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The tell-tale hearts: Donor-derived invasive fungal infections among orthotopic heart transplant recipients
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-03-31 DOI: 10.1016/j.mmcr.2025.100702
Jay Krishnan, Manuela Carugati, Rachel A. Miller, Cameron R. Wolfe, John R. Perfect, Julia A. Messina
{"title":"The tell-tale hearts: Donor-derived invasive fungal infections among orthotopic heart transplant recipients","authors":"Jay Krishnan,&nbsp;Manuela Carugati,&nbsp;Rachel A. Miller,&nbsp;Cameron R. Wolfe,&nbsp;John R. Perfect,&nbsp;Julia A. Messina","doi":"10.1016/j.mmcr.2025.100702","DOIUrl":"10.1016/j.mmcr.2025.100702","url":null,"abstract":"<div><div>Donor-derived invasive fungal infections among solid organ transplant recipients are rare but sometimes devastating events associated with notable morbidity and mortality. Here we describe two donor-derived fungal infections – one <em>Candida parapsilosis</em> complex infection and one <em>Aspergillus fumigatus</em> infection – that occurred among heart transplant recipients at a quaternary care center. Both recipients survived their infections, though with substantial morbidity despite aggressive surgical intervention and antifungal therapy.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"48 ","pages":"Article 100702"},"PeriodicalIF":1.6,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143748676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A fatal case of pulmonary cryptococcosis in an apparently immunocompetent patient from Cote D′ Ivoire
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-03-21 DOI: 10.1016/j.mmcr.2025.100701
Ahou Sandrine Konan , Kalou Dibert Zika , Affoué Sandrine Josette Kouakou , Appi Sandrine Kouamé , Malick Senanminfoun Soro , Koffi Daho Adoubryn
{"title":"A fatal case of pulmonary cryptococcosis in an apparently immunocompetent patient from Cote D′ Ivoire","authors":"Ahou Sandrine Konan ,&nbsp;Kalou Dibert Zika ,&nbsp;Affoué Sandrine Josette Kouakou ,&nbsp;Appi Sandrine Kouamé ,&nbsp;Malick Senanminfoun Soro ,&nbsp;Koffi Daho Adoubryn","doi":"10.1016/j.mmcr.2025.100701","DOIUrl":"10.1016/j.mmcr.2025.100701","url":null,"abstract":"<div><div>Cryptococcosis is an opportunistic mycosis caused by <em>Cryptococcus</em>, mainly affecting the immunocompromised. We report a case of pulmonary cryptococcosis within a 31-year-old immunocompetent patient admitted for painful chest swelling evolving for 4 months prior to admission. The chest X-Ray showed a rounded pulmonary opacity. The chest ultrasound revealed a pulmonary abscess diffusing under the skin. Direct examination using the Indian ink and the May-Grunwald Giemsa staining revealed encapsulated yeasts in the pus. The Culture of the pus on the Sabouraud medium with chloramphenicol confirmed the presence of <em>Cryptococcus neoformans</em>. Cryptococcal antigen was positive. This case reminds us that cryptococcosis should be considered even without immunosuppression.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"48 ","pages":"Article 100701"},"PeriodicalIF":1.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143697642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The diagnostic role of elevated serum cryptococcal antigen titers in patients with suspected cryptococcal meningitis when lumbar puncture is contraindicated: A case report
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-03-18 DOI: 10.1016/j.mmcr.2025.100700
Asmus Tukundane, Richard Kwizera, Lillian Tugume, Jayne Ellis, David R. Boulware, David B. Meya
