{"title":"Battling the breath-stealers: Blastomyces and Pseudomonas triggering acute respiratory distress syndrome (ARDS)","authors":"Dedeepya Gullapalli , Ali Raza , Amna Khan , Subramanya Shyam Ganti , Amina Pervaiz","doi":"10.1016/j.mmcr.2024.100655","DOIUrl":"https://doi.org/10.1016/j.mmcr.2024.100655","url":null,"abstract":"<div><p>Blastomycosis is an endemic disease in North America and commonly manifests with pulmonary symptoms. Blastomycosis should be consider when patients have persistent infiltrates on imaging in an endemic area. We present a case of a 46-year-old male who presented to the pulmonary clinic with fever, cough with production of yellowish-green sputum and culture of BAL-fluid showed growth of <em>Pseudomonas</em> spp. Antimicrobial therapy was started accordingly, but was not effective. A repeat bronchoscopy was performed and BAL-fluid culture was positive for <em>Blastomyces dermatitidis</em> and liposomal amphotericin B was initiated. Unfortunately, the patient died after withdrawing care.</p></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"45 ","pages":"Article 100655"},"PeriodicalIF":2.2,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2211753924000290/pdfft?md5=20ac0e8e871d7884b22af5cc6c24b3b7&pid=1-s2.0-S2211753924000290-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141428826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Penelope J. Teoh , Emma McGuire , Andrew M. Borman , Rebecca Gorton , Andrew J. Wilson , Chloe Merrion , Vanya Gant
{"title":"Invasive Trichoderma longibrachiatum infection in a neutropaenic patient","authors":"Penelope J. Teoh , Emma McGuire , Andrew M. Borman , Rebecca Gorton , Andrew J. Wilson , Chloe Merrion , Vanya Gant","doi":"10.1016/j.mmcr.2024.100656","DOIUrl":"10.1016/j.mmcr.2024.100656","url":null,"abstract":"<div><p>Invasive fungal infection is a life-threatening complication of chemotherapy and neutropaenia in the haematology population. <em>Trichoderma</em> species rarely cause human disease but have been reported to cause invasive infection in the immunosuppressed. We present a case of invasive <em>Trichoderma longibrachiatum</em> pulmonary infection with fatal outcome in a neutropaenic patient with acute myeloid leukaemia. 2012 Elsevier Ltd. All rights reserved.</p></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"45 ","pages":"Article 100656"},"PeriodicalIF":1.6,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2211753924000307/pdfft?md5=15c31a1b3a21ace0a1beb1eb67c4ff59&pid=1-s2.0-S2211753924000307-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141404779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Peritoneal dialysis-associated peritonitis due to infected umbilicus","authors":"Veerapat Wattanasatja , Jarubut Phisutrattanaporn , Natchaporn Doenphai , Sirirat Sirinual , Talerngsak Kanjanabuch","doi":"10.1016/j.mmcr.2024.100654","DOIUrl":"10.1016/j.mmcr.2024.100654","url":null,"abstract":"<div><p>We provide the first case report of peritoneal dialysis (PD)-associated peritonitis due to <em>Lasiodiplodia theobromae</em>, a known plant pathogen causing rotting and dieback in post-harvest citrus fruit, in immunocompetent patient with fungal colonization inside the PD catheter lumen. A root cause analysis suspected the patient's umbilical infection as the source of contamination. The fungal infection was established through microscopic examination of the PD catheter lumen and galactomannan testing in both serum and effluent. The species of pathogen was confirmed by DNA barcoding. The patient responded well to timely PD catheter removal and a 2-week course of oral voriconazole. Preventive strategies should prioritize hygiene practices, including umbilical care, to mitigate the risk of contamination and subsequent infections of fungal pathogens.</p></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"45 ","pages":"Article 100654"},"PeriodicalIF":2.2,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2211753924000289/pdfft?md5=67f689115adc9d97bb2904a2bd192c58&pid=1-s2.0-S2211753924000289-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141410188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Caregiver skin infection causing peritoneal dialysis-associated peritonitis","authors":"Rutchanee Chieochanthanakij , Veerapat Wattanasatja , Panthira Passorn , Dhammika Leshan Wannigama , Talerngsak Kanjanabuch","doi":"10.1016/j.mmcr.2024.100653","DOIUrl":"https://doi.org/10.1016/j.mmcr.2024.100653","url":null,"abstract":"<div><p>We present the first case report of peritoneal dialysis (PD)-associated peritonitis due to <em>Gibellulopsis nigrescens</em>, with the same pathogen detected in her caregiver's tinea capitis. This confirms that touch contamination from the caregiver's infection was the primary source of this rare organism. The species of pathogen causing peritonitis and her caregiver's scalp lesions were identified by DNA barcoding. The patient responded well to timely PD catheter removal and a 2-week course of systemic amphotericin B deoxycholate. Preventive strategies should prioritize hygiene practices, including maintaining adequate personal hygiene and practicing thorough hand washing, to mitigate the risk of touch contamination and subsequent infection with fungal pathogens.