Kyle L. Granger Jr. , Benjamin H. Goldblatt , Powell T. Slinkard , Megan A. Stadler , Mei Lun Mui , Charles T. Talbot
{"title":"一例来自非流行地区的犬链球菌肺炎:诊断挑战和成功的治疗结果","authors":"Kyle L. Granger Jr. , Benjamin H. Goldblatt , Powell T. Slinkard , Megan A. Stadler , Mei Lun Mui , Charles T. Talbot","doi":"10.1016/j.mmcr.2025.100741","DOIUrl":null,"url":null,"abstract":"<div><div>A 6-year-old Labrador Retriever presented with fever, cough, and labored breathing. Imaging revealed progressive pneumonia with intrathoracic lymphadenopathy. Initial testing yielded a positive <em>Histoplasma</em> urine antigen; however, fungal culture confirmed <em>Blastomyces helicus</em>. The dog improved on itraconazole, with normalization of clinical signs, C-reactive protein, imaging, and antigen tests. This case highlights diagnostic challenges of cross-reactivity in fungal antigen testing and emphasizes the importance of fungal culture in definitive diagnosis.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"50 ","pages":"Article 100741"},"PeriodicalIF":1.3000,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A case of Blastomyces helicus pneumonia in a dog from a non-endemic region: diagnostic challenges and successful treatment outcome\",\"authors\":\"Kyle L. Granger Jr. , Benjamin H. Goldblatt , Powell T. Slinkard , Megan A. Stadler , Mei Lun Mui , Charles T. Talbot\",\"doi\":\"10.1016/j.mmcr.2025.100741\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>A 6-year-old Labrador Retriever presented with fever, cough, and labored breathing. Imaging revealed progressive pneumonia with intrathoracic lymphadenopathy. Initial testing yielded a positive <em>Histoplasma</em> urine antigen; however, fungal culture confirmed <em>Blastomyces helicus</em>. The dog improved on itraconazole, with normalization of clinical signs, C-reactive protein, imaging, and antigen tests. This case highlights diagnostic challenges of cross-reactivity in fungal antigen testing and emphasizes the importance of fungal culture in definitive diagnosis.</div></div>\",\"PeriodicalId\":51724,\"journal\":{\"name\":\"Medical Mycology Case Reports\",\"volume\":\"50 \",\"pages\":\"Article 100741\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-09-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medical Mycology Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2211753925000508\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical Mycology Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2211753925000508","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
A case of Blastomyces helicus pneumonia in a dog from a non-endemic region: diagnostic challenges and successful treatment outcome
A 6-year-old Labrador Retriever presented with fever, cough, and labored breathing. Imaging revealed progressive pneumonia with intrathoracic lymphadenopathy. Initial testing yielded a positive Histoplasma urine antigen; however, fungal culture confirmed Blastomyces helicus. The dog improved on itraconazole, with normalization of clinical signs, C-reactive protein, imaging, and antigen tests. This case highlights diagnostic challenges of cross-reactivity in fungal antigen testing and emphasizes the importance of fungal culture in definitive diagnosis.