一种罕见真菌的新诊断方法:FcMBL有助于免疫功能低下新生儿异常柳条霉菌的鉴定

IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Mycology Case Reports Pub Date : 2023-10-21 DOI:10.1016/j.mmcr.2023.100614

Conor J. Higgins , Kerry-Anne Kite , Nigel Klein , Michael Super , Michael T. McCurdy , Darren Hargrave

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引用次数: 0

摘要

真菌血症对患者预后有负面影响，目前的诊断方法缺乏识别新出现的罕见真菌病的敏感性，真菌感染的患病率、种类和耐药性都在增加。我们报告了一例免疫功能低下的新生儿中的异常Wickerhamomyces，其中FcMBL珠状基质辅助激光解吸/电离飞行时间(MALDI-TOF)质谱(MS)在标准病原体鉴定方法前大约30小时进行了物种鉴定。采用基于FcMBL珠的MALDI-TOF质谱可以提高鉴定的速度和准确性，从而提高罕见病原体的治疗。

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A novel diagnostic method for a rare fungus: FcMBL facilitates Wickerhamomyces anomalus identification in an immunocompromised neonate

Fungemia negatively impacts patient outcomes, current diagnostics lack sensitivity to identify emerging rare mycoses, and fungal infections are increasing in prevalence, variety, and resistance. We report a case of Wickerhamomyces anomalus in an immunocompromised neonate in which FcMBL bead-based matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) resulted in species identification roughly 30 hours before standard pathogen identification methods. Deploying FcMBL bead-based MALDI-TOF MS may improve the speed and accuracy of identification, and therefore treatment, of rare pathogens.

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来源期刊

Medical Mycology Case Reports MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

47 days