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Fungal sepsis in a 7-month-old female: diagnosis through peripheral blood smear 7月龄女性真菌性败血症：通过外周血涂片诊断
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-05-22 DOI: 10.1016/j.mmcr.2025.100708
Yihun Bedaso , Tadesse Alemayehu , Amanuel Anegagregn Bizuneh , Dereje Zeleke Haile , Seble Seifu Zeleke , Mekdes Shifeta , Agete Tadewos Hirigo
{"title":"Fungal sepsis in a 7-month-old female: diagnosis through peripheral blood smear","authors":"Yihun Bedaso ,&nbsp;Tadesse Alemayehu ,&nbsp;Amanuel Anegagregn Bizuneh ,&nbsp;Dereje Zeleke Haile ,&nbsp;Seble Seifu Zeleke ,&nbsp;Mekdes Shifeta ,&nbsp;Agete Tadewos Hirigo","doi":"10.1016/j.mmcr.2025.100708","DOIUrl":"10.1016/j.mmcr.2025.100708","url":null,"abstract":"<div><div>We report a case of a 7-month-old female with prolonged high-grade fever unresponsive to broad-spectrum antibiotics and antimalarial drugs. Despite negative cultures and imaging, a Giemsa-stained peripheral blood smear on day 28 revealed yeast cells, suggesting fungal sepsis in the context of prolonged antibiotic exposure and thrombocytopenia. The patient responded well to oral fluconazole, with full clinical recovery. This case underscores the value of peripheral blood smear examination in diagnosing yeast infections in resource-limited settings.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"48 ","pages":"Article 100708"},"PeriodicalIF":1.6,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extensive and recurrent infection caused by Medicopsis romeroi in two immunocompromised patients 2例免疫功能低下患者由罗梅草引起广泛复发性感染
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-05-08 DOI: 10.1016/j.mmcr.2025.100706
Lotte Keikes , Marit S. van Sandwijk , Evert-Jan Kooi , Marieke Gittelbauer , Karin van Dijk
{"title":"Extensive and recurrent infection caused by Medicopsis romeroi in two immunocompromised patients","authors":"Lotte Keikes ,&nbsp;Marit S. van Sandwijk ,&nbsp;Evert-Jan Kooi ,&nbsp;Marieke Gittelbauer ,&nbsp;Karin van Dijk","doi":"10.1016/j.mmcr.2025.100706","DOIUrl":"10.1016/j.mmcr.2025.100706","url":null,"abstract":"<div><div><em>Medicopsis romeroi</em>, a rare brown-pigmented mold, is one of the causes of phaeohyphomycosis, a (sub)cutaneous or soft tissue fungal infection with formation of nodules, cysts or abscesses. Mainly immunocompromised patients are affected, who may experience a wider spectrum of disease with involvement of other tissues, such as the bones or the sinuses. No specific treatment recommendations are available, but surgical excision appears to be the mainstay of treatment, combined with (long-term) antifungal therapy. In this case series, we describe two immunocompromised patients with extensive and persistent skin lesions caused by <em>M</em>. <em>romeroi</em>, and clinical practice recommendations for optimal treatment.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"48 ","pages":"Article 100706"},"PeriodicalIF":1.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Invasive tracheal mucormycosis complicated by myiasis following tracheostomy in a diabetic patient: A case report 糖尿病气管切开术后浸润性气管毛霉病并发蝇蛆病1例
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-05-08 DOI: 10.1016/j.mmcr.2025.100707
Yuanjiang Zheng , Li Yang , Jianglin Yu , Shanyu Wang , Xianwei Ye
{"title":"Invasive tracheal mucormycosis complicated by myiasis following tracheostomy in a diabetic patient: A case report","authors":"Yuanjiang Zheng ,&nbsp;Li Yang ,&nbsp;Jianglin Yu ,&nbsp;Shanyu Wang ,&nbsp;Xianwei Ye","doi":"10.1016/j.mmcr.2025.100707","DOIUrl":"10.1016/j.mmcr.2025.100707","url":null,"abstract":"<div><div>Invasive tracheal mucormycosis is a rare but fatal opportunistic infection, particularly common in immunocompromised patients. This case report describes a 23-year-old female diabetic patient who developed invasive tracheal mucormycosis following a tracheostomy. The mucormycosis infection was brought under control after antifungal therapy and surgical debridement; however, due to multiple contributing factors, the patient subsequently developed myiasis. This case highlights the importance of early diagnosis, aggressive treatment, and proper tracheostomy management in preventing severe complications.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"48 ","pages":"Article 100707"},"PeriodicalIF":1.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful management of Lomentospora prolificans septic arthritis and osteomyelitis in an immunocompetent child: A case report 成功管理的增殖性门孢子虫感染性关节炎和骨髓炎在免疫能力的儿童：一个案例报告
