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Medical Mycology Case Reports最新文献

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Redefining Ultrasound's role in early diagnosis of hepatosplenic candidiasis during neutropenia: A pediatric case report in solid tumor 重新定义超声在中性粒细胞减少时肝脾念珠菌病早期诊断中的作用：一个儿童实体瘤病例报告
IF 1.3
Medical Mycology Case Reports Pub Date : 2026-03-01 Epub Date: 2026-03-06 DOI: 10.1016/j.mmcr.2026.100777
Francesca Cappozzo , Teresa Battaglia , Marta Nebiolo , Marcello Mariani , Virginia Livellara , Gabriele Gaggero , Elena Arkangelskaya , Maria Beatrice Damasio , Lorenzo Anfigeno , Camilla De Luca , Stefano Avanzini , Federico Palo , Massimo Conte , Elio Castagnola
{"title":"Redefining Ultrasound's role in early diagnosis of hepatosplenic candidiasis during neutropenia: A pediatric case report in solid tumor","authors":"Francesca Cappozzo ,&nbsp;Teresa Battaglia ,&nbsp;Marta Nebiolo ,&nbsp;Marcello Mariani ,&nbsp;Virginia Livellara ,&nbsp;Gabriele Gaggero ,&nbsp;Elena Arkangelskaya ,&nbsp;Maria Beatrice Damasio ,&nbsp;Lorenzo Anfigeno ,&nbsp;Camilla De Luca ,&nbsp;Stefano Avanzini ,&nbsp;Federico Palo ,&nbsp;Massimo Conte ,&nbsp;Elio Castagnola","doi":"10.1016/j.mmcr.2026.100777","DOIUrl":"10.1016/j.mmcr.2026.100777","url":null,"abstract":"<div><div>We report a case of hepatosplenic candidiasis (HSC) in a neutropenic child with ovarian teratoma. Using high-frequency ultrasonography, we detected subtle hypoechoic pseudonodules in the spleen during profound neutropenia (ANC 30/μL), challenging the dogma that lesions only appear after immune recovery. These precursors evolved into classic \"bull's-eye\" lesions. <em>Candida tropicalis</em> was confirmed via splenectomy. This case highlights high-frequency ultrasound's role in early HSC diagnosis before neutrophil recovery.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100777"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147397148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fungal meningoencephalitis caused by Phanerochaete sp.: Case report 平革菌引起的真菌性脑膜脑炎1例。
IF 1.3
Medical Mycology Case Reports Pub Date : 2026-03-01 Epub Date: 2026-01-23 DOI: 10.1016/j.mmcr.2026.100767
Juan Sebastián Sánchez León , Michel Cristian Grasel , Cecília Bittencourt Severo , Heryk Motta , Júlia Catarina Vieira Reuwsaat , Lívia Kmetzsch , Guilherme Girardi May , Paulo Renato Petersen Behar , Alessandro C. Pasqualotto , Carlos Roberto de Mello Rieder
{"title":"Fungal meningoencephalitis caused by Phanerochaete sp.: Case report","authors":"Juan Sebastián Sánchez León ,&nbsp;Michel Cristian Grasel ,&nbsp;Cecília Bittencourt Severo ,&nbsp;Heryk Motta ,&nbsp;Júlia Catarina Vieira Reuwsaat ,&nbsp;Lívia Kmetzsch ,&nbsp;Guilherme Girardi May ,&nbsp;Paulo Renato Petersen Behar ,&nbsp;Alessandro C. Pasqualotto ,&nbsp;Carlos Roberto de Mello Rieder","doi":"10.1016/j.mmcr.2026.100767","DOIUrl":"10.1016/j.mmcr.2026.100767","url":null,"abstract":"<div><div>We report the first case of fungal meningoencephalitis caused by <em>Phanerochaete</em> sp. in a previously healthy 51-year-old woman. The patient presented with progressive neurological decline and abnormal cerebrospinal fluid (CSF) findings. Neuroimaging suggested fungal infection, but conventional diagnostics were negative. Subsequently, fungal growth was obtained from CSF culture, and the isolate was identified as <em>Phanerochaete</em> sp. by DNA sequencing, an environmental basidiomycete not previously implicated in central nervous system disease. Antifungal therapy with voriconazole and amphotericin B led to mild clinical and radiological improvement, though significant neurological sequelae persisted. This case highlights the value of molecular diagnostics in identifying rare fungal pathogens and expanding our understanding of their pathogenic potential.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100767"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146144635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lomentospora prolificans infective endocarditis and cerebral mycotic aneurysm 传染性心内膜炎和脑真菌性动脉瘤
IF 1.3
Medical Mycology Case Reports Pub Date : 2026-03-01 Epub Date: 2026-02-10 DOI: 10.1016/j.mmcr.2026.100771
