Interactive Journal of Medical Research最新文献

{"title":"Multihealth Promotion Programs on Physical Health and Quality of Life in Older Adults: Quasi-Experimental Study.","authors":"Li-Yun Lee, Heng-Hsin Tung, George Liao, Su-Ju Liu, Zi-Yu Chen, Yea-Ru Yang","doi":"10.2196/65213","DOIUrl":"10.2196/65213","url":null,"abstract":"<p><strong>Background: </strong>Physical activity and appropriate nutrition are essential for older adults. Improving physical health and quality of life can lead to healthy aging.</p><p><strong>Objective: </strong>This study aims to investigate the long-term effects of multihealth promotion programs on the physical and mental health of older adults in communities.</p><p><strong>Methods: </strong>A quasi-experimental method was used to recruit 112 older adults voluntarily from a pharmacy in central Taiwan between April 2021 and February 2023. Participants were divided into an experimental group receiving a multihealth promotion program and a control group with no specific intervention. The study measured frailty, nutritional status, well-being, and quality of life using standardized tools such as the Clinical Frailty Scale (CFS), Mini-Nutritional Assessment-Short Form (MNA-SF), Well-being Scale for Elders, and the EQ-5D-3L. Data were analyzed using descriptive statistics, independent t tests, Pearson correlation, and generalized estimating equations.</p><p><strong>Results: </strong>A total of 112 participants were recruited. There were 64 (57.1%) in the experimental group and 48 (42.9%) in the control group. The experimental group exhibited significantly better quality of life (EQ-5D index) at weeks 12 (β=-.59; P=.01) and 24 (β=-.44; P=.04) compared to the control group. The experimental group muscle mass significantly increased at weeks 24 (β=4.29; P<.01) and 36 (β=3.03; P=.01). Upper limb strength improved significantly at weeks 12 (β=3.4; P=.04) and 36 (β=5; P=.01), while core strength showed significant gains at weeks 12 (β=4.43; P=.01) and 36 (β=6.99; P<.01). Lower limb strength increased significantly only at week 12 (β=4.15; P=.01). Overall physical performance improved significantly at weeks 12 (β=5.47; P<.01), 24 (β=5.17; P<.01), and 36 (β=8.79; P<.01).</p><p><strong>Conclusions: </strong>The study's findings highlight the practical benefits of interventions, including physical and social activities and nutritional support, in enhancing the quality of life and general physical health of older adults. This study's findings have significant implications for clinical practice. These findings can aid in the establishment of effective interventions for older adults.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov NCT05412251; https://clinicaltrials.gov/study/NCT05412251.</p>","PeriodicalId":51757,"journal":{"name":"Interactive Journal of Medical Research","volume":"14 ","pages":"e65213"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12082056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Prevention Focus and Sedentary Behavior in Older Adults: Cross-Sectional Study.","authors":"Jethro Raphael Suarez, Amber Blount, Kworweinski Lafontant, Joon-Hyuk Park, Rui Xie, Nichole Lighthall, Ladda Thiamwong","doi":"10.2196/63280","DOIUrl":"10.2196/63280","url":null,"abstract":"<p><strong>Background: </strong>Older adults engage in increased amounts of sedentary behavior (SB), which can result in a significant decline in muscle function and overall health. An understanding of the motivational driving factors that lead older adults to engage in SB can help to create effective intervention programs.</p><p><strong>Objective: </strong>This study aimed to determine the association between prevention and promotion focus with SB in older adults, as well as compare these associations with two factors (ie, age and BMI) that are commonly known to have an association with SB among older adults.</p><p><strong>Methods: </strong>A cross-sectional analysis was conducted among 93 community-dwelling older adults with a mean age of 74.98 (SD 6.68) years. Prevention and promotion focus were both assessed using the Regulatory Focus Questionnaire. Correlation analysis was performed to determine the associations between prevention focus, promotion focus, age, and BMI with SB. Anderson-Darling tests confirmed nonnormal data distributions for all factors (except age); therefore, Spearman rank correlation was used to determine correlations between factors. Comparative analysis of significant correlations was performed using Fisher Z transformation.</p><p><strong>Results: </strong>Prevention focus had the greatest statistically significant correlation with SB (ρ=0.296; P=.004), followed by BMI (ρ=0.204; P=.049). Both age (ρ=0.116; P=.27) and promotion focus (ρ=0.002; P=.99) had statistically insignificant correlations with SB, indicating no associations. The correlation between prevention focus and SB did not significantly differ from the correlation between BMI and SB (P=.51).