{"title":"The diagnostic role of elevated serum cryptococcal antigen titers in patients with suspected cryptococcal meningitis when lumbar puncture is contraindicated: A case report","authors":"Asmus Tukundane,&nbsp;Richard Kwizera,&nbsp;Lillian Tugume,&nbsp;Jayne Ellis,&nbsp;David R. Boulware,&nbsp;David B. Meya","doi":"10.1016/j.mmcr.2025.100700","DOIUrl":"10.1016/j.mmcr.2025.100700","url":null,"abstract":"<div><div>Cryptococcal meningitis is one of the major causes of death in sub-Saharan Africa among individuals with advanced HIV, and it is typically diagnosed through lumbar puncture (LP). However, LP may be contraindicated in some cases, causing a clinical dilemma and potential delay in treatment. We present the case of a 60-year-old female, newly diagnosed with HIV, who presented with a reduced level of consciousness and a positive serum cryptococcal antigen (CrAg) test (high titer = 1:320). Computerized tomographic (CT) brain imaging showed multiple nodular lesions, peri-lesional edema and a midline shift. Despite the contraindication for LP, a low volume lumbar puncture (1–2 mL) was performed in view of the elevated serum CrAg titers and patient's clinical symptoms, in order to rule in a definitive diagnosis of cryptococcal meningitis or exclude tuberculous meningitis. The patient was treated for cryptococcal meningitis and responded well. In patients with a positive serum CrAg test and contraindications to LP, an elevated titer (&gt;1:160) and neurological symptoms may guide the initiation of definitive treatment for cryptococcal meningitis, however further evaluation is needed.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"48 ","pages":"Article 100700"},"PeriodicalIF":1.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fungal peritonitis in a patient on peritoneal dialysis caused by Hyphopichia burtonii: A rare pathogen in human infection
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-03-07 DOI: 10.1016/j.mmcr.2025.100699
Estacio Mayra , Reino Alberto , Rodelo Joaquin , Ustariz Jose
{"title":"Fungal peritonitis in a patient on peritoneal dialysis caused by Hyphopichia burtonii: A rare pathogen in human infection","authors":"Estacio Mayra ,&nbsp;Reino Alberto ,&nbsp;Rodelo Joaquin ,&nbsp;Ustariz Jose","doi":"10.1016/j.mmcr.2025.100699","DOIUrl":"10.1016/j.mmcr.2025.100699","url":null,"abstract":"<div><div>Fungal peritonitis in peritoneal dialysis (PD) patients is rare but is associated with high morbidity and mortality. <em>Candida</em> species are the most common causative agents, but infections caused by unusual, often “nonpathogenic,” fungi are being increasingly reported. <em>Hyphopichia burtonii</em> is typically associated with food spoilage and has rarely been reported in human infections.</div><div>We describe the case of a 44-year-old female with end-stage renal disease on continuous ambulatory peritoneal dialysis (CAPD) who developed peritonitis caused by <em>Hyphopichia burtonii</em>. Following the identification of the fungus, the patient was put on hemodialysis, the peritoneal dialysis catheter was removed, and he was given fluconazole for two weeks having favorable clinical development.</div><div>2012 Elsevier Ltd. All rights reserved.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"48 ","pages":"Article 100699"},"PeriodicalIF":1.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143631726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disseminated histoplasmosis presenting as adrenal insufficiency: A case report
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-02-15 DOI: 10.1016/j.mmcr.2025.100698
Md. Asaduzzaman , Ranjon Kumer Roy , Suchanda Roy , Nasad Ahmed , Sazeda Akter , Monotush Ronjon Chando
{"title":"Disseminated histoplasmosis presenting as adrenal insufficiency: A case report","authors":"Md. Asaduzzaman ,&nbsp;Ranjon Kumer Roy ,&nbsp;Suchanda Roy ,&nbsp;Nasad Ahmed ,&nbsp;Sazeda Akter ,&nbsp;Monotush Ronjon Chando","doi":"10.1016/j.mmcr.2025.100698","DOIUrl":"10.1016/j.mmcr.2025.100698","url":null,"abstract":"<div><div>This report aims to highlight rarity of disseminated histoplasmosis (DH) presenting as adrenal insufficiency and the need for considering it in the differential diagnosis, even in non-endemic areas. A case is presented of a 69-year-old male patient with a background of hypertension and diabetes mellitus, with a persistent fever, significant loss of weight, and general weakness. Imaging studies showed adrenal masses in both adrenal glands, and laboratory tests showed hyperkalemia and hyponatremia. Hormonal tests confirmed the diagnosis of adrenal insufficiency. CT-guided adrenal biopsy confirmed the diagnosis of histoplasmosis. The patient received a 14-day course of Amphotericin B, followed by oral Itraconazole and glucocorticoid substitution therapy, with improvement in adrenal function over a period of time.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"47 ","pages":"Article 100698"},"PeriodicalIF":1.6,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Timely diagnosis and management of Quambalaria cyanescens-induced peritoneal dialysis peritonitis: A rare case highlighting the role of galactomannan testing