</p></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"44 ","pages":"Article 100653"},"PeriodicalIF":2.2,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2211753924000277/pdfft?md5=20137061a4d804a40f339242af53443f&pid=1-s2.0-S2211753924000277-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141244068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A renal mycosis of roach (Rutilus rutilus) caused by the Aureobasidium pullulans","authors":"Jiří Řehulka , Vit Hubka","doi":"10.1016/j.mmcr.2024.100652","DOIUrl":"https://doi.org/10.1016/j.mmcr.2024.100652","url":null,"abstract":"<div><p>Spontaneous mycosis caused by <em>Aureobasidium pullulans</em> is documented in roach in a cyprinid-prevalent water reservoir in Czechia. Gross pathological lesions included pale gills and splenomegaly, as revealed during necropsy examination. Histological examination showed extensive foci with fungal elements in the kidney. The isolated fungus was identified through phenotypic and molecular characterization, including phylogeny. This report represents the first case of <em>A. pullulans</em> infection in fish and cold-blooded vertebrates, to the best of our knowledge.</p></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"44 ","pages":"Article 100652"},"PeriodicalIF":2.2,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2211753924000265/pdfft?md5=6f310f1c4b266cfa0dda3e5097d51f48&pid=1-s2.0-S2211753924000265-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140951783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dan Zhang , Guofeng Mao , Meichun Liang , Guiqin Sun , Debao Yu
{"title":"Diagnosis and treatment of peritoneal dialysis associated mycotic peritonitis caused by Aspergillus fumigatus infection","authors":"Dan Zhang , Guofeng Mao , Meichun Liang , Guiqin Sun , Debao Yu","doi":"10.1016/j.mmcr.2024.100651","DOIUrl":"https://doi.org/10.1016/j.mmcr.2024.100651","url":null,"abstract":"<div><p><em>Aspergillus</em> peritonitis is a rare but highly severe complication of peritoneal dialysis with a high mortality rate. We report a case of <em>Aspergillus fumigatus</em> peritonitis. Despite early removal of the catheter and oral voriconazole antifungal treatment for 3 weeks, the treatment effect was unsatisfactory, resulting in prolonged hospital stay and affecting the patient's quality of life. After switching to liposomalAmphotericin B, inflammation indicators rapidly decreased and infection was controlled. Liposomalamphotericin B provides an option for treatment of <em>Aspergillus</em> peritonitis.</p></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"44 ","pages":"Article 100651"},"PeriodicalIF":2.2,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2211753924000253/pdfft?md5=4bb80f7fa94a6cb5ebe47ce90de2d636&pid=1-s2.0-S2211753924000253-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140823715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mariamalia Cob , Luisa F. López , D. Joseph Sexton , Adrián Fallas , Juan David Muñoz , Ricardo Gutiérrez
{"title":"Subcutaneous phaeohyphomycosis due to Phaeoacremonium venezuelense: The first clinical case report in Costa Rica","authors":"Mariamalia Cob , Luisa F. López , D. Joseph Sexton , Adrián Fallas , Juan David Muñoz , Ricardo Gutiérrez","doi":"10.1016/j.mmcr.2024.100650","DOIUrl":"https://doi.org/10.1016/j.mmcr.2024.100650","url":null,"abstract":"<div><p><em>Phaeoacremonium</em> is a genus of dematiaceous fungi that rarely causes human infections. We describe a case of subcutaneous infection in a 70-year-old diabetic man with lesions on the dorsum of the one foot. The agent was isolated, and for the final identification we performed matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) and DNA sequencing. After diagnosis, the patient underwent curettage of the cyst and received 100mg of Itraconazole, twice daily for 6 months. Clinical resolution of the lesion was observed after treatment. This is the first case of infection by <em>Phaeoacremonium venezuelense</em> reported in Costa Rica.</p></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"44 ","pages":"Article 100650"},"PeriodicalIF":2.2,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2211753924000241/pdfft?md5=555e1c7cf8ac709966a0e047b2fbfabb&pid=1-s2.0-S2211753924000241-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140816125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katrina J. Villegas MD , Nagihan Orhun MD , Sebastian Vera Garces , Sacide S. Ozgur MD , Patrick Michael MD , Ali Zahran MD , Daniel Rabinowitz MD