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-04-25 DOI: 10.1016/j.mmcr.2025.100704
Niall Johnston , Bradley Rockliff , Robert Duguid , Pamela Palasanthiran , Adam W. Bartlett , Phoebe CM. Willams , Brendan J. McMullan
{"title":"Successful management of Lomentospora prolificans septic arthritis and osteomyelitis in an immunocompetent child: A case report","authors":"Niall Johnston ,&nbsp;Bradley Rockliff ,&nbsp;Robert Duguid ,&nbsp;Pamela Palasanthiran ,&nbsp;Adam W. Bartlett ,&nbsp;Phoebe CM. Willams ,&nbsp;Brendan J. McMullan","doi":"10.1016/j.mmcr.2025.100704","DOIUrl":"10.1016/j.mmcr.2025.100704","url":null,"abstract":"<div><div>Available online We report a case of limb-threatening <em>Lomentospora prolificans</em> elbow infection in a 3-year-old immunocompetent boy following a closed fracture. Resolution of infection was achieved following combined aggressive debridement, combined antifungal therapy, voriconazole-loaded bone cement, and antiseptic joint irrigation. This highlights the need for early diagnosis and multi-modal surgical, medical and other novel adjunctive therapies in managing these difficult-to-treat infections. Increased research and improved access to novel antifungal drugs are essential to enhance treatment options for intrinsically multidrug-resistant fungal infections.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"48 ","pages":"Article 100704"},"PeriodicalIF":1.6,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143890885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cryptococcal endophthalmitis in a patient with malignancy: A case report and literature review 隐球菌性眼内炎合并恶性肿瘤1例报告并文献复习
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-04-23 DOI: 10.1016/j.mmcr.2025.100703
Kamonchanok Phaopraphat, Rujipas Sirijatuphat
{"title":"Cryptococcal endophthalmitis in a patient with malignancy: A case report and literature review","authors":"Kamonchanok Phaopraphat,&nbsp;Rujipas Sirijatuphat","doi":"10.1016/j.mmcr.2025.100703","DOIUrl":"10.1016/j.mmcr.2025.100703","url":null,"abstract":"<div><div>Cryptococcal endophthalmitis is a rare manifestation of cryptococcal infection, typically occurring in immunocompromised patients. In this case report, we present a 50-year-old female with advanced-stage lung cancer with multiple metastases presenting with blurred vision for 10 days. A diagnostic pars plana vitrectomy revealed <em>Cryptococcus neoformans</em> in the vitreous. She was treated with systemic amphotericin B and flucytosine, followed by fluconazole for consolidation and maintenance, along with intravitreal amphotericin B and voriconazole injections. Her visual acuity improved from counting fingers at 2 feet to 3/60, with a pinhole correction of 6/18 after 10 months of treatment.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"48 ","pages":"Article 100703"},"PeriodicalIF":1.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The tell-tale hearts: Donor-derived invasive fungal infections among orthotopic heart transplant recipients 揭露真相的心脏：原位心脏移植受者中供体来源的侵袭性真菌感染
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-03-31 DOI: 10.1016/j.mmcr.2025.100702
Jay Krishnan, Manuela Carugati, Rachel A. Miller, Cameron R. Wolfe, John R. Perfect, Julia A. Messina