</p><p><strong>Conclusions: </strong>Prevention focus was found to have a weak, but significant positive association with SB in older adults. Although age and BMI have been found to have an association with SB in previous literature, age was not associated with SB in this study, while BMI had a significant but relatively weaker association with SB than that with prevention focus. However, the association found between BMI and SB did not statistically differ from the association found between prevention focus and SB. These findings suggest that older adults could be driven to engage in increased amounts of SB due to having a dominant prevention focus, which revolves around thoughts of safety and avoiding negative consequences. The recognition of this association has the potential to aid in developing intervention programs that could promote shifting from prevention to promotion focus, thereby reducing SB in older adults.</p>","PeriodicalId":51757,"journal":{"name":"Interactive Journal of Medical Research","volume":"14 ","pages":"e63280"},"PeriodicalIF":1.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12183608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring 97 Years of Aedes aegypti as the Vector for Dengue, Yellow Fever, Zika, and Chikungunya (Diptera: Culicidae): Scientometric Analysis.","authors":"Yoon Ling Cheong, Sumarni Mohd Ghazali, Mohd Hazilas Mat Hashim, Mohd Khairuddin Che Ibrahim, Afzufira Amran, Tsye Yih Tiunh, Hui Li Lim, Yong Kang Cheah, Balvinder Singh Gill, Kuang Hock Lim","doi":"10.2196/65844","DOIUrl":"https://doi.org/10.2196/65844","url":null,"abstract":"<p><strong>Background: </strong>Aedes aegypti is an important vector that transmits dengue, Zika, chikungunya, and yellow fever viruses. Although research on Aedes aegypti has been conducted for decades, scientometric studies on Aedes aegypti are scarce, are limited to regions, and cover short periods. Thus, there is still a knowledge gap in the current trend, research focuses and directions, leading authors and collaboration, journal and citation impacts, countries, and worldwide collaborations.</p><p><strong>Objective: </strong>The objectives of the study are to investigate the research trend, focus and directions, citation impact, leading authors and collaboration, journals, and countries of the published works on Aedes aegypti to inform the current knowledge gaps and future direction of the control of the vector.</p><p><strong>Methods: </strong>In this study, we searched the Scopus database for articles on Aedes aegypti published from the year 1927 until April 5th, 2024, and included articles, reviews, books, and book chapters that were written in English. A total of 16,247 articles in 160 journals with 481,479 citations were included. Inconsistencies in authors' names were checked and cleaned using OpenRefine. The data were grouped into 4 periods; years 1927-1999, 2000-2009, 2010-2019, and 2020-2023. The relative growth rate and doubling time of publications were calculated. The analysis was conducted using VOSviewer, R bibliometrics, and citeSpace.</p><p><strong>Results: </strong>The overall RGR was 0.1. Doubling time increased from 9.3 in 1978-1998 to 12.1 in 2000-2009. The main research clusters were \"using Wolbachia,\" \"Dengue Zika,\" \"worldwide diversity,\" \"community support,\" \"larvicidal activity,\" \"mosquito genotype-dependent,\" and \"sterile insect technique.\" Journal of Medical Entomology was the leading journal (758/16,247, 4.7%). The most cited articles were authored by Halstead SB and team in Science (N=1355) and Kraemer MU and team in eLife (N=1324). The United States (5806/23,538, 24.7%) and Brazil (2035/23,538, 8.6%) were the top countries. Gubler DJ was the top co-cited author (n=2892) from 2000 to 2019. The co-cited author cluster patterns informed the significant specialty research on Aedes aegypti across time. Authors from various specialized research fields tended to collaborate across countries, especially neighboring countries. Countries with more research funding on the study of Aedes aegypti published more papers.</p><p><strong>Conclusions: </strong>Researchers or entomologists could understand the current knowledge gap on Aedes aegypti and plan for future research pathways. This study contributed to the public health stakeholders in improving the vector control interventions and elucidated the extent of research subject areas.</p>","PeriodicalId":51757,"journal":{"name":"Interactive Journal of Medical Research","volume":"14 ","pages":"e65844"},"PeriodicalIF":1.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Population Estimates of Self-Reported Depression and Anxiety in the US From a National Survey: Cross-Sectional Survey Study.","authors":"Yuvraj Pathak, Elvira Makk-Frid","doi":"10.2196/70626","DOIUrl":"https://doi.org/10.2196/70626","url":null,"abstract":"<p><strong>Unlabelled: </strong>This letter shows that that an estimated 31 million and 44 million adults self-report near-daily experiences of depression or anxiety, respectively. Of these, nearly a third have never spoken to a health care provider about it.