Robert Hand , J. Owen Robinson , Paul Cannell , Robert Larbalestier , Thomas Gliddon , Peter Boan
{"title":"Lomentospora prolificans infective endocarditis and cerebral mycotic aneurysm","authors":"Robert Hand ,&nbsp;J. Owen Robinson ,&nbsp;Paul Cannell ,&nbsp;Robert Larbalestier ,&nbsp;Thomas Gliddon ,&nbsp;Peter Boan","doi":"10.1016/j.mmcr.2026.100771","DOIUrl":"10.1016/j.mmcr.2026.100771","url":null,"abstract":"<div><div>Disseminated <em>Lomentospora prolificans</em> infection typically occurs in immunocompromised hosts and is almost universally fatal. We describe a case of <em>L. prolificans</em> native valve infective endocarditis with cerebral mycotic aneurysm after recovery from allogeneic stem cell transplant. The case is notable for minimal immunosuppression at diagnosis, and pathological evidence of infection at sites which looked normal at surgery or by imaging. With early surgery and olorofim the patient survived to 76 days after diagnosis.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100771"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146188985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fusarium solani infection induced cardiopulmonary failure in immunocompromised patients: Two case reports 免疫功能低下患者梭菌感染致心肺衰竭2例报告
IF 1.3
Medical Mycology Case Reports Pub Date : 2026-03-01 Epub Date: 2026-01-16 DOI: 10.1016/j.mmcr.2026.100763
Yuanying Zeng, Dan Chen, Fang Yang, Huaying Liu, Yuelin He, Chunfu Li
{"title":"Fusarium solani infection induced cardiopulmonary failure in immunocompromised patients: Two case reports","authors":"Yuanying Zeng,&nbsp;Dan Chen,&nbsp;Fang Yang,&nbsp;Huaying Liu,&nbsp;Yuelin He,&nbsp;Chunfu Li","doi":"10.1016/j.mmcr.2026.100763","DOIUrl":"10.1016/j.mmcr.2026.100763","url":null,"abstract":"<div><div>In patients with immune deficiencies, <em>fusarium solani</em> infections have a poor prognosis and a high mortality rate. Previous reports revealed patients with disseminated Fusarium infections often ultimately succumb to multi-organ failure, however, specific organs involved in the initial stages of failure and the progression of cardiopulmonary injuries are not described in detail. We here report the development of cardiopulmonary failure in two consecutive patients with <em>fusarium solani</em> infections.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100763"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146038160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antigen detection of Talaromyces infection in the US: Case report 美国Talaromyces感染的抗原检测：病例报告
IF 1.3
Medical Mycology Case Reports Pub Date : 2026-03-01 Epub Date: 2026-03-06 DOI: 10.1016/j.mmcr.2026.100778
Emily E. Evans , Jennifer Spicer , Vince Marconi , Thuy Le
{"title":"Antigen detection of Talaromyces infection in the US: Case report","authors":"Emily E. Evans ,&nbsp;Jennifer Spicer ,&nbsp;Vince Marconi ,&nbsp;Thuy Le","doi":"10.1016/j.mmcr.2026.100778","DOIUrl":"10.1016/j.mmcr.2026.100778","url":null,"abstract":"<div><div>Talaromycosis is an invasive fungal infection endemic in Southeast Asia and has emerged as a leading cause of HIV-related death in the highly endemic countries of Vietnam, Thailand and China. Travel-related cases have been increasingly reported in immunocompromised people since the 1980s. Lack of clinical suspicion and non-culture-based diagnostics prevent timely, accurate diagnosis and treatment. Here we describe a travel-related case of talaromycosis in whom the diagnosis was confirmed using Mp1p antigen detection, highlighting its clinical utility.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100778"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147397149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Systemic Rasamsonia argillacea infection in a German Shepherd dog 德国牧羊犬全身性血吸虫感染
IF 1.3
Medical Mycology Case Reports Pub Date : 2026-03-01 Epub Date: 2026-03-07 DOI: 10.1016/j.mmcr.2026.100779
Louisa Schmidt , Sebastian Reusch , Ilka McCormick-Smith , Jasmin Gerkrath , Martin Peters , Volker Rickerts