{"title":"The tell-tale hearts: Donor-derived invasive fungal infections among orthotopic heart transplant recipients","authors":"Jay Krishnan,&nbsp;Manuela Carugati,&nbsp;Rachel A. Miller,&nbsp;Cameron R. Wolfe,&nbsp;John R. Perfect,&nbsp;Julia A. Messina","doi":"10.1016/j.mmcr.2025.100702","DOIUrl":"10.1016/j.mmcr.2025.100702","url":null,"abstract":"<div><div>Donor-derived invasive fungal infections among solid organ transplant recipients are rare but sometimes devastating events associated with notable morbidity and mortality. Here we describe two donor-derived fungal infections – one <em>Candida parapsilosis</em> complex infection and one <em>Aspergillus fumigatus</em> infection – that occurred among heart transplant recipients at a quaternary care center. Both recipients survived their infections, though with substantial morbidity despite aggressive surgical intervention and antifungal therapy.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"48 ","pages":"Article 100702"},"PeriodicalIF":1.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A fatal case of pulmonary cryptococcosis in an apparently immunocompetent patient from Cote D′ Ivoire 肺隐球菌病的致命病例在一个明显免疫正常的病人从科特迪瓦
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-03-21 DOI: 10.1016/j.mmcr.2025.100701
Ahou Sandrine Konan , Kalou Dibert Zika , Affoué Sandrine Josette Kouakou , Appi Sandrine Kouamé , Malick Senanminfoun Soro , Koffi Daho Adoubryn
{"title":"A fatal case of pulmonary cryptococcosis in an apparently immunocompetent patient from Cote D′ Ivoire","authors":"Ahou Sandrine Konan ,&nbsp;Kalou Dibert Zika ,&nbsp;Affoué Sandrine Josette Kouakou ,&nbsp;Appi Sandrine Kouamé ,&nbsp;Malick Senanminfoun Soro ,&nbsp;Koffi Daho Adoubryn","doi":"10.1016/j.mmcr.2025.100701","DOIUrl":"10.1016/j.mmcr.2025.100701","url":null,"abstract":"<div><div>Cryptococcosis is an opportunistic mycosis caused by <em>Cryptococcus</em>, mainly affecting the immunocompromised. We report a case of pulmonary cryptococcosis within a 31-year-old immunocompetent patient admitted for painful chest swelling evolving for 4 months prior to admission. The chest X-Ray showed a rounded pulmonary opacity. The chest ultrasound revealed a pulmonary abscess diffusing under the skin. Direct examination using the Indian ink and the May-Grunwald Giemsa staining revealed encapsulated yeasts in the pus. The Culture of the pus on the Sabouraud medium with chloramphenicol confirmed the presence of <em>Cryptococcus neoformans</em>. Cryptococcal antigen was positive. This case reminds us that cryptococcosis should be considered even without immunosuppression.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"48 ","pages":"Article 100701"},"PeriodicalIF":1.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The diagnostic role of elevated serum cryptococcal antigen titers in patients with suspected cryptococcal meningitis when lumbar puncture is contraindicated: A case report 腰椎穿刺时血清隐球菌抗原滴度升高对疑似隐球菌性脑膜炎的诊断作用：1例报告
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-03-18 DOI: 10.1016/j.mmcr.2025.100700
Asmus Tukundane, Richard Kwizera, Lillian Tugume, Jayne Ellis, David R. Boulware, David B. Meya
{"title":"The diagnostic role of elevated serum cryptococcal antigen titers in patients with suspected cryptococcal meningitis when lumbar puncture is contraindicated: A case report","authors":"Asmus Tukundane,&nbsp;Richard Kwizera,&nbsp;Lillian Tugume,&nbsp;Jayne Ellis,&nbsp;David R. Boulware,&nbsp;David B. Meya","doi":"10.1016/j.mmcr.2025.100700","DOIUrl":"10.1016/j.mmcr.2025.100700","url":null,"abstract":"<div><div>Cryptococcal meningitis is one of the major causes of death in sub-Saharan Africa among individuals with advanced HIV, and it is typically diagnosed through lumbar puncture (LP). However, LP may be contraindicated in some cases, causing a clinical dilemma and potential delay in treatment. We present the case of a 60-year-old female, newly diagnosed with HIV, who presented with a reduced level of consciousness and a positive serum cryptococcal antigen (CrAg) test (high titer = 1:320). Computerized tomographic (CT) brain imaging showed multiple nodular lesions, peri-lesional edema and a midline shift. Despite the contraindication for LP, a low volume lumbar puncture (1–2 mL) was performed in view of the elevated serum CrAg titers and patient's clinical symptoms, in order to rule in a definitive diagnosis of cryptococcal meningitis or exclude tuberculous meningitis. The patient was treated for cryptococcal meningitis and responded well. In patients with a positive serum CrAg test and contraindications to LP, an elevated titer (&gt;1:160) and neurological symptoms may guide the initiation of definitive treatment for cryptococcal meningitis, however further evaluation is needed.