</p>","PeriodicalId":51757,"journal":{"name":"Interactive Journal of Medical Research","volume":"14 ","pages":"e70626"},"PeriodicalIF":1.9,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subtyping Service Receipt in Personality Disorder Services in South London: Observational Validation Study Using Latent Profile Analysis.","authors":"Jack Steadman, Rob Saunders, Mark Freestone, Robert Stewart","doi":"10.2196/55348","DOIUrl":"https://doi.org/10.2196/55348","url":null,"abstract":"<p><strong>Background: </strong>Personality disorders (PDs) are typically associated with higher mental health service use; however, individual patterns of engagement among patients with complex needs are poorly understood.</p><p><strong>Objective: </strong>The study aimed to identify subgroups of individuals based on patterns of service receipt in secondary mental health services and examine how routinely collected information is associated with these subgroups.</p><p><strong>Methods: </strong>A sample of 3941 patients diagnosed with a personality disorder and receiving care from secondary services in South London was identified using health care records covering an 11-year period from 2007 to 2018. Basic demographic information, service use, and treatment data were included in the analysis. Service use measures included the number of contacts with clinical teams and instances of did-not-attend.</p><p><strong>Results: </strong>Using a large sample of 3941 patients with a diagnosis of PD, latent profile analysis identified 2 subgroups characterized by low and high service receipt, denoted as profile 1 (n=2879, 73.05%) and profile 2 (n=1062, 26.95%), respectively. A 2-profile solution (P<.01) was preferred over a 3-profile solution, which was nonsignificant. In unconditional (t_3941,3939=19.53; P<.001; B=7.27; 95% CI 6.54-8) and conditional (t_3941,3937=-3.31; P<.001; B=-74.94; 95% CI -119.34 to -30.56) models, cluster membership was significantly related to receipt of nursing contacts, over and above other team contacts.</p><p><strong>Conclusions: </strong>These results suggest that routinely collected data may be used to classify likely engagement subtypes among patients with complex needs. The algorithm identified factors associated with service use and has the potential to inform clinical decision-making to improve treatment for individuals with complex needs.</p>","PeriodicalId":51757,"journal":{"name":"Interactive Journal of Medical Research","volume":"14 ","pages":"e55348"},"PeriodicalIF":1.9,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the Prioritization of Behavior Change Techniques for Long-Term Stroke Rehabilitation: Delphi Survey Study.","authors":"Agata Ewa Wróbel, Philip Cash, Anja Maier, John Paulin Hansen","doi":"10.2196/59172","DOIUrl":"10.2196/59172","url":null,"abstract":"<p><strong>Background: </strong>Stroke results in both physical disability and psychological distress. The impact can be minimized through rehabilitation, but it is a long-term process, making it difficult for patients to adhere to treatment. Thus, a better understanding of long-term behavior change interventions for patients with stroke is needed as well as how such interventions can support not only rehabilitation of motoric functions but also mental well-being.</p><p><strong>Objective: </strong>The aim of this study is to understand both the most important behavior change technique (BCT) clusters for long-term stroke rehabilitation in general as well as which are most relevant for each aspect of stroke rehabilitation: behavioral, cognitive, and emotional.</p><p><strong>Methods: </strong>We applied the 16 BCT clusters. The study used a 2-round Delphi survey, as reliable consensus was obtained among a group of 12 international experts. Experts represented three main backgrounds involved in behavioral intervention in the health context: (1) specialists in behavioral science (n=4), (2) behavioral designers (n=4), and (3) expert health care professionals (n=4). Experts were brought together in this way for the first time. In the first round, web-based questionnaires were used to collect data from the experts. This was followed by a personalized second round. Consensus was determined by statistically aggregating the responses and evaluating IQR and percentage consensus. BCT clusters reaching consensus (IQR ≤1 and percentage ≥50%) were then ranked.</p><p><strong>Results: </strong>In total, 12 of 16 BCT clusters reached consensus for general importance in stroke rehabilitation, with 11, 9, and 6 BCT clusters achieving consensus for, respectively, the behavioral, cognitive, and emotional aspects of rehabilitation. The overall most relevant BCT clusters were repetition and substitution, social support, feedback and monitoring, and self-belief, with similar outcomes for behavioral and cognitive rehabilitation. For emotional rehabilitation, social support and identity were emphasized. The least relevant BCT clusters were natural consequences, covert learning, and comparison of behavior.