{"title":"Systemic Rasamsonia argillacea infection in a German Shepherd dog","authors":"Louisa Schmidt ,&nbsp;Sebastian Reusch ,&nbsp;Ilka McCormick-Smith ,&nbsp;Jasmin Gerkrath ,&nbsp;Martin Peters ,&nbsp;Volker Rickerts","doi":"10.1016/j.mmcr.2026.100779","DOIUrl":"10.1016/j.mmcr.2026.100779","url":null,"abstract":"<div><div>This case report describes a disseminated <em>Rasamsonia (R.) argillacea</em> infection in a German shepherd dog involving internal and external lymph nodes, abdominal organs and one eye. <em>R. argillacea</em> is a member of the <em>R. argillacea</em> species complex, which is an emerging pathogen notable for azole resistance in the last decades. The dog was euthanised following 18 days of itraconazole therapy due to clinical deterioration.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100779"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147397151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From black particles to molecular proof: PD-associated peritonitis by Daldinia eschscholtzii 从黑色颗粒到分子证明：pd相关性腹膜炎的Daldinia eschscholtzii。
IF 1.3
Medical Mycology Case Reports Pub Date : 2026-03-01 Epub Date: 2026-02-13 DOI: 10.1016/j.mmcr.2026.100773
Patcharee Tedchai , Oranan Thamvichitkul , Charuwan Tiboonbun , Wissanu Srinu , Talerngsak Kanjanabuch
{"title":"From black particles to molecular proof: PD-associated peritonitis by Daldinia eschscholtzii","authors":"Patcharee Tedchai ,&nbsp;Oranan Thamvichitkul ,&nbsp;Charuwan Tiboonbun ,&nbsp;Wissanu Srinu ,&nbsp;Talerngsak Kanjanabuch","doi":"10.1016/j.mmcr.2026.100773","DOIUrl":"10.1016/j.mmcr.2026.100773","url":null,"abstract":"<div><div>Fungal infection in peritoneal dialysis (PD) is rare but devastating, especially with filamentous molds. We report a 60-year-old man on continuous ambulatory PD who presented with black particulate material in the PD transfer set and mild abdominal discomfort without cloudy effluent. PD effluent showed low-grade neutrophilic inflammation, and microscopy revealed dematiaceous septate hyphae. A slow-growing pigmented mold, initially misidentified as <em>Cladosporium</em>, was definitively identified as <em>Daldinia eschscholtzii</em> by multi-locus sequencing, supported by galactomannan positivity. This first report of PD-associated peritonitis due to <em>D. eschscholtzii</em> positions black intraluminal particles as an early visual warning sign of PD catheter-associated dematiaceous mold infection, underscoring the need for integrated mycological diagnostics before overt peritonitis develops.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100773"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147286208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Candida parapsilosis in a case of canine otitis media 犬中耳炎伴假丝酵母菌病1例
IF 1.3
Medical Mycology Case Reports Pub Date : 2026-03-01 Epub Date: 2026-01-30 DOI: 10.1016/j.mmcr.2026.100768
Belén Rivera Gómez-Barris , Ronar López , Leslye Camila del Río , Ailén Dumont Viollaz , Claudio Moreno , Pamela Thomson
{"title":"Candida parapsilosis in a case of canine otitis media","authors":"Belén Rivera Gómez-Barris ,&nbsp;Ronar López ,&nbsp;Leslye Camila del Río ,&nbsp;Ailén Dumont Viollaz ,&nbsp;Claudio Moreno ,&nbsp;Pamela Thomson","doi":"10.1016/j.mmcr.2026.100768","DOIUrl":"10.1016/j.mmcr.2026.100768","url":null,"abstract":"<div><div><em>Candida parapsilosis,</em> commonly present on the skin and mucous membranes, has been described as an opportunistic pathogen increasingly associated with infections. We present the first documented case of severe otitis media caused by this yeast species in a French Bulldog with a history of atopic dermatitis and seborrhea. The diagnosis was confirmed by culture and molecular methods. Susceptibility testing showed resistance only to fluconazole; however, antifungal therapy could not be initiated, as the patient died in an emergency room. This case highlights the potential of <em>C. parapsilosis</em> to cause serious ear infections and underscores the importance of early identification.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100768"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146188988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mixed mycotic infection in an immunocompromised host with advanced HIV diagnosed with the assistance of a Karius test 混合真菌感染在免疫功能低下的宿主与先进的艾滋病毒诊断协助卡里乌斯试验
IF 1.3
