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Concurrent pulmonary aspergillosis and phaeohyphomycosis due to Verruconis spp. in a stem cell transplant recipient with chronic graft-versus-host disease 慢性移植物抗宿主病干细胞移植受者由疣孢杆菌引起的并发肺曲霉病和褐丝菌病
IF 1.3
Medical Mycology Case Reports Pub Date : 2026-03-01 Epub Date: 2026-01-16 DOI: 10.1016/j.mmcr.2026.100764
Xosse Carreras , Francisco Machiavello Roman
{"title":"Concurrent pulmonary aspergillosis and phaeohyphomycosis due to Verruconis spp. in a stem cell transplant recipient with chronic graft-versus-host disease","authors":"Xosse Carreras ,&nbsp;Francisco Machiavello Roman","doi":"10.1016/j.mmcr.2026.100764","DOIUrl":"10.1016/j.mmcr.2026.100764","url":null,"abstract":"<div><div>Immunocompromised patients are at risk of complex invasive fungal infections. We report the case of a patient with profound immunosuppression following allogeneic stem cell transplantation who presented with a concurrent pulmonary infection due to <em>Aspergillus nidulans</em> and <em>Verruconis</em> spp. This case highlights the therapeutic challenges of managing simultaneous aspergillosis and phaeohyphomycosis in a patient with significant immune compromise.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100764"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146038158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An unusual granulomatous tinea due to Nannizzia incurvata in Germany without evidence of an acquisition from outside Europe and reduced itraconazole susceptibility 一例罕见的肉芽肿性癣，源于德国，无欧洲以外感染证据，伊曲康唑敏感性降低
IF 1.3
Medical Mycology Case Reports Pub Date : 2026-03-01 Epub Date: 2026-02-02 DOI: 10.1016/j.mmcr.2026.100769
Elisabeth Anke Schuldt, Karen Voss, Thomas Schwarz, Stephan Weidinger, Dora Violetta Stölzl, Jochen Brasch
{"title":"An unusual granulomatous tinea due to Nannizzia incurvata in Germany without evidence of an acquisition from outside Europe and reduced itraconazole susceptibility","authors":"Elisabeth Anke Schuldt,&nbsp;Karen Voss,&nbsp;Thomas Schwarz,&nbsp;Stephan Weidinger,&nbsp;Dora Violetta Stölzl,&nbsp;Jochen Brasch","doi":"10.1016/j.mmcr.2026.100769","DOIUrl":"10.1016/j.mmcr.2026.100769","url":null,"abstract":"<div><div><em>Nannizzia (N.) incurvata</em> is a rare geo- and zoophilic dermatophyte with human infections only sporadically reported from Europe. We describe an atypical skin infection with granulomas from Germany confirmed by culture, PCR, and histopathology. A reduced susceptibility to itraconazole (unreported for <em>N. incurvata</em> so far) prompted systemic treatment with terbinafine that resulted in complete healing. This case highlights the need for precise species identification, susceptibility testing, and awareness of emerging dermatophytes in Europe.</div></div><div><h3>2012 Elsevier Ltd</h3><div>All rights reserved.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100769"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146188986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mucormycotic osteomyelitis following anterior cruciate ligament reconstruction: A case report and literature review 前交叉韧带重建后毛霉菌性骨髓炎1例报告并文献复习
IF 1.3
Medical Mycology Case Reports Pub Date : 2026-03-01 Epub Date: 2026-02-10 DOI: 10.1016/j.mmcr.2026.100772
Phu Nguyen Hoang , Dong Phan Ba Vu , Tinh Pham Van , Thong Pham Quang , Hung Do Phuoc