</p><p><strong>Conclusions: </strong>This expert panel study using a 2-round Delphi survey ranked the importance of BCT clusters for long-term stroke rehabilitation. The process yielded a number of novel insights highlighting differences in importance between general rehabilitation and that specifically focused on the behavioral, cognitive, and emotional aspects of stroke recovery. This provides a first but important step toward unlocking the prioritization of BCT clusters for long-term intervention contexts such as stroke rehabilitation and enables effective intervention mapping addressing long-term behavior change and treatment adherence.</p>","PeriodicalId":51757,"journal":{"name":"Interactive Journal of Medical Research","volume":"14 ","pages":"e59172"},"PeriodicalIF":1.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Color of Drinking Survey Questionnaire for Measuring the Secondhand Impacts of High-Risk Drinking in College Settings: Validation Study.","authors":"Agustina Marconi, Reonda Washington, Amanda Jovaag, Courtney Blomme, Ashley Knobeloch, Vilma Irazola, Carolina Muros Cortés, Laura Gutierrez, Natalia Elorriaga","doi":"10.2196/64720","DOIUrl":"10.2196/64720","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The \"Color of Drinking\" is a study conducted at the University of Wisconsin-Madison. It examines the secondhand harms of high-risk drinking on college students of color and explores the connection between alcohol use and the campus racial climate. Since its findings were released in 2018, this study has received significant attention from other college settings around the country.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study aims to describe the development of the most recent version of the Color of Drinking questionnaire and to assess its internal consistency, test-retest reliability, and construct validity in a sample of undergraduate students attending the University of Wisconsin-Madison.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This is an observational, analytic study. Questionnaire design experts revised the original instrument, and in-depth cognitive interviews with students were conducted to evaluate comprehensibility and acceptability. The revised questionnaire was administered 2 times, 3 to 4 weeks apart, in a sample of undergraduate students. The following properties were studied: internal consistency in 4 sets of items (Cronbach α), test-retest reliability among closed-ended questions (κ statistics and intraclass correlation coefficient), and construct validity (associations with other validated instruments, such as the Alcohol Use Disorders Identification Test). For a section of questions showing low reliability, the answers to open questions and other in-depth interviews were carried out, and online surveys were conducted with another sample of undergraduate students to evaluate reliability after changes.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Eight students participated in the in-depth interviews, 177 responses from the online survey were included for the analysis of internal consistency, 115 for test-retest reliability, and 98 for construct validity. The 4 sets of items (sections) evaluated (\"impact of alcohol consumption on academics,\" \"impact of microaggressions,\" \"witnessing microaggressions and alcohol intoxication,\" and \"bystanders' interventions on alcohol intoxication\") presented good internal consistency (Cronbach α between 0.723 and 0.898). Most items showed moderate to substantial test-retest reliability; agreement was from 68.1% to 95.2%, and κ coefficients ranged from 0.214 to 0.8. For construct validity, correlations between the number of drinking days, the maximum number of drinks in a day and the Alcohol Use Disorders Identification Test score were moderate to high, r=0.630 (95% CI 0.533-0.719) and r=0.647 (95% CI 0.548-0.741), respectively. Due to low reliability, a section regarding \"health impacts\" has been redesigned, including 8 items for the personal consumption of alcohol and the consumption of others (Cronbach α 0.735 and 0.855, respectively; agreement between the first and the second time the questionnaire was administered were 83.4% and 99.1%, and most of the items with κ coefficient from 0.","PeriodicalId":51757,"journal":{"name":"Interactive Journal of Medical Research","volume":"14 ","pages":"e64720"},"PeriodicalIF":1.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11996142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interactive Effects of Weight Recording Frequency and the Volume of Chat Communication With Health Care Professionals on Weight Loss in mHealth Interventions for Noncommunicable Diseases: Retrospective Observational Study.","authors":"Yuta Hagiwara, Takuji Adachi, Masashi Kanai, Kotoe Shimizu, Shinpei Ishida, Takahiro Miki","doi":"10.2196/65863","DOIUrl":"10.2196/65863","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Mobile health (mHealth) apps are increasingly used for health promotion, particularly for managing noncommunicable diseases (NCDs) through behavior modification. Understanding the factors associated with successful weight loss in such interventions can improve program effectiveness.