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Endogenous Endophthalmitis: An underestimated serious complication in patients with disseminated fusariosis 内源性眼内炎：一种被低估的严重并发症
IF 1.3
Medical Mycology Case Reports Pub Date : 2025-09-30 DOI: 10.1016/j.mmcr.2025.100742
Fabianne Carlesse , Adriana Maria Paixao De Sousa DA. Silva , Barbara Pinto Nasr , Luiz Fernando Teixeira , Henrique Manoel Lederman , Ana Virginia Lopes de Sousa
{"title":"Endogenous Endophthalmitis: An underestimated serious complication in patients with disseminated fusariosis","authors":"Fabianne Carlesse , Adriana Maria Paixao De Sousa DA. Silva , Barbara Pinto Nasr , Luiz Fernando Teixeira , Henrique Manoel Lederman , Ana Virginia Lopes de Sousa","doi":"10.1016/j.mmcr.2025.100742","DOIUrl":"10.1016/j.mmcr.2025.100742","url":null,"abstract":"","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100742"},"PeriodicalIF":1.3,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disseminated subcutaneous sporotrichosis in an immunocompetent patient: A case report and a systematic literature review 免疫功能正常患者弥散性皮下孢子虫病：1例报告及系统文献回顾
IF 1.3
Medical Mycology Case Reports Pub Date : 2025-09-26 DOI: 10.1016/j.mmcr.2025.100739
Guangqi Zhu , Luwen Zhang , Yan Wang , Zheen Zhang
{"title":"Disseminated subcutaneous sporotrichosis in an immunocompetent patient: A case report and a systematic literature review","authors":"Guangqi Zhu ,&nbsp;Luwen Zhang ,&nbsp;Yan Wang ,&nbsp;Zheen Zhang","doi":"10.1016/j.mmcr.2025.100739","DOIUrl":"10.1016/j.mmcr.2025.100739","url":null,"abstract":"<div><div>Sporotrichosis is a subacute and chronic infectious disease caused by the infection of the skin, subcutaneous tissues, and nearby lymphatic vessels by the sporotrichosis complex. In this study, we report an immunocompetent case of disseminated subcutaneous sporotrichosis and provide a literature review of all case reports of disseminated subcutaneous sporotrichosis for which species identification was performed. A 74-year-old male patient with normal immune function was diagnosed with disseminated subcutaneous sporotrichosis. Sporadic red masses of varying sizes with local ulceration were observed on his right forearm, wrist, and little finger. Pathology of the mass in the right upper extremity indicated chronic suppurative inflammation of the subcutaneous soft tissue. The mNGS results indicated the presence of <em>Sporothrix schenckii</em>. Following the standard treatment with itraconazole, the patient's skin lesions healed without scarring or pigmentation. Disseminated subcutaneous sporotrichosis is less common in patients with a normal immune function. mNGS testing aids in the clear diagnosis of sporotrichosis and guides antifungal drug selection during treatment.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100739"},"PeriodicalIF":1.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recalcitrant dermatophytosis due to Trichophyton indotineae: A case series from Sarawak, Malaysia 印尼毛癣菌引起的顽固性皮肤真菌病：马来西亚沙捞越的病例系列
IF 1.3
Medical Mycology Case Reports Pub Date : 2025-09-26 DOI: 10.1016/j.mmcr.2025.100740
Xue Ting Tan , Siti Ayesha Siddiqa Saifuddin , Nur Intan Saidaah Mohamed Yusof , Hock Gin Teo , Min Moon Tang
