in the ASTX group compared to the TTD group, while superoxide dismutase (SOD), glutathione (GSH) and total antioxidant status (TAS) levels were increased (p < 0.05). Moreover, histopathological changes were significantly reduced in the group given ASTX (p < 0.0001). It was determined that ASTX administration increased Beclin-1 immunoreactivity in ischemic testicular tissue, while decreasing caspase-3 immunoreactivity (p < 0.0001). Our study is the first to investigate the antiautophagic and antiapoptotic properties of astaxanthin after testicular torsion/detorsion based on the close relationship of Beclin-1 and caspase-3 in ischemic tissues. Our results clearly demonstrate the protective effects of ASTX against ischemic damage in testicular tissue. In ischemic testicular tissue, ASTX contributes to the survival of cells by inducing autophagy and inhibiting the apoptosis.","PeriodicalId":519907,"journal":{"name":"Revista internacional de andrologia","volume":"22 1","pages":"29-37"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140912950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0