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;This study examined factors influencing weight change and the relationship between weight recording frequency and chat volume with health care professionals on weight loss in individuals with obesity and NCDs.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The participants had obesity (BMI ≥25 kg/m²) and were diagnosed with NCDs (eg, hypertension, diabetes, dyslipidemia). The program included 12 telephone consultations with health care professionals. Only participants who completed the full 6-month program, including all 12 telephone consultations, and provided an end-of-study weight were included in the analysis. The primary outcome was the rate of weight change, defined as the percentage change in weight from the initial period (first 14 days) to the final period (2 weeks before the last consultation), relative to the initial weight. The key independent variables were proportion of days with weight recording and chat communication volume (total messages exchanged). An interaction term between these variables was included to assess moderation effects in the regression analysis. The volume of communication was measured as the total number of messages exchanged, with each message, regardless of who sent it, being counted as 1 interaction. Health care staffs were instructed to send a single scheduled chat message per week following each biweekly phone consultation. These scheduled messages primarily included personalized feedback, reminders, and motivational support. In addition, providers responded to participant-initiated messages at any time during the program. Furthermore, 1 professional responded to each participant. Hierarchical multiple regression and simple slope analyses were conducted to identify relationships and interactions among these variables.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The final analysis of this study included 2423 participants. Significant negative associations were found between the rate of weight change and baseline BMI (β=-.10; P&lt;.001), proportion of days with weight recording (β=-.017; P&lt;.001), and communication volume (β=-.193; P&lt;.001). The interaction between proportion of days with weight recording and chat frequency also showed a significantly negative effect on weight change (β=-.01; P&lt;.001). Simple slope analysis showed that when the proportion of days with weight recording was +1 SD above the mean, frequent chats were associated with greater weight reduction (slope=-0.60; P&lt;.001), whereas no significant effect was observed at -1 SD (slope=-0.01; P=.94).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;The findings suggest that both the proportion of days with weight recording and communication volum","PeriodicalId":51757,"journal":{"name":"Interactive Journal of Medical Research","volume":"14 ","pages":"e65863"},"PeriodicalIF":1.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11968002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using an Electronic Immunization Registry (Aplikasi Sehat IndonesiaKu) in Indonesia: Cross-Sectional Study.","authors":"Dewi Nur Aisyah, Astri Utami, Fauziah Mauly Rahman, Nathasya Humaira Adriani, Fiqi Fitransyah, M Thoriqul Aziz Endryantoro, Prima Yosephine Hutapea, Gertrudis Tandy, Logan Manikam, Zisis Kozlakidis","doi":"10.2196/53849","DOIUrl":"10.2196/53849","url":null,"abstract":"<p><strong>Background: </strong>Electronic immunization registries (EIRs) are being increasingly used in low- and middle-income countries. In 2022, Indonesia's Ministry of Health introduced its first EIR, named Aplikasi Sehat IndonesiaKu (ASIK), as part of a comprehensive nationwide immunization program. This marked a conversion from traditional paper-based immunization reports to digital routine records encompassing a network of 10,000 primary health centers (puskesmas).</p><p><strong>Objective: </strong>This paper provides an overview of the use of ASIK as the first EIR in Indonesia. It describes the coverage of the nationwide immunization program (Bulan Imunisasi Anak Nasional) using ASIK data and assesses the implementation challenges associated with the adoption of the EIR in the context of Indonesia.</p><p><strong>Methods: </strong>Data were collected from primary care health workers' submitted reports using ASIK. The data were reported in real time, analyzed, and presented using a structured dashboard. Data on ASIK use were collected from the ASIK website. A quantitative assessment was conducted through a cross-sectional survey between September 2022 and October 2022. A set of questionnaires was used to collect feedback from ASIK users.