Rosemary Barnes, David A Enoch, Wendy Ingram, Jessica Martin, Jennifer Clay, Netta Tyler, P Lewis White
{"title":"Refractory fungal infection: Three case reports highlighting good practice.","authors":"Rosemary Barnes, David A Enoch, Wendy Ingram, Jessica Martin, Jennifer Clay, Netta Tyler, P Lewis White","doi":"10.1016/j.mmcr.2024.100688","DOIUrl":"https://doi.org/10.1016/j.mmcr.2024.100688","url":null,"abstract":"<p><p>Refractory invasive fungal disease is a significant clinical problem, with high morbidity, mortality and costs. The complex causes of refractory infection include breakthrough infection due to antifungal resistance (both innate and acquired), suboptimal therapy and impaired immune responses in critically ill or immunocompromised patients. This case series details three reports on the identification and management of refractory fungal infections, two cases of azole resistance and one case of resistant candidiasis, highlighting the importance of accurate diagnosis, monitoring, implementation of biomarkers (serological markers, PCR), antifungal susceptibility testing and antifungal stewardship to optimise management and minimise risks of emergence of drug resistance.</p>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"46 ","pages":"100688"},"PeriodicalIF":1.6,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11697122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Brenda Aceves-Sánchez, Estefano Rojas-Castañeda, Alfredo Ponce-de-León, Álvaro López-Iñiguez, Andrea Rangel-Cordero, Emilio Sánchez, Noel Salgado-Nesme, María F González-Lara
{"title":"Mucormycosis after liver transplant: Case series and literature review.","authors":"Brenda Aceves-Sánchez, Estefano Rojas-Castañeda, Alfredo Ponce-de-León, Álvaro López-Iñiguez, Andrea Rangel-Cordero, Emilio Sánchez, Noel Salgado-Nesme, María F González-Lara","doi":"10.1016/j.mmcr.2024.100686","DOIUrl":"10.1016/j.mmcr.2024.100686","url":null,"abstract":"<p><p>We describe two cases of possible healthcare-associated mucormycosis in liver transplant recipients. Mucorales may be acquired from environmental sources such as contaminated medical equipment, grafts or procedure related. Gastrointestinal mucormycosis is the second most common presentation in healthcare-associated infections. The high mortality rate of mucormycosis is due to low suspicion, insensitive diagnostic tests and rapid angioinvasion. Early antifungal treatment and surgical debridement are imperative to improve survival.</p>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"46 ","pages":"100686"},"PeriodicalIF":1.6,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11656075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrzej Kazimierz Jaworek , Przemysław Hałubiec , Paweł Marcin Krzyściak , Anna Wojas-Pelc , Jadwiga Wójkowska-Mach , Jacek Cezary Szepietowski
{"title":"Kerion-like lesions following an autoinoculation event in patient with chronic onychomycosis – Case report","authors":"Andrzej Kazimierz Jaworek , Przemysław Hałubiec , Paweł Marcin Krzyściak , Anna Wojas-Pelc , Jadwiga Wójkowska-Mach , Jacek Cezary Szepietowski","doi":"10.1016/j.mmcr.2024.100685","DOIUrl":"10.1016/j.mmcr.2024.100685","url":null,"abstract":"<div><div>We report a case of a 75-year-old male with suspected onychomycosis of the right hand and both feet who also developed kerion-like changes in the skin of his head and neck after recent inguinal hernia surgery. A mycological examination revealed the presence of <em>Trichophyton rubrum</em> in all affected sites. Treatment with oral terbinafine and topical isoconazole nitrate was started, resulting in a significant improvement in skin lesions. The case we present underscores the possibility of autoinoculation transmission of dermatophytes and the need for a careful evaluation of the coexistence of mycoses at different anatomical sites.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"46 ","pages":"Article 100685"},"PeriodicalIF":1.6,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Terenzio Cosio , Ruslana Gaeta Shumak , Cristiana Borselli , Fabio Artosi , Roberta Gaziano , Elena Campione
