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Medical Mycology Case Reports最新文献

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Candidemia due to Candida lambica in a neutropenic oncology patient: A rare case report 中性粒细胞减少肿瘤患者因蓝念珠菌引起的念珠菌血症：罕见病例报告
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-07-23 DOI: 10.1016/j.mmcr.2025.100720
Sanam Nami , Mortaza Raeisi , Zahra Ramezanalipour , Parviz Hassanpour
{"title":"Candidemia due to Candida lambica in a neutropenic oncology patient: A rare case report","authors":"Sanam Nami ,&nbsp;Mortaza Raeisi ,&nbsp;Zahra Ramezanalipour ,&nbsp;Parviz Hassanpour","doi":"10.1016/j.mmcr.2025.100720","DOIUrl":"10.1016/j.mmcr.2025.100720","url":null,"abstract":"<div><div>We report a rare case of <em>Candida lambica</em> candidemia in a 56-year-old male with acute myeloid leukemia undergoing intensive chemotherapy. Despite fluconazole prophylaxis, the patient developed persistent febrile neutropenia. Blood cultures grew yeast, later identified as <em>C. lambica</em> via ITS rDNA sequencing. Antifungal susceptibility testing revealed sensitivity to voriconazole and other antifungals resulting in clinical improvement following targeted therapy. This case highlights the growing clinical relevance of rare <em>non-albicans candida</em> species in immunocompromised hosts, the limitations of conventional diagnostics, and the importance of molecular tools and antifungal susceptibility testing in guiding effective treatment.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"49 ","pages":"Article 100720"},"PeriodicalIF":1.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atypical presentation for a gastrointestinal basidiobolomycosis and rare side effect of Voriconazole: A case report and literature review 胃肠道担子孢子菌病的不典型表现和伏立康唑的罕见副作用：1例报告和文献复习
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-07-17 DOI: 10.1016/j.mmcr.2025.100719
Albraa S. Abulhamail , Mohammed A. Alsubaie , Yara O. Bahawi
{"title":"Atypical presentation for a gastrointestinal basidiobolomycosis and rare side effect of Voriconazole: A case report and literature review","authors":"Albraa S. Abulhamail ,&nbsp;Mohammed A. Alsubaie ,&nbsp;Yara O. Bahawi","doi":"10.1016/j.mmcr.2025.100719","DOIUrl":"10.1016/j.mmcr.2025.100719","url":null,"abstract":"<div><div>Gastrointestinal basidiobolomycosis (GIB) is a rare fungal infection often misdiagnosed with other gastrointestinal disorders. We report a case of a 6-year-old boy from Saudi Arabia who presented with fever, abdominal pain, and weight loss, initially suspected to have inflammatory bowel disease. Despite antibiotics, symptoms persisted, leading to a GIB diagnosis with liver involvement. IV voriconazole improved his condition but caused visual hallucinations, managed by dose adjustments. This case underscores the need for early suspicion of GIB in endemic areas and highlights the importance of prompt diagnosis and a multidisciplinary approach to improve outcomes and reduce complications.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"49 ","pages":"Article 100719"},"PeriodicalIF":1.6,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magnusiomyces capitatus bloodstream infection in a patient with acute monocytic leukemia: A rare case report 急性单核细胞白血病患者头Magnusiomyces血流感染1例罕见报告
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-07-16 DOI: 10.1016/j.mmcr.2025.100718
Tian Qi , Mi Zhou , Xingchun Chen , Heping Xu , Weihua Pan , Xinying Ding
{"title":"Magnusiomyces capitatus bloodstream infection in a patient with acute monocytic leukemia: A rare case report","authors":"Tian Qi ,&nbsp;Mi Zhou ,&nbsp;Xingchun Chen ,&nbsp;Heping Xu ,&nbsp;Weihua Pan ,&nbsp;Xinying Ding","doi":"10.1016/j.mmcr.2025.100718","DOIUrl":"10.1016/j.mmcr.2025.100718","url":null,"abstract":"<div><div>A 26-year-old male with relapsed acute monocytic leukemia (AML-M5) in China developed <em>Magnusiomyces capitatus</em> fungemia during consolidation chemotherapy. Diagnosis was confirmed by MALDI-TOF MS and ITS sequencing. Antifungal susceptibility revealed resistance to echinocandins but sensitivity to amphotericin B. Serial (1,3)-β-D-glucan monitoring correlated with disease progression. This case highlights diagnostic challenges and therapeutic dilemmas in regions lacking epidemiological data.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"49 ","pages":"Article 100718"},"PeriodicalIF":1.6,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deep cutaneous phaeohyphomycosis caused by Cladophialophora boppii: A case report 深皮褐丝酵菌病1例