</p><p><strong>Results: </strong>A total of 93.5% (9708/10,382) of public health centers, 93.5% (6478/6928) of subdistricts, and 97.5% (501/514) of districts and cities in 34 provinces reported immunization data using ASIK. With >21 million data points recorded, the national coverage for immunization campaigns for measles-rubella; oral polio vaccine; inactivated polio vaccine; and diphtheria, pertussis, tetanus, hepatitis B, and Haemophilus influenzae type B vaccine were 50.1% (18,301,057/36,497,694), 36.2% (938,623/2,595,240), 30.7% (1,276,668/4,158,289), and 40.2% (1,371,104/3,407,900), respectively. The quantitative survey showed that, generally, users had a good understanding of ASIK as the EIR (650/809, 80.3%), 61.7% (489/793) of the users expressed that the user interface and user experience were overall good but could still be improved, 54% (422/781) of users expressed that the ASIK variable fit their needs yet could be improved further, and 59.1% (463/784) of users observed sporadic system interference. Challenges faced during the implementation of ASIK included a heavy workload burden for health workers, inadequate access to the internet at some places, system integration and readiness, and dual reporting using the paper-based format.</p><p><strong>Conclusions: </strong>The EIR is beneficial and helpful for monitoring vaccination coverage. Implementation and adoption of ASIK as Indonesia's first EIR still faces challenges related to human resources and digital infrastructure as the country transitions from paper-based reports to electronic or digital immunization reports. Continuous improvement, collaboration, and monitoring efforts are crucial to encourage the use of the EIR in Indonesia.</p>","PeriodicalId":51757,"journal":{"name":"Interactive Journal of Medical Research","volume":"14 ","pages":"e53849"},"PeriodicalIF":1.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11986391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucagon-Like Peptide-1 Receptor Agonists Combined With Personalized Digital Health Care for the Treatment of Metabolic Syndrome in Adults With Obesity: Retrospective Observational Study.","authors":"Hala Zakaria, Hadoun Jabri, Sheikha Alshehhi, Milena Caccelli, Joelle Debs, Yousef Said, Joudy Kattan, Noah Almarzooqi, Ali Hashemi, Ihsan Almarzooqi","doi":"10.2196/63079","DOIUrl":"10.2196/63079","url":null,"abstract":"<p><strong>Background: </strong>Metabolic syndrome (MetS) represents a complex and multifaceted health condition characterized by a clustering of interconnected metabolic abnormalities, including central obesity, insulin resistance, dyslipidemia, and hypertension. Effective management of MetS is crucial for reducing the risk of cardiovascular diseases and type 2 diabetes.</p><p><strong>Objective: </strong>This study aimed to assess the effectiveness of combining glucagon-like peptide-1 (GLP-1) and dual gastric inhibitory polypeptide (GIP)/GLP-1 agonists with a continuous, digitally delivered behavioral change model by an integrated care team, in treating MetS among individuals with obesity.</p><p><strong>Methods: </strong>The 6-month Zone.Health (meta[bolic]) weight loss program involved 51 participants (mean age 45, SD 10 years; mean BMI 35, SD 5 kg/m²), categorized by gender, and treated with either tirzepatide or semaglutide. Participants received continuous support via a digital health platform, which facilitated real time monitoring and personalized feedback from an integrated care team. Engagement levels with the digital platform, measured by the frequency of inbound interactions, were tracked and analyzed in relation to health outcomes.</p><p><strong>Results: </strong>Tirzepatide reduced waist circumference (WC) by -18.08 cm, compared with -13.04 cm with semaglutide (P<.001). Triglycerides decreased significantly with both drugs, with tirzepatide showing a reduction of -64.42 mg/dL and semaglutide -70.70 mg/dL (P<.001). Tirzepatide generally showed more pronounced improvements in fasting glucose, blood pressure (BP), low-density lipoprotein, and total cholesterol compared with semaglutide. Higher engagement with the digital health platform showed significant difference among the 3 groups; the group with the highest level of app-based interactions (≥25 interactions) had the greatest WC reduction (mean -19.04, SD 7.40 cm) compared with those with ≤15 interactions (mean -9.60, SD 5.10 cm; P=.002). Similarly, triglycerides showed the greatest reduction in the group with ≥25 interactions (mean -108.56, SD 77.06 mg/dL) compared with those with ≤15 interactions (mean -44.49, SD 50.85 mg/dL; P=.02). This group also exhibited the largest reduction in diastolic BP (mean -10.33, SD 7.40 mm Hg) compared with those with ≤15 interactions (mean -0.83, SD 7.83 mm Hg; P=.004), and the most substantial decrease in fasting glucose levels (mean -18.60, SD 10.82 mg/dL) compared with those with ≤15 interactions (mean -2.49, SD 27.54 mg/dL; P=.02). Participants in the highest quartile of digital engagement had a 60% greater likelihood of MetS reversal compared with those in the lowest quartile.</p><p><strong>Conclusions: </strong>This study shows that combining GLP-1 and dual GIP/GLP-1 agonists with a digital behavioral change model significantly improves MetS markers in individuals with obesity. Tirzepatide proved more effective than semaglutide, leading to gre","PeriodicalId":51757,"journal":{"name":"Interactive Journal of Medical Research","volume":"14 ","pages":"e63079"},"PeriodicalIF":1.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11967752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143732999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}