{"title":"Challenging case of tinea corporis and faciei in psoriatic patient treated with bimekizumab: The usefulness of mycological screening before biological therapies","authors":"Terenzio Cosio , Ruslana Gaeta Shumak , Cristiana Borselli , Fabio Artosi , Roberta Gaziano , Elena Campione","doi":"10.1016/j.mmcr.2024.100683","DOIUrl":"10.1016/j.mmcr.2024.100683","url":null,"abstract":"<div><div>Psoriasis is a multifactorial immune-mediated disorder linked to the interleukin (IL)-17 signalling pathway. We present an unusual case of <em>tinea corporis</em> and <em>faciei</em> caused by <em>Trichophyton tonsurans</em> that developed after starting the IL-17A/F inhibitor bimekizumab. Our case underlines how psoriatic patients, treated with IL-17 inhibitors, should be screened for cutaneous fungal infections before and during treatment, in order to exclude a concomitant infection or the risk of its exacerbation.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"46 ","pages":"Article 100683"},"PeriodicalIF":1.6,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Onychomycosis with gray-green staining caused by Fusarium solani","authors":"Yoshihito Mima , Masako Yamamoto , Koichi Makimura , Ken Iozumi","doi":"10.1016/j.mmcr.2024.100684","DOIUrl":"10.1016/j.mmcr.2024.100684","url":null,"abstract":"<div><div>We report a case of onychomycosis due to Fusarium solani with gray-green staining, which improved after nail plate removal and antifungal liquid of effinaconazole. Fungal cultures revealed light-brown and dark-green colonies. Gray-green nail might have occurred due to the combination of these colonies, which necessitated differentiation from green nail. Fusarium solani was detected on the genetic analysis of the colonies. Fusarium species reportedly produce yellow or red pigments; however, Fusarium species has not been previously reported to produce green pigments or forming dark-green colonies in fungal cultures.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"46 ","pages":"Article 100684"},"PeriodicalIF":1.6,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Estelle Sabourin , Clémentine De La Porte des Vaux , Nathanaël Veluppillai , Marie-Elisabeth Bougnoux , Eric Dannaoui , Olivier Lortholary
{"title":"Case report: Candida blankii osteo-articular infection in a patient with Chronic Granulomatous Disease","authors":"Estelle Sabourin , Clémentine De La Porte des Vaux , Nathanaël Veluppillai , Marie-Elisabeth Bougnoux , Eric Dannaoui , Olivier Lortholary","doi":"10.1016/j.mmcr.2024.100682","DOIUrl":"10.1016/j.mmcr.2024.100682","url":null,"abstract":"<div><div><em>Candida blankii</em> is a recently reported yeast causing rare cases of fungemia. This species presents high minimum inhibitory concentrations (MICs) to fluconazole and echinocandins. We report an atypical <em>C. blankii</em> metacarpophalangeal osteo-articular infection in a patient with Chronic Granulomatous Disease. The patient was initially treated by a combination of voriconazole and 5-fluorocytosine (5-FC). However, the treatment was subsequently changed to posaconazole and then to a combination of caspofungin and 5-FC.</div><div>2012 Elsevier Ltd. All rights reserved.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"46 ","pages":"Article 100682"},"PeriodicalIF":1.6,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142593811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kristoffer E. Leon , Timothy Mugabi , Tu Tran , Hawa Magembe , Caleb P. Skipper
{"title":"Utility of handheld non-mydriatic fundoscopy in a case of bilateral, reversible vision loss in an advanced HIV patient with cryptococcal meningitis in Sub-Saharan Africa","authors":"Kristoffer E. Leon , Timothy Mugabi , Tu Tran , Hawa Magembe , Caleb P. Skipper","doi":"10.1016/j.mmcr.2024.100680","DOIUrl":"10.1016/j.mmcr.2024.100680","url":null,"abstract":"<div><div>Cryptococcal meningitis is a fungal infection that is typically caused by <em>Cryptococcus neoformans</em> and most commonly seen in severely immunosuppressed patient. This disease causes severe neurologic disease due to elevated intracranial pressures. In this case report, we describe a patient with newly diagnosed HIV presenting to the hospital with cryptococcal meningitis complicated by sudden vision loss. We highlight the role of prompt diagnosis and treatment in the reversal of vision loss, with subsequent monitoring using a handheld, non-mydriatic fundus imaging device.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"46 ","pages":"Article 100680"},"PeriodicalIF":1.6,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142654257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Agustin N. Posso, Alvaro A. Perez-Meza, Paul Marquez, Daniel Garzon-Chavez