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-02-11 DOI: 10.1016/j.mmcr.2025.100697
Baramett Somtha , Kanjana Tianprasertkij , Supattra Promngam , Thunvarat Saejew , Talerngsak Kanjanabuch
{"title":"Timely diagnosis and management of Quambalaria cyanescens-induced peritoneal dialysis peritonitis: A rare case highlighting the role of galactomannan testing","authors":"Baramett Somtha ,&nbsp;Kanjana Tianprasertkij ,&nbsp;Supattra Promngam ,&nbsp;Thunvarat Saejew ,&nbsp;Talerngsak Kanjanabuch","doi":"10.1016/j.mmcr.2025.100697","DOIUrl":"10.1016/j.mmcr.2025.100697","url":null,"abstract":"<div><div>Fungal peritonitis in peritoneal dialysis (PD) presents significant challenges. We report the second <em>Quambalaria cyanescens</em>-related PD peritonitis in a 53-year-old male. Negative bacterial cultures and a positive galactomannan (GM) index in both PD effluent (PDE) (0.65) and serum (0.98) prompted early PD catheter removal on day 5. Molecular sequencing confirmed <em>Q. cyanescens</em>, with antifungal susceptibility testing revealing resistance to azoles and echinocandins but susceptibility to amphotericin B and isavuconazonium. Treatment with amphotericin B and voriconazole resolved symptoms, with no relapses during a two-year follow-up. This case highlights GM testing's critical role in guiding catheter removal and adherence to the 2022 ISPD Peritonitis Guidelines, ensuring favorable outcomes for rare fungal PD infections.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"47 ","pages":"Article 100697"},"PeriodicalIF":1.6,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143418858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
First human case of Eidernor doerrieniae colonization in a peritoneal dialysis catheter: A warning from silent contamination
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-02-11 DOI: 10.1016/j.mmcr.2025.100696
Phichit Songviriyavithaya , Aschariya Wipattanakitcharoen , Niparat Pikul , Dhammika Leshan Wannigama , Talerngsak Kanjanabuch
{"title":"First human case of Eidernor doerrieniae colonization in a peritoneal dialysis catheter: A warning from silent contamination","authors":"Phichit Songviriyavithaya ,&nbsp;Aschariya Wipattanakitcharoen ,&nbsp;Niparat Pikul ,&nbsp;Dhammika Leshan Wannigama ,&nbsp;Talerngsak Kanjanabuch","doi":"10.1016/j.mmcr.2025.100696","DOIUrl":"10.1016/j.mmcr.2025.100696","url":null,"abstract":"<div><div>This report documents the first human case of <em>Eidernor doerrieniae</em> colonization in a peritoneal dialysis catheter, identified through DNA sequencing after a 52-year-old man observed brownish particles within his catheter. Despite the absence of peritonitis symptoms, prompt catheter removal and antifungal therapy successfully resolved the infection. Fungal cultures revealed cerebriform (brain-like) colonies, confirmed as <em>E. doerrieniae</em> using multi-targeted molecular diagnostics. A wet contamination event three weeks earlier was identified as the likely source. This case underscores the importance of recognizing intraluminal particles as an indicator of fungal colonization and highlights the critical role of timely intervention and advanced diagnostics in preventing fungal peritonitis.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"47 ","pages":"Article 100696"},"PeriodicalIF":1.6,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143430183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Severe oropharyngeal candidiasis in an anemic pregnant woman: A case report
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-01-22 DOI: 10.1016/j.mmcr.2025.100694
Shuyan Quan , Hong Li , Kailing Li , Xuan Wang , Yang Xu , Peng Gu