{"title":"Mucormycotic osteomyelitis following anterior cruciate ligament reconstruction: A case report and literature review","authors":"Phu Nguyen Hoang ,&nbsp;Dong Phan Ba Vu ,&nbsp;Tinh Pham Van ,&nbsp;Thong Pham Quang ,&nbsp;Hung Do Phuoc","doi":"10.1016/j.mmcr.2026.100772","DOIUrl":"10.1016/j.mmcr.2026.100772","url":null,"abstract":"<div><div>We report a case of femoral osteomyelitis caused by <em>Mucorales</em> in a young, healthy male patient following ACL reconstruction. Fungal osteomyelitis of the extremities is a rare condition primarily caused by <em>Aspergillus</em> or <em>Candida</em> in immunocompromised patients. Diagnosis is often delayed until standard antibiotic regimens fail. Current guidelines recommend systemic amphotericin B with surgical debridement; however, the drug's clinical use is restricted by severe nephrotoxicity. To mitigate systemic toxicity, amphotericin B–loaded Polymethyl Methacrylate (PMMA) spacers have been investigated, though drug release remains short-lived. Early diagnosis—suggested by cortical and medullary bone destruction on imaging—along with timely amphotericin B therapy and surgical debridement, remains the cornerstone of effective management.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100772"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146188989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First isolation of Prototheca bovis from a bottlenose dolphin (Tursiops truncatus) 首次从宽吻海豚（Tursiops truncatus）中分离到牛原囊
IF 1.3
Medical Mycology Case Reports Pub Date : 2025-12-01 Epub Date: 2025-10-24 DOI: 10.1016/j.mmcr.2025.100746
Chika Shirakata , Kanon Tsurumi , Koichi Makimura , Rui Kano
{"title":"First isolation of Prototheca bovis from a bottlenose dolphin (Tursiops truncatus)","authors":"Chika Shirakata ,&nbsp;Kanon Tsurumi ,&nbsp;Koichi Makimura ,&nbsp;Rui Kano","doi":"10.1016/j.mmcr.2025.100746","DOIUrl":"10.1016/j.mmcr.2025.100746","url":null,"abstract":"<div><div>To our knowledge, this is the first report of <em>Prototheca</em> sp. isolated from the digestive tract of a dolphin. A captive-born female bottlenose dolphin (<em>Tursiops truncatus</em>) weighing 165 kg that was housed at Enoshima Aquarium presented with a slightly elevated body temperature and candida-like yeasts in stomach fluid and feces. Gastroscopy revealed cobblestone-like thickening of the mucosa with a few ulcers in the forestomach. <em>Prototheca bovis</em> was isolated from the biopsy specimen of the lesion.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100746"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isavuconazole: Need for therapeutic drug monitoring and CYP polymorphism testing Isavuconazole：需要进行治疗药物监测和CYP多态性检测
IF 1.3
Medical Mycology Case Reports Pub Date : 2025-12-01 Epub Date: 2025-09-19 DOI: 10.1016/j.mmcr.2025.100736
Rajeev Soman, Sanraksha Mayya, Rahul Doshi, Inderdeep Singh, Sushrut Ganpule
{"title":"Isavuconazole: Need for therapeutic drug monitoring and CYP polymorphism testing","authors":"Rajeev Soman,&nbsp;Sanraksha Mayya,&nbsp;Rahul Doshi,&nbsp;Inderdeep Singh,&nbsp;Sushrut Ganpule","doi":"10.1016/j.mmcr.2025.100736","DOIUrl":"10.1016/j.mmcr.2025.100736","url":null,"abstract":"<div><div>In this patient of invasive sinusitis due to Rhizopus arrhizus, Therapeutic drug monitoring (TDM) showed a high trough level (88mg/L) of isavuconazole on standard doses. Genotyping revealed CYP3A5∗3/∗3 polymorphism which indicated poor metabolism of isavuconazole. Switching to posaconazole was attempted but there was intolerance to posaconazole. To our knowledge, this is the first patient in whom both TDM and CYP genotyping were used to plan very low and infrequent doses of isavuconazole.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100736"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endogenous Endophthalmitis: An underestimated serious complication in patients with disseminated fusariosis 内源性眼内炎：一种被低估的严重并发症
IF 1.3
Medical Mycology Case Reports Pub Date : 2025-12-01 Epub Date: 2025-09-30 DOI: 10.1016/j.mmcr.2025.100742
Fabianne Carlesse , Adriana Maria Paixao De Sousa DA. Silva , Barbara Pinto Nasr , Luiz Fernando Teixeira , Henrique Manoel Lederman , Ana Virginia Lopes de Sousa