{"title":"Recalcitrant dermatophytosis due to Trichophyton indotineae: A case series from Sarawak, Malaysia","authors":"Xue Ting Tan ,&nbsp;Siti Ayesha Siddiqa Saifuddin ,&nbsp;Nur Intan Saidaah Mohamed Yusof ,&nbsp;Hock Gin Teo ,&nbsp;Min Moon Tang","doi":"10.1016/j.mmcr.2025.100740","DOIUrl":"10.1016/j.mmcr.2025.100740","url":null,"abstract":"<div><div>The development of terbinafine-resistant <em>Trichophyton indotineae</em> has made the treatment of dermatophytosis a challenging task globally. We herein report three recalcitrant tinea infections in Sarawak, Malaysia. The ITS sequencing and phylogenetic analysis have confirmed <em>T. indotineae</em>. Furthermore, all isolates carried the Leu393Ser mutation in the <em>SQLE</em> gene, and associated with high terbinafine MICs. However, the voriconazole and itraconazole susceptibilities were variable. The successful azole therapy guided by susceptibility testing (voriconazole/itraconazole) had achieved clinical resolution in one case.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100740"},"PeriodicalIF":1.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145222113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of Blastomyces helicus pneumonia in a dog from a non-endemic region: diagnostic challenges and successful treatment outcome 一例来自非流行地区的犬链球菌肺炎：诊断挑战和成功的治疗结果
IF 1.3
Medical Mycology Case Reports Pub Date : 2025-09-26 DOI: 10.1016/j.mmcr.2025.100741
Kyle L. Granger Jr. , Benjamin H. Goldblatt , Powell T. Slinkard , Megan A. Stadler , Mei Lun Mui , Charles T. Talbot
{"title":"A case of Blastomyces helicus pneumonia in a dog from a non-endemic region: diagnostic challenges and successful treatment outcome","authors":"Kyle L. Granger Jr. ,&nbsp;Benjamin H. Goldblatt ,&nbsp;Powell T. Slinkard ,&nbsp;Megan A. Stadler ,&nbsp;Mei Lun Mui ,&nbsp;Charles T. Talbot","doi":"10.1016/j.mmcr.2025.100741","DOIUrl":"10.1016/j.mmcr.2025.100741","url":null,"abstract":"<div><div>A 6-year-old Labrador Retriever presented with fever, cough, and labored breathing. Imaging revealed progressive pneumonia with intrathoracic lymphadenopathy. Initial testing yielded a positive <em>Histoplasma</em> urine antigen; however, fungal culture confirmed <em>Blastomyces helicus</em>. The dog improved on itraconazole, with normalization of clinical signs, C-reactive protein, imaging, and antigen tests. This case highlights diagnostic challenges of cross-reactivity in fungal antigen testing and emphasizes the importance of fungal culture in definitive diagnosis.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100741"},"PeriodicalIF":1.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tinea genitalis profunda caused by Microsporum canis: A case report and literature review 犬小孢子虫致生殖器深癣1例并文献复习
IF 1.3
Medical Mycology Case Reports Pub Date : 2025-09-23 DOI: 10.1016/j.mmcr.2025.100738
Samet Öner, Ceylan Avcı
{"title":"Tinea genitalis profunda caused by Microsporum canis: A case report and literature review","authors":"Samet Öner,&nbsp;Ceylan Avcı","doi":"10.1016/j.mmcr.2025.100738","DOIUrl":"10.1016/j.mmcr.2025.100738","url":null,"abstract":"<div><div>Deep dermatophytosis in the genital region is rare and often misdiagnosed due to its inflammatory presentation mimicking bacterial or other dermatoses. We report the case of a 23-year-old woman presenting with painful, exudative plaques in the pubogenital area. Initial empirical antibiotic therapy failed. Fungal culture revealed Microsporum canis. Treatment with systemic terbinafine followed by itraconazole led to clinical improvement. The lesion healed with scarring alopecia and post-inflammatory hyperpigmentation. Given the overlapping features with both kerion and Majocchi granuloma, this case was classified as tinea profunda. This case highlights the importance of considering deep dermatophytosis in the differential diagnosis of genital inflammatory and suppurative lesions, especially when initial treatments fail.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100738"},"PeriodicalIF":1.3,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disseminated Scedosporium boydii infection with pulmonary and cerebral involvement in a patient with COPD: A case report 慢性阻塞性肺病患者弥散性波地孢子菌感染并发肺和脑受累1例报告