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-07-14 DOI: 10.1016/j.mmcr.2025.100717
Thuy Thanh Cavens , Janneke de Vries , Suzanne Verleisdonk-Bolhaar , Jochem B. Buil , Arienne van Marion
{"title":"Deep cutaneous phaeohyphomycosis caused by Cladophialophora boppii: A case report","authors":"Thuy Thanh Cavens ,&nbsp;Janneke de Vries ,&nbsp;Suzanne Verleisdonk-Bolhaar ,&nbsp;Jochem B. Buil ,&nbsp;Arienne van Marion","doi":"10.1016/j.mmcr.2025.100717","DOIUrl":"10.1016/j.mmcr.2025.100717","url":null,"abstract":"<div><div><em>Cladophialophora boppii</em> is a dematiaceous fungus rarely causing cutaneous and respiratory infections. We present a case of deep cutaneous infection in a 69-year-old patient in the Netherlands with stage IV breast cancer on dexamethasone therapy. The patient exhibited a skin plaque lesion, and biopsy revealed pigmented, septate hyphae without muriform cells, consistent with a diagnosis of phaeohyphomycosis. Surgical excision and culture confirmed <em>C. boppii</em>. Afterwards the patient received a three-week course of itraconazole, which led to infection resolution. This report and review of literature underscores the diagnostic and therapeutic approaches for managing deep cutaneous infections caused by <em>C. boppii</em>.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"49 ","pages":"Article 100717"},"PeriodicalIF":1.6,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disseminated sporotrichosis caused by Sporothrix brasiliensis with testicular involvement 累及睾丸的巴西孢子丝菌引起的播散性孢子菌病
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-06-30 DOI: 10.1016/j.mmcr.2025.100716
Regielly Caroline Raimundo Cognialli , Matheus Hideki Taborda , Bruno Hassunuma Carneiro , Carolina Melchior do Prado , Mariana Marques Wolski , Giovanni Luis Breda , Bram Spruijtenburg , Vânia Aparecida Vicente , Eelco F.J. Meijer , Flávio de Queiroz-Telles
{"title":"Disseminated sporotrichosis caused by Sporothrix brasiliensis with testicular involvement","authors":"Regielly Caroline Raimundo Cognialli ,&nbsp;Matheus Hideki Taborda ,&nbsp;Bruno Hassunuma Carneiro ,&nbsp;Carolina Melchior do Prado ,&nbsp;Mariana Marques Wolski ,&nbsp;Giovanni Luis Breda ,&nbsp;Bram Spruijtenburg ,&nbsp;Vânia Aparecida Vicente ,&nbsp;Eelco F.J. Meijer ,&nbsp;Flávio de Queiroz-Telles","doi":"10.1016/j.mmcr.2025.100716","DOIUrl":"10.1016/j.mmcr.2025.100716","url":null,"abstract":"<div><div>Sporotrichosis is a growing public health concern especially due <em>Sporothrix brasiliensis</em>. We report a case of disseminated sporotrichosis involving the meninges, lungs, and testicles in a 35-year-old homeless man from Curitiba, Brazil. Fungal culture, histopathology, and molecular identification confirmed <em>S. brasiliensis</em> infection. Notably, testicular involvement—a rare complication of sporotrichosis—was initially misdiagnosed as a malignant tumor, leading to orchiectomy. A literature review identified only four previous cases of testicular sporotrichosis. This case underscores the potential for atypical presentations in immunocompromised patients and highlights the need for clinical vigilance in endemic regions, given the rising incidence of sporotrichosis.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"49 ","pages":"Article 100716"},"PeriodicalIF":1.6,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The association of Yarrowia lipolytica with onychomycosis 脂肪肝耶氏菌与甲癣的关系
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-06-21 DOI: 10.1016/j.mmcr.2025.100715
Julia R. Major , Claire A. Warren , Paul A. Rowley