{"title":"Endogenous Endophthalmitis: An underestimated serious complication in patients with disseminated fusariosis","authors":"Fabianne Carlesse ,&nbsp;Adriana Maria Paixao De Sousa DA. Silva ,&nbsp;Barbara Pinto Nasr ,&nbsp;Luiz Fernando Teixeira ,&nbsp;Henrique Manoel Lederman ,&nbsp;Ana Virginia Lopes de Sousa","doi":"10.1016/j.mmcr.2025.100742","DOIUrl":"10.1016/j.mmcr.2025.100742","url":null,"abstract":"","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100742"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nannizziopsis arthrosporioides infection mimicking ophidiomycosis in ball pythons (Python regius) 球蟒体内模拟蛇霉病的Nannizziopsis arthrosporioides感染
IF 1.3
Medical Mycology Case Reports Pub Date : 2025-12-01 Epub Date: 2025-09-13 DOI: 10.1016/j.mmcr.2025.100733
Krista A. Keller , Laura Adamovicz , Cathy Johnson-Delaney , Karen A. Terio
{"title":"Nannizziopsis arthrosporioides infection mimicking ophidiomycosis in ball pythons (Python regius)","authors":"Krista A. Keller ,&nbsp;Laura Adamovicz ,&nbsp;Cathy Johnson-Delaney ,&nbsp;Karen A. Terio","doi":"10.1016/j.mmcr.2025.100733","DOIUrl":"10.1016/j.mmcr.2025.100733","url":null,"abstract":"<div><div>A wild caught snake presented with progressive dermatopathy and was euthanized due to a clinical suspicion for ophiomycosis. Over the next 7 days, six additional ball pythons, maintained in the same room but in separate cages from the index case developed similar progressive dermatomycoses and were euthanized. Histopathologic evaluation showed dermal granulomas with intralesional fungi and DNA from the lesions clustered in a monophyletic group with other isolates of <em>N. athrosporioides</em>. Colony and microscopic morphology of fungus from these cases matched published descriptions of <em>N. arthrosporioides</em>. While ophidiomycosis may be a major differential for dermatomycosis in snakes, molecular confirmation should be pursued, as additional fungi may cause similar lesions in this taxon.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100733"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145107436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Odontogenic-onset mucormycosis: A case series from a tertiary care institute in North India 牙源性毛霉菌病：来自印度北部三级保健机构的病例系列
IF 1.3
Medical Mycology Case Reports Pub Date : 2025-12-01 Epub Date: 2025-09-11 DOI: 10.1016/j.mmcr.2025.100730
Sandeep Rao Kordcal , Ishan Gupta , Kanika Chaudhary , Md Tariq Maula , Rahul Yadav , Gagandeep Singh , Manish Soneja , Immaculata Xess
{"title":"Odontogenic-onset mucormycosis: A case series from a tertiary care institute in North India","authors":"Sandeep Rao Kordcal ,&nbsp;Ishan Gupta ,&nbsp;Kanika Chaudhary ,&nbsp;Md Tariq Maula ,&nbsp;Rahul Yadav ,&nbsp;Gagandeep Singh ,&nbsp;Manish Soneja ,&nbsp;Immaculata Xess","doi":"10.1016/j.mmcr.2025.100730","DOIUrl":"10.1016/j.mmcr.2025.100730","url":null,"abstract":"<div><div>Mucormycosis is an angio-invasive, opportunistic fungal infection, which usually affects individuals with poorly controlled diabetes mellitus. While rhino-orbital-cerebral mucormycosis (ROCM) has been described in the English language literature, odontogenic-onset mucormycosis (OOM) is an emerging clinical entity, which is characterized by a unique port of entry, a distinct mode of onset and clinic-radiological features. We report a series of five cases of OOM managed in a tertiary care centre in North India. This series underscores the critical need for heightened awareness among dental practitioners about this entity, and highlights the importance of adhering to strict aseptic precautions.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100730"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145061191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disseminated subcutaneous sporotrichosis in an immunocompetent patient: A case report and a systematic literature review 免疫功能正常患者弥散性皮下孢子虫病：1例报告及系统文献回顾
