Verbeke Frederick , Vanhee Frederik , Boudewijns Michaël , Coorevits Liselotte , De Bel Annelies
{"title":"Bisifusarium dimerum species complex central line-associated bloodstream infection in an immunocompetent patient","authors":"Verbeke Frederick , Vanhee Frederik , Boudewijns Michaël , Coorevits Liselotte , De Bel Annelies","doi":"10.1016/j.mmcr.2023.07.003","DOIUrl":"https://doi.org/10.1016/j.mmcr.2023.07.003","url":null,"abstract":"<div><p>Albeit invasive fusariosis is extremely rare in immunocompetent patients, we describe an immunocompetent patient suffering from a central line-associated blood stream infection (CLABSI) and the difficulties in distinguishing between blood culture contamination and clinical significance.</p></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"41 ","pages":"Pages 33-35"},"PeriodicalIF":2.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49724206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Subcutaneous mycosis caused by filamentous basidiomycete Megasporoporia setulosa-first report of human infection","authors":"Arghadip Samaddar , Twishi Shrimali, Anuradha Sharma","doi":"10.1016/j.mmcr.2023.07.002","DOIUrl":"https://doi.org/10.1016/j.mmcr.2023.07.002","url":null,"abstract":"<div><p>Filamentous basidiomycetes are an emerging cause of human infection in tropical and subtropical regions. We report a case of subcutaneous infection caused by the shelf fungus, <em>Megasporoporia setulosa</em>, in an immunocompetent male. This is also the first report of human infection caused by this filamentous basidiomycete. Identification of the fungus could only be achieved by sequencing the ITS and LSU regions of rDNA. The patient recovered following surgery and treatment with amphotericin B and oral itraconazole. This report underscores the cross-kingdom pathogenicity of plant fungi and the importance of molecular tools for definitive identification of nonsporulating fungal species.</p></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"41 ","pages":"Pages 27-32"},"PeriodicalIF":2.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49724196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A visceral mycosis in farmed rainbow trout (Oncorhynchus mykiss) caused by Neopyrenochaeta submersa","authors":"Jiří Řehulka , Alena Kubátová , Vit Hubka","doi":"10.1016/j.mmcr.2023.05.001","DOIUrl":"https://doi.org/10.1016/j.mmcr.2023.05.001","url":null,"abstract":"<div><p>A mycotic infection manifesting as abdominal distension with free serous fluid accumulation in the coelomic cavity is documented in farmed rainbow trout. Histological examination using PAS and silver staining revealed the presence of numerous fungal hyphae in the spleen and gastrointestinal wall. The isolated fungus was sterile and identified by using phylogenetic analysis based on four loci as <em>Neopyrenochaeta submersa</em>. This is the first time this fungus has been reported as pathogen.</p></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"41 ","pages":"Pages 4-7"},"PeriodicalIF":2.2,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49737380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cíntia Ávila Souza, Ana Carolina Baião Silva, Mirena Ide, Rodrigo Leite Azevedo, Paulo Eduardo Neves Ferreira Velho, Andrea Fernandes Eloy da Costa França
{"title":"Genital cutaneous ulcer as a manifestation of systemic mycosis: A rare presentation","authors":"Cíntia Ávila Souza, Ana Carolina Baião Silva, Mirena Ide, Rodrigo Leite Azevedo, Paulo Eduardo Neves Ferreira Velho, Andrea Fernandes Eloy da Costa França","doi":"10.1016/j.mmcr.2023.100605","DOIUrl":"10.1016/j.mmcr.2023.100605","url":null,"abstract":"<div><p>Paracoccidioidomycosis is a systemic mycosis caused by the fungus Paracoccidioides sp. The genital cutaneous manifestation is rare, with few reports in the literature. We report a case of a male farmer, who presented with a genital cutaneous ulcer for 2 years, without respiratory symptoms. Clinical and histological findings showed paracoccidioidomycosis. This pathology must be considered as an etiology of an ulcerated lesion in the genital tract, even in the absence of respiratory or systemic manifestations.</p></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"42 ","pages":"Article 100605"},"PeriodicalIF":2.2,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d3/6c/main.PMC10482884.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10223040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alejandro Hernández Solis , Saul Javier Rabadan Armenta , Javier Araiza Santibáñez , Alexandro Bonifaz , Fryda Jareth Serna Valle , Eliasib Mojica Jaimes
{"title":"Necrotizing pneumonia due to Saprochaete capitata in a patient with diabetes mellitus. Case report","authors":"Alejandro Hernández Solis , Saul Javier Rabadan Armenta , Javier Araiza Santibáñez , Alexandro Bonifaz , Fryda Jareth Serna Valle , Eliasib Mojica Jaimes","doi":"10.1016/j.mmcr.2023.08.006","DOIUrl":"https://doi.org/10.1016/j.mmcr.2023.08.006","url":null,"abstract":"<div><p><em>Saprochaete capitata</em> is a yeast-like fungus of the Dipodascaceae family, capable of colonizing the skin and the respiratory and gastrointestinal tracts. We present a 56-year-old man with diabetes mellitus who was admitted to the hospital presenting with fever, cough and hemoptysis. The diagnosis of necrotizing pneumonia was made by direct microscopy of the bronchoalveolar lavage fluid showed and <em>Saprochaete capitata</em> was identified by Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight (MALDI-TOF MS®). Treatment consisted of itraconazole 200 mg every 12 hours orally for 30 days, leading to clinical and radiological improvement. <em>Saprochaete capitata</em> infection is a rare cause of pulmonary mycoses.