IF 1.3
Medical Mycology Case Reports Pub Date : 2025-09-20 DOI: 10.1016/j.mmcr.2025.100737
Parviz Hassanpour , Seyed Jamal Hashemi , Zahra Ramezanalipour , Sanam Nami , Behrooz Naghili
{"title":"Disseminated Scedosporium boydii infection with pulmonary and cerebral involvement in a patient with COPD: A case report","authors":"Parviz Hassanpour ,&nbsp;Seyed Jamal Hashemi ,&nbsp;Zahra Ramezanalipour ,&nbsp;Sanam Nami ,&nbsp;Behrooz Naghili","doi":"10.1016/j.mmcr.2025.100737","DOIUrl":"10.1016/j.mmcr.2025.100737","url":null,"abstract":"<div><div>A 51-year-old Iranian man survived a severe respiratory illness but later died from a brain abscess caused by <em>Scedosporium boydii</em>, identified post-mortem. The case highlights the importance of comprehensive care, including adherence to treatment, regular follow-ups, and the use of both culture-based and molecular diagnostics. Incomplete treatment likely contributed to the fatal outcome. A key limitation of this report is the absence of MRI images due to a technical malfunction, preventing further radiological assessment. This case stresses the need for sustained and thorough medical management in complex infections to improve patient outcomes.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100737"},"PeriodicalIF":1.3,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dual fungal endocarditis in a pediatric dialysis patient: First case of Aspergillus flavus and Candida parapsilosis co-infection 双重真菌性心内膜炎的儿童透析患者：黄曲霉和假丝酵母菌共同感染的第一例
IF 1.3
Medical Mycology Case Reports Pub Date : 2025-09-20 DOI: 10.1016/j.mmcr.2025.100735
Tasneem Shamsi Basha , Amina Bakro , Hari Pankaj Vanam , Akela Ghazawi , Areej AlGhamdi , Fatima Al Dhaheri
{"title":"Dual fungal endocarditis in a pediatric dialysis patient: First case of Aspergillus flavus and Candida parapsilosis co-infection","authors":"Tasneem Shamsi Basha ,&nbsp;Amina Bakro ,&nbsp;Hari Pankaj Vanam ,&nbsp;Akela Ghazawi ,&nbsp;Areej AlGhamdi ,&nbsp;Fatima Al Dhaheri","doi":"10.1016/j.mmcr.2025.100735","DOIUrl":"10.1016/j.mmcr.2025.100735","url":null,"abstract":"<div><div>We report the first pediatric case of dual fungal infective endocarditis (IE) caused by <em>Aspergillus flavus</em> and <em>Candida parapsilosis</em> in a dialysis-dependent child from a conflict-affected region. Diagnosis was supported by galactomannan monitoring, histopathology, and molecular sequencing. Management required early surgery and prolonged dual antifungal therapy. Despite the rarity and severity of such coinfections, the patient survived. This case highlights the importance of early recognition, multidisciplinary care, and aggressive treatment in pediatric fungal IE.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100735"},"PeriodicalIF":1.3,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145107437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isavuconazole: Need for therapeutic drug monitoring and CYP polymorphism testing Isavuconazole：需要进行治疗药物监测和CYP多态性检测
IF 1.3
Medical Mycology Case Reports Pub Date : 2025-09-19 DOI: 10.1016/j.mmcr.2025.100736
Rajeev Soman, Sanraksha Mayya, Rahul Doshi, Inderdeep Singh, Sushrut Ganpule