IF 1.3
Medical Mycology Case Reports Pub Date : 2025-12-01 Epub Date: 2025-09-26 DOI: 10.1016/j.mmcr.2025.100739
Guangqi Zhu , Luwen Zhang , Yan Wang , Zheen Zhang
{"title":"Disseminated subcutaneous sporotrichosis in an immunocompetent patient: A case report and a systematic literature review","authors":"Guangqi Zhu ,&nbsp;Luwen Zhang ,&nbsp;Yan Wang ,&nbsp;Zheen Zhang","doi":"10.1016/j.mmcr.2025.100739","DOIUrl":"10.1016/j.mmcr.2025.100739","url":null,"abstract":"<div><div>Sporotrichosis is a subacute and chronic infectious disease caused by the infection of the skin, subcutaneous tissues, and nearby lymphatic vessels by the sporotrichosis complex. In this study, we report an immunocompetent case of disseminated subcutaneous sporotrichosis and provide a literature review of all case reports of disseminated subcutaneous sporotrichosis for which species identification was performed. A 74-year-old male patient with normal immune function was diagnosed with disseminated subcutaneous sporotrichosis. Sporadic red masses of varying sizes with local ulceration were observed on his right forearm, wrist, and little finger. Pathology of the mass in the right upper extremity indicated chronic suppurative inflammation of the subcutaneous soft tissue. The mNGS results indicated the presence of <em>Sporothrix schenckii</em>. Following the standard treatment with itraconazole, the patient's skin lesions healed without scarring or pigmentation. Disseminated subcutaneous sporotrichosis is less common in patients with a normal immune function. mNGS testing aids in the clear diagnosis of sporotrichosis and guides antifungal drug selection during treatment.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100739"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combined intracavitary, systemic antifungal and surgical treatment of Chronic Pulmonary Aspergillosis: experience from an immunocompromised patient 慢性肺曲霉病腔内、全身抗真菌和手术联合治疗：来自免疫功能低下患者的经验
IF 1.3
Medical Mycology Case Reports Pub Date : 2025-12-01 Epub Date: 2025-10-13 DOI: 10.1016/j.mmcr.2025.100743
Anne Haglund , Jelena Stankovic , Thomas Decker Christensen , Lise Kristensen , Karen Rokkedal Lausch
{"title":"Combined intracavitary, systemic antifungal and surgical treatment of Chronic Pulmonary Aspergillosis: experience from an immunocompromised patient","authors":"Anne Haglund ,&nbsp;Jelena Stankovic ,&nbsp;Thomas Decker Christensen ,&nbsp;Lise Kristensen ,&nbsp;Karen Rokkedal Lausch","doi":"10.1016/j.mmcr.2025.100743","DOIUrl":"10.1016/j.mmcr.2025.100743","url":null,"abstract":"<div><div>We present a complex case of Chronic Pulmonary Aspergillosis (CPA) caused by <em>Aspergillus fumigatus</em> in a pre-existing lung cavity in an immunocompromised patient with granulomatosis with polyangiitis. Initial treatment with voriconazole was limited due to adverse effects and emerging azole resistance.<em>Aspergillus</em> Subsequent therapy with intravenous and intracavitary amphotericin B was also poorly tolerated and clinically insufficient. The patient underwent left-sided thoracotomy with decortication. As a novel approach, the patient recieved Post-surgical instillation of liposomal amphotericin B directly into the resected cavity, combined with systemic antifungal therapy. Subsequently the patient recovered with long-term remission. This case highlights the potential role of post-operative intracavitary antifungal instillation as an adjunctive strategy in refractory CPA, particularly when conventional medical therapy fails.2012 Elsevier Ltd. All rights reserved.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100743"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145362997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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