{"title":"Severe oropharyngeal candidiasis in an anemic pregnant woman: A case report","authors":"Shuyan Quan ,&nbsp;Hong Li ,&nbsp;Kailing Li ,&nbsp;Xuan Wang ,&nbsp;Yang Xu ,&nbsp;Peng Gu","doi":"10.1016/j.mmcr.2025.100694","DOIUrl":"10.1016/j.mmcr.2025.100694","url":null,"abstract":"<div><div>Hormonal fluctuations during pregnancy increase susceptibility to <em>Candida</em> infections, typically presenting as vulvovaginal candidiasis, but rarely as oropharyngeal candidiasis. We report a rare case of a woman being pregnant for 27 + 1 weeks with twins with oropharyngeal candidiasis, likely attributed to nutritional anemia and adverse reactions of amoxicillin. Following a thorough literature review and evaluation of medication safety during pregnancy regarding route, dosage, and gestational stage, we treated the patient with fluconazole and piperacillin-tazobactam. The patient fully recovered and successfully delivered two infants via cesarean section at term, with no adverse reactions noted during a six-month follow-up.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"47 ","pages":"Article 100694"},"PeriodicalIF":1.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case report of childhood onychomycosis caused by the rare yeast Kodamaea ohmeri
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-01-20 DOI: 10.1016/j.mmcr.2025.100695
Thi Minh Chau Ngo , Dong Duong Ton That , Phuong Anh Ton Nu , Le Chi Cao , My Nguyen Thi Tra , Thi Quynh Trang Tran
{"title":"A case report of childhood onychomycosis caused by the rare yeast Kodamaea ohmeri","authors":"Thi Minh Chau Ngo ,&nbsp;Dong Duong Ton That ,&nbsp;Phuong Anh Ton Nu ,&nbsp;Le Chi Cao ,&nbsp;My Nguyen Thi Tra ,&nbsp;Thi Quynh Trang Tran","doi":"10.1016/j.mmcr.2025.100695","DOIUrl":"10.1016/j.mmcr.2025.100695","url":null,"abstract":"<div><div>Onychomycosis is an uncommon disease in pediatric patients with dermatophytes and <em>Candida</em> spp. being the main causative agents. <em>Kodamaea ohmeri</em> has recently emerged as a human pathogen, including an onychomycosis causative agent. Here, we report the first case of childhood onychomycosis caused by <em>K. ohmeri</em> in Vietnam, presenting clinically as a white superficial onychomycosis. Fungal identification was confirmed by sequencing of the ITS1-2 region. Antifungal susceptibility testing revealed low minimum inhibitory concentrations for all tested agents, except fluconazole and caspofungin. The patient was treated with 2 % ketoconazole cream one month, resulting in complete resolution of the nail damage with no relapse observed after six months.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"47 ","pages":"Article 100695"},"PeriodicalIF":1.6,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastrointestinal mucormycosis by Mucor indicus: A report of two cases
IF 1.6
Medical Mycology Case Reports Pub Date : 2025-01-20 DOI: 10.1016/j.mmcr.2025.100693
Alex Rivero , Megan Shaughnessy , Jessica Oswald , Nicholas Goodhope , Margret Oethinger
{"title":"Gastrointestinal mucormycosis by Mucor indicus: A report of two cases","authors":"Alex Rivero ,&nbsp;Megan Shaughnessy ,&nbsp;Jessica Oswald ,&nbsp;Nicholas Goodhope ,&nbsp;Margret Oethinger","doi":"10.1016/j.mmcr.2025.100693","DOIUrl":"10.1016/j.mmcr.2025.100693","url":null,"abstract":"<div><div>Mucormycosis is an invasive infection caused by fungi of the order Mucorales, typically affecting immunocompromised individuals, and rarely involving the gastrointestinal tract. We report two cases of gastrointestinal mucormycosis by <em>Mucor indicus:</em> a 77-year-old woman with a gastric ulcer and a 25-year-old man with liver lesions. Both were treated with surgery and liposomal amphotericin B; only one survived. Recognizing gastrointestinal mucormycosis in the correct clinical context is essential and requires timely surgical and antifungal treatment.</div><div>2012 Elsevier Ltd. All rights reserved.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"47 ","pages":"Article 100693"},"PeriodicalIF":1.6,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143162248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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