{"title":"Isavuconazole: Need for therapeutic drug monitoring and CYP polymorphism testing","authors":"Rajeev Soman,&nbsp;Sanraksha Mayya,&nbsp;Rahul Doshi,&nbsp;Inderdeep Singh,&nbsp;Sushrut Ganpule","doi":"10.1016/j.mmcr.2025.100736","DOIUrl":"10.1016/j.mmcr.2025.100736","url":null,"abstract":"<div><div>In this patient of invasive sinusitis due to Rhizopus arrhizus, Therapeutic drug monitoring (TDM) showed a high trough level (88mg/L) of isavuconazole on standard doses. Genotyping revealed CYP3A5∗3/∗3 polymorphism which indicated poor metabolism of isavuconazole. Switching to posaconazole was attempted but there was intolerance to posaconazole. To our knowledge, this is the first patient in whom both TDM and CYP genotyping were used to plan very low and infrequent doses of isavuconazole.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100736"},"PeriodicalIF":1.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rasamsonia argillacea brain abscess in a lung transplant recipient: an unexpected infection by an unusual fungal pathogen 肺移植受者脑脓肿：一种不寻常的真菌病原体引起的意外感染
IF 1.3
Medical Mycology Case Reports Pub Date : 2025-09-16 DOI: 10.1016/j.mmcr.2025.100727
Raphaël Schils , Michaël Desjardins , Charles Poirier , Hugo Chapdelaine , Marie-Pierre Fournier Gosselin , Philippe J. Dufresne , Me-Linh Luong
{"title":"Rasamsonia argillacea brain abscess in a lung transplant recipient: an unexpected infection by an unusual fungal pathogen","authors":"Raphaël Schils ,&nbsp;Michaël Desjardins ,&nbsp;Charles Poirier ,&nbsp;Hugo Chapdelaine ,&nbsp;Marie-Pierre Fournier Gosselin ,&nbsp;Philippe J. Dufresne ,&nbsp;Me-Linh Luong","doi":"10.1016/j.mmcr.2025.100727","DOIUrl":"10.1016/j.mmcr.2025.100727","url":null,"abstract":"<div><div>Fungal infections are an important cause of morbidity and mortality after lung transplantation. While Aspergillus sp. is the most common implicated organism, rare and emerging molds are increasingly reported. We report a case of <em>Rasamsonia argillacea</em> (formerly <em>Geosmithia argillacea</em>) brain abscess in a lung transplant recipient and highlight the unique characteristics associated with this unusual pathogen.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100727"},"PeriodicalIF":1.3,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nannizziopsis arthrosporioides infection mimicking ophidiomycosis in ball pythons (Python regius) 球蟒体内模拟蛇霉病的Nannizziopsis arthrosporioides感染
IF 1.3
Medical Mycology Case Reports Pub Date : 2025-09-13 DOI: 10.1016/j.mmcr.2025.100733
Krista A. Keller , Laura Adamovicz , Cathy Johnson-Delaney , Karen A. Terio
{"title":"Nannizziopsis arthrosporioides infection mimicking ophidiomycosis in ball pythons (Python regius)","authors":"Krista A. Keller ,&nbsp;Laura Adamovicz ,&nbsp;Cathy Johnson-Delaney ,&nbsp;Karen A. Terio","doi":"10.1016/j.mmcr.2025.100733","DOIUrl":"10.1016/j.mmcr.2025.100733","url":null,"abstract":"<div><div>A wild caught snake presented with progressive dermatopathy and was euthanized due to a clinical suspicion for ophiomycosis. Over the next 7 days, six additional ball pythons, maintained in the same room but in separate cages from the index case developed similar progressive dermatomycoses and were euthanized. Histopathologic evaluation showed dermal granulomas with intralesional fungi and DNA from the lesions clustered in a monophyletic group with other isolates of <em>N. athrosporioides</em>. Colony and microscopic morphology of fungus from these cases matched published descriptions of <em>N. arthrosporioides</em>. While ophidiomycosis may be a major differential for dermatomycosis in snakes, molecular confirmation should be pursued, as additional fungi may cause similar lesions in this taxon.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100733"},"PeriodicalIF":1.3,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145107436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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