</p></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"42 ","pages":"Article 100603"},"PeriodicalIF":2.2,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49781989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An unusual case of disseminated cryptococcosis in an immunocompetent host presenting with verrucous skin lesions","authors":"Heloi Stefani , Laís Lopes Almeida Gomes , Fernanda Gonçalves Moya","doi":"10.1016/j.mmcr.2023.100606","DOIUrl":"10.1016/j.mmcr.2023.100606","url":null,"abstract":"<div><p>Disseminated cryptococcosis, commonly linked to immunocompromised conditions like HIV infection, is exceedingly rare in immunocompetent individuals. This case report presents a rare case of disseminated cryptococcosis in an immunocompetent patient, who manifested with fever, weight loss, neurological manifestations, and distinct verrucous skin lesions. Mycological cultures and histopathological assessments were conducted, leading to the identification of <em>Cryptococcus neoformans</em> var. <em>gattii</em> within both lung and skin biopsies. This case highlights the significance of considering this yeast infection within immunocompetent individuals and the necessity for promptly initiating appropriate antifungal therapy to enhance patient outcomes.</p></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"42 ","pages":"Article 100606"},"PeriodicalIF":2.2,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10482876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10225153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ana Cristina Gallotti , Mar Lombera , Karen Pinto , Ignacio Pinilla , Oscar Zaragoza , María Soledad Cuétara
{"title":"Kazachstania slooffiae, an emerging pathogen to watch for in humans?","authors":"Ana Cristina Gallotti , Mar Lombera , Karen Pinto , Ignacio Pinilla , Oscar Zaragoza , María Soledad Cuétara","doi":"10.1016/j.mmcr.2023.08.007","DOIUrl":"https://doi.org/10.1016/j.mmcr.2023.08.007","url":null,"abstract":"<div><p>In an 80-year-old man with long-term dysphagia, an upper endoscopy was performed and biopsy samples collected for microbiological and pathological tests, showing fungal structures. <em>Kazachstania slooffiae</em> was isolated in microbiological cultures that were later confirmed with DNA sequencing. Susceptibility tests were performed, and antifungal treatment was initiated with a clinical, pathological, and microbiological response.</p></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"42 ","pages":"Article 100604"},"PeriodicalIF":2.2,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49781990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jord W. Raymakers , Daan A.R. Castelijn , Caroline E. Rutten , Caspar J. Hodiamont
{"title":"Fusariosis in patients with hematological malignancies: Two case reports","authors":"Jord W. Raymakers , Daan A.R. Castelijn , Caroline E. Rutten , Caspar J. Hodiamont","doi":"10.1016/j.mmcr.2023.08.005","DOIUrl":"10.1016/j.mmcr.2023.08.005","url":null,"abstract":"<div><p>Immunosuppressed patients with hematological malignancies are at risk for invasive fungal infections (IFI), including infections with <em>Fusarium</em> species (spp.), which are increasingly reported. Particularly at risk are patients with acute myeloid leukemia (AML) treated with high-dose cytarabine as remission-induction therapy. Whether cytarabine increases the risk of IFI in comparison to other chemotherapy remains not fully determined. Additionally, no clear correlation between the in vitro established minimal inhibitory concentrations (MICs) of antifungal agents and clinical outcome has been established for fusariosis. To increase awareness and knowledge of invasive fusariosis, we report two cases of <em>Fusarium</em> spp. infections in neutropenic patients following treatment with cytarabine for AML. Despite high MICs for azoles both patients were treated with an azole in combination with liposomal amphotericin B. The combination therapy was successful in one patient, however the other patient did not survive the disseminated <em>Fusarium</em> infection.</p></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"42 ","pages":"Article 100602"},"PeriodicalIF":2.2,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41151298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G.I. Butel-Simoes , H. Kua , A. Safdar , M. Graham , T. Korman , Z. Meher-Homji
{"title":"Cryptococcal laryngitis in an immunocompetent asthmatic patient using inhaled corticosteroids","authors":"G.I. Butel-Simoes , H. Kua , A. Safdar , M. Graham , T. Korman , Z. Meher-Homji","doi":"10.1016/j.mmcr.2023.08.002","DOIUrl":"10.1016/j.mmcr.2023.08.002","url":null,"abstract":"<div><p>We present a case of laryngeal <em>cryptococcosis</em> caused by <em>cryptococcosis neoformans</em> var. <em>grubii</em> affecting a patient using excessive inhaled corticosteroids. The patient experienced symptoms for several months prior to specialist review and the visualization of a mass lesion by nasopharyngoscopy. Fortunately a biopsy was performed and through histopathology & microbiological assessment a diagnosis of cryptococcal laryngitis was made. Treatment with 6 months of fluconazole resulted in clinical cure and resolution of symptoms. It is important to raise awareness of the risk of non-Candida fungal infections in patients on high dose corticosteroids, especially in the post covid era were steroids are more commonly prescribed.</p></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"42 ","pages":"Article 100599"},"PeriodicalIF":2.2,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fa/a8/main.PMC10506085.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41154563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Paratracheal abscess by plant fungus Chondrostereum purpureum- first case report of human infection","authors":"Soma Dutta, Ujjwayini Ray","doi":"10.1016/j.mmcr.2023.03.001","DOIUrl":"https://doi.org/10.1016/j.mmcr.2023.03.001","url":null,"abstract":"<div><p><em>Chondrostereum purpureum,</em> is a plant fungus causing silver leaf disease of plants, particularly of the rose family. Here we report a case of paratracheal abscess caused by <em>C. purpureum.</em> This is a first of its kind of a case wherein this plant fungus caused disease in a human. Conventional techniques (microscopy and culture) failed to identify the fungus. Only by sequencing, the identity of this unusual pathogen could be revealed. This case highlights the potential of environmental plant fungi to cause disease in humans and stresses the importance of molecular techniques to identify the causative fungal species.</p></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"40 ","pages":"Pages 30-32"},"PeriodicalIF":2.2,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49739614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}