{"title":"The association of Yarrowia lipolytica with onychomycosis","authors":"Julia R. Major ,&nbsp;Claire A. Warren ,&nbsp;Paul A. Rowley","doi":"10.1016/j.mmcr.2025.100715","DOIUrl":"10.1016/j.mmcr.2025.100715","url":null,"abstract":"<div><div>Onychomycosis, a common fungal nail infection, is typically caused by dermatophytes or <em>Candida</em> species, but rare fungal pathogens can also be involved. We describe a 20-year-old woman with persistent nail shedding who was unresponsive to standard antifungal treatments. Microscopic nail examination, fungal culture, and ITS sequencing repeatedly identified the presence of <em>Yarrowia lipolytica</em> (formerly <em>Candida lipolytica</em>), a dimorphic yeast more often associated with systemic bloodstream infections and not previously identified in patients with onychomycosis. Susceptibility testing revealed the resistance of <em>Y. lipolytica</em> isolates to multiple antifungal azoles, complicating future treatment strategies for the patient. Commonly found in hydrocarbon-rich environments and an important organism for biotechnology, <em>Y. lipolytica</em> has industrial applications but is also capable of causing opportunistic infections in vulnerable patient populations. This case highlights the importance of thorough microbial identification and susceptibility testing in cases of treatment-resistant onychomycosis.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"49 ","pages":"Article 100715"},"PeriodicalIF":1.6,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144365679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Invasive Trichoderma longibrachiatum breakthrough infection in a hematology patient 血液学患者侵袭性长尾木霉突破感染1例
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-06-12 DOI: 10.1016/j.mmcr.2025.100709
Yuri Vanbiervliet , Robina Aerts , Ellen Boon , Toine Mercier , Ann-Sophie Jacob , Marijke Peetermans , Koen Debackere , Katrien Lagrou , Johan Maertens
{"title":"Invasive Trichoderma longibrachiatum breakthrough infection in a hematology patient","authors":"Yuri Vanbiervliet ,&nbsp;Robina Aerts ,&nbsp;Ellen Boon ,&nbsp;Toine Mercier ,&nbsp;Ann-Sophie Jacob ,&nbsp;Marijke Peetermans ,&nbsp;Koen Debackere ,&nbsp;Katrien Lagrou ,&nbsp;Johan Maertens","doi":"10.1016/j.mmcr.2025.100709","DOIUrl":"10.1016/j.mmcr.2025.100709","url":null,"abstract":"<div><div><em>Trichoderma</em> species are emerging as pathogens, causing invasive fungal infections, particularly in immunocompromised individuals. We report the case of a 61-year-old neutropenic female with hepatosplenic T-cell lymphoma and profound neutropenia, who developed a breakthrough infection with <em>Trichoderma longibrachiatum</em> while receiving liposomal amphotericin B for probable invasive pulmonary aspergillosis. Despite combination antifungal therapy the patient ultimately succumbed to multiple organ failure. <em>Trichoderma longibrachiatum</em> and <em>Aspergillus fumigatus</em> were identified as causative fungal pathogens. Antifungal susceptibility testing of the <em>T. longibrachiatum</em> isolate revealed resistance to isavuconazole but susceptibility to amphotericin B, voriconazole, itraconazole and olorofim.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"49 ","pages":"Article 100709"},"PeriodicalIF":1.6,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144288722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Angiographically occult catastrophe: A rare case of aspergillus-induced subarachnoid hemorrhage without mycotic aneurysms following apparent bacterial abscess resolution 血管造影隐蔽性灾难：一例罕见的曲霉引起的蛛网膜下腔出血，在明显的细菌性脓肿消退后无真菌性动脉瘤
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-06-10 DOI: 10.1016/j.mmcr.2025.100714
Moustafa A. Mansour , Salma Medhat , Mohamed Abdel-Fattah El-Salamoni , Hamdi Nabawi Mostafa