{"title":"A unique presentation of subcutaneous Cutaneotrichosporon debeurmannianum infection: A case report of a diagnostic challenge","authors":"Agustin N. Posso, Alvaro A. Perez-Meza, Paul Marquez, Daniel Garzon-Chavez","doi":"10.1016/j.mmcr.2024.100681","DOIUrl":"10.1016/j.mmcr.2024.100681","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Cutaneotrichosporon debeurmannianum</em> is a yeast-like anamorphic rare fungus commonly found in tropical areas. This case report is the first one located in South America.</div></div><div><h3>Case report</h3><div>A 67-year-old patient presented with a 5-year history of right foot pain attributed to foot trauma while at sea 5 years prior. During surgical exploration, an impressive whitish cerebriform-like cyst was encountered. Genetic analysis using the genes ITS1, ITS4, LSU-R, and LSU-F was performed, and a phylogenetic tree identified <em>C. debeurmannianum</em>.</div></div><div><h3>Conclusion</h3><div>A complete characterization of this fungus which causes human disease has not yet been achieved and more research is needed.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"46 ","pages":"Article 100681"},"PeriodicalIF":1.6,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142529496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dermatophytosis caused by Trichophyton benhamiae in a sea lion. First report","authors":"Ronar López , Víctor Silva , Viviana Bown , Patricio Godoy-Martínez , Pamela Thomson","doi":"10.1016/j.mmcr.2024.100679","DOIUrl":"10.1016/j.mmcr.2024.100679","url":null,"abstract":"<div><div>Fungal infections in marine animals, particularly pinnipeds, have seen a notable increase, often linked to compromised immune systems in captive environments. <em>Trichophyton</em> species, while common in terrestrial mammals, have sporadically caused dermatophytosis in pinnipeds. A South American sea lion (<em>Otaria byronia</em>) presented with <em>Trichophyton benhamiae</em> infection, marking the first such case in this species. Effective treatment combined oral terbinafine with topical ozonized oil, supported by silymarin for liver protection. Accurate fungal identification and sensitivity testing were key to the successful management and recovery of the patient.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"46 ","pages":"Article 100679"},"PeriodicalIF":1.6,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142572532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaixuan Yuan , Xiaoxiao Wang , Yong Ling, Ye Long, Zhuoxi Chen, Yunhu Zhao
{"title":"First case of fungal peritonitis caused by Neosartorya hiratsukae in China","authors":"Kaixuan Yuan , Xiaoxiao Wang , Yong Ling, Ye Long, Zhuoxi Chen, Yunhu Zhao","doi":"10.1016/j.mmcr.2024.100676","DOIUrl":"10.1016/j.mmcr.2024.100676","url":null,"abstract":"<div><div>Fungal peritonitis, an uncommon complication in continuous ambulatory peritoneal dialysis (CAPD), has recently garnered increased attention due to its incidence and potential mortality. To the best of our knowledge, this is the first confirmed case of <em>Neosartorya hiratsukae</em> (<em>N. hiratsukae</em>) causing CAPD-related peritonitis in a patient with chronic nephrotic syndrome in Guangzhou, China. After prompt removal of the peritoneal catheter and active antifungal therapy, no clinical manifestations of peritonitis were observed. Our report underscores the importance of enhancing clinical awareness regarding <em>N. hiratsukae</em> and ensuring timely diagnosis in cases of CAPD-related fungal peritonitis.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"46 ","pages":"Article 100676"},"PeriodicalIF":1.6,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142530143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}