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"48 ","pages":"Article 100700"},"PeriodicalIF":1.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fungal peritonitis in a patient on peritoneal dialysis caused by Hyphopichia burtonii: A rare pathogen in human infection 一例腹膜透析患者的真菌性腹膜炎是由一种罕见的人类感染病原体——伯顿丝酵菌引起的
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-03-07 DOI: 10.1016/j.mmcr.2025.100699
Estacio Mayra , Reino Alberto , Rodelo Joaquin , Ustariz Jose
{"title":"Fungal peritonitis in a patient on peritoneal dialysis caused by Hyphopichia burtonii: A rare pathogen in human infection","authors":"Estacio Mayra ,&nbsp;Reino Alberto ,&nbsp;Rodelo Joaquin ,&nbsp;Ustariz Jose","doi":"10.1016/j.mmcr.2025.100699","DOIUrl":"10.1016/j.mmcr.2025.100699","url":null,"abstract":"<div><div>Fungal peritonitis in peritoneal dialysis (PD) patients is rare but is associated with high morbidity and mortality. <em>Candida</em> species are the most common causative agents, but infections caused by unusual, often “nonpathogenic,” fungi are being increasingly reported. <em>Hyphopichia burtonii</em> is typically associated with food spoilage and has rarely been reported in human infections.</div><div>We describe the case of a 44-year-old female with end-stage renal disease on continuous ambulatory peritoneal dialysis (CAPD) who developed peritonitis caused by <em>Hyphopichia burtonii</em>. Following the identification of the fungus, the patient was put on hemodialysis, the peritoneal dialysis catheter was removed, and he was given fluconazole for two weeks having favorable clinical development.</div><div>2012 Elsevier Ltd. All rights reserved.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"48 ","pages":"Article 100699"},"PeriodicalIF":1.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143631726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disseminated histoplasmosis presenting as adrenal insufficiency: A case report 表现为肾上腺功能不全的播散性组织浆菌病1例
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-02-15 DOI: 10.1016/j.mmcr.2025.100698
Md. Asaduzzaman , Ranjon Kumer Roy , Suchanda Roy , Nasad Ahmed , Sazeda Akter , Monotush Ronjon Chando
{"title":"Disseminated histoplasmosis presenting as adrenal insufficiency: A case report","authors":"Md. Asaduzzaman ,&nbsp;Ranjon Kumer Roy ,&nbsp;Suchanda Roy ,&nbsp;Nasad Ahmed ,&nbsp;Sazeda Akter ,&nbsp;Monotush Ronjon Chando","doi":"10.1016/j.mmcr.2025.100698","DOIUrl":"10.1016/j.mmcr.2025.100698","url":null,"abstract":"<div><div>This report aims to highlight rarity of disseminated histoplasmosis (DH) presenting as adrenal insufficiency and the need for considering it in the differential diagnosis, even in non-endemic areas. A case is presented of a 69-year-old male patient with a background of hypertension and diabetes mellitus, with a persistent fever, significant loss of weight, and general weakness. Imaging studies showed adrenal masses in both adrenal glands, and laboratory tests showed hyperkalemia and hyponatremia. Hormonal tests confirmed the diagnosis of adrenal insufficiency. CT-guided adrenal biopsy confirmed the diagnosis of histoplasmosis. The patient received a 14-day course of Amphotericin B, followed by oral Itraconazole and glucocorticoid substitution therapy, with improvement in adrenal function over a period of time.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"47 ","pages":"Article 100698"},"PeriodicalIF":1.6,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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