Medical Mycology Case Reports Pub Date : 2026-03-01 Epub Date: 2026-01-22 DOI: 10.1016/j.mmcr.2026.100761
Elise Hyser, Shirisha Pasula
{"title":"Mixed mycotic infection in an immunocompromised host with advanced HIV diagnosed with the assistance of a Karius test","authors":"Elise Hyser,&nbsp;Shirisha Pasula","doi":"10.1016/j.mmcr.2026.100761","DOIUrl":"10.1016/j.mmcr.2026.100761","url":null,"abstract":"<div><div>We report the case of a 35-year-old female with advanced HIV diagnosed with a mixed mycotic infection. Diagnosis was assisted by Karius test. She was admitted with postpartum psychosis and developed fever and acute hypoxic respiratory failure initially thought to be from a bacterial hospital-acquired pneumonia. Due to lack of sufficient improvement on appropriate antibiotics, a broad infectious workup was sent. A Karius test was performed early during the workup. It returned positive for <em>Pneumocystis jirovecii</em>, <em>Coccidioides posadasii</em>, and <em>Histoplasma capsulatum</em>. Eventually a standard work up returned with a positive bronchoalveolar lavage (BAL) <em>Pneumocystis jirovecii pneumonia (PJP)</em> test by direct fluorescent antibody (DFA), positive <em>Histoplasma</em> urine antigen, and positive serum coccidioidal titer of 1:16, corroborating the diagnosis of mixed mycotic infection. She was treated with a 21-day course of trimethoprim-sulfamethoxazole followed by primaquine and clindamycin for <em>PJP</em>. She clinically improved with over 3 weeks of IV amphotericin B to cover for histoplasmosis and coccidioidomycosis, which was later de-escalated to oral itraconazole. She was instructed to follow up in clinic where bictegravir/emtricitabine/tenofovir alafenamide was initiated. This case highlights the utility of building a broad differential diagnosis as mixed mycotic infections can coexist in an immunocompromised host, and of utilizing a Karius test early in the course of illness in an immunocompromised patient to expedite a diagnosis. This case also demonstrates the need to recognize the changing geographic distribution of fungal infections.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100761"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146078043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful treatment of 40-year chronic auricular cutaneous infection caused by multidrug-resistant Fusarium proliferatum via 5-aminolevulinic acid photodynamic therapy: A case report 5-氨基乙酰丙酸光动力疗法治疗40年多药耐药增生性镰刀菌所致耳穴皮肤慢性感染1例
IF 1.3
Medical Mycology Case Reports Pub Date : 2026-03-01 Epub Date: 2025-11-28 DOI: 10.1016/j.mmcr.2025.100755
Huiyu Zhang , Yahui Feng , Yiping Liang , Sisi Wang , Dongmei Shi
{"title":"Successful treatment of 40-year chronic auricular cutaneous infection caused by multidrug-resistant Fusarium proliferatum via 5-aminolevulinic acid photodynamic therapy: A case report","authors":"Huiyu Zhang ,&nbsp;Yahui Feng ,&nbsp;Yiping Liang ,&nbsp;Sisi Wang ,&nbsp;Dongmei Shi","doi":"10.1016/j.mmcr.2025.100755","DOIUrl":"10.1016/j.mmcr.2025.100755","url":null,"abstract":"<div><div>We report the case of a 66-year-old woman with a 40-year history of a chronic <em>Fusarium proliferatum</em> infection on the right auricle. In vitro susceptibility testing showed resistance to common antifungals, including voriconazole and amphotericin B. Following the failure of conventional antifungal therapies, 5-aminolevulinic acid-photodynamic therapy (ALA-PDT) was initiated as monotherapy. The patient underwent 10 treatment sessions, with the ALA concentration and light parameters adjusted based on the auricle's anatomy. Post-treatment follow-up demonstrated complete resolution of the lesions, with no recurrence or scar formation observed. This case highlights the efficacy and safety of ALA-PDT for multidrug-resistant <em>Fusarium proliferatum</em> infections in specific anatomical sites, providing a valuable alternative for clinical management of refractory superficial fungal infections.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"51 ","pages":"Article 100755"},"PeriodicalIF":1.3,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145841753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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