{"title":"Angiographically occult catastrophe: A rare case of aspergillus-induced subarachnoid hemorrhage without mycotic aneurysms following apparent bacterial abscess resolution","authors":"Moustafa A. Mansour ,&nbsp;Salma Medhat ,&nbsp;Mohamed Abdel-Fattah El-Salamoni ,&nbsp;Hamdi Nabawi Mostafa","doi":"10.1016/j.mmcr.2025.100714","DOIUrl":"10.1016/j.mmcr.2025.100714","url":null,"abstract":"<div><div>This report details a fatal case of cerebral aspergillosis in a cirrhotic patient where radiographic resolution of a presumed bacterial brain abscess concealed advancing fungal vasculitis, culminating in fatal subarachnoid hemorrhage (SAH). A woman in her 60s exhibited temporal abscess improvement on antibiotics but died weeks later from SAH. Autopsy revealed <em>Aspergillus</em>-driven small-vessel vasculopathy without aneurysms, with lung involvement confirming hematogenous spread.</div><div>Key findings challenge neuro-infectious norms: (1) fungal progression despite bacterial treatment response; (2) SAH from direct venular invasion, an angiographically silent phenotype; and (3) cirrhosis enabling dissemination without classic immunosuppression. Diagnosis was delayed due to negative cultures and absent pulmonary symptoms.</div><div>The case mandates aggressive fungal surveillance (CSF PCR, vascular imaging) in cirrhotic patients with CNS infections, even amid antibiotic success, and underscores cirrhosis as a silent risk factor for disseminated fungal disease. It argues for preemptive antifungals in high-risk cohorts and warns against equating radiographic improvement with microbiologic cure.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"49 ","pages":"Article 100714"},"PeriodicalIF":1.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic cavitary pulmonary histoplasmosis treated with isavuconazole after a hypersensitivity reaction to itraconazole 伊曲康唑过敏反应后用异维康唑治疗慢性空洞肺组织胞浆菌病
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-06-07 DOI: 10.1016/j.mmcr.2025.100711
Miguel E. Cervera-Hernandez , Sunit P. Jariwala
{"title":"Chronic cavitary pulmonary histoplasmosis treated with isavuconazole after a hypersensitivity reaction to itraconazole","authors":"Miguel E. Cervera-Hernandez ,&nbsp;Sunit P. Jariwala","doi":"10.1016/j.mmcr.2025.100711","DOIUrl":"10.1016/j.mmcr.2025.100711","url":null,"abstract":"<div><div>Chronic cavitary pulmonary histoplasmosis requires prolonged treatment with itraconazole. However, hypersensitivity reactions to itraconazole, though rare, pose a challenge due to limited data on the efficacy and cross-reactivity of the newer azoles. We present a case of chronic cavitary pulmonary histoplasmosis successfully treated with isavuconazole following an itraconazole-induced hypersensitivity reaction, highlighting its potential as an alternative therapy in such cases.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"49 ","pages":"Article 100711"},"PeriodicalIF":1.6,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of osteoarticular invasion by Coccidioides Sp disseminated infection 球虫弥散性感染侵袭骨关节的影响
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-06-07 DOI: 10.1016/j.mmcr.2025.100710
Arvilla Salas Nora , Ovalle Mireles Itzel , Falcón Escobedo Reynaldo , Dimas Pecina Víctor , Rodriguez Ávalos Marcos , Perales Martínez Diana
{"title":"The impact of osteoarticular invasion by Coccidioides Sp disseminated infection","authors":"Arvilla Salas Nora ,&nbsp;Ovalle Mireles Itzel ,&nbsp;Falcón Escobedo Reynaldo ,&nbsp;Dimas Pecina Víctor ,&nbsp;Rodriguez Ávalos Marcos ,&nbsp;Perales Martínez Diana","doi":"10.1016/j.mmcr.2025.100710","DOIUrl":"10.1016/j.mmcr.2025.100710","url":null,"abstract":"<div><div>Coccidioidomycosis is a fungal infection caused by <em>Coccidioides immitis</em> and <em>C. posadasii</em>. It leads to significant morbidity and mortality in both immunocompetent and immunocompromised individuals and is more prevalent in endemic regions. Fungal bone infections are rare, and osteoarticular involvement typically occurs secondary to hematogenous dissemination or direct cutaneous inoculation with contiguous spread. This case demonstrates osteoarticular involvement and the spread to adjacent structures, causing pain, restricting mobility, and deteriorating the patient's quality of life.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"49 ","pages":"Article 100710"},"PeriodicalIF":1.6,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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