{"title":"Unilateral renal fungus ball caused by Candida glabrata","authors":"Katrina J. Villegas MD , Nagihan Orhun MD , Sebastian Vera Garces , Sacide S. Ozgur MD , Patrick Michael MD , Ali Zahran MD , Daniel Rabinowitz MD","doi":"10.1016/j.mmcr.2024.100649","DOIUrl":"https://doi.org/10.1016/j.mmcr.2024.100649","url":null,"abstract":"<div><p>A 46-year-old diabetic woman with unilateral renal fungus ball was successfully treated with antifungal therapy, endoscopic extraction and ureteral stent placement. The patient was initially treated for a right staghorn calculus, thereafter developed urinary symptoms. Imaging revealed distal left ureter filling defects and a previous stent at the ureteropelvic junction. Urine culture confirmed <em>Candida glabrata</em> sensitive to Micafungin. Bilateral ureteroscopy facilitated the extraction of a left renal pelvis fungus ball. This case underscores the challenges in diagnosing fungal UTIs in patients with predisposing factors, and highlights a combined medical and surgical approach for effective treatment of renal fungus balls.</p></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"44 ","pages":"Article 100649"},"PeriodicalIF":2.2,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S221175392400023X/pdfft?md5=b22b9ba7f14135abf192c8dacb011684&pid=1-s2.0-S221175392400023X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140558665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammad Rizwan Zafar , Thomas Whitfield , Sabeen Khurshid Zaidi , Sanjeewani Weerakoon , Joel Paul , Riina Rautemaa-Richardson
{"title":"Histoplasma capsulatum as a cause for prolonged pulmonary illness in an immunocompetent returning traveller from Bangladesh","authors":"Muhammad Rizwan Zafar , Thomas Whitfield , Sabeen Khurshid Zaidi , Sanjeewani Weerakoon , Joel Paul , Riina Rautemaa-Richardson","doi":"10.1016/j.mmcr.2024.100647","DOIUrl":"https://doi.org/10.1016/j.mmcr.2024.100647","url":null,"abstract":"<div><p>Fungal infections can be challenging to diagnose in returning travellers due to their non-specific clinical manifestations and changing epidemiology. We present a case of progressive disseminated histoplasmosis in a returning traveller from Bangladesh. The patient had a progressive and prolonged respiratory illness necessitating mechanical ventilatory support. The clue to potential fungal aetiology was provided by serum fungal markers - 1-3-β-D-glucan and <em>Aspergillus</em> galactomannan. Diagnosis was eventually made using panfungal PCR on bronchioalveolar lavage fluid.</p></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"44 ","pages":"Article 100647"},"PeriodicalIF":2.2,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2211753924000216/pdfft?md5=2d8cae5c55e2d853fb3dae6a0dfeb21b&pid=1-s2.0-S2211753924000216-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140551711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marie Louise Aicher , Jeanne Bisch-Karatas , Alexander Maurer , Franca Wagner , Martin Wartenberg , Stefan Zimmerli
{"title":"Rare case of a chronic rhinocerebral mucormycosis","authors":"Marie Louise Aicher , Jeanne Bisch-Karatas , Alexander Maurer , Franca Wagner , Martin Wartenberg , Stefan Zimmerli","doi":"10.1016/j.mmcr.2024.100648","DOIUrl":"https://doi.org/10.1016/j.mmcr.2024.100648","url":null,"abstract":"<div><p>We describe a case of rhino-orbital-cerebral mucormycosis (ROCM) in a diabetic patient. She presented with cavernous sinus syndrome and ischemia of the optic nerve. Initially unremarkable findings in the nasal cavity and paranasal sinus delayed early diagnosis. Within two weeks, a follow-up MRI showing progressive orbital inflammation, thrombosis of the cavernous sinus and erosive destruction of the left middle nasal concha together with necrotic black tissue in the left nasal cavity and destruction of the maxillary sinus demonstrated in a consecutively performed ethmoidectomy, finally gave way to diagnosis. Definite diagnosis was established by histopathology and culture. Treatment consisted of a combination of liposomal Amphotericin B, partial surgical resection and improved diabetes control. Despite insufficient surgical treatment, the progression of the disease was remarkably slow – a typical hallmark of chronic ROCM.</p><p>With this case report we aim to underline the difficulties in establishing a prompt diagnosis of ROCM and to remind readers of its chronic form.</p><p>2012 Elsevier Ltd. All rights reserved.</p></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"44 ","pages":"Article 100648"},"PeriodicalIF":2.2,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2211753924000228/pdfft?md5=010625ca07f772f5df28f39267781908&pid=1-s2.0-S2211753924000228-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140552687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}